| cisplatin / Generic mfg. |
NCT00230451: Pre-operative Chemotherapy and Radiation Therapy for Esophageal Carcinoma |
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| Completed | 2 | | US | Radiation, Paclitaxel, Cisplatin, 5-Fluorouracil | University of Michigan Rogel Cancer Center | Esophageal Cancer | 12/99 | 07/08 | | |
NCT00003055: Cisplatin and Irinotecan in Treating Patients With Locally Advanced or Metastatic Esophageal or Gastric Cancer |
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| Completed | 2 | | US | cisplatin, irinotecan hydrochloride | Memorial Sloan Kettering Cancer Center, National Cancer Institute (NCI) | Esophageal Cancer, Gastric Cancer | 04/01 | 04/01 | | |
NCT00006038: Combination Chemotherapy Followed by Surgery and Intraperitoneal Chemotherapy in Treating Patients With Locally Advanced Stomach Cancer |
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| Completed | 2 | | US | cisplatin, docetaxel, floxuridine, fluorouracil, leucovorin calcium, conventional surgery | Memorial Sloan Kettering Cancer Center, National Cancer Institute (NCI) | Esophageal Cancer, Gastric Cancer | 02/03 | 02/03 | | |
NCT00042510: Safety and Efficacy of G17DT Immunogen in the Treatment of Gastric and Gastroesophageal Cancer |
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| Completed | 2 | 103 | US | Treatment group | Cancer Advances Inc. | Stomach Neoplasms, Esophageal Neoplasms | 02/03 | 07/04 | | |
SAKK 75/02, NCT00072033: Neoadjuvant Docetaxel and Cisplatin Plus Chemoradiotherapy Followed By Surgery in Treating Patients With Locally Advanced, Resectable Esophageal Cancer |
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| Completed | 2 | 66 | Europe | Cisplatin and Docetaxel | Swiss Group for Clinical Cancer Research | Esophageal Cancer | 03/03 | 05/10 | | |
NCT00003237: Combination Chemotherapy After Surgery in Treating Patients With Cancer of the Esophagus or Stomach |
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| Completed | 2 | 55 | US, RoW | cisplatin, paclitaxel, surgical procedure | Eastern Cooperative Oncology Group, National Cancer Institute (NCI) | Esophageal Cancer, Gastric Cancer | 10/03 | | | |
NCT00030862: Combination Chemotherapy in Treating Patients With Locally Advanced or Metastatic Cancer of the Esophagus |
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| Completed | 2 | | US | cisplatin, irinotecan hydrochloride | Memorial Sloan Kettering Cancer Center, National Cancer Institute (NCI) | Esophageal Cancer | 12/03 | 12/03 | | |
NCT00021320: Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Esophageal Cancer |
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| Completed | 2 | 21 | US | cisplatin, fluorouracil, paclitaxel, conventional surgery, neoadjuvant therapy, radiation therapy | Fox Chase Cancer Center, National Cancer Institute (NCI) | Esophageal Cancer | 01/04 | 04/09 | | |
NCT00137852: Cisplatin, CPT-11 and Celecoxib With Radiation Therapy and Surgery for Operable Esophageal Cancer |
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| Completed | 2 | 35 | US | Cisplatin, Irinotecan, CPT-11, Celecoxib, Radiation Therapy, Esophagectomy | Dana-Farber Cancer Institute, Brigham and Women's Hospital, Massachusetts General Hospital, Pharmacia | Esophageal Cancer | 08/04 | 09/17 | | |
NCT00003087: Combination Chemotherapy, Radiation Therapy and Surgery in Treating Patients With Cancer of the Esophagus |
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| Completed | 2 | 25 | US | cisplatin, paclitaxel, surgical procedure, radiation therapy | Memorial Sloan Kettering Cancer Center, National Cancer Institute (NCI) | Esophageal Cancer | 02/05 | 02/05 | | |
NCT00165464: Taxotere, Cisplatin and Irinotecan (CPT-11) for Esophagogastric Cancer |
