hydrochlorothiazide / Generic mfg. |
NCT00649597: Fasting Study of Benazepril HCl and Hydrochlorothiazide Tablets 20 mg/25 mg to Lotensin HCT® Tablets 20 mg/25 mg |
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| Completed | 1 | 56 | US | Benazepril HCl and Hydrochlorothiazide Tablets 20 mg/25 mg, Lotensin HCT® Tablets 20 mg/25 mg | Mylan Pharmaceuticals Inc | Healthy | 12/02 | 12/02 | | |
NCT00649038: Fed Study of Benazepril HCl and Hydrochlorothiazide Tablets 20 mg/25 mg to Lotensin HCT® Tablets 20 mg/25 mg |
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| Completed | 1 | 24 | US | Benazepril HCl and Hydrochlorothiazide Tablets 20 mg/25 mg, Lotensin HCT® Tablets 20 mg/25 mg | Mylan Pharmaceuticals Inc | Healthy | 12/02 | 12/02 | | |
NCT00649233: Food Study of Metoprolol Tartrate/Hydrochlorothiazide Tablets 100/50 mg to Lopressor HCT® Tablets 100/50 mg |
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| Completed | 1 | 32 | US | Metoprolol Tartrate/Hydrochlorothiazide Tablets 100/50 mg, Lopressor HCT® Tablets 100/50 mg | Mylan Pharmaceuticals Inc | Healthy | 02/03 | 02/03 | | |
NCT00649688: Fasting Study of Metoprolol Tartrate/Hydrochlorothiazide Tablets 100/50 mg and Lopressor HCT® Tablets 100/50 mg |
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| Completed | 1 | 32 | US | Metoprolol Tartrate/Hydrochlorothiazide Tablets 100/50 mg, Lopressor HCT® Tablets 100/50 mg | Mylan Pharmaceuticals Inc | Healthy | 02/03 | 02/03 | | |
NCT00648011: Food Study of Quinapril HCl and Hydrochlorothiazide Tablets 20 mg/25 mg to Accuretic™ Tablets 20 mg/25 mg |
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| Completed | 1 | 44 | US | Quinapril HCl and Hydrochlorothiazide Tablets 20 mg/25 mg, Accuretic™ Tablets 20 mg/25 mg | Mylan Pharmaceuticals Inc | Healthy | 08/03 | 09/03 | | |
NCT00649441: Fasting Study of Quinapril HCl and Hydrochlorothiazide Tablets 20 mg/25 mg to Accuretic™ Tablets 20 mg/25 mg |
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| Completed | 1 | 60 | US | Quinapril HCl and Hydrochlorothiazide Tablets 20 mg/25 mg, Accuretic™ Tablets 20 mg/25 mg | Mylan Pharmaceuticals Inc | Healthy | 09/03 | 09/03 | | |
NCT00834067: Moexipril HCl/Hydrochlorothiazide 15/25 mg Tablets Under Non-Fasting Conditions |
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| Completed | 1 | 60 | US | Moexipril HCl/hydrochlorothiazide 15/25 mg tablets, UNIRETIC® 15/25 mg tablets | Teva Pharmaceuticals USA | Healthy | 11/03 | 11/03 | | |
NCT00835042: Moexipril HCL/Hydrochlorothiazide 15/25 mg Tablets Under Fasting Conditions |
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| Completed | 1 | 60 | US | Moexipril HCl/hydrochlorothiazide 15/25 mg tablets, UNIRETIC® 15/25 mg tablets | Teva Pharmaceuticals USA | Healthy | 11/03 | 11/03 | | |
NCT00649324: Fasting Study of Hydrochlorothiazide Tablets 50 mg to Hydrochlorothiazide Tablets 50 mg |
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| Completed | 1 | 40 | US | Hydrochlorothiazide Tablets 50 mg, Hydrochlorothiazide Tablets (50 mg | Mylan Pharmaceuticals Inc | Healthy | 10/05 | 10/05 | | |
NCT00671424: A Study To Compare Effects Of GSK189075 In Combination With Either Furosemide Or Hydrochlorothiazide |
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| Completed | 1 | 48 | US | Hydrochlorothiazide (HCTZ), Remogliflozin etabonate (GSK189075), Furosemide | GlaxoSmithKline | Type 2 Diabetes Mellitus, Diabetes Mellitus, Type 2 | 05/08 | 05/08 | | |
NCT00923533: A Study to Evaluate the Safety and Pharmacokinetics After Oral Concurrent Administration of Fimasartan and Hydrochlorothiazide in Healthy Male Volunteers |
