Active, not recruiting

4

550

 

University of New South Wales/Kirby Institute, University of New South Wales/Kirby Institute, Abbott, Merck Sharpe & Dohme, amfAR

Human Immunodeficiency Virus (HIV) -1 infection

 

 

Ongoing

4

30

Europe

Kaletra, Film-coated tablet, Kaletra

The Newcastle upon Tyne Hospitals NHS Foundation Trust, AbbVie Limited

Cognitive function and sleep pattern in HIV-1 patients, HIV-1 infection, Diseases [C] - Immune System Diseases [C20]

 

 

Ongoing

4

200

Europe

VIRAMUNE*60CPR 200MG, REYATAZ*60CPS 150MG, KIVEXA*BL 30CPR RIV 600MG+300M, NORVIR*4FL 84CPS MOLLI 100MG, KALETRA*BLIST 180CPS MOLLI, VIRAMUNE*60CPR 200MG, REYATAZ*60CPS 150MG, KIVEXA*BL 30CPR RIV 600MG+300M, NORVIR*4FL 84CPS MOLLI 100MG, KALETRA*BLIST 180CPS MOLLI

AZIENDA OSPEDALIERA DI BOLOGNA POLICLINICO S. ORSOLA M. MALPIGHI

HIV infection Infezione da HIV

 

 

Ongoing

4

92

Europe

Kaletra, Truvada, Kaletra, Truvada, Zidovudina, Kaletra, Truvada, Zidovudina

Dr. Miguel Cervero

Pacientes diagnosticados de infección por VIH con CD4 < 100 células/microlitro, que comienzan por primera vez tratamiento antirretrovial.

 

 

Ongoing

4

32

Europe

KALETRA, KIVEXA, REYATAZ, TRUVADA, NORVIR, KALETRA, KIVEXA, REYATAZ, TRUVADA, NORVIR

AZIENDA OSPEDALIERA S. GERARDO DI MONZA

HIV infection

 

 

Ongoing

4

112

Europe

Dolutegravir, Darunavir, Atazanavir, Kaletra, Ritonavir, Fosamprenavir, INVIRASE, Tivicay, Prezista, Reyataz, Kaletra, Norvir, Telzir, Invirase, Tivicay, Prezista, Reyataz, Kaletra, Norvir, Telzir, Invirase

St Stephen\'s AIDS Trust, NEAT-ID, Viiv Healthcare Ltd

HIV infection

 

 

Ongoing

4

108

Europe

Tablet, Lopinavir/Ritonavir Accord, Dolquine, Zitromax

Basque Health Service, Basque Health Service

Covid-19 infection Infección por Covid-19, Covid-19 infection Infección por Covid-19, Diseases [C] - Virus Diseases [C02]

 

 

Not yet recruiting

4

205

 

oral chloroquine phosphate ;oral Lopinavir/ritonavir ;chloroquine phosphate plus Lopinavir/ritonavir ;oral chloroquine phosphate ;oral Lopinavir/ritonavir

The Fifth Affiliated Hospital of Sun Yat-Sen University; The Fifth Affiliated Hospital of Sun Yat-Sen University, Self fund-raising

novel coronavirus pneumonia (COVID-19)

 

 

Recruiting

4

90

 

On the basis of routine medical treatment, the patients were given Novaferon Atomization inhalation, 20ug each time, twice a day, 7-14 days. ;On the basis of routine medical treatment, the patients were given lopinavir / ritonavir tablets (Kaletra) twice a day, twice each time, 7-14 days. ;On the basis of routine medical treatment, combined with Novafron and Kaletra, the usage and course of treatment are the same as above.

