| hydrochlorothiazide / Generic mfg. |
NCT03921736: Reversal of an Unfavorable Effect of Hydrochlorothiazide Compared to Angiotensin Converting Enzyme Inhibitor on Serum Uric Acid and Oxypurines Levels by Estrogen-progestin Therapy in Hypertensive Postmenopausal Women. |
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| Completed | 4 | 180 | NA | Perindopril, Hydrochlorothiazide, Estracomb TTS | Anna Posadzy-Małaczyńska | Hypertension, Hyperuricemia, Menopause | 03/01 | 11/05 | | |
| Completed | 4 | 22000 | US | Verapamil SR/Trandolapril/Hydrochlorothiazide (HCTZ), Atenolol/HCTZ/Trandolapril | University of Florida, Abbott | Hypertension, Coronary Artery Disease | | 02/03 | | |
NCT00651287: A Study to Evaluate the Efficacy and Safety of Quinapril or Quinapril Plus Hydrochlorothiazide in Patients With Mild to Moderate Hypertension |
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| Completed | 4 | 200 | RoW | quinapril 20 mg, quinapril 20 mg plus hydrochlorothiazide 12.5 mg, quinapril 40 mg | Pfizer | Hypertension | | 06/04 | | |
NCT00847834: Irbesartan-Hydrochlorothiazide Phase IV Study: Treatment of Hypertension in Chinese Population |
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| Completed | 4 | 968 | RoW | Irbesartan 150mg / Hydrochlorothiazide 12.5mg, Irbesartan 150mg | Sanofi | Hypertension | 06/04 | | | |
| Completed | 4 | 76 | NA | VALSARTAN+HYDROCHLOROTHIAZIDE | Novartis | HYPERTENSION | 12/04 | 12/04 | | |
NCT00277472: Efficacy and Safety of Valsartan/Hydrochlorothiazide Combination Therapy in Patients With Hypertension |
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| Completed | 4 | 300 | US | Valsartan/Hydrochlorothiazide, Co-Diovan, Diovan HCT, HCTZ, hydrochlorothiazice, water pill | Novartis | Hypertension | 11/05 | | | |
NCT00170937: A 16 Week Study to Evaluate the Effect on Insulin Sensitivity of Valsartan (320 mg) and Hydrochlorothiazide (25 mg) Combined and Alone, in Patients With Metabolic Syndrome |
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| Completed | 4 | 507 | US | valsartan plus hydrochlorothiazide | Novartis | METABOLIC SYNDROME, HYPERTENSION, PRE-HYPERTENSION | 03/06 | | | |
NCT00232882: Pharmacodynamic Influences of Candesartan, Atenolol, Hydrochlorothiazide and Drug Combinations in Hypertensive Patients. |
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| Completed | 4 | 86 | Canada | Candesartan Thiazide, Atenolol Thiazide, Thiazide Candesartan | Institut de Recherches Cliniques de Montreal, Ottawa Hospital Research Institute | Hypertension | 04/06 | 04/06 | | |
NCT00280540: Efficacy and Safety of Valsartan/Hydrochlorothiazide Combination Therapy in Patients With Hypertension |
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| Completed | 4 | 648 | US | Valsartan/Hydrochlorothiazide | Novartis | Hypertension | 08/06 | | | |
NCT00171561: Valsartan/Hydrochlorothiazide Combination vs Amlodipine in Patients With Hypertension, Diabetes, and Albuminuria. |
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| Completed | 4 | 144 | Europe | valsartan/hydrochlorothiazide | Novartis | Hypertension | 09/06 | 09/06 | | |
| Completed | 4 | 400 | Europe, RoW | Irbesartan, Avapro, Hydrochlorothiazide | Bristol-Myers Squibb, Sanofi | Metabolic Syndrome, Hypertension | 02/07 | 02/07 | | |
| Completed | 4 | 144 | NA | Fluvastatin, Lescol, Valsartan, Diovan, Hydrochlorothiazide | Novartis | Hypertension, Dyslypidaemia | 03/07 | 03/07 | | |
VALENCE, NCT00171132: Valsartan Versus Atenolol on Exercise Capacity in Hypertensive Overweight Postmenopausal Women |
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| Completed | 4 | 64 | Europe | valsartan, atenolol, hydrochlorothiazide | Novartis | Hypertension | 08/07 | 08/07 | | |
NCT00487123: Efficacy of the New Closure Device in Improving Patient Compliance in Treatment of Hypertension With Valsartan+/-Hydrochlorothiazide (HCTZ) at 6 Months |
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| Completed | 4 | | RoW | Valsartan+/- Hydrochlorothiazide | Novartis | Hypertension | 09/07 | 09/07 | | |
NCT00426478: Safety and Efficacy of Valsartan Plus Hydrochlorothiazide and Amlodipine in Hypertensive Patients |
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| Completed | 4 | 80 | RoW | Valsartan plus Hydrochlorothiazide (80mg/12.5mg), Amlodipine (5mg) | Novartis | Hypertension | | 09/07 | | |
