Online Trial Tracker - Larvol Sigma

Trial + Data / Events

Status

Region

Interventions

Sponsor

Conditions

Primary compl

Study compl

dacarbazine / Generic mfg.

2010-023484-17: Sarcomas de partes blandas localizados de alto riesgo de extremidades y pared de tronco en adultos: un enfoque integrador que incluye tratamiento con medicamentos antitumorales estándar comparado con tratamientos específicos para las diferentes variedades histológicas como primer tratamiento.

Ongoing

250

Europe

epirrubicina, ifosfamida, Gemcitabina, Docetaxel, Etoposido, FARMIBLASTINA, Dacarbazina, epirubicin, ifosfamide, gemcitabine, docetaksel, etoposide, dacarbazine, epirubicin, ifosfamide, gemcitabine, docetaksel, etoposide, dacarbazine

ITALIAN SARCOMA GROUP, Grupo Español de Investigación en Sarcomas, Italian Sarcoma Group, , Grupo Español de Investigación en Sarcomas, NHS (diagnostic and therapeutic procedures), Eurosarc, funded by project/grant FP7

High risk localized soft tissue sarcomas typical of the adult

2019-003014-13: Interest of peri operative CHemotherapy In patients with CINSARC high-risk localized grade 1 or 2 Soft Tissue Sarcoma. Intérêt de la chimiothérapie péri-opératoire chez les patients porteurs de sarcomes des tissus mous localisés de grade 1 ou 2, définis à HAUT RISQUE par la signature CINSARC.

Not yet recruiting

600

Europe

DOXORUBICIN, IFOSFAMIDE, DACARBAZINE, Solution for infusion, Powder for solution for injection, Powder for solution for infusion

INSTITUT CLAUDIUS REGAUD, Direction Générale de l’Offre de Soins (DGOS)

Soft Tissue Sarcoma Sarcome des tissus mous, Soft Tissue Sarcoma Sarcome des tissus mous, Diseases [C] - Cancer [C04]

APROMISS, NCT03016819 / 2017-001655-31: Phase III Trial of Anlotinib, Catequentinib in Advanced Alveolar Soft Part Sarcoma, Leiomyosarcoma, Synovial Sarcoma

Active, not recruiting

325

Europe, US, RoW

AL3818, Catequentenib, Anlotinib, Dacarbazine, DTIC, AL3818 or placebo

Advenchen Laboratories, LLC

Alveolar Soft Part Sarcoma, Leiomyosarcoma, Synovial Sarcoma, Soft-Tissue Sarcoma

12/24

06/25

ISG-STS-1001, NCT01710176: Localized High-Risk Soft Tissue Sarcomas Of The Extremities And Trunk Wall In Adults: An Integrating Approach Comprising Standard Vs Histotype-Tailored Neoadjuvant Chemotherapy

Active, not recruiting

550

Europe

epirubicin 60 mg/m2/day (days 1, 2) and ifosfamide 3 g/m2/day (days 1, 2, 3), gemcitabine 900 mg/m2 (days 1 and 8) and docetaxel 75 mg/m2 (day 8), trabectedin 1.3 mg/m2, high-dose ifosfamide 14 g/m2, given in in 14 days, etoposide 150 mg/m2/day (days 1, 2, 3) and ifosfamide 3g/m2/day (days 1, 2, 3), gemcitabine 1800 mg/m2 (day 1) and dacarbazine 500 mg/m2 (day 1)

Italian Sarcoma Group, French Sarcoma Group, Grupo Espanol de Investigacion en Sarcomas

Localized High-risk Soft Tissue Sarcomas of the Extremities and Trunk Wall in Adults

06/24

CIRSARC, NCT03805022: Benefit of Intensified Peri-operative Chemotherapy Within High-risk CINSARC Patients With Resectable Soft-tissue Sarcomas

Recruiting

351

Europe

Doxorubicin, Ifosfamide or dacarbazine, At the discretion of the investigator

Institut Bergonié, Novartis, Chugai Pharma France

Non-metastatic Soft-tissue Sarcoma, Resectable

02/25

SUNRISELMS, NCT05269355: A Study of Unesbulin in Participants With Advanced Leiomyosarcoma (LMS)

Active, not recruiting

2/3

360

Europe, Canada, US, RoW

Unesbulin, PTC596, Dacarbazine, DTIC, Placebo

PTC Therapeutics

Leiomyosarcoma

06/24

FLASH, NCT04733183: Efficacy and Safety of L19TNF in Previously Treated Patients With Advanced Stage or Metastatic Soft-tissue Sarcoma

Recruiting

Europe

Dacarbazine, DTIC, onfekafusp alfa, L19TNF

Philogen S.p.A.

Soft Tissue Sarcoma

12/24

NCT04727242: CytoreductiveSurgery & HIPEC w/Gemcitabine+Chemotherapy w/Dacarbazine in Uterine Leiomyosarcoma

Recruiting

Gemcitabine, Gemzar, Infugem, difluorodeoxycytidine hydrochloride, Dacarbazine, Dimethyl (triazeno) imidazolecarboxamide, Dacarbazine - DTIC, Biocarbazine, Cytoreductive Surgery, Functional Assessment of Cancer Therapy (FACT) G questionnaire, Computed Tomography (CT) or Magnetic Resonance Imaging (MRI) Scan, Gadolinium

Kristen Ganjoo

LMS - Leiomyosarcoma, Uterine Leiomyosarcoma

01/25

TAGGED, NCT04535271: Metronomic Trabectedin, Gemcitabine, and Dacarbazine for Leiomyosarcoma

Recruiting

Trabectedin, Gemcitabine, Dacarbazine

Sarcoma Oncology Research Center, LLC

Leiomyosarcoma

09/24

12/24

ImmunoSarc, NCT03277924 / 2016-004040-10: Trial of Sunitinib and/or Nivolumab Plus Chemotherapy in Advanced Soft Tissue and Bone Sarcomas

Recruiting

1/2

270

Europe

Sunitinib 37.5 MG, Sunitinib 25 MG [Sutent], Sutent, Nivolumab 100 MG/10 ML [Opdivo], Opdivo, Epirubicin, Ifosfamide, Doxorubicin, Dacarbazine, Cisplatin, Methotrexate

Grupo Espanol de Investigacion en Sarcomas

Soft Tissue Sarcoma, Bone Sarcoma

06/25

NCT03761095: A Study of Unesbulin (PTC596) in Combination With Dacarbazine in Participants With Advanced Leiomyosarcoma (LMS)

Completed

Unesbulin, PTC596, Dacarbazine, DTIC

PTC Therapeutics

Leiomyosarcoma

02/24

NCT04893356: Impact of O6-methylguanine-DNA Methyltransferase (MGMT) Promoter Methylation and MGMT Expression on Dacarbazine Treated Sarcoma Patients (MGMT)

Active, not recruiting

N/A

Europe

O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation and MGMT expression on dacarbazine treated sarcoma patients

National Cancer Institute, Naples

Sarcoma

02/22

01/25



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