The First Hospital of Changsha; The Second Xiangya Hospital of Central South University; The First Hospital of Changsha, Self financing and application for scientific research funds

Novel Coronavirus Pneumonia (COVID-19)

 

 

Recruiting

4

150

RoW

Remdesivir, Hydroxychloroquine, Tocilizumab, Actemra, Lopinavir/ Ritonavir, kaletra, Ivermectin, Iverazine

October 6 University, Beni-Suef University

Covid19, Pneumonia

03/21

04/21

Not yet recruiting

4

200

 

Zidovudine 300mg twice daily / tenofovir 300mg once daily + lamivudine 300mg once daily + nevirapine 200mg twice daily / efavirenz 600mg once daily ;Lopinavir/ritonavir 500mg twice daily + lamivudine 300mg once daily

The Fifth Affilated Hosipital Of Sun Yat-sen University; The Fifth Affiliated Hosipital Of Sun Yat-sen University, Hospital funding and self-finacing

AIDS

 

 

 

3/4

2

Europe

NA, NA, INVIRASE*270 CPS 200 MG, NORVIR*336 CPS MOLLI 100 MG, CRIXIVAN*180 CPS 400 MG, VIRACEPT*270 CPR 250 MG, FORTOVASE*180 CPS 200 MG, AGENERASE*240 CPS 150 MG, KALETRA*180 CPS BLISTER, VIRAMUNE*60 CPR 200 MG, SUSTIVA*90 CPS 200 MG, RETROVIR* 28 CPR 300 MG, VIDEX 400*30 CPS 400 MG, HIVID 0,750*100 CPR 0,750 MG, ZERIT 40*56 CPS 40 MG, EPIVIR*60 CPR 150 MG, COMBIVIR*60CPR BL 150/300MG, ZIAGEN*60 CPR RIV. 300 MG, TRIZIVIR*60 CPR RIV. BLISTER, VIREAD*30 CPR 245 MG, FUZEON*90MG/ML 60FL+60FL+60S

National Institute of Allergy and Infectious Diseases, National Institutes of Health, COMMUNITY PROGRAMS FOR CLINICAL RESEARCH ON AIDS

HIV infection

 

 

Ongoing

3

50

Europe

KALETRA, COPEGUS, PEGASYS, KALETRA, COPEGUS, PEGASYS

OSPEDALE S. RAFFAELE

patients affected by HIV and chronic HCV or compensated cirrhosis

 

 

 

3

32

Europe

Kaletra (Lopinavir Ritonavir), MK-0518, KALETRA, KALETRA

Merck Sharp & Dohme de España, S.A., Merck & Co., Inc., Merck Sharp & Dohme Limited, MERCK SHARP DOHME, Merck Sharp & Dohme, Lda.

HIV Infection

 

12/08

Ongoing

3

1000

Europe

Coated tablet, Capsule, Dolquine 200 mg comprimidos recubiertos., azitromicina cinfa 500 mg comprimidos, Kaletra

Fundación para la investigación Biomedica Hospital Universitario La Paz, Servicio de Farmacología Clínica. Unidad de Ensayos Clínicos (UCICEC)

Patients infected with COVID19 Pacientes infectados con COVID19, Patients infected with COVID19 Pacientes infectados con COVID19, Diseases [C] - Virus Diseases [C02]

 

 

Ongoing

3

100000

Europe

remdesivir, Lyophilisate for solution for infusion, Coated tablet, Powder and solution for solution for injection, Kaletra, Rebif, Plaquenil

Masaryk University, World Health Organisation, Masaryk University

COVID-19 COVID-19, COVID-19 COVID-19, Diseases [C] - Virus Diseases [C02]

 

 

Active, not recruiting

3

123

Canada

Lopinavir/ritonavir, Kaletra, Aluvia

Unity Health Toronto

Coronavirus Infections, Post-exposure Prophylaxis

08/21

03/22

Completed

3

1552

Europe

Remdesivir, Lopinavir/ritonavir, Interferon Beta-1A, Hydroxychloroquine, Standard of care, AZD7442, Placebo

