Neoplasms, Connective and Soft Tissue  >>  melphalan  >>  Phase 2
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9 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
melphalan / Generic mfg.
NCT00165139: Intensive Chemo-Radiotherapy With Peripheral Blood Progenitor Cell Rescue for Children With Advanced Neuroblastoma and Sarcomas

Completed
2
20
US
Vincristine, Cyclophosphamide, Adriamycin, Etoposide (VP-16), Cisplatin, Carboplatin, Melphalan, Ifosfamide, G-CSF (granulocyte-colony stimulating factor), Mesna
Dana-Farber Cancer Institute, Boston Children's Hospital, Children's Hospital of Philadelphia
Neuroblastoma, Ewings Sarcoma, Non-rhabdomyosarcoma Soft Tissue Sarcoma
11/00
02/09
NCT00001335: New Therapeutic Strategies for Patients With Ewing's Sarcoma Family of Tumors, High Risk Rhabdomyosarcoma, and Neuroblastoma

Completed
2
90
US
ADR-529, Topotecan, G-CSF
National Cancer Institute (NCI)
Ewing's Sarcoma, Neuroblastoma, Rhabdomyosarcoma
 
01/02
NCT00019968: Isolated Limb Perfusion of Melphalan With or Without Tumor Necrosis Factor in Treating Patients With Soft Tissue Sarcoma of the Arm or Leg

Completed
2
NA
melphalan, tumor necrosis factor
National Institutes of Health Clinical Center (CC)
Stage IVB Adult Soft Tissue Sarcoma, Stage IIB Adult Soft Tissue Sarcoma, Stage IIC Adult Soft Tissue Sarcoma, Recurrent Adult Soft Tissue Sarcoma, Stage IVA Adult Soft Tissue Sarcoma, Stage III Adult Soft Tissue Sarcoma
 
03/02
NCT00004250: Isolated Limb Infusion of Chemotherapy in Treating Patients With Melanoma or Soft Tissue Sarcoma of the Arm or Leg That Cannot Be Removed By Surgery

Completed
2
35
US
dactinomycin, isolated limb perfusion, melphalan
Memorial Sloan Kettering Cancer Center, National Cancer Institute (NCI)
Melanoma (Skin), Sarcoma
06/07
 
NCT00043979: Stem Cell Transplantation in Patients With High-Risk and Recurrent Pediatric Sarcomas

Completed
2
60
US
F-18 Fluorodeoxyglucose, FDG, therapeutic allogeneic lymphocytes, cyclophosphamide, Cytoxan, cyclosporine, Sandimmune, doxorubicin hydrochloride, Adriamycin, etoposide, Vepesid, fludarabine phosphate, Fludara, melphalan, Alkeran, prednisone, Deltasone, sirolimus, Rapamune, tacrolimus, Prograf, vincristine sulfate, Oncovin, peripheral blood stem cell transplantation, PBSCT, Filgrastim, Peripheral Blood Stem Cell donation
National Cancer Institute (NCI)
Sarcoma
05/09
12/11
NCT00357396: Busulfan, Melphalan, and Thiotepa Followed By a Donor Stem Cell Transplant in Treating Patients With High-Risk Ewing's Tumors

Completed
2
10
US
graft versus host disease prophylaxis/therapy, busulfan, melphalan, thiotepa, allogeneic bone marrow transplantation, allogeneic hematopoietic stem cell transplantation, peripheral blood stem cell transplantation
Memorial Sloan Kettering Cancer Center, National Cancer Institute (NCI)
Sarcoma
10/09
10/09
NCT00002601: Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Sarcoma

Completed
2
13
US
filgrastim, cisplatin, doxorubicin hydrochloride, ifosfamide, melphalan, peripheral blood stem cell transplantation
City of Hope Medical Center, National Cancer Institute (NCI)
Sarcoma
09/14
09/14
NCT02259348: Repeat Transplantation for Relapsed or Refractory Hematologic Malignancies Following Prior Transplantation

Terminated
2
12
US
Cyclophosphamide, Cytoxan, Fludarabine, Fludara, Fludarabine monophosphate, G-CSF, Filgrastim, Neupogen®, Interleukin-2, IL-2, Aldesleukin, Melphalan, L-phenylalanine mustard, Phenylalanine mustard, L-PAM, L-sarcolysin, Alkeran®, Thiotepa, ThioplexV, TESPA, TSPA, Rituximab, Rituxan™, Natural killer cell therapy, NK cell therapy, T-cell depleted HPC transplant, HPC,A Infusion(ɑ/β T cell depleted), CD45RA-depleted HPC transplant
St. Jude Children's Research Hospital
Acute Lymphoblastic Leukemia (ALL), Acute Myeloid Leukemia (AML), Myeloid Sarcoma, Chronic Myelogenous Leukemia (CML), Juvenile Myelomonocytic Leukemia (JMML), Myelodysplastic Syndrome (MDS), Non-Hodgkin Lymphoma (NHL)
04/15
03/16
NCT00003425: Phase I/II Study of Escalating-Dose Melphalan w/Autologous SCS & Amifostine Cytoprotect

Completed
1/2
25
US
filgrastim, amifostine trihydrate, WR-2721, cyclophosphamide, melphalan, peripheral blood stem cell transplantation
University of Kentucky
Breast Cancer, Leukemia, Lymphoma, Neuroblastoma, Ovarian Cancer, Sarcoma, Unspecified Adult Solid Tumor, Protocol Specific
07/02
 

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