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| Completed | 2 | 54 | US | Taxotere, Cisplatin, Irinotecan | Dana-Farber Cancer Institute, Massachusetts General Hospital, Beth Israel Deaconess Medical Center, Brigham and Women's Hospital, Aventis Pharmaceuticals | Esophageal Cancer, Gastric Cancer, GE Junction Cancer | 03/05 | 04/09 | | |
NCT00165191: Doxorubicin, Cisplatin, 5-Fluorouracil in Patients With Advanced Adenocarcinoma of the Stomach or Esophagus |
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| Completed | 2 | 32 | US | Doxorubicin, Cisplatin, 5-fluorouracil | Dana-Farber Cancer Institute, Brigham and Women's Hospital, Massachusetts General Hospital | Adenocarcinoma of Stomach, Adenocarcinoma of GE Junction, Adenocarcinoma of Esophagus | 01/06 | 01/06 | | |
NCT00183807: A Study of Irinotecan, Cisplatin and Celebrex in Patients With Metastatic or Unresectable Esophageal Cancer |
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| Terminated | 2 | 6 | US | irinotecan, cisplatin, celecoxib | University of Southern California, Pfizer | Esophageal Cancer | 02/06 | 03/08 | | |
NCT00208936: Phase II Study of Pre-Operative Chemotherapy in Patients With Resectable Local-Regional Carcinoma of Esophagus |
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| Terminated | 2 | 20 | US | Taxol, Cisplatin, 5-Fluorouracil, G-CSF | Emory University | Esophageal Diseases | 03/06 | | | |
NCT00002984: Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Advanced or Metastatic Cancer of the Esophagus |
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| Completed | 2 | 26 | US | cisplatin, fluorouracil, 5-FU, paclitaxel, surgical procedure, radiation therapy | UNC Lineberger Comprehensive Cancer Center, National Cancer Institute (NCI) | Esophageal Cancer | 05/06 | 01/07 | | |
NCT00011960: Chemotherapy and Radiation Therapy With or Without Fluorouracil in Treating Patients With Cancer of the Stomach Who Have Undergone Surgery |
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| Completed | 2 | | US | cisplatin, paclitaxel, adjuvant therapy, radiation therapy | Radiation Therapy Oncology Group, National Cancer Institute (NCI) | Esophageal Cancer, Gastric Cancer | 05/06 | | | |
NCT00009880: Combination Chemotherapy Plus Radiation Therapy With or Without Fluorouracil in Treating Patients With Cancer of the Esophagus or Stomach |
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| Completed | 2 | | US | filgrastim, cisplatin, fluorouracil, paclitaxel, radiation therapy | Radiation Therapy Oncology Group, National Cancer Institute (NCI) | Esophageal Cancer, Gastric Cancer | 07/06 | | | |
NCT00520091: Irinotecan, Cisplatin, and Radiation Therapy With or Without Celecoxib in Treating Patients With Stage II, Stage III, or Stage IV Esophageal Cancer |
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| Completed | 2 | 14 | US | CPT- 11, Irinotecan, Cisplatin, Cis-diammine-dichloro-platinum, Celecoxib, Radiation, Surgery | UNC Lineberger Comprehensive Cancer Center, National Cancer Institute (NCI) | Esophageal Cancer | 11/06 | 09/10 | | |
NCT00216008: Pharmacogenomic Study of Docetaxel and Cisplatin, Followed by Docetaxel, Cisplatin and Irradiation. |
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| Terminated | 2 | 42 | US | docetaxel, cisplatin, radiation, surgery | H. Lee Moffitt Cancer Center and Research Institute, Aventis Pharmaceuticals | Esophageal Adenocarcinomas, Adenocarcinomas of the Gastroesophageal Junction | 02/07 | 02/07 | | |
NCT00069953: Combination Chemotherapy Followed By Chemoradiotherapy, With or Without Surgery, in Treating Patients With Resectable Locally Advanced Cancer of the Esophagus or Gastroesophageal Junction |
