| hydrochlorothiazide / Generic mfg. |
NCT00778713: Bioequivalence Study of Fosinopril Sodium / Hydrochlorothiazide 20/ 12.5 mg Tablets Under Fed Conditions |
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| Completed | N/A | 33 | US | Fosinopril sodium and hydrochlorothiazide 20-12.5 mg tablets | Ranbaxy Laboratories Limited | Healthy | 03/03 | 04/03 | | |
NCT00777972: Bioequivalence Study of Fosinopril Sodium/ Hydrochlorothiazide 20/ 12.5 mg Tablets Under Fasting Conditions |
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| Completed | N/A | 34 | US | Fosinopril sodium and hydrochlorothiazide 20-12.5 mg tablets | Ranbaxy Laboratories Limited | Healthy | 03/03 | 04/03 | | |
NCT00778726: Bioequivalence Study of Benazepril HCl / Hydrochlorothiazide 20 mg/ 25 mg Tablets Under Fasting Conditions |
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| Completed | N/A | 42 | US | Benazepril HCl/ Hydrochlorothiazide 20 mg/ 25 mg Tablets | Ranbaxy Laboratories Limited | Healthy | 10/04 | 12/04 | | |
NCT00778674: Bioequivalence Study of Benazepril HCl / Hydrochlorothiazide 20 mg/ 25 mg Tablets Under Fed Conditions |
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| Completed | N/A | 30 | US | Benazepril HCl/ Hydrochlorothiazide 20 mg/ 25 mg Tablets | Ranbaxy Laboratories Limited | Healthy | 10/04 | 12/04 | | |
NCT00872235: Bioequivalence Study of Quinapril Hydrochloride 20 mg and Hydrochlorothiazide 25 mg Tablets Under Fed Conditions |
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| Completed | N/A | 40 | RoW | fixed-dose combination of quinapril 20 mg and hydrochlorothiazide 25 mg tablets | Ranbaxy Laboratories Limited | Healthy | 07/05 | 11/05 | | |
NCT00214825: Aldosterone and Vascular Disease in Diabetes Mellitus |
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| Completed | N/A | 46 | US | eplerenone, Hydrochlorothiazide | Brigham and Women's Hospital, National Institutes of Health (NIH) | Diabetes Mellitus, Endothelial Dysfunction, Albuminuria | 03/06 | 03/06 | | |
| Completed | N/A | 150 | Canada | Hydrochlorothiazide | University of British Columbia, Canadian Institutes of Health Research (CIHR) | Hypertension | 06/06 | 06/06 | | |
NCT02336607: The Effects on Blood Pressure Control, Pulse Wave Velocity, as Well as Safety and Tolerability of Felodipine Sustained Release in Chinese Patients. |
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| Completed | N/A | 529 | RoW | Felodipine tablet (Plendil) alone, Felodipine tablet (Plendil)+Hydrochlorothiazide, Felodipine tablet (Plendil)+Metoprolol tablet (Betaloc ZOK), Felodipine tablets (Plendil)+Lisinopril (Zestril) | AstraZeneca | Hypertension | 06/06 | 08/06 | | |
NCT00776646: Bioequivalence Study of Hydrochlorothiazide 50mg Tablets Under Fasting Conditions |
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| Completed | N/A | 36 | RoW | hydrochlorothiazide 50 mg tablet | Ranbaxy Laboratories Limited, IPCA Laboratories Ltd. | Healthy | 06/06 | 08/06 | | |
CoCa, NCT00608153: Compliance of Patients With Essential Hypertension Treated With Candesartan or Candesartan/Hydrochlorothiazide |
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| Completed | N/A | 1773 | Europe | | AstraZeneca | Essential Hypertension | | 09/07 | | |
NCT01712139: Crossover Bioequivalence Study of Irbesartan HCTZ 300/25 mg Tablets Under Fasted Conditions |
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| Completed | N/A | 37 | US | Irbesartan and Hydrochlorothiazide, Avalide | Roxane Laboratories | Hypertension | 09/07 | 09/07 | | |
NCT01712126: Crossover Bioequivalence Study of Irbesartan Hydrochlorothiazide 300/25 mg Tablets Under Fed Conditions |
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| Completed | N/A | 40 | US | Irbesartan and Hydrochlorothiazide, Avalide | Roxane Laboratories | Hypertension | 09/07 | 09/07 | | |
