Zinbryta (daclizumab) / Biogen, AbbVie  >>  Phase 4
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21 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Zinbryta (daclizumab) / Biogen, AbbVie
NCT00048165: A Study to Evaluate the Efficacy and Safety of Zenapax in Combination With CellCept, Cyclosporine, and Corticosteroids in Patients Undergoing Cardiac Transplantation

Completed
4
434
US, Canada, Europe
Daclizumab, Zenapax, Methylprednisolone, Mycophenolate mofetil, Placebo, cyclosporine
Hoffmann-La Roche
Heart Transplantation
08/02
08/02
NCT00685061: Thymoglobulin Versus Campath-1H Versus Daclizumab in Adult, Primary Deceased Donor Renal Transplantation

Completed
4
90
US
Thymoglobulin, Campath-1H, Alemtuzumab, Daclizumab, Zenapax
University of Miami
Renal Transplantation
09/04
09/05
NCT00363116: A Trial of Two Daclizumab Dosing Strategies vs. No Induction Treatment With Tacrolimus, Mycophenolate Mofetil , & Steroids for the Prevention of Acute Allograft Rejection in Simultaneous Kidney/Pancreas Transplant Recipients

Completed
4
298
US, Canada
Daclizumab
University of Cincinnati, Roche Pharma AG, University of Tennessee
Acute Allograft Rejection in Simultaneous Kidney/Pancreas Transplant Recipients
12/04
12/04
NCT00138970: Calcineurin Inhibitor-Free Immunosuppression in Renal Transplant Recipients at Low Immunogenic Risk

Completed
4
70
Europe
Zenapax®, CellCept® and prednisolone, Sandimmun Neoral®, CellCept® and prednisolone
University of Oslo School of Pharmacy
Renal Transplant Recipients
 
02/05
2004-005055-33: Evaluating the safety and efficacy of mycophenolate mofetil, daclizumab and a single, initial week of corticosteroids in combination with tacrolimus or sirolimus with continued steroid as mainstay immunosuppression in comparison to current standard immunosuppression (mycophenolate mofetil, tacrolimus and continued corticosteroids) in renal transplantation.

Terminated
4
180
Europe
Zenapax, Cellcept, Prograf, Rapamune, Ro 24-7375, Ro 106-1443, Not available, Concentrate for solution for infusion, Capsule*, Tablet, Powder for infusion*, Zenapax, Cellcept, Prograf, Rapamune
Barts and the London NHS Trust
Renal Transplantation
 
 
NCT02576145: A Study to Assess Immune Response in Pediatric Kidney Transplant Recipients Treated With Daclizumab (Zenapax)

Completed
4
11
US
DT, Daclizumab, Zenapax, KLH
Hoffmann-La Roche
Kidney Transplantation
01/06
01/06
NCT00163657: Study of Liver Transplant For End-Stage Liver Disease Caused By Chronic Hepatitis C Infection

Completed
4
312
US
Daclizumub, Zenapax, Tacrolimus, Prograf, Cyclosporine, Neoral, MMF, mycophenolate mofetil
Baylor Research Institute, Baylor Health Care System, Emory University, University of Southern California, Mayo Clinic - Scottsdale/Phoenix, Arizona, New York Presbyterian Hospital, Oregon Health and Science University, New York University, University of Cincinnati, University of Alabama at Birmingham, The University of Texas Health Science Center at San Antonio, University of Chicago, University of California, San Francisco, Mayo Clinic - Rochester, Minnesota, Medical University of South Carolina, University of Virginia, Lahey Clinic, University of Medicine and Dentistry of New Jersey, Northwestern Memorial Hospital
End Stage Liver Disease, Hepatitis C
04/06
01/07
NCT00231764: MMF, Daclizumab and Corticosteroids as Mainstay Immunosuppression in Renal Transplant Patients

Completed
4
1760
Canada, Europe, RoW
daclizumab
Ekberg, Henrik, M.D., Prof. Philip Halloran, Edmonton, Canada (sponsor), Prof. Yves Vanrenterghem, Leuven, Belgium (Steering Committee Member), Prof. Pierre Daloze, Montréal, Canada (Steering Committee Member), Prof. Thomas C. Pearson, Atlanta, USA (Steering Committee Member), Prof. Ulrich Frei, Berlin, Germany (Steering Committee Member), Prof. Flavio Vincenti, San Francisco, USA (Ass. Steering Committee Member), Prof. Josep Grinyo, Barcelona, Spain (Ass. Steering Committee Member), Hoffmann-La Roche
Kidney Transplantation
05/06
02/08
NCT00681343: Thymoglobulin Versus Campath-1H Versus Daclizumab in Adult, Primary Living Donor Renal Transplantation

Completed
4
38
US
Thymoglobulin, Campath-1H, Alemtuzumab, Daclizumab, Zenapax
University of Miami, Hoffmann-La Roche
Living-Donor Kidney Transplant
10/06
10/07
NCT01046955: Thymoglobulin Versus Alemtuzumab Versus Daclizumab in Living Donor Renal Transplantation