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| Completed | 2 | 43 | US | filgrastim, G-CSF, pegfilgrastim, PEG-G-CSF, cisplatin, fluorouracil, 5-FU, paclitaxel, conventional surgery, radiation therapy | Radiation Therapy Oncology Group, National Cancer Institute (NCI), NRG Oncology | Esophageal Cancer | 03/07 | 12/16 | | |
NCT00077545: 3-AP Plus Cisplatin in Treating Patients With Recurrent or Metastatic Adenocarcinoma of the Esophagus or Gastroesophageal Junction |
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| Completed | 2 | 39 | US | triapine, cisplatin | National Cancer Institute (NCI) | Adenocarcinoma of the Esophagus, Recurrent Esophageal Cancer, Stage IV Esophageal Cancer | 03/07 | | | |
NCT00215995: Cisplatin and Irinotecan Chemotherapy, Followed by ZD 1839 (Iressa) in Patients With Esophageal or Gastric Carcinomas |
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| Completed | 2 | 21 | US | Cisplatin, Platinol, Platinol-AQ, Irinotecan, Camptosar, ZD 1839, Iressa | H. Lee Moffitt Cancer Center and Research Institute, AstraZeneca | Esophageal Cancer, Gastric Cancer | 05/07 | 05/07 | | |
NCT00004897: Combination Chemotherapy and Interferon Alfa Followed by Surgery and/or Radiation Therapy in Treating Patients With Stage I, Stage II, or Stage III Esophageal Cancer |
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| Terminated | 2 | | US | recombinant interferon alfa, cisplatin, fluorouracil, hydroxyurea, leucovorin calcium, conventional surgery, radiation therapy | Northwestern University, National Cancer Institute (NCI) | Esophageal Cancer | 07/07 | 11/07 | | |
NCT00258323: Radiotherapy,Chemotherapy,Before and After Surgery in Advanced Esophageal or Gastroesophageal Junction Cancer |
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| Completed | 2 | 80 | US | cisplatin, CDDP, fluorouracil, 5 FU, Iressa, ZD 1839, conventional surgery, radiation therapy | Case Comprehensive Cancer Center, National Cancer Institute (NCI) | Esophageal Cancer | 07/07 | 02/10 | | |
NCT00084604: Irinotecan, Cisplatin, and Bevacizumab in Treating Patients With Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma |
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| Completed | 2 | 47 | US | irinotecan hydrochloride, Campto, Camptosar, CPT-11, irinotecan, U-101440E, bevacizumab, anti-VEGF humanized monoclonal antibody, anti-VEGF monoclonal antibody, Avastin, rhuMAb VEGF, cisplatin, CACP, CDDP, CPDD, DDP, computed tomography, tomography, computed, laboratory biomarker analysis | National Cancer Institute (NCI) | Adenocarcinoma of the Gastroesophageal Junction, Diffuse Adenocarcinoma of the Stomach, Intestinal Adenocarcinoma of the Stomach, Mixed Adenocarcinoma of the Stomach, Recurrent Gastric Cancer, Stage IIIA Gastric Cancer, Stage IIIB Gastric Cancer, Stage IIIC Gastric Cancer, Stage IV Gastric Cancer | 10/07 | | | |
NCT00160030: Study Comparing Radiochemotherapy With Folfox 4 Regimen or 5FU-Cisplatin in Patients With Inoperable Esophageal Cancer |
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| Completed | 2 | 97 | Europe | FOLFOX 4, 5-FU / Cisplatin | Sanofi | Esophageal Neoplasms | 10/07 | | | |
NCT00165490: Combination Chemotherapy, Radiation Therapy and Surgery for Esophageal Cancer |
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| Completed | 2 | 19 | US | Cetuximab, Cisplatin, Irinotecan, Radiation therapy, Surgery | Dana-Farber Cancer Institute, Brigham and Women's Hospital | Adenocarcinoma of Esophagus, Squamous Cell Carcinoma of Esophagus | 11/07 | 11/14 | | |
SAKK 76/02, NCT00238407: Docetaxel, Cisplatin, and Radiation Therapy in Treating Patients With Locally Advanced Esophageal Cancer That Cannot Be Removed By Surgery |
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| Completed | 2 | 21 | Europe | Docetaxel and Cisplatin, Radiotherapy | Swiss Group for Clinical Cancer Research | Esophageal Cancer | 02/08 | 08/10 | | |
