| Zavicefta (ceftazidime/avibactam) / Pfizer, AbbVie |
NCT01291602: A Study to Assess the Safety, Tolerability and Pharmacokinetics of NXL104 Alone and in Combination With Ceftazidime Administered as Single and Repeated Intravenous Doses in Healthy Japanese Subjects |
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| Completed | 1 | 15 | US | NXL104, CAZ104, Placebo | Pfizer | Healthy Male and Female Japanese Volunteers | 04/11 | 04/11 | | |
NCT01290900: A Single-centre, Randomised, Double-blind, Placebo-controlled, Four Way Crossover Phase I Study to Investigate the Effect on QT/QTc Interval of Ceftazidime NXL104 or Ceftaroline Fosamil NXL104, Compared With Placebo, Using Moxifloxacin (Avelox®) as a Positive Control, in Healthy Male Volunteers |
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| Completed | 1 | 54 | US | NXL104, Ceftaroline, Placebo Infusion, Ceftazidime, Moxifloxacin | Pfizer | Healthy Male Volunteers | 05/11 | 05/11 | | |
NCT01395420: Study to Assess the Concentration of Avibactam and Ceftazidime in Epithelial Lining Fluid and Plasma |
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| Completed | 1 | 45 | Europe | CAZ104, CAZ104 (2000mg Ceftazidime/500mg Avibactam), CAZ104 (3000mg Ceftazidime/1000mg Avibactam) | Pfizer | Healthy | 07/12 | 07/12 | | |
NCT01534247: A Study to Assess the Levels of CAZ-AVI and Metronidazole in the Blood When Given Together and Separately |
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| Completed | 1 | 28 | US | CAZ-AVI, metronidazole, CAZ-AVI + metronidazole | Pfizer, Forest Laboratories | Healthy | 07/12 | 07/12 | | |
NCT01430910: A Study to Assess the Levels of Two Antibiotics in the Blood When Given Together and Separately |
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| Completed | 1 | 43 | Europe | CAZ104, Avibactam, Ceftazidime | Pfizer | Healthy | 10/12 | 10/12 | | |
NCT01920399: A Phase I Study to Assess the Safety, Tolerability and PK of Ceftazidime-Avibactam in Healthy Chinese Subjects |
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| Completed | 1 | 42 | RoW | CAZ-AVI, 0.9% Normal Saline | Pfizer | Healthy Volunteers | 11/13 | 11/13 | | |
NCT01789528: A Study to Investigate the Effect of Administration of Ceftazidime-avibactam (CAZ-AVI) and Ceftaroline Fosamil -Avibactam (CXL) on the Intestinal Flora of Healthy Volunteers |
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| Completed | 1 | 48 | Europe | CAZ-AVI, Cohort 1, CXL, Cohort 2 | Pfizer | Pharmacokinetics, Open Label, CAZ-AVI, CXL, Effect on Intestinal Flora, Safety | 03/14 | 03/14 | | |
| Completed | 1 | 35 | US | CAZ-AVI | Pfizer, Forest Laboratories | Systemic Infections | 10/14 | 10/14 | | |
NCT04040621 / 2018-002841-12: Single-dose PK Study of Ceftazidime-Avibactam In Hospitalized Children Receiving Systemic Antibiotics for Nosocomial Pneumonia |
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| Terminated | 1 | 4 | RoW | Ceftazidime-avibactam | Pfizer, AbbVie | Hospitalized Children With Suspected or Confirmed Nosocomial Pneumonia | 04/21 | 05/21 | | |