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| Completed | 1 | 34 | RoW | Fimasartan, Hydrochlorothiazide | Boryung Pharmaceutical Co., Ltd | Essential Hypertension | 05/09 | 08/09 | | |
NCT00871871: Multiple Dose Effects of Hydrochlorothiazide and Isosorbide Mononitrate on Glucose Homeostasis (MK-0000-117)(Completed) |
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| Completed | 1 | 64 | RoW | Hydrochlorothiazide (HCTZ), HCTZ, Comparator: Placebo to HCTZ, Isosorbide mononitrate (ISMN), Comparator: Placebo to ISMN | Merck Sharp & Dohme LLC | Hypertension | 02/10 | 03/10 | | |
NCT01276288: Pharmacodynamics and Pharmacokinetics of Empagliflozin and Torasemide in Patients With Type 2 Diabetes |
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| Completed | 1 | 23 | Europe | BI 10773, hydrochlorothiazide, torasemide | Boehringer Ingelheim | Diabetes Mellitus, Type 2 | 06/11 | | | |
NCT02962258: BE Study of Torrent's Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide Tab - Fed Conditions |
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| Completed | 1 | 34 | US | Torrent's Olmesartaan medoxomil, Amlodipine and Hydrochlorothiazide Tablets, Tribenzor of Daichi Sankyo Inc. USA | Torrent Pharmaceuticals Limited | Healthy Subjects | 06/11 | 06/11 | | |
NCT02962336: Bioequivalence Study of Torrent's Olmesartan Medoxomil, Amlodipine and Hydrochloride Tablets Under Fasting Conditions. |
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| Completed | 1 | 34 | US | Torrent's Olmesartan medoxomil, Amlodipine and Hydrochlorothiazide Tablets, Tribenzor Tablets of Daichi Sankyo Inc, USA | Torrent Pharmaceuticals Limited | Healthy Subjects | 06/11 | 06/11 | | |
NCT01294631: A Pharmacodynamics, Pharmacokinetics, and Safety Study of Hydrochlorothiazide and Canagliflozin in Healthy Volunteers |
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| Completed | 1 | 30 | US | Canagliflozin 300 mg once daily and HCTZ 25 mg once daily | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Healthy | 07/11 | 07/11 | | |
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NCT01370655: A Study of MK-7145 Compared to Placebo and Hydrochlorothiazide for Lowering Blood Pressure in Male Participants With Hypertension (MK-7145-009) |
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| Completed | 1 | 46 | NA | MK-7145, Hydrochlorothiazide (HCTZ), Placebo to MK-7145, Placebo to HCTZ | Merck Sharp & Dohme LLC | Hypertension | 12/11 | 01/12 | | |
| Completed | 1 | 69 | US | Hydrochlorothiazide (HCTZ), HCTZ, Aliskiren 150 mg (ALI 150), Tekturna, Spironolactone (SPL 25), Aldactone, Aliskiren 300 mg (ALI 300), Spironolactone 50 mg (SPL 50) | Vanderbilt University Medical Center | Metabolic Diseases, Diabetes Mellitus, Endocrine System Diseases, Glucose Metabolism Disorders | 07/12 | 09/13 | | |
NCT01827878: Bioequivalence Study of Lisinopril and Hydrochlorothiazide Tablets (20+25) mg Under Fed Conditions |
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| Completed | 1 | 48 | RoW | Lisinopril and Hydrochlorothiazide Tablets (20+25) mg, Test product, Zestoretic® 20/25 lisinopril/hydrochlorothiazide Tablets, Reference product | IPCA Laboratories Ltd. | Fed | 10/12 | 10/12 | | |
NCT01831700: Bioequivalence Study of Lisinopril and Hydrochlorothiazide Tablets (20+25) mg Under Fasting Conditions |
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| Completed | 1 | 48 | RoW | Lisinopril and Hydrochlorothiazide Tablets (20+25) mg, Test product, Zestoretic® 20/25 lisinopril/hydrochlorothiazide Tablets, Reference product | IPCA Laboratories Ltd. | Fasting | 10/12 | 10/12 | | |
NCT01087749: Pharmacokinetic Study in Patients With Chronic Kidney Disease and Healthy Volunteers |