NCT00253370: Sorafenib, Docetaxel, and Cisplatin in Treating Patients With Metastatic or Advanced Gastric or Gastroesophageal Junction Cancer |
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| Completed | 2 | 44 | US | BAY 43-9006, Sorafenib (NSC724772), BAY 54-9085 (tosylate salt), docetaxel, Taxotere, RP 56976, NSC #628503, cisplatin, Cis-diaminedichloroplatinum, Cis-diaminedichloroplatinum (II), diaminedichloroplatinum, cis-platinum, platinum, Platinol, Platinol-AQ, DDP, CDDP, DACP, NSC 119875. | National Cancer Institute (NCI) | Adenocarcinoma of the Gastroesophageal Junction, Metastatic Gastric Cancer, Advanced Unresectable Gastric Cancer | 05/08 | 09/10 | | |
| Completed | 2 | 72 | Europe | Matuzumab, EMD 72000, Epirubicin, Cisplatin, Capecitabine | Merck KGaA, Darmstadt, Germany | Esophageal Cancer, Gastric Cancer | 07/08 | 08/08 | | |
NCT00259402: Oxaliplatin in Esophagus Cancer (Advanced) 1st Line |
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| Completed | 2 | 41 | Europe | Oxaliplatin + cisplatin + 5-Fluorouracil (5-FU) | Sanofi | Esophageal Neoplasms | 10/08 | 10/08 | | |
NCT00394433: Docetaxel, Cisplatin, Irinotecan and Bevacizumab (TPCA) in Metastatic Esophageal and Gastric Cancer |
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| Completed | 2 | 38 | US | Bevacizumab, Avastin, Docetaxel, Taxotere, Docefrez, Cisplatin, Platinol-AQ, Platinol, Irinotecan, Camptosar | Dana-Farber Cancer Institute, Brigham and Women's Hospital, Massachusetts General Hospital, Genentech, Inc. | Esophageal Cancer, Stomach Cancer | 11/08 | 10/16 | | |
NCT00033657: Radiation Therapy and Chemotherapy Before and After Surgery in Treating Patients With Esophageal Cancer |
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| Completed | 2 | 97 | US | cisplatin, cis-platinum, platinum, Platinol, Platinol-AQ, DDP, CDDP, DACP, NSC 119875, irinotecan hydrochloride, Camptothecin-11, CPT-11, Camptosar, paclitaxel, Taxol, NSC 125973, conventional surgery, radiation therapy | Eastern Cooperative Oncology Group, National Cancer Institute (NCI) | Esophageal Cancer, Gastric Cancer | 09/09 | 10/09 | | |
NCT00109850: S0414 Cetuximab, Combo Chemo, and RT in Locally Advanced Esophageal Cancer |
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| Terminated | 2 | 22 | US | cetuximab, Erbitux, cisplatin, Platinol, irinotecan hydrochloride, CPT-11, radiation therapy, RT, TRT | Southwest Oncology Group, National Cancer Institute (NCI) | Esophageal Cancer | 09/09 | 05/12 | | |
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NCT00590031: Phase II Trial of Preoperative Combined Modality Therapy for Esophageal Carcinoma: Cisplatin-Irinotecan Followed by Radiation Therapy With Concurrent Cisplatin and Irinotecan. |
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| Completed | 2 | 61 | US | Cisplatin, Irinotecan, External Beam Radiation Therapy | Memorial Sloan Kettering Cancer Center | Esophageal Carcinoma | 12/09 | 12/09 | | |
NCT01640860: Concurrent Chemoradiotherapy With Docetaxel and Cisplatin in Esophageal Cancer |
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| Completed | 2 | 36 | RoW | | Chonnam National University Hospital, Sanofi | Esophageal Cancer | 12/09 | 12/11 | | |
NCT00220129: Neoadjuvant Epirubicin, Cisplatin and Capecitabine (ECX) Followed by Definitive Chemoradiation With/Without Surgery for Squamous Cell Carcinoma of the Oesophagus |
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| Completed | 2 | 16 | Europe | Epirubicin, Cisplatin, Capecitabine, Surgical Resection | Royal Marsden NHS Foundation Trust | Oesophageal Carcinoma | | | | |
