| chlorthalidone / Generic mfg. |
NCT01033071: Efficacy and Safety of Azilsartan Medoxomil and Chlorthalidone Compared to Olmesartan Medoxomil and Hydrochlorothiazide in Participants With Moderate to Severe Hypertension. |
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| Completed | 3b | 1071 | US, Canada | Azilsartan medoxomil and chlorthalidone, azilsartan medoxomil plus chlorthalidone, TAK-491CLD, Olmesartan medoxomil and hydrochlorothiazide, Benicar HCT® | Takeda | Essential Hypertension | 10/10 | 11/10 | | |
| Completed | 3 | 233 | US | hydrochlorothiazide, diet, potassium supplementation, diet, magnesium supplementation, triamterene, chlorthalidone | University of California, San Francisco, National Heart, Lung, and Blood Institute (NHLBI) | Cardiovascular Diseases, Death, Sudden, Cardiac, Heart Arrest, Heart Diseases, Hypertension | 09/89 | | | |
NCT00000513: Trial of Antihypertensive Intervention Management |
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| Completed | 3 | | US | diet, reducing, diet, sodium-restricted, chlorthalidone, atenolol | National Heart, Lung, and Blood Institute (NHLBI) | Cardiovascular Diseases, Heart Diseases, Hypertension, Vascular Diseases | | 11/94 | | |
NCT00000514: Systolic Hypertension in the Elderly Program (SHEP) |
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| Completed | 3 | | US | chlorthalidone, atenolol, reserpine | National Heart, Lung, and Blood Institute (NHLBI), National Institute on Aging (NIA) | Cardiovascular Diseases, Cerebrovascular Disorders, Heart Diseases, Hypertension | | 10/96 | | |
| Completed | 3 | | US | Inhibitors, ACE, amlodipine, lisinopril, doxazosin, chlorthalidone, pravastatin, diet, fat-restricted | National Heart, Lung, and Blood Institute (NHLBI) | Cardiovascular Diseases, Coronary Disease, Diabetes Mellitus, Heart Diseases, Hypercholesterolemia, Hypertension, Myocardial Infarction, Myocardial Ischemia, Heart Failure | 03/02 | 03/02 | | |
NCT00591773: Efficacy and Safety of Azilsartan Medoxomil Co-Administered With Chlorthalidone in Participants With Essential Hypertension |
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| Completed | 3 | 551 | US | Azilsartan medoxomil and chlorthalidone, TAK-491, Edarbi, Chlorthalidone, Thalitone | Takeda | Hypertension | 03/09 | 03/09 | | |
NCT00696384: A Safety and Tolerability Study of Azilsartan Medoxomil in Participants With Essential Hypertension |
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| Completed | 3 | 418 | US, RoW | Azilsartan medoxomil, TAK-491, Edarbi, Azilsartan medoxomil, with or without chlorthalidone and other non-angiotensin II receptor blocker antihypertensive medications., Placebo | Takeda | Hypertension | 04/09 | 04/09 | | |
| Completed | 3 | 10251 | US, Canada | Anti-hyperglycemic Agents, glimepiride (Amaryl), metformin (Glucophage), repaglinide (Gluconorm, Prandin), rosiglitazone (Avandia), pioglitazone (Actos), human regular insulin (Novolin ge Toronto), human NPH (Novolin N), human mixed (Novolin 70/30), human isophane (Novolin ge NPH), human 30/70 (Novolin ge 30/70), insulin aspart (NovoRapid, NovoLog), insulin detemir (Levemir), human regular insulin (Novolin R), insulin glargine (Lantus), Acarbose, Anti-hypertensive Agents, benazepril (Lotensin, Zestril, Altace), chlorthalidone (Thalitone), metoprolol (Toprol XL), diltiazem (Tiazac), plendil (Felodipine), terazosin (Hytrin), candesartan (Atacand), valsartan (Diovan), furosemide, reserpine, hydralazine, carvedilol (Coreg), triamterene / hydrochlorothiazide (Dyazide), metoprolol / hydrochlorothiazide(Lopressor HCT), benazepril / hydrochlorothiazide (Lotensin HCT), lisinopril / hydrochlorothiazide (Zestoretic), candesartan / hydrochlorothiazide (Atacand HCT), valsartan / hydrochlorothiazide (Diovan HCT), amlodipine / benazepril (Lotrel), Blinded fenofibrate or placebo plus simvastatin, fenofibrate (Tricor) | National Heart, Lung, and Blood Institute (NHLBI), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute on Aging (NIA), National Eye Institute (NEI), Centers for Disease Control and Prevention | Atherosclerosis, Cardiovascular Diseases, Hypercholesterolemia, Hypertension, Diabetes Mellitus, Type 2, Diabetes Mellitus, Coronary Disease | 06/09 | 12/12 | | |
NCT00818883: Efficacy and Safety of Azilsartan Medoxomil and Chlorthalidone in Participants With Moderate to Severe Hypertension |
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| Completed | 3 | 609 | US, RoW | Azilsartan medoxomil and chlorthalidone, TAK-491, TAK-491CLD, Azilsartan medoxomil and hydrochlorothiazide | Takeda | Essential Hypertension | 11/09 | 11/09 | | |
NCT00695955: One-Year Safety and Tolerability Study of Azilsartan Medoxomil in Participants With Essential Hypertension |
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| Completed | 3 | 669 | US, RoW | Azilsartan medoxomil with or without add-on chlorthalidone, TAK-491, Edarbi, Azilsartan medoxomil with or without add-on hydrochlorothiazide | Takeda | Hypertension | 05/10 | 05/10 | | |
NCT00847626 / 2008-004218-28: Efficacy and Safety of Azilsartan Medoxomil Combined With Chlorthalidone in Participants With Moderate to Severe Hypertension |
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| Completed | 3 | 1711 | US, RoW | Azilsartan medoxomil and chlorthalidone, TAK-491CLD, Chlorthalidone, Azilsartan medoxomil | Takeda | Hypertension | 05/10 | 07/10 | | |
NCT00846365: Efficacy and Safety of Azilsartan Medoxomil Plus Chlorthalidone in Participants With Moderate to Severe Hypertension |
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| Completed | 3 | 1085 | US, RoW | Azilsartan medoxomil and chlorthalidone, azilsartan medoxomil, chlorthalidone, TAK-491, TAK-491CLD, Olmesartan medoxomil-hydrochlorothiazide, Benicar HCT® | Takeda | Essential Hypertension | 06/10 | 06/10 | | |
COMFORT, NCT00670787: Combination Pill of Losartan Potassium and Hydrochlorothiazide for Improvement of Medication Compliance Trial |
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| Completed | 3 | 207 | Japan | Combination pill of losartan and hydrochlorothiazide, Preminent | Kyushu University | Hypertension | 11/10 | 02/11 | | |
NCT00241839: Uric Acid and Hypertension in African Americans |
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| Completed | 3 | 150 | US | Allopurinol, Zyloprim, Placebo, sugar pill, Chlorthalidone, Potassium chloride | University of Florida | Cardiovascular Diseases, Heart Diseases, Hypertension | 05/11 | 05/11 | | |
NCT00996281 / 2008-008260-28: Safety and Tolerability of Azilsartan Medoxomil Plus Chlorthalidone Compared to Olmesartan Medoxomil Plus Hydrochlorothiazide in Participants With Essential Hypertension |
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| Completed | 3 | 837 | Europe | Azilsartan medoxomil and chlorthalidone, TAK-491CLD, Olmesartan medoxomil and hydrochlorothiazide, Benicar HCT®, Olmetec Plus® | Takeda | Essential Hypertension | 11/11 | 11/11 | | |
NCT01309828 / 2010-023098-21: Long-Term Safety of Azilsartan Medoxomil and Chlorthalidone Compared to Olmesartan Medoxomil and Hydrochlorothiazide in Participants With Hypertension and Kidney Disease |
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| Completed | 3 | 153 | Europe, RoW | Azilsartan medoxomil and chlorthalidone, TAK-491CLD, Olmesartan medoxomil and hydrochlorothiazide, Olmesartan medoxomil, Hydrochlorothiazide, Benicar hydrochlorothiazide, Olmetec Plus | Takeda | Safety | 10/12 | 10/12 | | |