NCT00171054: Efficacy and Safety of Valsartan Versus Amlodipine in Postmenopausal Women With Hypertension |
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| Completed | 4 | 125 | Europe | Valsartan 320 mg, Amlodipine 10 mg, Hydrochlorothiazide | Novartis | Hypertension | 10/07 | 10/07 | | |
NCT00425997: Efficacy of Valsartan/Hydrochlorothiazide Versus Amlodipine and Hydrochlorothiazide in Patients Hypertension |
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| Completed | 4 | 480 | US | Valsartan/HCTZ, amlodipine, HCTZ | Novartis | Hypertension | 10/07 | 10/07 | | |
NCT00400777: Efficacy and Safety of Valsartan, Hydrochlorothiazide and Amlodipine Combination Therapy in Hypertension |
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| Completed | 4 | 460 | RoW | Valsartan, hydrochlorothiazide and amlodipine | Novartis | Hypertension | 11/07 | 06/08 | | |
NCT00439738: Safety/Efficacy of Valsartan/Hydrochlorothiazide Combination Compared to Hydrochlorothiazide in Obese Hypertensive Adults |
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| Completed | 4 | 412 | US | HCTZ + Amlodipine, Valsartan/HCTZ | Novartis Pharmaceuticals | Hypertension | 11/07 | | | |
NCT00264212: AMISH : Aprovel for Management of Isolated Systolic Hypertension |
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| Completed | 4 | 436 | RoW | irbesartan and irbesartan-hydrochlorothiazide | Sanofi, Bristol-Myers Squibb | Hypertension | | | | |
NCT00687206: Efficacy and Safety of Valsartan Plus Hydrochlorothiazide in Patients With Slight Hypertension and Target Organ Damage |
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| Completed | 4 | 20 | Europe | Valsartan 160mg plus HCT 25mg, Corixil 160/25mg, Cotareg 160/25mg | Federico II University | Hypertension, Ventricular Remodeling, Erectile Dysfunctions | 05/08 | 12/08 | | |
| Completed | 4 | 188 | Europe | Candesartan and Hydrochlorothiazide, BLOPRESS PLUS®, Hydrochlorothiazide (HCT) | Takeda | Obesity, Hypertension | 09/08 | 09/08 | | |
NCT00443612: Irbesartan/Hydrochlorothiazide National Taiwan University Hospital Listing |
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| Completed | 4 | 60 | RoW | Irbesartan/Hydrochlorothiazide, Irbesartan | Sanofi | Hypertension | 10/08 | | | |
| Completed | 4 | 3712 | RoW | ASA, Atenolol, hydrochlorothiazide, ACE inhibitor, Statin, Health Promotion | The George Institute, Byrraju Foundation, The Future Forum, UK | Myocardial Infarction, Angina Pectoris, Cerebrovascular Accidents, Diabetes Mellitus | 12/08 | 06/09 | | |
NCT00813722: Effect of Active Telephone Calls in the Compliance of Hypertensive Patients With Treatment |
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| Unknown status | 4 | 400 | RoW | phone call, phone calls, amlodipine (calcium chanel blocker) and losartan (at1 antagonist), atenolol (beta blocker) and hydrochlorothiazide (diuretic) | University of Sao Paulo | Blood Pressure | 01/09 | 06/09 | | |
NCT00690521: A Comparison of Hydrochlorothiazide and Metolazone in Combination With Furosemide in Congestive Heart Failure Patients |
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| Unknown status | 4 | 13 | US | metolazone or hydrochlorothiazide | University of New Mexico | Congestive Heart Failure | 01/09 | 01/09 | | |
NCT00605202: Effect of Licorice and Hydrochlorothiazide on Plasma Potassium |
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| Completed | 4 | 10 | Europe | Hydrochlorothiazide, Hydrex semi, ATC C03AA03, Licorice, Pepe Original candy | University of Oulu | Hypokalemia | 01/09 | 01/09 | | |
| Completed | 4 | 214 | RoW | Candesartan Cilexetil, Atacand, Hydrochlorothiazide, HCTZ, Diazide | AstraZeneca | Stage II Hypertension | 03/09 | 03/09 | | |
NCT00670566: Irbesartan/Hydrochlorothiazide to Control Elevated Blood Pressure to Target in Moderate to Severe Hypertensive Patients |
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| Completed | 4 | 503 | RoW | irbesartan/hydrochlorothiazide, CoAprovel | Sanofi | Hypertension | 03/09 | | | |
ATLAAST, NCT00739596: Blood Pressure Lowering of Aliskiren Hydrochlorothiazide (HCTZ) Versus Amlodipine in Stage 2 Hypertension in African Americans |