NCT00220103: Pre-operative Epirubicin, Cisplatin, and Capecitabine in Patients With Newly Diagnosed Localised Oesophageal Adenocarcinoma |
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| Completed | 2 | 80 | Europe | epirubicin, capecitabine, cisplatin, Surgical resection | Royal Marsden NHS Foundation Trust | Adenocarcinoma of Oesophagus | | | | |
NCT00583674 / 2007-003573-50: Phase 2 Study of AMG 386 (20060439) in Combination With Cisplatin & Capecitabine in Subjects With Metastatic Gastric, Gastroesophageal Junction, or Distal Esophageal Adenocarcinoma |
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| Completed | 2 | 171 | US, Europe, RoW | AMG 386 placebo, AMG 386 10mg/kg, AMG 386 3mg/kg, Cisplatin, Capecitabine | Amgen | Gastrointestinal Cancer | 03/10 | 06/12 | | |
EXCEL, NCT00815308: Erbitux Combined With Chemo-radiotherapy in Esophageal Squamous Cell Carcinoma |
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| Completed | 2 | 55 | RoW | cetuximab (Erbitux), erbitux, Paclitaxel, Cisplatin, Radiation, Conformal Radiotherapy, Intensity Modulated Radiotherapy | Shandong Cancer Hospital and Institute, Chinese Academy of Medical Sciences, Peking University Cancer Hospital & Institute, Hebei Fourth Hospital, Jiangsu Cancer Institute & Hospital, RenJi Hospital, The Affiliated Cancer Hospital of Zhengzhou University, West China Hospital | Esophageal Cancer | 07/10 | 07/10 | | |
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NCT00397904: Cetuximab, Cisplatin, and Irinotecan in Treating Patients With Metastatic Esophageal Cancer, Gastroesophageal Junction Cancer, or Gastric Cancer That Did Not Respond to Previous Irinotecan and Cisplatin |
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| Completed | 2 | 16 | US | cetuximab, cisplatin, irinotecan hydrochloride, immunohistochemistry staining method, laboratory biomarker analysis, biopsy | Memorial Sloan Kettering Cancer Center, National Cancer Institute (NCI) | Esophageal Cancer, Gastric Cancer | 09/10 | 09/10 | | |
NCT00570531: Phase II Trial for Patients With Loco-Regional Esophageal Carcinoma |
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| Terminated | 2 | 6 | US | Bevacizumab, Avastin, Paclitaxel, Cisplatin, 5-Fluorouracil, Radiation Therapy, Esophagectomy | University of Michigan Rogel Cancer Center, Genentech, Inc. | Loco-regional Esophageal Cancer | 10/10 | 06/13 | | |
NCT00051480: Study of TNFeradeâ„¢ Gene Therapy, Radiation, 5-FU and Cisplatin in Esophageal Cancer |
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| Completed | 2 | | US | TNFerade | GenVec | Esophageal Cancer | | | | |
NCT00848783: Irinotecan/Cisplatin, Potentially Curative Surgery With or Without Floxuridine, Followed by Capecitabine for Stomach and Gastro-esophageal Junction (GEJ) Cancers |
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| Terminated | 2 | 8 | US | Irinotecan, CPT-11, Cisplatin, Surgery, Floxuridine, FUDR, Capecitabine, Xeloda | NYU Langone Health | Gastric Cancer, Gastric Adenocarcinoma, Esophageal Cancer | 08/11 | 09/12 | | |
| Completed | 2 | 41 | Europe | Oxaliplatin, Sorafenib | Grupo Espanol Multidisciplinario del Cancer Digestivo | Advanced or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma (Relapsed After a Cisplatin Based Treatment) | 10/11 | 12/11 | | |
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NCT00757172: Panitumumab, Docetaxel, Cisplatin, Radiation Therapy, and Surgery in Treating Patients With Newly Diagnosed, Locally Advanced Esophageal Cancer or Cancer of the Gastroesophageal Junction |
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| Completed | 2 | 70 | US | panitumumab, cisplatin, docetaxel, neoadjuvant therapy, therapeutic conventional surgery, radiation therapy | Alliance for Clinical Trials in Oncology, National Cancer Institute (NCI), Amgen | Adenocarcinoma of the Gastroesophageal Junction, Esophageal Cancer | 11/11 | 12/14 | | |