Institut National de la Santé Et de la Recherche Médicale, France

Corona Virus Infection

07/22

09/23

Recruiting

3

20000

Europe, Canada, Japan, US, RoW

Ceftriaxone, Moxifloxacin or Levofloxacin, Piperacillin-tazobactam, Ceftaroline, Amoxicillin-clavulanate, Standard course macrolide, Extended course macrolide, No systemic corticosteroid, Fixed-duration Hydrocortisone, Shock-dependent hydrocortisone, Fixed-duration higher dose Hydrocortisone, No antiviral agent for influenza, Five-days oseltamivir, Ten-days oseltamivir, No antiviral agent for COVID-19, Lopinavir / Ritonavir, Hydroxychloroquine, Hydroxychloroquine + lopinavir/ritonavir, Ivermectin, No immune modulation for COVID-19, Interferon beta-1a, IFN-β1a, Anakinra, Tocilizumab, Sarilumab, Local standard venous thromboprophylaxis, Therapeutic dose anticoagulation, Conventional low dose thromboprophylaxis, Intermediate dose thromboprophylaxis, Continuation of therapeutic dose anticoagulation, No immunoglobulin, Convalescent plasma, Delayed administration of convalescent plasma, No vitamin C, Vitamin C, No antiplatelet, Aspirin, acetylsalicylic acid, P2Y12 inhibitor, Clopidogrel, Prasugrel, Ticagrelor, No simvastatin, Simvastatin, Placebo, Eritoran, Apremilast, Clinician-preferred mechanical ventilation strategy, Protocolised mechanical ventilation strategy, No renin-angiotensin system inhibitor, Angiotensin converting enzyme inhibitor, Ramipril, Lisinopril, Perindopril, Enalapril, Trandolapril, Captopril, Angiotensin Receptor Blockers, Losartan, Valsartan, Candesartan, Irbesartan, Telmisartan, Olmesartan, ARB + DMX-200, No cysteamine, Cysteamine, Fixed-duration dexamethasone, Baloxavir Marboxil, Five-days oseltamivir + baloxavir marboxil, Ten-days oseltamivir + baloxavir marboxil, No endothelial modulator, Imatinib, No Immune Modulator for Influenza, Baricitinib, Nirmatrelvir/ritonavir, Paxlovid, Remdesivir, Nirmatrelvir/ritonavir + remdesivir

UMC Utrecht, Australian and New Zealand Intensive Care Research Centre, Medical Research Institute of New Zealand, Unity Health, Berry Consultants, Global Coalition for Adaptive Research, University of Pittsburgh Medical Center, Intensive Care National Audit & Research Centre, St. Marianna University School of Medicine, National Intensive Care Surveillance MORU, National University Hospital, Singapore

Community-acquired Pneumonia, Influenza, COVID-19

02/26

02/28

Active, not recruiting

2/3

67

RoW

Nevirapine, NVP, Kaletra, LPV/r, Lamivudine, 3TC, Zidovudine, ZDV

Harvard School of Public Health (HSPH), Ragon Institute of MGH, MIT and Harvard, Brigham and Women's Hospital, University of California, San Diego

HIV, Pediatric AIDS

11/20

06/29

Recruiting

2b

294

RoW

Lopinavir/Ritonavir 200 MG-50 MG Oral Tablet, LPV/r, Aluvia, Telmisartan 40Mg Oral Tablet, TMS, Micardis, Pritor, Atorvastatin 20 Mg Oral Tablet, ATV, Tahor

French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS), Université de Bordeaux, PACCI Program

COVID-19, COVID-19 Drug Treatment, Severe Acute Respiratory Syndrome Coronavirus 2

03/21

03/21

Ongoing

2

60

Europe

CELSENTRI, TRUVADA, KALETRA, CELSENTRI, TRUVADA, KALETRA

OSPEDALE S. RAFFAELE

naive HIV affected patients

 

 

Ongoing

2

240

Europe

Favipiravir, Lopinavir/ritonavir, Tablet, Lopinavir/ritonavir

University College London Comprehensive Clinical Trial Unit, LifeArc

SARS-CoV-2 (Corona virus) infection, COVID-19, Diseases [C] - Virus Diseases [C02]

 

 

Not yet recruiting

2

16

Europe

Kaletra, Ribavirin, Film-coated tablet, KALETRA - Filmtabletten 200 mg/50 mg, Ribavirin-ratiopharm® 200 mg Filmtabletten

Medizinische Universität Wien; Universitätsklinik für Klinische Pharmakologie, Medizinische Universität Wien

Healthy volunteers, Healthy volunteers, Diseases [C] - Virus Diseases [C02]