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| Completed | 1 | 24 | US | Propranolol, Propranolol Hydrochloride, Ciplar, Ciplar LA, Inderal, Inderal LA, Avlocardyl, Deralin, Dociton, Inderalici, InnoPran XL, Sumial, Anaprilinum, Bedranol SR, Losartan, Cozaar, Losartan potassium, Anin, Eprosartan, Teveten, Eprozar, Teveten HCT (paired with hydrochlorothiazide), Teveten Plus (paired with hydrochlorothiazide) | University of California, San Francisco | Kidney Disease | 12/12 | 12/12 | | |
| Completed | 1 | 24 | | taking the reference formulation first, then taking the test preparation ;taking the test preparation first, then taking the reference formulation | The first affiliated hospital, School of Medicine, Zhejiang University; None, Provided by Zhejiang Hisun Pharmaceutical Co. Ltd. | hypertension | | | | |
NCT00990301: A Study to Compare the Relative Bioavailability of Moexipril HCl/Hydrochlorothiazide in Healthy Adult Volunteers Under Fasting Conditions |
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| Completed | 1 | 48 | US | Moexipril HCl/ Hydrochlorothiazide 15mg/ 25mg Tablet, Paddock Laboratories, Inc., Uniretic® 15mg/25mg Tablets | Paddock Laboratories, Inc. | Healthy | | | | |
NCT02094924: A Relative Bioavailability Study of a Fixed Dose Combination (FDC) Tablets of GSK587323 |
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| Completed | 1 | 16 | RoW | GSK587323, FDC of candesartan cilexetil 16 mg and HCTZ 12.5mg | GlaxoSmithKline | Hypertension | 05/14 | 05/14 | | |
NCT00574834: Mechanisms of Ramipril Reduction in the Onset of Type 2 Diabetes |
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| Terminated | 1 | 17 | US | Ramipril, Altace, HCTZ-hydrochlorothiazide, Brand Names: HydroDIURIL, Microzide, Ramipril+HCTZ, Altace and HydroDIURIL, Microzide | University of Maryland, Baltimore, King Pharmaceuticals is now a wholly owned subsidiary of Pfizer | Metabolic Syndrome | 08/14 | 08/14 | | |
NCT02121535: Bioequivalence Study of Telmisartan Between T80/A5/H12.5 mg FDC Tablet and T80/A5 mg Tab and H12.5 mg Tab Concomitant Use |
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| Completed | 1 | 72 | Japan | T80/A5 mg FDC tablet, H12.5 mg tablet, T80/A5/H12.5 ng FDC tablet, H12.5 mf tablet, T80/A5/H12.5 mg FDC tablet | Boehringer Ingelheim | Healthy | 08/14 | 08/14 | | |
NCT00223717: Treatment of Supine Hypertension in Autonomic Failure |
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| Completed | 1 | 152 | US | Clonidine, Catapres, Nitroglycerin transdermal, Nitro-Dur, Dipyridamole/ Aspirin (Aggrenox), Aggrenox, Desmopressin (DDAVP), DDAVP, Sildenafil, Viagra, Nifedipine, Adalat, Hydralazine, Hydrochlorothiazide, Microzide, Placebo, Bosentan, Tracleer, Diltiazem, Cardizem, Eplerenone, Inspra, guanfacine, Tenex, L-arginine, captopril, capoten, carbidopa, Lodosyn, losartan, cozaar, metoprolol tartrate, lopressor, nebivolol hydrochloride, Bystolic, prazosin hydrochloride, Minipress, tamsulosin hydrochloride, Flomax, Head-up tilt., HUT, aliskiren, Tekturna, Local heat stress, heating pad | Vanderbilt University | Hypertension | 01/17 | 01/17 | | |
NCT02744456: N-of-1 Trials for Blood Pressure Medications in Adults |
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| Completed | 1 | 10 | US | Losartan, Losartan potassium tablets, Cozaar, Amlodipine, Amlodipine besylate tablets, Norvasc, Hydrochlorothiazide, HCTZ, Hydrochlorothiazide tablets | Columbia University | Hypertension, High Blood Pressure | 08/17 | 12/17 | | |
NCT03390465: Drug Interaction Study of Fimasartan/Amlodipine/Hydrochlorothiazide in Healthy Male Subjects |