Completed
4
38
US
Anti-Thymocyte Globulin vs Campath-1H vs Daclizumab, Thymoglobulin, Zenapax
University of Miami, Hoffmann-La Roche
End-Stage Renal Disease, Living Donors
04/07
12/08
ALHAMBRA, NCT00290069 / 2005-001854-25: Renal Function Optimization With Mycophenolate Mofetil (MMF) Immunosuppressor Regimes

Unknown status
4
94
Europe
Tacrolimus, Rapamycin
Sociedad Andaluza de Trasplantes de Organos y Tejidos
Kidney Diseases, Graft Rejection
 
 
NCT00493194 / 2004-004115-38: Fibrosis in Renal Allografts

Unknown status
4
100
Europe
sirolimus, cyclosporine, daclizumab
University Hospital, Antwerp, Wyeth is now a wholly owned subsidiary of Pfizer, Hoffmann-La Roche
Kidney Failure, Chronic, Transplantation, Immunosuppression, Interstitial Fibrosis
 
07/07
NCT00574470: Anti Cytokine Combination Therapy With Daclizumab and Infliximab for Treatment of Steroid Refractory Acute GVHD

Completed
4
3
US
daclizumab, infliximab
University of Iowa
Graft vs Host Disease
11/07
08/08
NCT02554955: A Study of Daclizumab (Zenapax) in Combination With Mycophenolate Mofetil (CellCept) and Sirolimus in Prevention of Acute Rejection in Heart Transplant Participants

Completed
4
36
Europe
Daclizumab, Zenapax, Mycophenolate mofetil, CellCept, Silrolimus
Hoffmann-La Roche
Heart Transplantation
12/07
12/07
2005-001496-35: A single centre, randomised controlled, open label study of rituximab as induction therapy in kidney transplantation.

Terminated
4
120
Europe
Zenapax, MabThera, Ro 24-7375, Ro 45-2294, Intravenous infusion, Concentrate for solution for infusion, Zenopax, MabThera
Cambridge University Hospitals NHS Foundation Trust
Renal Transplantation
 
 
NCT01172418: Randomized Trial of 2 Antibody Induction Steroid Avoidance Protocols

Completed
4
200
US
Alemtuzumab, Campath-1H (Alemtuzumab), Daclizumab, Zenapax (Daclizumab), Thymoglobulin, rATG (rabbit antithymocyte globulin)
University of Miami
Transplant; Failure, Kidney
05/10
05/10
MUST, NCT00132691: Multicenter Uveitis Steroid Treatment () Trial

Completed
4
255
US, Europe, RoW
fluocinolone acetonide intraocular implant, NDC 24208-416-01, oral corticosteroid with immunosuppressive agents as needed, Permitted immunosuppressive agents:, - Alkylating agents, cyclophosphamide (Cytoxan), chlorambacil, - Antimetabolities, azathioprine (Imuran), azathioprine chlorambucil (Leukeran), methotrexate (Rheumatrex and others), mycophenolate mofetil (Cellcept), - T-cell inhibitors, cyclosporine (Neoral, Sandimmune and other trade names), tacrolimus, - Biologics, infliximab, daclizumab, other biologics
JHSPH Center for Clinical Trials, National Eye Institute (NEI)
Uveitis
12/10
12/10
NCT00246129 / 2005-002856-17: CamTac Trial:Campath-Tacrolimus vs IL2R MoAb/Tacrolimus/MMF in Renal Transplantation

Completed
4
123
Europe
Campath, Alemtuzumab, Daclizumab, Zinbryta
EMagnusson
Kidney Transplantation, Kidney Diseases, Kidney Failure
06/11
06/11
NCT01418430: Pilot Study of Combination Therapy With CHOP-Zenapax (CHOP-daclizumab)

Completed
4
Europe
CHOP-daclizumab, CHOP-Zenapax
King's College Hospital NHS Trust
HTLV-I Associated Adult T-cell Leukaemia/Lymphoma (ATLL)
 
 
2005-003383-39: A randomized, open-label, multi-center study comparing a steroid sparing regimen versus standard steroid regimen in combination with daclizumab, mycophenolate mofetil and sirolimus in the prevention of acute renal allograft rejection.Estudio abierto, aleatorizado, multicéntrico, nacional, comparando un régimen libre de esteroides frente a un régimen de esteroides estándar, en combinación con Daclizumab, Micofenolato Mofetil y Sirolimus, en la prevención del rechazo agudo en trasplante renal.

Ongoing
4
144
Europe
Rapamune, Daclizumab, Rapamune, ZENAPAX, Rapamune, ZENAPAX
Roche Farma S.A.
Renal Transplant
 
 
2007-003023-20: TACROLIMUS – DACLIZUMAB - MYCOPHENOLATE MOFETIL IMMUNE PROPHYLAXISIN PEDIATRIC LIVER TRANSPLANTATION. An open, pilot, investigator-driven study in 20 recipients

Ongoing
4
50
Europe
Prograft, Cellcept, Zenapax, Prograft, Cellcept, Zenapax
Cliniques universitaires Saint-Luc
Liver transplantation
 
 

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