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| Completed | 4 | 332 | US | Aliskiren Hydrochlorothiazide (HCTZ): 8 weeks, Amlodipine: 8 weeks | Novartis Pharmaceuticals | Hypertension | 03/09 | 03/09 | | |
NCT00654745: 18 Week Study Evaluating Safety and Efficacy of Olmesartan, Amlodipine, and Hydrochlorothiazide, in Type 2 Diabetics |
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| Completed | 4 | 207 | US | Amlodipine, Norvasc, amlodipine / olmesartan medoxomil combination, Azor, Hydrochlorothiazide | Daiichi Sankyo, Inc. | Type 2 Diabetes, Hypertension | 04/09 | 06/09 | | |
ACTION, NCT00760266: Blood Pressure Lowering of Aliskiren HCTZ Compared to HCTZ in Stage 2 Systolic Hypertension in Older Population |
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| Completed | 4 | 451 | US | Aliskiren, Hydrochlorothiazide | Novartis | Hypertension | 04/09 | 04/09 | | |
NCT00698646: Efficacy and Safety of Valsartan/Hydrochlorothiazide Combination Compared to Valsartan Monotherapy or Hydrochlorothiazide Monotherapy in Elderly (>70) With Mild-moderate Hypertension. |
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| Completed | 4 | 384 | US | Valsartan + HCTZ, Valsartan, HCTZ | Novartis Pharmaceuticals | Hypertension | 06/09 | 06/09 | | |
| Completed | 4 | 832 | RoW | Irbesartan - Hydrochlorothiazide | Sanofi | Hypertension | 07/09 | 07/09 | | |
NCT00224549: PHARES Study: Management of Resistant Hypertension |
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| Completed | 4 | 180 | Europe | irbesartan, amlodipine and hydrochlorothiazide | Assistance Publique - Hôpitaux de Paris | Hypertension | 08/09 | 08/09 | | |
| Completed | 4 | 99 | US | Hydrochlorothiazide, Lisinopril, Lisinopril and Hydrochlorothiazide, Nifedipine XL, Metoprolol tartrate, Lopressor, Atenolol, Valsartan, Doxazosin, Clonidine, Hydralazine, Metoprolol succinate, Toprol XL, Amlodipine, Norvasc | Creighton University | Hypertension | 08/09 | 11/09 | | |
| Withdrawn | 4 | 0 | US | Valsartan, Diovan, Hydrochlorothiazide, HCTZ | University of Texas Southwestern Medical Center, Novartis Pharmaceuticals | Metabolic Syndrome, Lipotoxicity | 08/09 | 08/09 | | |
| Completed | 4 | 256 | Europe | Aliskiren, Hydrochlorothiazide, Amlodipine | Novartis | Essential Hypertension ( Mild to Moderate) | 08/09 | 08/09 | | |
BP CRUSH, NCT00791258: A Dose Escalation Study of a Combination Antihypertensive Drug in the Treatment of Various Groups of Patients Who do Not Respond to Single Drug Treatment of Their High Blood Pressure |
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| Completed | 4 | 999 | US | amlodipine and olmesartan medoxomil tablets, AZOR Tablets, hydrochlorothiazide tablets | Daiichi Sankyo, Inc., Integrium | Hypertension | 08/09 | 09/09 | | |
MEAD, NCT00887510: Metabolic Effects of Antihypertensive Drugs on People With Metabolic Syndrome (The Study) |
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| Completed | 4 | 24 | US | Hydrochlorothiazide, Trandolapril | University of Florida, National Heart, Lung, and Blood Institute (NHLBI) | Hypertension | 11/09 | 11/09 | | |
AIMS, NCT00797316: Aliskiren Plus HCTZ Compared to Aliskiren in Metabolic Syndrome Patients With Stage 2 Systolic Hypertension |
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| Completed | 4 | 532 | US | Aliskiren, Hydrochlorothiazide | Novartis | Hypertension | 12/09 | 12/09 | | |
COSIMA2, NCT00500604: Efficacy of Irbesartan/Hydrochlorothiazide Versus Valsartan/Hydrochlorothiazide in Mild to Moderate Hypertension |
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| Completed | 4 | 1617 | RoW | Irbesartan/hydrochlorothiazide, Valsartan/hydrochlorothiazide, Hydrochlorothiazide | Sanofi | Hypertension | 01/10 | 01/10 | | |
ASTRIDE, NCT00787605: Aliskiren HCTZ Compared to Amlodipine in Patients With Stage 2 Systolic Hypertension and Diabetes Mellitus |
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| Completed | 4 | 860 | US | Amlodipine, Hydrochlorothiazide (HCTZ), Aliskiren | Novartis | Hypertension, Diabetes Mellitus | 01/10 | 01/10 | | |
ASCENT, NCT00942994: Aliskiren/Amlodipine/Hydrochlorothiazide (HCTZ) Versus Aliskiren/Amlodipine in US Minority Patients With Stage II Systolic Hypertension |
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| Completed | 4 | 412 | US | Aliskiren/Amlodipine, Aliskiren/Amlodipine and Hydrochlorothiazide (HCTZ) | Novartis | Hypertension | 03/10 | | | |