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| Completed | 1 | 36 | RoW | Fimasartan/Amlodipine combination drug, Hydrochlorothiazide, FAH | Boryung Pharmaceutical Co., Ltd | Drug-Drug Interaction | 01/18 | 01/18 | | |
NCT03387657: A Drug to Drug Interaction Study of Sotagliflozin With Hydrochlorothiazide |
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| Completed | 1 | 16 | US | Sotagliflozin (SAR439954), Hydrochlorothiazide | Sanofi | Type 2 Diabetes Mellitus | 03/18 | 03/18 | | |
NCT03629067: Combination of Fimasartan/Amlodipine/Hydrochlorothiazide in Healthy Male Subjects |
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| Completed | 1 | 60 | RoW | Treatment T, FAH, Treatment R, FA/H | Boryung Pharmaceutical Co., Ltd | Pharmacokinetics | 11/18 | 12/18 | | |
NCT04197622: Generation of Biological Samples Positive to Hydrochlorothiazide for Anti-doping Control |
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| Completed | 1 | 3 | Europe | Hydrochlorothiazide | Parc de Salut Mar | Healthy Volunteers | 03/19 | 03/19 | | |
NCT06083116: Drug-Drug Interaction Study Between Henagliflozin Proline and Hydrochlorothiazide |
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| Completed | 1 | 12 | RoW | Hydrochlorothiazide、Henagliflozin Proline | Jiangsu HengRui Medicine Co., Ltd. | Diabetes in Adults | 10/19 | 10/19 | | |
| Unknown status | 1 | 15000 | NA | Captopril 25Mg, Hydrochlorothiazide 25Mg Oral Tablet,, Atenolol, Losartan potassium 50mg, Clonidine | Centro Neurológico de Pesquisa e Reabiitação, Brazil | Hypertension, Blood Pressure | 06/20 | 06/21 | | |
NCT03971929: Safety and Effect Study of SHR0532 (Drug Code) Tablets in Patients With Mild Hypertension |
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| Completed | 1 | 36 | RoW | SHR0532, SHR placebo, Hydrochlorothiazide 25 mg | Jiangsu HengRui Medicine Co., Ltd. | Hypertension | 09/20 | 09/20 | | |
NCT04654312: Study to Evaluate the Influence of Hydrochlorothiazide on Dermal Photosensitivity and DNA Stability - a Pilot Study (HCTox Study) |
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| Completed | 1 | 30 | Europe | Hydrochlorothiazide, HCT, Placebo | Universität des Saarlandes | Photosensitivity | 07/21 | 07/21 | | |
NCT04964050: A Bioequivalence Study Between Capozide Versus ACE-Hemmer-ratiopharm in Healthy Adult Participants Under Fasting Conditions |
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| Withdrawn | 1 | 0 | NA | Capozide, ACE-Hemmer-Ratiopharm | GlaxoSmithKline | Healthy Volunteers | 05/22 | 05/22 | | |
ChiCTR2200062994: A randomized, open-label, two-sequence, two-agent, four-cycle, fully replicated crossover bioequivalence trial of a single oral dose of valsartan and hydrochlorothiazide tablets in healthy subjects |
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| Not yet recruiting | 1 | 112 | | R-T-R-T ;R-T-R-T ;T-R-T-R ;T-R-T-R | Huzhou Central Hospital; Zhejiang Ingle Pharmaceutical Co., Ltd., Zhejiang Ingle Pharmaceutical Co., Ltd. | Hypertension in all stages | | | | |
| Recruiting | 1 | 36 | US | Hydrochlorothiazide 12.5mg, HCTZ, Placebo | University of Kansas Medical Center | Chronic Pain, Hypertension, Diuretics Drug Reactions, SCS | 12/24 | 12/24 | | |
| Recruiting | 1 | 78 | US | Clonidine, Hydrochlorothiazide, Placebo | University of Iowa | Hypertension, Systolic, Stiffness, Aortic | 06/25 | 12/25 | | |
| Recruiting | 1 | 60 | US | Hydrochlorothiazide 12.5Mg Tab, Hydrochlorothiazide, Clonidine Pill, Clonidine, Placebo | University of Kansas Medical Center | Blood Pressure, Diabetes, Obesity, Insulin Resistance, Diuretics Drug Reactions, Sympathetic Nerve Activity | 07/25 | 07/25 | | |