CandLE, NCT00607633: Candesartan and Candesartan/ Hydrochlorothiazide in the Treatment of Patients With Hypertension and LVH |
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| Completed | N/A | 686 | Europe | | AstraZeneca | Essential Hypertension, Left Ventricular Hypertrophy | | 10/07 | | |
NCT00872781: Bioequivalence Study of Quinapril Hydrochloride 20 mg and Hydrochlorothiazide 25 mg Tablets Under Fasting Conditions |
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| Completed | N/A | 64 | RoW | fixed dose combination of Quinapril HCl 20 mg and Hydrochlorothiazide 25 mg tablets | Ranbaxy Laboratories Limited | Healthy | 10/07 | 12/07 | | |
| Completed | N/A | 1200 | US | Hydrochlorothiazide, Candesartan | Mayo Clinic, National Heart, Lung, and Blood Institute (NHLBI) | Cardiovascular Diseases, Heart Diseases, Hypertension | 01/08 | 01/08 | | |
NCT00700583: Alpha-blocker Plus Diuretic Combination Therapy as Second-line Treatment for Nocturia in Men |
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| Completed | N/A | 72 | RoW | combination therapy of terazosin and hydrochlorothiazide | Seoul National University Hospital | Nocturia | 06/08 | 06/08 | | |
COMBAT, NCT00526279: COmpliance and Efficacy in Mono and Combination Tablet Study ATacand/Atacand Plus |
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| Completed | N/A | 9000 | RoW | | AstraZeneca | Hypertension | 08/08 | 08/08 | | |
NCT00690521: A Comparison of Hydrochlorothiazide and Metolazone in Combination With Furosemide in Congestive Heart Failure Patients |
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| Completed | N/A | 8 | US | Treatment of Furosemide + Hydrochlorothiazide, Treatment of Furosemide + Metolazone | University of New Mexico | Congestive Heart Failure | 11/09 | 11/09 | | |
NCT00160160: Comparison of Eprosartan/HCT Versus Enalapril/HCT in Hypertensives With Type II Diabetes |
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| Completed | N/A | 440 | Canada, Europe | eprosartan/HCTZ | Solvay Pharmaceuticals | Hypertension, Type 2 Diabetes | | | | |
NCT00617877: Antihypertensive Response to Losartan and Genetic Polymorphisms |
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| Completed | N/A | 800 | Europe | losartan potassium, Comparator: Hydrochlorothiazide | Merck Sharp & Dohme LLC | Hypertension | 06/09 | 06/09 | | |
NASAA, NCT00999752: Study to Determine the Effects of Nebivolol and Hydrochlorothiazide in African Americans With Hypertension |
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| Completed | N/A | 40 | US | Nebivolol, Bystolic, Hydrochlorothiazide, HCTZ | InVasc Therapeutics, Inc. | Hypertension | 02/10 | 05/10 | | |
NCT01071681: Survey to Assess Why People Are Not Responding to Treatment in Hypertension |
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| Completed | N/A | 1589 | Europe | Telmisartan (Kinzal/Pritor, BAY68-9291) | Bayer, International Clinical Trials Association | Arterial Hypertension | 09/10 | 09/10 | | |
NCT00761904: The Effect of Providing Free Samples of Generic Cardiovascular Medications to Physicians |
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| Unknown status | N/A | 660 | US | Free Generic Samples (hydrochlorothiazide, simvastatin) | Brigham and Women's Hospital | Hypertension, Hyperlipidemia | 04/11 | 04/11 | | |
Lodoz OS, NCT01080742: An Observational Study to Evaluate the Efficacy of Lodoz in a Population of Hypertensive Patients |
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| Completed | N/A | 1007 | RoW | Lodoz (Combination of bisoprolol and hydrochlorothiazide), Lodoz | Merck KGaA, Darmstadt, Germany | Hypertension | 06/11 | 12/11 | | |
NCT00935805: Glycemic And Blood Pressure Control In Type 2 Diabetes, In A Primary Care Unit: A Staged Management Strategy |
