| Creon (pancrelipase delayed-release) / AbbVie, Eisai |
| Recruiting | 4 | 24 | | | Box Hill Hospital Department of Surgery, Box Hill Hospital Surgical department | Pancreatic exocrine insufficiency (PEI) | | | | |
NCT00957151: Evaluation of the Digestive and Metabolic Utilisation of Dietary Protein in Patients With Chronic Pancreatitis |
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| Completed | 4 | 12 | Europe | Creon | Hospital Avicenne, Solvay Pharmaceuticals | Chronic Pancreatitis | 08/05 | 08/05 | | |
NCT00160186: Gastrectomy Study: Study to Investigate the Effect of Creon 25000 Minimicrospheres on Body Mass Index (BMI) in Patients After Gastrectomy |
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| Completed | 4 | 40 | Europe | Pancreatin, Placebo | Solvay Pharmaceuticals | Gastrectomy | 05/06 | 05/06 | | |
| Completed | 4 | 58 | Europe | Creon, Placebo | Abbott Products, Quintiles, Inc., Data Map GmbH | Pancreatic Insufficiency | 06/11 | 06/11 | | |
2013-002748-10: Clinical trial to assess the efficacy of pancreatic enzyme replacement therapy in patients with pancreatic exocrine insufficiency secondary to type 1 diabetes mellitus. Ensayo clínico para evaluar la eficacia del tratamiento sustitutivo con enzimas pancreáticas en pacientes con insuficiencia pancreática exocrina secundaria a diabetes mellitus tipo 1 |
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| Ongoing | 4 | 50 | Europe | Creon 25.000, PL 00512/0150, Capsule, Kreon 25.000 | Fundación para la Investigación en Enfermedades del Aparato Digestivo, Fundación para la Investigación en Enfermedades del Aparato Digestivo | Patients with pancreatic exocrine insufficiency (PEI) secondary to type 1 diabetes mellitus (DM) Pacientes con insuficiencia pancreática exocrina (IPE) secundaria a diabetes mellitus (DM) tipo 1, Patients with type 1 diabetes mellitus and maldigestion Pacientes con diabetes mellitus tipo 1 y maldigestión, Diseases [C] - Digestive System Diseases [C06] | | | | |
| Terminated | 4 | 2 | Europe | Creon, Placebo | Sheffield Teaching Hospitals NHS Foundation Trust | Patients With Coeliac Disease and Chronic Diarrhoea (>3 Loose/ Liquid Motions a Day for More Than 4 Weeks), Patients With Pancreatic Exocrine Insufficiency | 08/14 | 08/14 | | |
NCT02009410 / 2013-001347-31: A Study to Assess the Effect of Creon® on Pancreatic Exocrine Insufficiency in Subjects With Diabetes Mellitus Type 2 |
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| Withdrawn | 4 | 0 | Europe | Creon, Creon 25000 matching Placebo | Abbott, Nuvisan, Datamap, ClinIntel, Catalent | Exocrine Pancreatic Insufficiency in Subjects With Diabetes Mellitus Type 2 | 08/14 | 08/14 | | |
2008-005993-12: A three month double-blind, randomized, placebo-controlled, parallel group, multi-center study with Creon® 25.000 MMS? in subjects after an attack of acute pancreatitis suffering from pancreatic exocrine insufficiency, followed by an open-label long-term extension of nine months.Estudio multicéntrico, aleatorizado, doble ciego, controlado conplacebo, de grupos paralelos y de tres meses de duración conCreon® 25.000 MMS en sujetos afectados por una insuficiencia pancreática exocrina tras un episodio de pancreatitis aguda, seguido de una extensión a largo plazo en régimen abierto de nueve meses. |
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| Terminated | 4 | 124 | Europe | Capsule*, Creon forte | Solvay Pharmaceutical GmbH | Pancreatic exocrine insufficiency after acute pancreatitis.Insuficiencia pancreática exocrina tras un episodio de pancreatitis aguda. | | | | |
2013-005310-35: Pancreatic enzyme replacement therapy (PERT) in subjects with pancreatic exocrine insufficiency (PEI) after acute necrotizing pancreatitis tratamiento sustitutivo con enzimas pancreáticas (TSEP) en sujetos tras un episodio de pancreatitis aguda necrotizante que padecen insuficiencia exocrina pancreática (IPE) |
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| Ongoing | 4 | 68 | Europe | Creon 25000, PL 00512/0150, Capsule, Kreon 25.000 | Fundación para la Investigación en Enfermedades del Aparato Digestivo, Fundación para la Investigación en Enfermedades del Aparato Digestivo | Patients 2 weeks after discharge from the hospital after an attack of acute necrotizing pancreatitis Pacientes dos semanas tras el alta hospitalaria despues de un episodio de pancreatitis aguda necrotizante, Patients after an attack of acute necrotizing pancreatitis Pacientes tras un episodio de pancreatitis aguda necrotizante, Diseases [C] - Digestive System Diseases [C06] | | | | |
2015-002570-20: Optimizing treatment of maldigestion in patients with chronic pancreatitis |
