hydrochlorothiazide / Generic mfg.  >>  Phase 1
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41 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
hydrochlorothiazide / Generic mfg.
NCT00649597: Fasting Study of Benazepril HCl and Hydrochlorothiazide Tablets 20 mg/25 mg to Lotensin HCT® Tablets 20 mg/25 mg

Completed
1
56
US
Benazepril HCl and Hydrochlorothiazide Tablets 20 mg/25 mg, Lotensin HCT® Tablets 20 mg/25 mg
Mylan Pharmaceuticals Inc
Healthy
12/02
12/02
NCT00649038: Fed Study of Benazepril HCl and Hydrochlorothiazide Tablets 20 mg/25 mg to Lotensin HCT® Tablets 20 mg/25 mg

Completed
1
24
US
Benazepril HCl and Hydrochlorothiazide Tablets 20 mg/25 mg, Lotensin HCT® Tablets 20 mg/25 mg
Mylan Pharmaceuticals Inc
Healthy
12/02
12/02
NCT00649233: Food Study of Metoprolol Tartrate/Hydrochlorothiazide Tablets 100/50 mg to Lopressor HCT® Tablets 100/50 mg

Completed
1
32
US
Metoprolol Tartrate/Hydrochlorothiazide Tablets 100/50 mg, Lopressor HCT® Tablets 100/50 mg
Mylan Pharmaceuticals Inc
Healthy
02/03
02/03
NCT00649688: Fasting Study of Metoprolol Tartrate/Hydrochlorothiazide Tablets 100/50 mg and Lopressor HCT® Tablets 100/50 mg

Completed
1
32
US
Metoprolol Tartrate/Hydrochlorothiazide Tablets 100/50 mg, Lopressor HCT® Tablets 100/50 mg
Mylan Pharmaceuticals Inc
Healthy
02/03
02/03
NCT00648011: Food Study of Quinapril HCl and Hydrochlorothiazide Tablets 20 mg/25 mg to Accuretic™ Tablets 20 mg/25 mg

Completed
1
44
US
Quinapril HCl and Hydrochlorothiazide Tablets 20 mg/25 mg, Accuretic™ Tablets 20 mg/25 mg
Mylan Pharmaceuticals Inc
Healthy
08/03
09/03
NCT00649441: Fasting Study of Quinapril HCl and Hydrochlorothiazide Tablets 20 mg/25 mg to Accuretic™ Tablets 20 mg/25 mg

Completed
1
60
US
Quinapril HCl and Hydrochlorothiazide Tablets 20 mg/25 mg, Accuretic™ Tablets 20 mg/25 mg
Mylan Pharmaceuticals Inc
Healthy
09/03
09/03
NCT00834067: Moexipril HCl/Hydrochlorothiazide 15/25 mg Tablets Under Non-Fasting Conditions

Completed
1
60
US
Moexipril HCl/hydrochlorothiazide 15/25 mg tablets, UNIRETIC® 15/25 mg tablets
Teva Pharmaceuticals USA
Healthy
11/03
11/03
NCT00835042: Moexipril HCL/Hydrochlorothiazide 15/25 mg Tablets Under Fasting Conditions

Completed
1
60
US
Moexipril HCl/hydrochlorothiazide 15/25 mg tablets, UNIRETIC® 15/25 mg tablets
Teva Pharmaceuticals USA
Healthy
11/03
11/03
NCT00649324: Fasting Study of Hydrochlorothiazide Tablets 50 mg to Hydrochlorothiazide Tablets 50 mg

Completed
1
40
US
Hydrochlorothiazide Tablets 50 mg, Hydrochlorothiazide Tablets (50 mg
Mylan Pharmaceuticals Inc
Healthy
10/05
10/05
NCT00671424: A Study To Compare Effects Of GSK189075 In Combination With Either Furosemide Or Hydrochlorothiazide

Completed
1
48
US
Hydrochlorothiazide (HCTZ), Remogliflozin etabonate (GSK189075), Furosemide
GlaxoSmithKline
Type 2 Diabetes Mellitus, Diabetes Mellitus, Type 2
05/08
05/08
NCT00923533: A Study to Evaluate the Safety and Pharmacokinetics After Oral Concurrent Administration of Fimasartan and Hydrochlorothiazide in Healthy Male Volunteers