| Completed | 4 | 107 | Europe, RoW | Candesartan cilexetil and hydrochlorothiazide, Blopress, Atacand®, Amias, Ratacand, Kenzen, Blopressid | Takeda | Hypertension | 05/10 | 06/10 | | |
NCT01375322: ADDM Study - Amtrel and Co-Diovan in Type 2 Diabetes Mellitus Hypertension Patients With Microalbuminuria |
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| Completed | 4 | 226 | RoW | Amlodipine+Benazepril, Amtrel®, Valsartan+Hydrochlorothiazide, Co-Diovan® | TSH Biopharm Corporation Limited | Hypertension, Diabetes Mellitus, Type 2, Albuminuria | 06/10 | 06/10 | | |
NCT00744237: Study of the Glycemic Effects of Nebivolol Compared With Metoprolol and HCTZ in Diabetic Hypertensive Patients |
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| Completed | 4 | 231 | US | Nebivolol, Bystolic (TM), Metoprolol ER, HCTZ, Hydrochlorothorazide | Forest Laboratories | Hypertension, Type 2 Diabetes Mellitus | 07/10 | | | |
NCT00673790: The Blood Pressure and Metabolic Effects of Nebivolol in Hypertensive Patients With Impaired Glucose Tolerance or Impaired Fasting Glucose |
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| Completed | 4 | 537 | US | Nebivolol with concomitant losartan or lisinopril, HCTZ with concomitant losartan or lisinopril, Placebo with concomitant losartan or lisinopril | Forest Laboratories | Hypertension | 07/10 | 07/10 | | |
AISHA, NCT00980187: A Comparison of Indapamide SR 1.5 mg With HCTZ 25 mg, in Combination With an ACE-inhibitor, in Patients With Mild to Moderate AHT and Type 2 DM |
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| Completed | 4 | 56 | Europe | Hydrochlorothiazide, Nefrix, Indapamide, Indapamid LPH | LaborMed Pharma S.A. | Hypertension, Type 2 Diabetes Mellitus | 08/10 | 08/10 | | |
ACADEMY, NCT01070030: Efficacy and Safety of Combination Therapy of Aliskiren/Amlodipine or Aliskiren/Amlodipine/Hydrochlorothiazide in Patients With Stage II Hypertension |
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| Completed | 4 | 230 | RoW | Aliskiren/Amlodipine (150/5 mg/day, 300/10 mg/day) , Aliskiren/Amlodipine/Hydrochlorothiazide (300/10/12.5 mg/day, 300/10/25 mg/day) | Novartis | Stage II Hypertension | 10/10 | 10/10 | | |
NCT00246519: Pharmacogenomic Evaluation of Antihypertensive Responses |
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| Completed | 4 | 1701 | US | Hydrochlorothiazide, Aquazide H or HydroDIURIL or Microzide, Lopressor, Atenolol | University of Florida | Hypertension | 12/10 | 12/10 | | |
| Completed | 4 | 120 | Europe | hydrochlorothiazide, valsartan, 80 mg once-a-day | Radboud University Medical Center | Primary Hypertension | 12/10 | 03/11 | | |
| Completed | 4 | 2337 | US, RoW | Valsartan and hydrochlorothiazide (HCTZ) - monotherapy, Valsartan and amlodipine, Usual care, Valsartan, Valsartan and hydrochlorothiazide (HCTZ) - combination arm | Novartis Pharmaceuticals, Baker Heart and Diabetes Institute | Hypertension | 07/11 | 07/11 | | |
ANDROMEDA, NCT01056731: A Clinical Study With Aliskiren Alone or in Combination Therapy With Diuretic Hctz in Venezuelan Hypertensive Patients. |
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| Completed | 4 | 253 | RoW | Aliskiren and HCTZ | Novartis | High Blood Pressure | 10/11 | 10/11 | | |
| Completed | 4 | 32 | Europe | Aliskiren, Brand name: Ralisez, ATC-code: C09XA02, Moxonidine, No brand name (generic product), ATC-code: C02AC05, Hydrochlorothiazide, ATC-code: C03AA03, Placebo (for aliskiren), Placebo (for moxonidine and hydrochlorothiazide) | UMC Utrecht, Novartis Pharmaceuticals | Hypertension, Abdominal Obesity, Metabolic Syndrome | 02/12 | 02/12 | | |
NOAAH, NCT01030458: Newer Versus Older Antihypertensive Agents in African Hypertensive Patients () Trial |
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| Completed | 4 | 183 | RoW | amlodipine 5/10 mg per day plus valsartan 160 mg/day, ExForge®, hydrochlorothiazide 6.25 mg/day plus bisoprolol 5/10 mg/day, Lodoz® | KU Leuven, University of Kinshasa, Yaounde Central Hospital, University of Yaounde, University of Libreville, Institute of Cardiology Abidjan, University of Ilorin Teaching Hospital, University of Nigeria, Enugu Campus, Hospital Aristide Le Dantec, Dakar, Senegal | Blood Pressure | 03/12 | 03/12 | | |
