| Resolor (prucalopride) / J&J, Takeda |
2010-023996-25: The effect of fluoxetine and 5-HT4 serotonin receptor agonists on cerebral axonal energy metabolism and glutamate levels in multiple sclerosis. |
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| Ongoing | 4 | 32 | Europe | fluoxetine, Cisapride, Prucalopride, Coated tablet | | Multiple sclerosis (both relapsing remitting and progressive forms) | | | | |
| Completed | 4 | 364 | Europe, RoW | placebo, prucalopride | Shire | Constipation | 12/12 | 12/12 | | |
2012-004367-44: A STUDY TO COMPARE THE EFFECT OF A STIMULANT LAXATIVE (SODIUM PICOSULFATE) AND OF A PROKINETIC DRUG (PRUCALOPRIDE) ON SENSITIVITY AND MOTILITY OF THE LEFT COLON IN HEALTHY SUBJECTS |
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| Ongoing | 4 | 10 | Europe | SODIUM PICOSULFATE, PRUCALOPRIDE, Tablet, Coated tablet, GUTTALAX, RESOLOR | KU LEUVEN, KULEUVEN | SENSORY AND MOTOR RESPONSE OF DESCENDING COLON TO DISTENSION WILL BE STUDIED IN HEALTHY SUBJECTS, HEALTHY SUBJECTS, Body processes [G] - Physiological processes [G07] | | | | |
2013-002705-65: The effect of Prucalopride (Resolor) on the stomach motor function and the stomach sensitivity |
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| Ongoing | 4 | 20 | Europe | Resolor | TARGID, TARGID, KULeuven | Functional dyspepsia, Functional dyspepsia is a medical condition characterized by chronic or recurrent pain in the upper abdomen, upper abdominal fullness and feeling full earlier than expected when eating., Diseases [C] - Digestive System Diseases [C06] | | | | |
| Completed | 4 | 13 | Europe, US | prucalopride, Resolor (Marketed name in Europe), PEG 3350, Movicol | Shire | Chronic Constipation | 11/13 | 11/13 | | |
2014-000361-52: Pilot study: Anti-inflammatory effect of stimulation of the intestinal nervous system: a potential new therapy to accelerate gastric emptying |
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| Ongoing | 4 | 30 | Europe | Resolor, M0001, Film-coated tablet, Resolor | KULeuven, KULeuven | Patients undergoing pancreaduodenectomy due to benign or malignant tumor drug will be studied for prokinetic or anti-inflammatory effects, because they are known to influence gastrointestinal motility, Patients undergoing partial or full resection of the pancreas due to benign or malignant tumor, Body processes [G] - Digestive System and Oral Physiological Phenomena [G10] | | | | |
| Unknown status | 4 | 30 | Europe | prucalopride, Resolor, placebo | Universitaire Ziekenhuizen Leuven | Gastroparesis | 09/15 | | | |
2013-000821-30: CLINICAL RESPONSE TO 5HT4 RECEPTORS AGONIST (PRUCALOPRIDE): GASTROCOLIC REFLEX ESTUDIO DEL REFLEJO GASTROCOLICO: INFLUENCIA DE PRUCALOPRIDA |
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| Ongoing | 4 | 10 | Europe | Resolor, Resolor | Enrique Rey DÃaz-Rubio, fundacion investigación biomedica hospital clinico san carlos | chronic constipation estreñimiento cronico | | | | |
NCT03279341: Effect of PEG, Bisacodyl and Prucalopride on Colonic Motility in Healthy Subjects |
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| Completed | 4 | 10 | Europe | polyethylene glycol, macrogol, PEG, Bisacodyl, Dulcolax, Prucalopride, Resolor | University Hospital, Gasthuisberg | Chronic Constipation | 03/16 | 03/16 | | |
2012-005348-92: PROGASS PRucalopride On the GAstreonteric transit in Systemic Sclerosis PROGASS Studio per valutare l’effetto gastroenterico della Prucalopride in pazienti affetti da sclerosi sistemica |