Completed
1
34
RoW
Fimasartan, Hydrochlorothiazide
Boryung Pharmaceutical Co., Ltd
Essential Hypertension
05/09
08/09
NCT00871871: Multiple Dose Effects of Hydrochlorothiazide and Isosorbide Mononitrate on Glucose Homeostasis (MK-0000-117)(Completed)

Completed
1
64
RoW
Hydrochlorothiazide (HCTZ), HCTZ, Comparator: Placebo to HCTZ, Isosorbide mononitrate (ISMN), Comparator: Placebo to ISMN
Merck Sharp & Dohme LLC
Hypertension
02/10
03/10
NCT01276288: Pharmacodynamics and Pharmacokinetics of Empagliflozin and Torasemide in Patients With Type 2 Diabetes

Completed
1
23
Europe
BI 10773, hydrochlorothiazide, torasemide
Boehringer Ingelheim
Diabetes Mellitus, Type 2
06/11
 
NCT02962258: BE Study of Torrent's Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide Tab - Fed Conditions

Completed
1
34
US
Torrent's Olmesartaan medoxomil, Amlodipine and Hydrochlorothiazide Tablets, Tribenzor of Daichi Sankyo Inc. USA
Torrent Pharmaceuticals Limited
Healthy Subjects
06/11
06/11
NCT02962336: Bioequivalence Study of Torrent's Olmesartan Medoxomil, Amlodipine and Hydrochloride Tablets Under Fasting Conditions.

Completed
1
34
US
Torrent's Olmesartan medoxomil, Amlodipine and Hydrochlorothiazide Tablets, Tribenzor Tablets of Daichi Sankyo Inc, USA
Torrent Pharmaceuticals Limited
Healthy Subjects
06/11
06/11
NCT01294631: A Pharmacodynamics, Pharmacokinetics, and Safety Study of Hydrochlorothiazide and Canagliflozin in Healthy Volunteers

Checkmark Pharmacodynamics, pharmacokinetics, and safety in healthy subjects
Apr 2014 - Apr 2014: Pharmacodynamics, pharmacokinetics, and safety in healthy subjects
Checkmark
Apr 2014 - Apr 2014: 
Completed
1
30
US
Canagliflozin 300 mg once daily and HCTZ 25 mg once daily
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Healthy
07/11
07/11
NCT01370655: A Study of MK-7145 Compared to Placebo and Hydrochlorothiazide for Lowering Blood Pressure in Male Participants With Hypertension (MK-7145-009)

Completed
1
46
NA
MK-7145, Hydrochlorothiazide (HCTZ), Placebo to MK-7145, Placebo to HCTZ
Merck Sharp & Dohme LLC
Hypertension
12/11
01/12
NCT01103245: Aldosterone and the Metabolic Syndrome

Completed
1
69
US
Hydrochlorothiazide (HCTZ), HCTZ, Aliskiren 150 mg (ALI 150), Tekturna, Spironolactone (SPL 25), Aldactone, Aliskiren 300 mg (ALI 300), Spironolactone 50 mg (SPL 50)
Vanderbilt University Medical Center
Metabolic Diseases, Diabetes Mellitus, Endocrine System Diseases, Glucose Metabolism Disorders
07/12
09/13
NCT01827878: Bioequivalence Study of Lisinopril and Hydrochlorothiazide Tablets (20+25) mg Under Fed Conditions

Completed
1
48
RoW
Lisinopril and Hydrochlorothiazide Tablets (20+25) mg, Test product, Zestoretic® 20/25 lisinopril/hydrochlorothiazide Tablets, Reference product
IPCA Laboratories Ltd.
Fed
10/12
10/12
NCT01831700: Bioequivalence Study of Lisinopril and Hydrochlorothiazide Tablets (20+25) mg Under Fasting Conditions

Completed
1
48
RoW
Lisinopril and Hydrochlorothiazide Tablets (20+25) mg, Test product, Zestoretic® 20/25 lisinopril/hydrochlorothiazide Tablets, Reference product
IPCA Laboratories Ltd.
Fasting
10/12
10/12
NCT01087749: Pharmacokinetic Study in Patients With Chronic Kidney Disease and Healthy Volunteers