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| Unknown status | N/A | 124 | RoW | Metformin, Initial drug added to non-pharmacological measures, Glybenclamide, Second oral agent to be added, NPH insulin, Insulin added to or substituted for OA, Hydrochlorothiazide, Inital RX for hypertension, Propranolol, Introduced if diuretic + captopril do not control BP, Captopril, Added to hydrochlorothiazide if BP not attained, Amlodipine, Added to previous if BP control BP not satisfactory | Hospital de Clinicas de Porto Alegre, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul, Brazil | Diabetes Mellitus, Arterial Hypertension | 01/12 | 07/12 | | |
NCT00656331: The Pleiotropic Effects of Atorvastatin When Combined With Common Antihypertenisve Medications. |
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| Withdrawn | N/A | 20 | US | Amlodipine and Hydrocholorothiazide | University of New Mexico | Hypertension | 06/12 | 06/12 | | |
NCT02016183: Candesartan Cilexetil / Hydrochlorothiazide Combination Tablets Special Drug Use Surveillance: Long-term Use (12 Months) |
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| Completed | N/A | 3222 | Japan | Candesartan cilexetil / hydrochlorothiazide, ECARD® Combination Tablets LD&HD | Takeda | Hypertension | 09/12 | 09/12 | | |
| Completed | N/A | 24 | RoW | Valsartan/Hydrochlorothiazide, Fixed dose combination, Pharmacokinetic interaction, Valsartan, Hydrochlorothiazide | Damanhour University | Healthy Normotensive Participants | 12/12 | 12/12 | | |
| Completed | N/A | 24 | RoW | Valsartan/Hydrochlorothiazide, Valsartan, Hydrochlorothiazide | Damanhour University | Healthy Normotensive Participants | 12/12 | 12/12 | | |
| Completed | N/A | 8 | US | Hydrochlorothiazide, HCTZ | Oregon Health and Science University, Oregon Clinical and Translational Research Institute | Gitelman Syndrome | 01/13 | 09/13 | | |
NCT01858610: Drug Interaction Between Irbesartan and Hydrochlorothiazide |
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| Completed | N/A | 18 | RoW | Irbeasartan/hydrochlorothiazide, Fixed dose combination, Irbesartan, Hydrochlorothiazide | Damanhour University | Healthy | 04/13 | 04/13 | | |
NCT01506505: The Evening Versus Morning Polypill Utilization Study |
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| Completed | N/A | 78 | Europe | Cardiovascular Agents, Acetylsalicylic acid 80 mg, Simvastatin 40 mg, Lisinopril 10 mg, Hydrochlorothiazide 12,5 mg | UMC Utrecht | Cardiovascular Disease, Cerebrovascular Disease, Peripheral Arterial Disease | 07/13 | 07/13 | | |
1HAT, NCT01258764: Hypertensive Ambulatory Trial to Compare the Efficacy of HCTZ and Lisinopril |
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| Completed | N/A | 2 | US | Lisinopril, Prinivil, Zestril, ACE inhibitor, Hydrochlorothiazide, Aquazide H, Carozide, Diaqua, Esidrix, Ezide, Hydro Par, HydroDIURIL, Hydrocot, Hydrokraft, Loqua, Oretic, Thiazide, HCTZ | Scripps Translational Science Institute | Hypertension, Grade 1, Hypertension Treatment, N of 1 Study Design, Hypertension | 03/14 | 03/14 | | |
NCT01658657: A Pilot Study of Plasma Renin Activity Guided vs Generic Combination Therapy for Hypertension |
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| Completed | N/A | 17 | US | Hydrochlorothiazide, Lisinopril, Amlodipine, metoprolol, lisinopril/hydrochlorothiazide | University of North Carolina, Chapel Hill, Cornell University, Wake Forest University Health Sciences | Hypertension, Plasma Renin Activity | 07/14 | 07/14 | | |
ChiCTR-IOR-15006718: Cost-effectiveness of nitrendipine plus hydrochlorothiazide or metoprolol in the treatment of hypertension |
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| Completed | N/A | 800 | | antihypertension regents | National center for cardiovascular diseases Fuwai hospital; Fuwai hospital, National Key R&D Program in the Twelfth Five-year Plan (No.2012BAJ18B04) | Hypertension | | | | |
NCT02412761: Series of N-of-1 Crossover Trials of Antihypertensive Therapy in Adolescents With Essential Hypertension |