NCT01172431: Indapamide Versus Hydrochlorothiazide in Elderly Hypertensive Patients With Renal Insufficiency |
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| Completed | 4 | 240 | RoW | Indapamide, Hydrochlorothiazide | West China Hospital | Hypertension, Renal Insufficiency | 03/12 | 12/13 | | |
ChiCTR-OCH-12002710: Pharmacogenetics study of hydrochlorothiazide and felodipine in Chinese hypertensive patients |
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| Completed | 4 | 1325 | | Hydrochlorothiazide ;Hydrochlorothiazide+Felodipine | Institute of Clinical Pharmacology, Central South University; Institute of Clinical Pharmacology, Central South University, 863 project | Hypertension | | | | |
NCT00994253: Evaluating the Effect of Aliskiren Versus HCTZ on Coronary Flow Reserve in Hypertensive Type II Diabetics |
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| Withdrawn | 4 | 0 | US | Aliskiren, Tekturna, Hydrochlorothiazide, HCTZ | William Beaumont Hospitals, Novartis Pharmaceuticals | Hypertension, Diabetes Type 2 | 12/12 | 12/12 | | |
| Completed | 4 | 124 | US | Salt loading, Hydrochlorothiazide (HCTZ), Hydrochlorothiazide, HCTZ, Apo-Hydro, Aquazide H, Dichlotride, Hydrodiuril, HydroSaluric, Microzide, Esidrex, Oretic. | University of Maryland, Baltimore, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Hypertension | 12/12 | 03/13 | | |
NCT01519635: Effect of Aliskiren and Hydrochlorothiazide on Kidney Oxygenation in Patients With Hypertension |
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| Completed | 4 | 24 | Europe | Aliskiren, Rasilez, Hydrochlorothiazide, Esidrex | Centre Hospitalier Universitaire Vaudois | Hypertension | 10/14 | 10/14 | | |
NCT01822860: Chlorthalidone Compared to Hydrochlorothiazide on Endothelial Function |
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| Withdrawn | 4 | 0 | US | Chlorthalidone 12.5 mg, Hydrochlorothiazide 25 mg, Placebo | Creighton University | Hypertension | 02/15 | 02/15 | | |
NCT01977430: Clinical Trial to Compare Effectiveness of Diuretics in Hemodialysis Patients With Residual Renal Function |
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| Unknown status | 4 | 36 | Europe | Hydrochlorothiazide and furosemide | Corporacion Parc Tauli | Chronic Kidney Insufficiency, Hemodialysis Treatment, Diuresis Preserved | 03/15 | 03/15 | | |
NCT02427880: Role of Acetazolamide and Hydrochlorothiazide Followed by Furosemide in Treating Nephrotic Edema |
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| Completed | 4 | 20 | RoW | Acetazolamide and Hydrochlorothiazide Followed by Furosemide, Diamox Sequels and Microzide Followed by Lasix, Furosemide and Hydrochlorothiazide Followed by Furosemide, Lasix and Microzide Followed by Lasix | Shiraz University of Medical Sciences | Nephrotic Syndrome, Edema | 06/15 | 06/15 | | |
2008-000804-10: Valsartan 160 mg and hydrochlorothiazide 25 mg in subject suffering from arterial hypertension stage 1 or high normal with organ damage |
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| Ongoing | 4 | 20 | Europe | CORIXIL, CORIXIL | UNIVERSITA, DEGLI STUDI DI NAPOLI FEDERICO II | Arterial Hypertension with organ damage | | | | |
2008-005006-39: Study on the vascular effects of ACE-I + CA-antagonist (Enalapril + Lercanidipine) versus ACE-I + diuretic (Enalapril + hydrochlorothiazidE) combinations in hypertensive patients with metabolic syndrome not sufficiently controlled by ACE-I monotherapy |
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| Ongoing | 4 | 200 | Europe | Tablet | AZIENDA OSPEDALIERA PISANA | hypertensive patients of either sex aged 40-69 years | | | | |
2009-017464-17: Arterial Hypertension in patients with elevated aldosterone to renin ratio but negative confirmatory test for Primary Aldosteronism: comparison between anti-hypertensive efficacy of potassium canrenoate and hydrochlorothiazide |
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| Ongoing | 4 | 50 | Europe | Coated tablet, Tablet | AZIENDA OSPEDALIERA ISTITUTI OSPITALIERI DI VERONA | Arterial hypertension associated with elevated ARR | | | | |
2010-022232-37: Effects of a combination treatment with lercanidipine + enalapril vs. lercanidipine + hydrochlorothiazide on blood pressure and endothelial function in essential hypertensive patients |
