recombinant human arylsulfatase A (TAK-611) / Takeda  >>  Phase 2
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7 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
recombinant human arylsulfatase A (TAK-611) / Takeda
NCT01303146: Efficacy METAZYM for the Treatment Metachromatic Leukodystrophy Treated With Hematopoietic Stem Cell Transplantation

Completed
2
1
Europe
rhARSA, HGT-1111, Metazym
Assistance Publique - Hôpitaux de Paris, European Leukodystrophy Association, Zymenex A/S, Shire
Metachromatic Leukodystrophy
03/10
04/10
HGT-MLD-049, NCT00681811 / 2008-000084-41: Open-Label Extension Study of Recombinant Human Arylsulfatase A (HGT-1111) in Late Infantile MLD

Terminated
2
11
Europe
HGT-1111, rhASA, Metazym
Shire
Late Infantile Metachromatic Leukodystrophy
10/10
10/10
2007-007165-20: A single center, open-label, non-randomized, uncontrolled, multiple-dose study of the efficacy and safety of Metazym (recombinant human arylsulfatase A or rhASA) for the treatment of MLD patients with high residual level of voluntary function

Ongoing
2
6
Europe
Metazym, rhASA,
Shire Pharmaceuticals Ireland Limited
Metachromatic Leukodystrophy (MLD) in late infantile patients
 
 
EMBOLDEN, NCT03771898 / 2018-003291-12: A Study of Intrathecal SHP611 in Children With Metachromatic Leukodystrophy

Active, not recruiting
2
36
Europe, Canada, Japan, US, RoW
SHP611, HGT-1110, TAK-611, recombinant human arylsulfatase A [rhASA]
Shire, Takeda Development Center Americas, Inc.
Metachromatic Leukodystrophy (MLD)
03/23
03/25
HGT-MLD-048, NCT00633139 / 2007-006345-40: Long-term Metazym Treatment of Patients With Late Infantile Metachromatic Leukodystrophy (MLD)

Completed
1/2
13
Europe
Recombinant human Arylsulfatase A (rhASA), Metazym, HGT-1111
Shire
Late Infantile Metachromatic Leukodystrophy
11/08
11/08
IDEAMLD, NCT01510028 / 2011-002044-28: Multicenter Study of HGT-1110 Administered Intrathecally in Children With Metachromatic Leukodystrophy (MLD)

Completed
1/2
24
Europe, Japan, RoW
Recombinant human arylsulfatase A, HGT-1110, rhASA
Shire
Metachromatic Leukodystrophy (MLD)
01/17
01/17
NCT01887938 / 2012-003775-20: An Efficacy and Safety Study of HGT-1110 in Participants With Metachromatic Leukodystrophy

Active, not recruiting
1/2
24
Europe, Japan, RoW
HGT-1110, Recombinant human arylsulfatase A
Shire, Takeda Development Center Americas, Inc.
Metachromatic Leukodystrophy (MLD)
12/24
12/24

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