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| Completed | N/A | 42 | US | Lisinopril, Angiotensin-converting enzyme inhibitor, Amlodipine, Dihydropyridine calcium channel blocker, Hydrochlorothiazide, Thiazide diuretic | The University of Texas Health Science Center, Houston | Essential Hypertension | 07/16 | 07/16 | | |
| Completed | N/A | 104 | US | Exercise, ACE inhibitor + exercise, Perindopril, Thiazide diuretic + exercise, Hydrochlorothiazide, Angiotensin receptor blocker + exercise, Losartan | University of Florida, American Heart Association | Hypertension, Aging | 06/17 | 06/17 | | |
NCT02711670: Night Time Use of Thiazide Diuretics for Improved Reduction in Stone Risk in Stone Formers With Elevated Urine Calcium |
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| Completed | N/A | 10 | US | chlorthalidone, Hydrochlorothiazide | VA New York Harbor Healthcare System | Kidney Stones | 06/17 | 06/17 | | |
NCT04371874: The Standardized Management of Hypertension in Rural Shaanxi |
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| Completed | N/A | 1210 | RoW | Hydrochlorothiazide, Captopril, Nitrendipine, Aspirin, medications were uniformly supplied by the Chinese government | First Affiliated Hospital Xi'an Jiaotong University | Hypertension | 07/17 | 02/19 | | |
NCT02591160: Optimal HCTZ Cessation for Diagnosis of Hyperparathyroidism |
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| Completed | N/A | 2 | US | HCTZ cessation | University of Missouri-Columbia | Hyperparathyroidism | 09/17 | 09/17 | | |
NCT03082742: The Effect of Diuretics on Mineral and Bone Disorder in Chronic Kidney Disease Patients |
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| Unknown status | N/A | 52 | RoW | Hydrochlorothiazide, Furosemide | University of Sao Paulo General Hospital | Secondary Hyperparathyroidism, Chronic Kidney Disease | 06/18 | 06/18 | | |
ChiCTR-IOR-17014105: First-Line Antihypertensive comparison for Tibetan mild-moderate hypertension (FLAT): study protocol for a randomized crossover controlled trial |
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| Not yet recruiting | N/A | 531 | | three consecutively allocated 8-week treatment cycles with irbesartan, amlodipine and hydrochlorothiazide | West China Hospital, Sichuan University; Level of the institution：, Supportive technology funding from Sichuan provincial science and Technology Department | Hypertenison | | | | |
NCT03021265: To Evaluate Real-world Safety, Effectiveness and Appropriate Use of Micatrio® Combination Tablets Treatment in Patients With Hypertension |
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| Completed | N/A | 676 | Japan | T80/A5/H12.5 FDC, MICATRIO | Boehringer Ingelheim | Hypertension | 04/19 | 04/19 | | |
NCT03951558: Comparison of the Impact of Diet vs Thiazide in BMD in Children With Idiopathic Hypercalciuria |
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| Unknown status | N/A | 90 | RoW | Diet for calciuria prevention, Diet for hypercalciuria, Hydrochlorothiazide, Hydroclorothiazide in hypercalciuria | Hospital Infantil de Mexico Federico Gomez | Hypercalciuria; Idiopathic, Nephrolithiasis | 06/19 | 06/20 | | |
| Completed | N/A | 1411 | Europe | diuretics, hydrochlorothiazide, bumetanide, furosemide, albumin, fluid restriction, renal replacement, ultrafiltration | Central Hospital, Nancy, France, Ministry of Health, France | Fluid Shifts, Critical Care | 07/19 | 05/20 | | |
PUZZLE, NCT03006796: Observational Study of Azilsartan/Chlorthalidone and Irbesartan/Hydrochlorothiazide in Hypertension and Obesity. |
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| Completed | N/A | 94 | RoW | | Russian Heart Failure Society | Arterial Hypertension | 02/20 | 03/20 | | |
NCT04182854: Use of Diuretics in Maintenance Hemodialysis Patients Undergoing Bioimpedance-guided Fluid Management |