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| Ongoing | 4 | 24 | Europe | Tablet | AZIENDA OSPEDALIERA SPEDALI CIVILI DI BRESCIA | primary hypertension | | | | |
2012-005129-57: Efficacy and safety of a medicine containing the active substance valsartan, or a medicine (fixed-dose combination) containing the two active substances valsartan and hydrochlorothiazide in the treatment of patients with high blood pressure. |
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| | 4 | 70 | Europe | Valsacor, Valsaden, Valsacor, Valsaden | Krka, d.d., Novo mesto, KRKA ÄŒR, s.r.o., Krka, d.d., Novo mesto, KRKA ÄŒR, s.r.o. | Patients with mild to moderate arterial hypertension. | | | | |
| Not yet recruiting | 4 | 100 | | felodipine 5mg; hydrochlorothiazide 25mg | Institute of Clinical Pharmacology, Central South University; Level of the institution：, Self-financing | Hypertension | | | | |
NCT02217852: Treatment of Hypertension in Tibetan Adult Population |
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| Unknown status | 4 | 800 | RoW | Nitrendipine, Hydrochlorothiazide, Captopril,Hydrochlorothiazide, Beijing hypotensive No.0, compound hypotensive tablet | West China Hospital | Hypertension | 01/16 | 07/16 | | |
NCT02710071: Treatment of OSA Associated Hypertension With Nebivolol or Hydrochlorothiazide |
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| Completed | 4 | 41 | NA | Nebivolol, Bystolic, Hydrochlorothiazide, Hydrodiuril | University of California, San Diego | Hypertension | 04/16 | 04/16 | | |
| Completed | 4 | 41 | NA | Guanfacine, Tenex, Hydrochlorothiazide, Hydrodiuril | University of California, San Diego | Obstructive Sleep Apnea | 06/16 | 08/16 | | |
SMAC AF, NCT00438113: Atrial Substrate Modification With Aggressive Blood Pressure Lowering to Prevent AF |
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| Completed | 4 | 184 | Canada | Aggressive Blood Pressure control, Accupril, Atenolol, Norvasc, Terazosin, Hydrochlorothiazide | Nova Scotia Health Authority, Nova Scotia Health Research Foundation | Atrial Fibrillation | 09/16 | 09/16 | | |
APPROVE, NCT01819441: Stratification of Blood Pressure Control Against Progress of Cerebral Small Vessel Diseases in Poststroke Patients |
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| Unknown status | 4 | 1200 | RoW | Azelnidipine, BeiQi, Perindopril, YiTai, hydrochlorothiazide | Yining Huang | Cerebral Small Vessel Diseases | 12/16 | 12/16 | | |
NCT02100462: Chlorthalidone and HCTZ Impacts on Platelet Activation |
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| Unknown status | 4 | 30 | US | Chlorthalidone 12.5 mg, Hydrochlorothiazide 25 mg, Aspirin 81 mg | Creighton University, Dialysis Clinic, Inc. | Hypertension | 12/16 | 12/16 | | |
NCT02817503: Feasibility Study of the Intensive Systolic Blood Pressure Control |
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| Unknown status | 4 | 100 | RoW | Standard BP control, Enalapril-folic acid,amlodipine,hydrochlorothiazide, Moderate BP control, Intensive BP control | Second Affiliated Hospital of Nanchang University, Peking University First Hospital | Hypertension, Hyperhomocysteinemia | 12/16 | 12/16 | | |
| Unknown status | 4 | 120 | Europe | Enalapril/hydrochlorothiazide, To be determined, Placebo | Erasmus Medical Center, ZonMw: The Netherlands Organisation for Health Research and Development | Essential Hypertension | 05/17 | 05/17 | | |
NCT01748123: EBMtrialcentral- Comparing Initial Diuretic Therapies Using a Collaborative Network |
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| Withdrawn | 4 | 0 | US | Chlorthalidone, Hygroton, Tenoretic, Hydrochlorothiazide, Apo-hydro, Aquazide h, Dichlotride, Oretic | Johns Hopkins University | Hypertension | 06/17 | 06/18 | | |
2017-002175-25: Effects on blood pressure and central sympathetic nerve traffic by SGLT2-inhibition with empagliflozin compared to hydrochlorothiazide in patients with type 2 diabetes mellitus |
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| Ongoing | 4 | 60 | Europe | Film-coated tablet, Tablet, Jardiance®, HCT-ratiopharm® 25 mg Tabletten | Profil Institut für Stoffwechselforschung GmbH, Boehringer Ingelheim Pharma GmbH & Co. KG | type 2 diabetes mellitus, type 2 diabetes mellitus, Diseases [C] - Nutritional and Metabolic Diseases [C18] | | | | |