Completed
1
24
US
Propranolol, Propranolol Hydrochloride, Ciplar, Ciplar LA, Inderal, Inderal LA, Avlocardyl, Deralin, Dociton, Inderalici, InnoPran XL, Sumial, Anaprilinum, Bedranol SR, Losartan, Cozaar, Losartan potassium, Anin, Eprosartan, Teveten, Eprozar, Teveten HCT (paired with hydrochlorothiazide), Teveten Plus (paired with hydrochlorothiazide)
University of California, San Francisco
Kidney Disease
12/12
12/12

Completed
1
24
 
taking the reference formulation first, then taking the test preparation ;taking the test preparation first, then taking the reference formulation
The first affiliated hospital, School of Medicine, Zhejiang University; None, Provided by Zhejiang Hisun Pharmaceutical Co. Ltd.
hypertension
 
 
NCT00990301: A Study to Compare the Relative Bioavailability of Moexipril HCl/Hydrochlorothiazide in Healthy Adult Volunteers Under Fasting Conditions

Completed
1
48
US
Moexipril HCl/ Hydrochlorothiazide 15mg/ 25mg Tablet, Paddock Laboratories, Inc., Uniretic® 15mg/25mg Tablets
Paddock Laboratories, Inc.
Healthy
 
 
NCT02094924: A Relative Bioavailability Study of a Fixed Dose Combination (FDC) Tablets of GSK587323

Completed
1
16
RoW
GSK587323, FDC of candesartan cilexetil 16 mg and HCTZ 12.5mg
GlaxoSmithKline
Hypertension
05/14
05/14
NCT00574834: Mechanisms of Ramipril Reduction in the Onset of Type 2 Diabetes

Terminated
1
17
US
Ramipril, Altace, HCTZ-hydrochlorothiazide, Brand Names: HydroDIURIL, Microzide, Ramipril+HCTZ, Altace and HydroDIURIL, Microzide
University of Maryland, Baltimore, King Pharmaceuticals is now a wholly owned subsidiary of Pfizer
Metabolic Syndrome
08/14
08/14
NCT02121535: Bioequivalence Study of Telmisartan Between T80/A5/H12.5 mg FDC Tablet and T80/A5 mg Tab and H12.5 mg Tab Concomitant Use

Completed
1
72
Japan
T80/A5 mg FDC tablet, H12.5 mg tablet, T80/A5/H12.5 ng FDC tablet, H12.5 mf tablet, T80/A5/H12.5 mg FDC tablet
Boehringer Ingelheim
Healthy
08/14
08/14
NCT00223717: Treatment of Supine Hypertension in Autonomic Failure

Completed
1
152
US
Clonidine, Catapres, Nitroglycerin transdermal, Nitro-Dur, Dipyridamole/ Aspirin (Aggrenox), Aggrenox, Desmopressin (DDAVP), DDAVP, Sildenafil, Viagra, Nifedipine, Adalat, Hydralazine, Hydrochlorothiazide, Microzide, Placebo, Bosentan, Tracleer, Diltiazem, Cardizem, Eplerenone, Inspra, guanfacine, Tenex, L-arginine, captopril, capoten, carbidopa, Lodosyn, losartan, cozaar, metoprolol tartrate, lopressor, nebivolol hydrochloride, Bystolic, prazosin hydrochloride, Minipress, tamsulosin hydrochloride, Flomax, Head-up tilt., HUT, aliskiren, Tekturna, Local heat stress, heating pad
Vanderbilt University
Hypertension
01/17
01/17
NCT02744456: N-of-1 Trials for Blood Pressure Medications in Adults

Completed
1
10
US
Losartan, Losartan potassium tablets, Cozaar, Amlodipine, Amlodipine besylate tablets, Norvasc, Hydrochlorothiazide, HCTZ, Hydrochlorothiazide tablets
Columbia University
Hypertension, High Blood Pressure
08/17
12/17
NCT03390465: Drug Interaction Study of Fimasartan/Amlodipine/Hydrochlorothiazide in Healthy Male Subjects