CARD, NCT01191450: Safety and Efficacy of Chlorthalidone + Amiloride to Elderly Patients Treatment With Arterial Hypertension |
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| Unknown status | 3 | 280 | RoW | Chlorthalidone 25 mg + amiloride hydrochloride 5 mg, Diupress® (Eurofarma Laboratórios Ltda.), Higroton® Laboratório Novartis | Eurofarma Laboratorios S.A. | Arterial Hypertension | 11/12 | 11/12 | | |
NCT01456169 / 2011-000220-16: A Study to Evaluate the Effectiveness and Safety of a Fixed Dose Combination of Azilsartan Medoxomil and Chlorthalidone in Patients With High Blood Pressure Who do Not Achieve Target Blood Pressure Following Treatment With Azilsartan Medoxomil Alone |
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| Completed | 3 | 507 | Europe, RoW | Azilsartan medoxomil/placebo, TAK-491, EDARBI, Azilsartan medoxomil - chlorthalidone, TAK-491CLD, Edarbyclor | Takeda | Essential Hypertension | 12/12 | 01/13 | | |
| Completed | 3 | 730 | RoW | Chlorthalidone plus amiloride, diuretic, placebo | Hospital de Clinicas de Porto Alegre, Financiadora de Estudos e Projetos | Pre-hypertension, Hypertension, Cardiovascular Disease | 09/14 | 09/14 | | |
NCT01850160: Efficacy/Safety Study of Valsartan and Chlorthalidone Conjugate Treatment Compared to Simple Treatment for Hypertension |
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| Completed | 3 | 124 | RoW | GROUP A: Valsartan plus Chlorthalidone, Chlorthalidone Drug Combination, Valsartan Drug Combination, Antihypertensive Agents, GROUP B: Valsartan, Angiotensin II Receptor Antagonist, GROUP C: Chlorthalidone, Sodium Chloride Symporter Inhibitors, Diuretics | Farma de Colombia SA | Hypertension | 03/15 | 05/15 | | |
NCT01896661: Effect of Antihypertensive Agents Over Sleep Apnea |
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| Completed | 3 | 53 | RoW | Diuretics, Chlorthalidone/Amiloride, Calcium Channel Blockers, Amlodipine | Hospital de Clinicas de Porto Alegre | Hypertension, Obstructive Sleep Apnea | 12/15 | 02/16 | | |
TT, NCT02644395: Thiazide Diuretics for Hypertension in Kidney Transplant Recipients Using Tacrolimus |
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| Completed | 3 | 49 | Europe | Chlorthalidone, Amlodipine | Erasmus Medical Center | Hypertension, Kidney Transplantation | 12/15 | 12/16 | | |
DOSA-2, NCT02896621: Effect of Antihypertensive Agents on Diastolic Function in Patients With Sleep Apnea |
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| Completed | 3 | 69 | RoW | Chlorthalidone plus amiloride, Chlo+Ami, Amlodipine, Amlo | Hospital de Clinicas de Porto Alegre | Hypertension, Sleep Apnea | 02/16 | 02/17 | | |
NCT02620163: Efficacy & Safety Study of YH22162 vs Telmisartan/Amlodipine in Patients With Hypertension Inappropriately Controlled on Telmisartan/Amlodipine Treatment |
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| Completed | 3 | 381 | RoW | telmisartan/amlodipine 40/5mg, Twynsta 40/5 mg, YH22162 40/5/12.5 mg, telmisartan/amlodipine/chlorthalidone 40/5/12.5 mg, telmisartan/amlodipine 80/5mg, Twynsta 80/5 mg, YH22162 80/5/25 mg, telmisartan/amlodipine/chlorthalidone 80/5/25 mg, telmisartan/amlodipine 40/5mg placebo, Twynsta 40/5 mg placebo, YH22162 40/5/12.5 mg placebo, telmisartan/amlodipine/chlorthalidone 40/5/12.5 mg placebo, telmisartan/amlodipine 80/5mg placebo, YH22162 80/5/25 mg placebo, telmisartan/amlodipine/chlorthalidone 80/5/25 mg placebo | Yuhan Corporation | Hypertension | 12/16 | 12/16 | | |
NCT02521233: Efficacy and Safety of Candesartan Associated With Chlorthalidone in Essential Arterial Hypertension Control |