BEAHIT, NCT02646397: Benidipine and Hydrochlorothiazide in Fosinopril Treated Chronic Kidney Disease Patients With Hypertension |
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| Unknown status | 4 | 508 | RoW | Fosinopril, Fosinopril Sodium, Squibb Brand of Fosinopril Sodium, Fosinil, Benidipine, benidipine hydrochloride, Hydrochlorothiazide, HCTZ, Dichlothiazide, HydroDIURIL | Shanghai Changzheng Hospital, First Affiliated Hospital of Zhejiang University, Zhongda Hospital, Ruijin Hospital, The First Affiliated Hospital of Zhengzhou University, Sichuan Provincial People's Hospital, The Second Affiliated Hospital of Dalian Medical University, The First Affiliated Hospital of Anhui Medical University | Chronic Kidney Disease | 12/17 | 12/17 | | |
ChiCTR-IPR-17012046: First-Line Antihypertensive comparison for Tibetan mild-moderate hypertension (FLAT): study protocol for a randomized crossover controlled trial |
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| Not yet recruiting | 4 | 1593 | | omelsartan ;amlodipine ;hydrochlorothiazide | West China hospital, Sichuan university; West China hospital, Sichuan university, Funds from Science and technology department of Sichuan province | Hypertension | | | | |
Creole, NCT02742467: Comparison of Three Combination Therapies in Lowering Blood Pressure in Black Africans |
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| Completed | 4 | 702 | RoW | Perindopril plus Amlodipine, Perindopril plus Hydrochlorothiazide, Amlodipine plus Hydrochlorothiazide | University of Abuja, Imperial College London, University of Cape Town, Hôpital Edouard Herriot, University of Nairobi, University College Hospital, Ibadan, Hospital General De Douala, Mulago Hospital, Uganda | Hypertension | 06/18 | 06/18 | | |
ChiCTR-IPR-17013419: A randomized controlled trial of primary hypertension treated by diuretics combined with ARB compared to with CCB |
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| Not yet recruiting | 4 | 100 | | Erbesartan 150mg+ hydrochlorothiazide 12.5mg ;lercanidipine 10mg+ hydrochlorothiazide 12.5mg | Second Affiliated Hospital of Chongqing Medical University; Second Affiliated Hospital of Chongqing Medical University, Chongqing science and technology commission fund | primary hypertention | | | | |
ChiCTR-IPR-17013413: Research on chronic disease management by internet and application of diuretics in people with hypertension |
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| Not yet recruiting | 4 | 3750 | | hydrochlorothiazide ;Join hypertensive WeChat platform ;Join hypertensive WeChat platform | Second Affiliated Hospital of Chongqing Medical University; Second Affiliated Hospital of Chongqing Medical University, Chongqing science and technology commission fund | primary hypertention | | | | |
UFLC, NCT02046395: Effect of Renin-angiotensin-system Blockade on Urinary Free Light Chains in Patients With Type 2 Diabetes Mellitus |
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| Completed | 4 | 28 | US | amlodipine, hydralazine, terazosin or hydrochlorothiazide, Norvasc | Tulane University School of Medicine | Type 2 Diabetes, Hypertension | 12/19 | 12/19 | | |
CLOROTIC, NCT01647932: Safety and Efficacy of the Combination of Loop With Thiazide-type Diuretics in Patients With Decompensated Heart Failure |
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| Completed | 4 | 232 | Europe | hydrochlorothiazide, Placebo | Spanish Society of Internal Medicine | Heart Failure | 12/19 | 12/19 | | |
| Unknown status | 4 | 30 | Europe | Dapagliflozin 10 MG, DAPA, Hydrochlorothiazide 12.5mg, HCT | University of Pisa | Renal Function Disorder, Glucose Metabolism Disorders | 12/19 | 04/20 | | |
NCT04521023: A Clinical Trial to Evaluate the Blood Pressure Lowering Effect of a Candemore Plus Tab Versus Cantabell Tab in Hypertensive Patients Inadequately Controlled by Candesartan Monotherapy |
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| Completed | 4 | 132 | RoW | Cantabell Tab, Candemore Plus Tab | Chong Kun Dang Pharmaceutical | Hypertension | 01/20 | 06/20 | | |
| Completed | 4 | 75 | Europe | Empagliflozin, Jardiance, Hydrochlorothiazide 25 mg, HCT | Profil Institut für Stoffwechselforschung GmbH | Type 2 Diabetes Mellitus | 04/20 | 04/20 | | |