Completed
1
36
RoW
Fimasartan/Amlodipine combination drug, Hydrochlorothiazide, FAH
Boryung Pharmaceutical Co., Ltd
Drug-Drug Interaction
01/18
01/18
NCT03387657: A Drug to Drug Interaction Study of Sotagliflozin With Hydrochlorothiazide

Completed
1
16
US
Sotagliflozin (SAR439954), Hydrochlorothiazide
Sanofi
Type 2 Diabetes Mellitus
03/18
03/18
NCT03629067: Combination of Fimasartan/Amlodipine/Hydrochlorothiazide in Healthy Male Subjects

Completed
1
60
RoW
Treatment T, FAH, Treatment R, FA/H
Boryung Pharmaceutical Co., Ltd
Pharmacokinetics
11/18
12/18
NCT04197622: Generation of Biological Samples Positive to Hydrochlorothiazide for Anti-doping Control

Completed
1
3
Europe
Hydrochlorothiazide
Parc de Salut Mar
Healthy Volunteers
03/19
03/19
NCT06083116: Drug-Drug Interaction Study Between Henagliflozin Proline and Hydrochlorothiazide

Completed
1
12
RoW
Hydrochlorothiazide、Henagliflozin Proline
Jiangsu HengRui Medicine Co., Ltd.
Diabetes in Adults
10/19
10/19
MatCH, NCT03147092: Matão Controlling Hypertension ( Study): Rationale and Design

Unknown status
1
15000
NA
Captopril 25Mg, Hydrochlorothiazide 25Mg Oral Tablet,, Atenolol, Losartan potassium 50mg, Clonidine
Centro Neurológico de Pesquisa e Reabiitação, Brazil
Hypertension, Blood Pressure
06/20
06/21
NCT03971929: Safety and Effect Study of SHR0532 (Drug Code) Tablets in Patients With Mild Hypertension

Completed
1
36
RoW
SHR0532, SHR placebo, Hydrochlorothiazide 25 mg
Jiangsu HengRui Medicine Co., Ltd.
Hypertension
09/20
09/20
NCT04654312: Study to Evaluate the Influence of Hydrochlorothiazide on Dermal Photosensitivity and DNA Stability - a Pilot Study (HCTox Study)

Completed
1
30
Europe
Hydrochlorothiazide, HCT, Placebo
Universität des Saarlandes
Photosensitivity
07/21
07/21
NCT04964050: A Bioequivalence Study Between Capozide Versus ACE-Hemmer-ratiopharm in Healthy Adult Participants Under Fasting Conditions

Withdrawn
1
0
NA
Capozide, ACE-Hemmer-Ratiopharm
GlaxoSmithKline
Healthy Volunteers
05/22
05/22
ChiCTR2200062994: A randomized, open-label, two-sequence, two-agent, four-cycle, fully replicated crossover bioequivalence trial of a single oral dose of valsartan and hydrochlorothiazide tablets in healthy subjects

Not yet recruiting
1
112
 
R-T-R-T ;R-T-R-T ;T-R-T-R ;T-R-T-R
Huzhou Central Hospital; Zhejiang Ingle Pharmaceutical Co., Ltd., Zhejiang Ingle Pharmaceutical Co., Ltd.
Hypertension in all stages
 
 
PASSION, NCT04676399: Improving Pain Management Via Spinal Cord Stimulation and Blood Pressure Reduction

Recruiting
1
36
US
Hydrochlorothiazide 12.5mg, HCTZ, Placebo
University of Kansas Medical Center
Chronic Pain, Hypertension, Diuretics Drug Reactions, SCS
12/24
12/24
SELECT, NCT04423627: Sympathetic Regulation of Large Artery Stiffness in Humans With ISH

Recruiting
1
78
US
Clonidine, Hydrochlorothiazide, Placebo
University of Iowa
Hypertension, Systolic, Stiffness, Aortic
06/25
12/25
MAPLE, NCT04934228: Mitigating the Pro-inflammatory Phenotype of Obesity

Recruiting
1
60
US
Hydrochlorothiazide 12.5Mg Tab, Hydrochlorothiazide, Clonidine Pill, Clonidine, Placebo
University of Kansas Medical Center
Blood Pressure, Diabetes, Obesity, Insulin Resistance, Diuretics Drug Reactions, Sympathetic Nerve Activity
07/25
07/25

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