Sarcoma  >>  Xpovio (selinexor)  >>  Phase 2
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6 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Xpovio (selinexor) / Karyopharm
NCT05333458: Testing Atezolizumab With or Without Selinexor in Patients >= 18 Years Old With Alveolar Soft Part Sarcoma, the Axiom Study

Recruiting
2
77
US
Atezolizumab, MPDL 3280A, MPDL 328OA, MPDL-3280A, MPDL3280A, MPDL328OA, RG7446, RO5541267, Tecentriq, Biopsy, BIOPSY_TYPE, Bx, Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Selinexor, ATG-010, CRM1 Nuclear Export Inhibitor KPT-330, KPT-330, Nexpovio, Selective Inhibitor of Nuclear Export KPT-330, SINE KPT-330, Xpovio
National Cancer Institute (NCI)
Advanced Alveolar Soft Part Sarcoma, Advanced Soft Tissue Sarcoma, Metastatic Alveolar Soft Part Sarcoma, Unresectable Alveolar Soft Part Sarcoma
05/25
05/25
SeliSarc, NCT06114004: Selinexor Plus Gemcitabine in Selected Advanced Soft-tissue Sarcoma

Recruiting
2
88
Europe
Selinexor 20 MG, KPT-330, Gemcitabine
Asociación Europea y Latinoamericana SELNET para la Investigación en Sarcomas
Sarcoma,Soft Tissue
05/26
05/26
NCT05985161: A Study of Selinexor in People With Wilms Tumors and Other Solid Tumors

Recruiting
2
36
US
Selinexor
Memorial Sloan Kettering Cancer Center
Wilms Tumor, Rhabdoid Tumor, Malignant Peripheral Nerve Sheath Tumors, MPNST, Nephroblastoma, XPO1 Gene Mutation, Solid Tumor
08/29
08/29
2017-004761-28: A study of selinexor in combination with imatinib in patients with metastatic and/or unresectable gastrointestinal tumors (GISTs) Estudio de Selinexor en combinación con imatinib en pacientes con tumores gastrointestinales (GISTs) metastasicos o irresecables

Not yet recruiting
1/2
41
Europe
Selinexor, Glivec, KTP-330, STI571, Coated tablet, Tablet, Glivec
Grupo Español de Investigación en Sarcomas, Karyopharm
Gastrointestinal stromal tumor (GIST) Tumor del estroma gastrointestinal, Gastrointestinal stromal tumor (GIST) is a rare cancer affecting the digestive tract or nearby structures within the abdomen. Tumor del estroma gastrointestinal es un cancer raro que afecta el tracto digestivo y otras estructuras adyacentes en el abdomen, Diseases [C] - Cancer [C04]
 
 
SeliGIST, NCT04138381: Selinexor as Single Agent and With Imatinib in Metastatic and/or Unresectable Gastrointestinal Stromal Tumors

Active, not recruiting
1/2
30
Europe
Selinexor, Drug Combination, Single agent, Imatinib
Grupo Espanol de Investigacion en Sarcomas
Maximum Tolerated Dose, GIST, Metastatic Adult Soft Tissue Sarcoma, Drug Toxicity, Drug Use
04/23
04/23
NCT06239272: NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS)

Recruiting
1/2
139
US
Surgical resection, Proton beam radiation therapy, Pazopanib, VOTRIENT®, Ifosfamide, Ifex, Doxorubicin, Adriamycin®, Rubex®, Selinexor, XPOVIO®
St. Jude Children's Research Hospital
Non-rhabdomyosarcoma, Adipocytic Neoplasm, Liposarcoma
06/34
06/37

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