 

 

Recruiting

1/2

40

RoW

Wharton's jelly derived Mesenchymal stem cells., Hydroxychloroquine, lopinavir/ritonavir or azithromycin and placebo (standard therapy)

BioXcellerator, Clinical Somer

Acute Respiratory Distress Syndrome

12/21

04/22

Ongoing

1

48

Europe

Prezista 75mg filmcoated tablet, Prezista 150mg filmcoated tablet, Prezista 400 mg filmcoated tablet, Prezista 600mg filmcoated tablet, Prezista 100 mg/ml suspension for oral intake, Oral solution, Film-coated tablet, Kaletra (80mg + 20mg)/ ml, Kaletra 100 mg/25 mg, Kaletra 200 mg/50 mg, Norvir 100 mg, Norvir 80 mg/ml, PREZISTA 75 mg filmcoated tablets, PREZISTA 150 mg filmcoated tablets, PREZISTA 400 mg filmcoated tablets, PREZISTA 600 mg filmcoated tablets, PREZISTA 100 mg/ml suspension for oral intake

Decan of Medical Faculty of Goethe University Frankfurt, Ethic committee, university hospital goethe university, Hector foundation

Paediatric patients with diagnosed HIV1-infection aged 2 to 17 years paediatrische Patienten mit diagnostizierter HIV1-Infektion im Alter von 2 bis 17 Jahren, children between 2 and 17 years diagnosed HIV1-positive HIV1-positive Kinder im Alter von 2-17 Jahren, Diseases [C] - Virus Diseases [C02]

 

 

Recruiting

1

21

US

Lopinavir / Ritonavir

University of Wisconsin, Madison, Wisconsin Partnership Program

High-Grade Anal Intraepithelial Neoplasia

06/25

06/25

Completed

N/A

195

 

Tenofovir (TDF) + Kaletra (ritonavir and lopinavir mixture) + lamivudine (3TC)combination antiretroviral therapy ;Tenofovir (TDF) + Kaletra (ritonavir and lopinavir mixture) + lamivudine (3TC)combination antiretroviral therapy

Key Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital, China Medical University; Disease Prevention and Control Center of Henan Province, the Twelfth Five-Year Project on Tackling Key Problems of National Science and Technology (2012ZX10001002-002-013)

AIDS

 

 

Completed

N/A

237

 

abidor,lopinavir/ritonavir plus recombinant interferon alpha-2b(rIFN alpha-2b) ;,lopinavir/ritonavir plus recombinant interferon alpha-2b(rIFN alpha-2b)

Li Lanjuan; The First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang Key Research and Development Plan Emergency Project (2020C03123); National Major Projects of the 13th Five-year Plan ( 2017ZX10204401002008)

COVID-19

 

 

Recruiting

N/A

90

 

alpha-Interferon atomization ;Lopinavir and Ritonavir + alpha-Interferon atomization ;Favipiravir + alpha-Interferon atomization

The Third People's Hospital of Shenzhen; The Third People's Hospital of Shenzhen, Self-financing

novel coronavirus pneumonia (COVID-19)

 

 

Not yet recruiting

N/A

20

 

Routine treatment (Pure western medicine): Lopinavir-ritonavir tablet combined with recombinant human interferon alpha 2b injection ;(Integrated Chinese and western medicine): Lopinavir-ritonavir tablet combined with recombinant human interferon alpha 2b injection(routine treatment)+Qing-Wen Bai-Du-Yin formula granules

The 5th Medical Center Chinese PLA General Hospital; The 5th Medical Center Chinese PLA General Hospital, COVID-19 emergency research project of Chinese PLA general hospital

Novel Coronavirus Pneumonia (COVID-19)

 

 

 

 

 

 

Not yet recruiting

N/A

100

 

DRV/c (800mg/150mg QD) + Conventional treatment containing thymosin (1.6 mg SC QOD) ;LPV/r (400mg/100mg bid) + Conventional treatment containing thymosin (1.6 mg SC QOD) ;Conventional treatment containing thymosin (1.6 mg SC QOD)