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| Ongoing | 4 | 30 | Europe | Creon 25000, PL 00512/0150, Capsule, Kreon 25000 | Department of gastroenterology. University Hospital of Santiago, Dpt. of Gastroenterology. University Hospital of Santiago | Patients diagnosed of chronic pancreatitis with pancreatic exocrine insufficiency under pancreatic enzyme replacement therapy Pacientes diagnosticados de pancreatitis crónica con insuficiencia pancreática exocrina bajo tratamiento enzimático sustitutivo, Pancreatic exocrine insufficiency (maldigestion) in patients with chronic pancreatitis Insuficiencia pancreática exocrina en pacientes con pancreatitis crónica, Diseases [C] - Digestive System Diseases [C06] | | | | |
2018-000242-19: Preoperative supplementation of pancreatic enzymes for Whipple’s procedure for malignancies (PREPARE). |
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| Ongoing | 4 | 128 | Europe | Creon 25000, Capsule, hard, Creon 25000 | University Hospitals Southampton NHS Trust, Mylan Products, Abbott Laboratories Hannover, Catalent Schorndorf | Patients undergoing Whipple’s procedure for pancreatic head tumours, Whipple procedure is a major surgical operation involving resection of the pancreas, duodenum, and other organs. This operation is performed to treat cancerous tumours on the head of the pancreas., Diseases [C] - Cancer [C04] | | | | |
2017-001227-45: Pancreatic replacement therapy and glycaemic control in diabetes |
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| Completed | 4 | 18 | Europe | Creon, Capsule, Creon | Portsmouth Hospitals NHS Trust, Mylan | Type 1 diabetes and type 2 diabetes mellitusPancreatic exocrine insufficiency, DiabetesPancreatic insufficiency, Diseases [C] - Hormonal diseases [C19] | | | | |
NCT04315311: Study Of Effects Of Oral CREON Capsules In Adult Participants With Exocrine Pancreatic Insufficiency Not Due To Cystic Fibrosis, Chronic Pancreatitis, Pancreatectomy, Or Pancreatic Cancer |
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| Withdrawn | 4 | 0 | NA | CREON, Pancrelipase, ABT-SLV245 | AbbVie | Exocrine Pancreatic Insufficiency (EPI) | 09/21 | 09/21 | | |
NCT03859869: A Study of Creon (Pancrelipase) in Resected and Non-resected Pancreatic Cancer Participants With Exocrine Pancreatic Insufficiency (EPI) |
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| Terminated | 4 | 1 | US | Pancrelipase, Creon, Placebo | AbbVie | Exocrine Pancreatic Insufficiency (EPI) | 03/22 | 03/22 | | |
2021-005874-24: Clinical trial to evaluate the efficacy of the oral treatment with pancreatic enzymes in patients with pancreatic cancer, who are not suitable for surgical therapy. Ensayo clínico para evaluar el impacto del tratamiento oral con enzimas pancreáticas en pacientes con cáncer de páncreas que no son candidatos a intervención quirúrgica. |
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| Ongoing | 4 | 100 | Europe | Creon / Kreon 35000, Capsule, Creon 35,000 | Juan Enrique Domínguez Muñoz, Viatris | pancreatic exocrine insufficiency (PEI) in patients with unresectable pancreatic cancer., controlled trial of pancreatic enzyme replacement therapy (PERT) for pancreatic exocrine insufficiency (PEI) in patients with unresectable pancreatic cancer., Diseases [C] - Digestive System Diseases [C06] | | | | |
NCT03924947: A Study to Compare US Marketed Creon Manufactured With a Modernized Process at an Alternate Manufacturing Site and Manufactured With the Approved Manufacturing Process at an Alternate Active Pharmaceutical Ingredient Site, in Participants With Exocrine Pancreatic Insufficiency Due to Cystic Fibrosis |
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| Completed | 4 | 36 | US | Pancrelipase, Creon, ABT-SLV-245, Creon MP, Creon AAPIS | AbbVie | Cystic Fibrosis | 07/22 | 07/22 | | |
NCT05069597: Study to Evaluate Symptoms of Exocrine Pancreatic Insufficiency in Adult Participants With Cystic Fibrosis or Chronic Pancreatitis Treated With Creon |
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| Completed | 4 | 30 | US | CREON, Pancrelipase | AbbVie | Cystic Fibrosis, Chronic Pancreatitis | 07/23 | 08/23 | | |
PERT-AP, NCT06477159: Pancreatic Enzyme Replacement Therapy for Acute Pancreatitis-Associated Exocrine Pancreatic Insufficiency |
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| Recruiting | 4 | 60 | US | Pancrelipase Capsules, CREON | Ohio State University, University of Pittsburgh, University of Illinois Chicago, University of Southern California, New York University, AbbVie | Exocrine Pancreatic Insufficiency | 12/26 | 07/27 | | |
| Recruiting | 4 | 100 | Europe | creon 35.000 Ph.U (R), Best Standarard of Care | Hospital Clinico Universitario de Santiago, Complejo Hospitalario de Navarra, Karolinska Institutet, San Raffaele University Hospital, Italy, Beaujon Hospital | Unresectable Pancreatic Cancer | 06/26 | 12/26 | | |