NCT03640221: Ertugliflozin Versus Hydrochlorothiazide in Reducing Sympathetic Neural Overactivity in Patients With Hypertension and Recently-diagnosed Type 2 Diabetes. |
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| Withdrawn | 4 | 0 | US | Ertugliflozin, SGLT2 inhibitor, Hydrochlorothiazide 12.5mg, mild antihypertensive comparator, Microneurography, SKNA recordings, Static Handgrip, Post-handgrip forearm vascular occlusion, Testing of the Arterial Baroreflex Function | Cedars-Sinai Medical Center, Merck Sharp & Dohme LLC | Hypertension, Diabetes Mellitus, Type 2 | 05/20 | 08/20 | | |
| Suspended | 4 | 2414 | Europe | Thiazide or Thiazide-like diuretics, Hydrochlorothiazide, metolazone, chlorthalidone, chlorothiazide, bendroflumethiazide, indapamide, Calcium Channel Blockers, Amlodipine, diltiazem, felodipine, nicardipine, nifedipine, nimodipine, nitrendipine, verapamil, ACE inhibitor, Benazepril, captopril, enalapril, fosinopril, lisinopril, perindopril, quinapril, ramipril, trandolapril, Angiotensin receptor blocker, Candesartan, eprosartan, irbesartan, losartan, olmesartan, telmisartan, valsartan | National University of Ireland, Galway, Ireland | Hypertension, COVID-19 | 07/21 | 12/21 | | |
| Recruiting | 4 | 300 | Europe | Furosemide, Hydrochlorothiazide | University Hospital, Clermont-Ferrand, University Hospital, Grenoble, Hospices Civils de Lyon, Hôpital de la Croix-Rousse, CH Puy en Velay, CH Moulins-Yzeure, CH Riom, Infirmerie Protestante de Lyon, CH Issoire, CH Annecy Genevois | Heart Failure, Acute Heart Failure, Chronic Heart Failure | 12/21 | 12/21 | | |
ChiCTR-IPR-17012048: First-line Antihypertensive Combinations comparison for Tibetan high-risk hypertension |
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| Not yet recruiting | 4 | 3417 | | omelsartan+amlodipine ;omelsartan+hydrochlorothiazide ;amlodipine+hydrochlorothiazide | Cardiovascular department of West China hospital; West China Hospital, Sichuan University, Funds from science and technology department of Sichuan province | Hypertension | | | | |
ACE, NCT05049616: Oral Combined Hydrochlorothiazide/Lisinopril Versus Oral Nifedipine for Postpartum Hypertension |
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| Active, not recruiting | 4 | 70 | US | ACE Inhibitors and Diuretics, NIFEdipine ER | The University of Texas Health Science Center, Houston | Hypertension in Pregnancy, Postpartum Preeclampsia | 06/22 | 10/23 | | |
NCT03423355: Dapagliflozin Effect on Erythropoiesis and Physical Fitness |
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| Withdrawn | 4 | 0 | Europe | Dapagliflozin (Forxiga®), Hydrochlorothiazide 25 mg, Placebo matching Dapagliflozin | University Hospital Tuebingen | Type 2 Diabetes Mellitus (T2DM) | 03/23 | 12/23 | | |
ATLAS, NCT03109795: Anxiety-mediated Impairments in Large Elastic Artery Function and the Autonomic Nervous System |
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| Terminated | 4 | 30 | US | Clonidine Pill, Hydrochlorothiazide | University of Iowa | Anxiety, Hypertension | 06/23 | 06/23 | | |
ChiCTR2300067920: The efficacy of Chinese traditional single pill containing quadruple combination of blood pressure medicines versus valsartan/hydrochlorothiazide in patients with hypertension: a multicenter, open-label, non-inferiority, randomized controlled study |
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| Not yet recruiting | 4 | 1332 | | take compound reserpine and triamterene tablets ;take valsartan/hydrochlorothiazide | West China Hospital of Sichuan University; Huarun Shuanghe Limin Pharmaceutical (Ji'nan) Co., Ltd., Huarun Shuanghe Limin Pharmaceutical (Ji'nan) Co., Ltd. | Hypertension | | | | |
| Recruiting | 4 | 46 | US | Diuretic augmentation (hydrochlorothiazide, chlorthalidone, furosemide, torsemide, or bumetanide) | VA Office of Research and Development | Chronic Kidney Disease, Hypertension | 07/25 | 07/25 | | |
NCT05443932: Dapagliflozin and Hydrochlorothiazide in Recurring Kidney Stone Patients |
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| Not yet recruiting | 4 | 32 | Europe | Dapagliflozin, Hydrochlorothiazide | Medical University of Vienna | Urolithiasis, Hyperoxaluria | 12/24 | 12/25 | | |