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| Recruiting | N/A | 46 | RoW | Furosemid hydrochlorothiazide | Capital Medical University | Diuretic Abuse | 02/20 | 07/21 | | |
NCT04467931: ACEI or ARB and COVID-19 Severity and Mortality in US Veterans |
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| Completed | N/A | 22213 | US | ACEI/ARB, benazepril, captopril, enalapril, fosinopril, lisinopril, moexipril, perindopril, quinapril, ramipril, trandolapril, azilsartan, candesartan, eprosartan, irbesartan, losartan, olmesartan, telmisartan, valsartan, Non-ACEI/ARB, doxazosin, prazosin, terazosin, acebutolol, nebivolol, atenolol, betaxolol, bisoprolol, metoprolol, pindolol, penbutolol, carvedilol, labetalol, nadolol, propranolol, timolol, amlodipine, felodipine, isradipine, nifedipine, nicardipine, nisoldipine, diltiazem, verapamil, clonidine, guanfacine, guanabenz, methyldopa, reserpine, hydralazine, minoxidil, aliskiren, spironolactone, eplerenone, bumetanide, furosemide, ethacrynic acid, torsemide, amiloride, triamterene, bendroflumethiazide, chlorothiazide, chlorthalidone, hydrochlorothiazide, indapamide, metolazone, ACEI, ARB | University of Utah, VA Salt Lake City Health Care System, University of Pennsylvania, Wake Forest University Health Sciences, University of Florida, Johns Hopkins Bloomberg School of Public Health, Boston University, Northwestern University, Edith Nourse Rogers Memorial Veterans Hospital, Columbia University, MedStar Georgetown University Hospital | Hypertension, COVID | 10/20 | 12/20 | | |
| Completed | N/A | 2953748 | Canada | Hydrochlorothiazide, ATC C03AA03, Angiotensin-converting enzyme (ACE) inhibitors, ATC C09A, C09B | Canadian Network for Observational Drug Effect Studies, CNODES, Drug Safety and Effectiveness Network, Canada, Canadian Institutes of Health Research (CIHR) | Non-melanoma Skin Cancer, Melanoma, Hypertension | 03/21 | 03/21 | | |
DIISCCO, NCT04103411: Effect of High-Intensity Interval Training Compared to Hydrochlorothiazide on Ambulatory Blood Pressure |
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| Unknown status | N/A | 60 | Canada | 24h-Ambulatory Blood Pressure, Cognition, Cardiovascular Health, Mobility | Anil Nigam | Hypertension,Essential, Exercise Activity | 06/21 | 01/22 | | |
ChiCTR-IOR-17014104: First-line Antihypertensive Combinations comparison for Tibetan high-risk hypertension (FACT): study protocol for an open label, paralleled, multi-center randomized controlled trial |
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| Not yet recruiting | N/A | 3417 | | irbesartan/amlodipine (maximum titrated to 300/10 mg) ;irbesartan/hydrochlorothiazide (maximum titrated to 300/25 mg) ;amlodipine/hydrochlorothiazide (maximum titrated to 10/25 mg) | West China Hospital, Sichuan University; Level of the institution：, Supportive technology funding from Sichuan provincial science and Technology Department | Hypertenison | | | | |
ChiCTR1900025446: Study for the safety and effectiveness of Wen-Yang Zhen-Shuai granule in treatment of chronic heart failure (Yang deficiency and water flooding syndrome) |
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| Not yet recruiting | N/A | 300 | | hydrochlorothiazide, enalaprilat, Metoprolol tartrate, Isosorbide mononitrate tablets ;Wen-Yang Zhen-Shuai granules + hydrochlorothiazide, enalaprilat, Metoprolol tartrate, Isosorbide mononitrate tablets | The First Affiliated Hospital of Hu'nan University of Traditional Chinese Medicine; The First Affiliated Hospital of Hu'nan University of Traditional Chinese Medicine, State administration of traditional Chinese medicine | the chronic heart failure | | | | |
NCT03261375: To Evaluate Safety and Efficacy of a Radiofrequency Renal Denervation System in Treatment of Essential Hypertension |