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| Ongoing | 4 | 40 | Europe | RESOLOR*28CPR RIV 2MG, RESOLOR*28CPR RIV 2MG | FONDAZIONE IRCCS CA\' GRANDA OSPEDALE MAGGIORE POLICLINICO DI MILANO, Shire Italia S.p.A | Sysemic sclerosis with gastroenteric involvement (constipation) Sclerosi sistemica con interessamento gastroenterico (stipsi) | | | | |
NCT02228616: Efficacy and Safety of Prucalopride in Combination With Polyethylene Glycol or Lactulose in Women With Chronic Constipation |
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| Completed | 4 | 280 | RoW | Prucalopride, Polyethylene glycol (PEG), Lactulose | Xian-Janssen Pharmaceutical Ltd. | Constipation | 09/16 | 09/16 | | |
NCT02781493: Efficacy of Prucalopride Plus Polyethylene Glycol in Bowel Preparation for Colonoscopy |
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| Unknown status | 4 | 600 | RoW | 2 mg Prucalopride plus 2 L Polyethylene Glycol regimen, 2 mg Placebo plus 2 L Polyethylene Glycol regimen | Shandong University, Binzhou People's Hospital, Tai'an People's Hospital, Linyi People's Hospital | Prucalopride Plus Polyethylene Glycol in Bowel Preparation for Colonoscopyp | 03/17 | 03/17 | | |
NCT02806206: Prucalopride Prior to Small Bowel Capsule Endoscopy |
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| Unknown status | 4 | 122 | Canada | Prucalopride, Restoran, Placebo, Sugar pill | University of British Columbia | Gastrointestinal Hemorrhage, Crohn Disease, Celiac Disease, Intestinal Diseases, Inflammatory Bowel Diseases | 05/17 | 05/17 | | |
2017-004175-31: A study to investigate the efficacy of prucalopride to treat typical reflux symptoms in patients with gastro-esophageal reflux disease Een studie om de efficaciteit van prucalopride in de behandeling van reflux symptomen in patiënten met gastro-oesofageale reflux ziekte. |
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| Ongoing | 4 | 60 | Europe | Resolor, Coated tablet, Resolor 2mg | TARGID, KU Leuven, TARGID, KU Leuven | refractory gastro-esophageal reflux disease refractaire gastro-oesofagale reflux ziekte, refractory gastro-oesophageal reflux disease refractaire gastro-oesofagale reflux ziekte, Body processes [G] - Digestive System and Oral Physiological Phenomena [G10] | | | | |
NCT03676374: Prucalopride Treatment for Refractory Gastro-esophageal Reflux Disease |
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| Unknown status | 4 | 60 | Europe | Prucalopride, Placebo Oral Tablet | Universitaire Ziekenhuizen Leuven | GERD | 04/21 | 04/21 | | |
NCT04985669: Study of Comparative Effectiveness of Prucalopride and Lubiprostone in Constipation Predominant Irritable Bowel Syndrome |
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| Recruiting | 4 | 140 | RoW | Prucalopride 2mg, calopride | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | Patient Satisfaction | 02/22 | 03/22 | | |
NCT02425774: Anti-inflammatory Effect of Pre-operative Stimulation of the Cholinergic Anti-Inflammatory Pathway |
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| Recruiting | 4 | 30 | Europe | Vagus stimulation, Sham stimulation, Prucalopride, Placebo | KU Leuven, Universitaire Ziekenhuizen KU Leuven | Postoperative Ileus | 12/25 | 12/25 | | |
NCT05455359: Gastrointestinal Dysmotility on Aspiration Risk |
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| Not yet recruiting | 4 | 120 | NA | Prucalopride, Famotidine | Boston Children's Hospital | Esophageal Motility Disorders, Gastric Motor Dysfunction, Aspiration Pneumonia, Gastro Esophageal Reflux | 07/27 | 07/27 | | |