Zhongnan Hospital of Wuhan University; Zhongnan Hospital of Wuhan University, self-financing

novel coronavirus pneumonia (COVID-19)

 

 

Recruiting

N/A

60

 

traditional Chinese medicine treatment ;Lopinavir / Ritonavir ;traditional Chinese medicine treatment and Lopinavir / Ritonavir

China Academy of Chinese Medical Sciences; China Academy of Chinese Medical Sciences, National Key Research and Development Program Fund (No.2020YFC0841500)

novel coronavirus pneumonia (COVID-19)

 

 

Recruiting

N/A

108

 

Ribavirin + Interferon alpha-1b ;lopinavir / ritonavir + interferon alpha-1b ;Ribavirin + LPV/r+Interferon alpha-1b

Chongqing Public Health Medical Center; Chongqing Public Health Medical Center, Chongqing Science and Technology Bureau

Novel Coronavirus Pneumonia (COVID-19)

 

 

Recruiting

N/A

106

Europe

Low-dose radiotherapy, Hydroxychloroquine Sulfate, Dolquine, Ritonavir/lopinavir, Kaletra, Tocilizumab Injection [Actemra], Actemra, Azithromycin, Corticosteroid, Low molecular weight heparin, Oxygen supply

Grupo de Investigación Clínica en Oncología Radioterapia, Hospital Universitario Madrid Sanchinarro, Hospital del Mar, Hospital Universitari Sant Joan de Reus

Pneumonia, Viral

09/21

11/21

Completed

N/A

1000

Europe

Any drug used to treat Covid-19

Groupe Hospitalier Pitie-Salpetriere, CMC Ambroise Paré

Coronavirus, Iatrogenic Disease, Acute Kidney Injury, ARDS, Human

01/23

01/23

Recruiting

N/A

5000

Canada, US

The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:, Aminocaproic acid, Amiodarone, Bosentan, Budesonide, Cefdinir, Cefepime, Ceftazidime, Clindamycin, Clobazam, Dexamethasone, Dexmedetomidine, Dextroamphetamine/Amphetamine, Fosfomycin, Furosemide, Gabapentin, Guanfacine, Hydrocortisone, Labetalol, Meropenem, Metformin, Milrinone, Nalbuphine, Nicardipine, Nifedipine, Oseltamivir, Oxycodone, Risperidone, Sertraline, Sevelamer Carbonate / Sevelamer Hydrochloride, Spironolactone, Terbutaline, Tranexamic acid, Voriconazole, Zolpidem, Azithromycin, Lopinavir/Ritonavir, Ribavirin, Tocilizumab, Anakinra, Aspirin, Canakinumab, Colchicine, Interferon, Remdesivir, Ruxolitinib, Sarilumab, Abatacept, Infliximab

Duke University, The Emmes Company, LLC, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension, Urinary Tract Infections in Children, Hypertension, Pain, Hyperphosphatemia, Primary Hyperaldosteronism, Edema, Hypokalemia, Heart Failure, Hemophilia, Menorrhagia, Insomnia, Pneumonia, Skin Infection, Arrythmia, Asthma in Children, Bronchopulmonary Dysplasia, Adrenal Insufficiency, Fibrinolysis; Hemorrhage, Attention Deficit Hyperactivity Disorder, Multisystem Inflammatory Syndrome in Children (MIS-C), Kawasaki Disease, Coagulation Disorder, Down Syndrome

Recruiting

N/A

325

US, RoW

Bictegravir (BIC), Tenofovir alafenamide (TAF), Cabotegravir (CAB), Dolutegravir (DTG), Atazanavir/ritonavir (ATV/r), Darunavir/ritonavir (DRV/r), Lopinavir/ritonavir (LPV/r), Cobicistat, Ritonavir, First-Line TB Treatment, Second-Line TB Treatment, Doravirine (DOR)

National Institute of Allergy and Infectious Diseases (NIAID), International Maternal Pediatric Adolescent AIDS Clinical Trials Group, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institute of Mental Health (NIMH), Gilead Sciences, ViiV Healthcare, Merck Sharp & Dohme LLC

HIV Infections, Tuberculosis

03/26

03/26