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| Completed | N/A | 205 | RoW | Renal Artery Radiofrequency Ablation System (Generator and Catheter ), Antihypertensive Agents, Nifedipine and hydrochlorothiazide, Sham Procedure | Shanghai Golden Leaf MedTec Co. Ltd | Hypertension | 12/22 | 12/22 | | |
NCT05125224: Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Dihydropyridine Calcium Channel Blockers Versus Hydrochlorothiazide |
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| Active, not recruiting | N/A | 163720 | US | Dihydropyridine calcium channel blocker, Hydrochlorothiazide | Brigham and Women's Hospital, National Institute on Aging (NIA), Rutgers University, Johns Hopkins University | Hypertension | 07/23 | 12/23 | | |
ChiCTR2000038715: Comparison of different combination therapies in Lowering blood pressure and target organ protection in Fujian Province: COOPERATION STUDY 2x4 Factorial randomized open label multicenter trial |
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| Not yet recruiting | N/A | 1236 | | amlodipine + valsartan ;amlodipine + betaloc sustained-release tablets ;amlodipine + hydrochlorothiazide ;valsartan+hydrochlorothiazide ;amlodipine + valsartan +hydrochlorothiazide ;amlodipine+ valsartan+betaloc sustained-release tablets | The First Clinical Medical College, Fujian Medical University; The First Clinical Medical College, Fujian Medical University, Fujian Science and Technology Innovation Joint Fund Project | Hypertation | | | | |
NCT05413057: An OS to Evaluate Effectiveness and Safety of Fixed-dose Combinations of FMS/AML or FMS/AML/HCTZ |
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| Recruiting | N/A | 20000 | RoW | | Boryung Pharmaceutical Co., Ltd | Hypertension,Essential | 06/26 | 06/26 | | |
FASTR-EU, NCT06362668: EU Sites: Fluid Management of Acute Decompensated Heart Failure With Reprieve Decongestion Management System |
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| Recruiting | N/A | 30 | Europe | Reprieve Decongestion Management System, Diuretic (furosemide, bumetanide, torsemide, hydrochlorothiazide, and/or acetazolamide) | Reprieve Cardiovascular, Inc | Acute Decompensated Heart Failure | 10/24 | 12/24 | | |
NCT03511118: Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants |
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| Recruiting | N/A | 1600 | Canada, US | Tranexamic acid (TXA), labetalol, metformin, nifedipine, clindamycin, oxycodone, azithromycin, escitalopram, sertraline, ondansetron, Ciprofloxacin, Doxycycline, Levofloxacin, Methylphenidate, Sumatriptan, Citalopram, Cyclobenzaprine, Furosemide, Gabapentin, Hydrochlorothiazide, Hydroxyurea, Rosuvastatin, Topiramate, Trazodone, Valganciclovir, Venlafaxine, Verapamil, Remdesivir, Anakinra, Tocilizumab, Fluvoxamine, Amoxicillin, Bupropion, Duloxetine, Hydrocodone, Levetiracetam, Paroxetine, Buprenorphine | Duke University, The Emmes Company, LLC, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Lactating Women on Select DOI, Breastfed Infants of Mothers on Select DOI | 09/24 | 07/26 | | |
ChiCTR2200055240: A multicenter randomized controlled study of hydrochlorothiazide on the morbidity of hypertension in prehypertensive population with high salt threshold |
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| Recruiting | N/A | 2550 | | Hydrochlorothiazide ;Placebo | Daping Hospital of Third Military Medical University; Army Medical Center of PLA, Training program of clinical scientific research talents of Army Medical University (No:40142-3028) | Prehypertension | | | | |
NCT03476551: Bariatric Surgery and Pharmacokinetics of Hydrochlorothiazide |
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| Recruiting | N/A | 12 | Europe | Hydrochlorothiazide, Dichlothiazide, Esidrix, Hypothiazide | Norwegian University of Science and Technology, St. Olavs Hospital, Volvat Medisinsk Senter Stokkan, Namsos Hospital, Alesund Hospital | Obesity, Morbid | 10/26 | 10/26 | | |