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| Withdrawn | 3 | 0 | NA | Candesartan + Chlorthalidone (8mg+12,5mg), Candesartan + Chlorthalidone, Candesartan + Chlorthalidone (8 mg + 25 mg), losartan+hydrochlorothiazide, Hyzaar ® | EMS | Essential Arterial Hypertension | 05/17 | 08/17 | | |
2016-001809-16: Efficacy and safety of chlorthalidone 25 mg in patients with hypertension. Έλεγχος της αποτελεσματικότητας και ασφάλειας της δόσης 25 mg χλωÏθαλιδόνης σε ασθενείς με Ï…Ï€ÎÏταση. |
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| Completed | 3 | 44 | Europe | Unidone Tablets 25mg/tab, Tablet | Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A., Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A. | BP lowering effect of chlorthalidone 25 mg in essential hypertensive patients. ΕπίδÏαση της θεÏαπείας με χλωÏθαλιδόνη στην αÏτηÏιακή πίεση σε ασθενείς με μη θεÏαπευόμενη ή μη ελεγχόμενη ιδιοπαθή Ï…Ï€ÎÏταση., Efficacy and safety of chlorthalidone in patients with hypertension . Αποτελεσματικότητα και ασφάλεια της χλωÏθαλιδόνης σε ασθενείς με Ï…Ï€ÎÏταση., Diseases [C] - Cardiovascular Diseases [C14] | | | | |
NCT03928145: Efficacy of Chlorthalidone and Hydrochlorothiazide Combined With Amiloride on Blood Pressure in Primary Hypertension. |
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| Unknown status | 3 | 84 | RoW | Chlorthalidone 25 mg, Chlorthalidone, Hydrochlorothiazide 50 mg, Hydrochlorothiazide, Amiloride 20 mg, Amiloride, Amiloride 10 mg | Hospital de Clinicas de Porto Alegre, Instituto de Cardiologia do Rio Grande do Sul | Hypertension | 07/21 | 07/21 | | |
| Completed | 3 | 20723 | US | Hydrochlorothiazide (HCTZ), HCTZ, Chlorthalidone (CTD), CTD | VA Office of Research and Development | Hypertension | 10/22 | 12/22 | | |
OPTION TREAT, NCT05920005: Candesartan Cilexetil + Chlorthalidone + Amlodipine Versus Exforge HCT®️ for Systemic Arterial Hypertension |
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| Recruiting | 3 | 698 | RoW | candesartan cilexetil + chlorthalidone + amlodipine, Exforge HCT® (valsartan 160mg + hydrochlorothiazide 12.5mg + amlodipine 5mg) | Hospital Israelita Albert Einstein, Libbs Farmacêutica LTDA | Hypertension | 12/23 | 07/24 | | |
NCT02493322: Efficacy and Safety of Olmesartan Associated With Chlorthalidone in Essential Arterial Hypertension Control |
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| Not yet recruiting | 3 | 261 | NA | Olmesartan Medoxomil 20mg + Chlorthalidone 12,5mg, Olmesartan medoxomil 20mg + Chlortalidone 25mg, Olmesartan 20mg + hydrochlorothiazide 12,5mg, Benicar HCT® | EMS | Essential Arterial Hypertension | 06/26 | 11/26 | | |
NCT02483936: Efficacy and Safety of Olmesartan Associated With Chlorthalidone Versus Benicar HCT® in Essential Hypertension Control |
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| Not yet recruiting | 3 | 348 | NA | Olmesartan medoxomil 40mg + chlorthalidone 12,5mg, Olmesartan medoxomil 40mg + chlorthalidone 25mg, Olmesartan 40mg + Hydrochlorothiazide 12,5mg, Benicar HCT, Olmesartan 40mg + Hydrochlorothiazide 25mg | EMS | Arterial Hypertension | 06/25 | 09/26 | | |
NCT05580510: " Evaluation of Safety and Efficacy of Empagliflozin and Sacubitril/Valsartan for CHF With Reduced Ejection Fraction in ACHD " |
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| Not yet recruiting | 2/3 | 160 | RoW | Sacubitril 49 MG / Valsartan 51 MG [Entresto] BID, Entresto, Empagliflozin 10 MG OD, Jardiance | Instituto Nacional de Cardiologia Ignacio Chavez, Boehringer Ingelheim laboratory | Congenital Heart Disease, Heart Failure, Heart Failure With Reduced Ejection Fraction | 07/23 | 03/24 | | |