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NCT00390416: Study of Docetaxel, Cisplatin, and Fluorouracil (Modified DCF) With Bevacizumab in Patients With Unresectable or Metastatic Gastroesophageal Adenocarcinoma |
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| Completed | 2 | 48 | US | Docetaxel, Cisplatin, Fluorouracil, Bevacizumab, Leucovorin | Memorial Sloan Kettering Cancer Center, Sanofi, Genentech, Inc. | Stomach Neoplasms, Esophageal Neoplasms | 01/12 | 01/12 | | |
NCT00601705: Epirubicin, Oxaliplatin and Fluorouracil (EOF) in Cancer of the Esophagus, Gastroesophageal Junction, or Stomach |
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| Completed | 2 | 61 | US | cisplatin, epirubicin hydrochloride, fluorouracil, oxaliplatin, adjuvant therapy, neoadjuvant therapy | Case Comprehensive Cancer Center, National Cancer Institute (NCI) | Esophageal Cancer, Gastric Cancer | 03/12 | 01/15 | | |
| Terminated | 2 | 4 | Europe | CRT + Panitumumab, Concurrent chemoradiation therapy without panitumumab | Radboud University Medical Center | Irresectable Squamous Cell or Adenocarcinoma of the Oesophagus | 04/12 | 10/12 | | |
NCT02133612: Adjuvant Chemotherapy With Paclitaxel and Cisplatin in Lymph Node-Positive Thoracic Esophageal Squamous Cell Carcinoma |
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| Completed | 2 | 43 | RoW | paclitaxel; cisplatin, Paclitaxel Injection, Beijing Union Pharmaceutical Factory | Chinese Academy of Medical Sciences | Esophageal Cancer | 05/12 | 05/14 | | |
nabPCESCC, NCT01258192: Neoadjuvant Chemotherapy With Nab-paclitaxel Plus Cisplatin for Stage â…¡-â…¢ Esophageal Cancer Patients |
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| Completed | 2 | 35 | RoW | albumin-bound paclitaxel plus cisplatin, nab-paclitaxel | Zhejiang Cancer Hospital, Second Affiliated Hospital, School of Medicine, Zhejiang University | Esophageal Squamous Cell Carcinoma | 10/12 | 10/12 | | |
NCT00733889 / 2006-001880-42: A Study to Evaluate the Combination of Cetuximab and Chemotherapy as Neoadjuvant Therapy Followed Concomitant Chemoradiotherapy Plus Cetuximab in Locoregional Esophageal Carcinoma |
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| Completed | 2 | 50 | Europe | cetuximab and chemotherapy (docetaxel, cisplatin, 5-fluorouracil) | Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD), Merck Sharp & Dohme LLC, Sanofi | Esophageal Carcinoma | 11/12 | 11/12 | | |
NCT00316862: Cisplatin, Irinotecan, and Radiation Therapy in Treating Patients With Esophageal Cancer or Gastroesophageal Junction Cancer That Can Be Removed By Surgery |
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| Completed | 2 | 82 | US | cisplatin, irinotecan hydrochloride, therapeutic conventional surgery, radiation therapy, irradiation, radiotherapy, therapy, radiation | Alliance for Clinical Trials in Oncology, National Cancer Institute (NCI) | Esophageal Cancer | 12/12 | 10/14 | | |
| Terminated | 2 | 50 | Europe | 5-FU, Cisplatin, Taxotere, Docetaxel, Cetuximab, Erbitux, Radiation during chemoradio-immunotherapy | Arbeitsgemeinschaft medikamentoese Tumortherapie, Merck Sharp & Dohme LLC, Sanofi | Esophageal Cancer | 12/12 | 12/12 | | |
NCT00493025: Paclitaxel, Cisplatin, Gefitinib, and Radiation Therapy Followed by Surgery and Gefitinib in Treating Patients With Locally Advanced Cancer of the Esophagus or Gastroesophageal Junction That Can Be Removed By Surgery |
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| Terminated | 2 | 19 | US | cisplatin, gefitinib, Combined Modality Paclitaxel, Cisplatin, ZD1839 and Radiotherapy Followed by Postoperative ZD1839, paclitaxel, adjuvant therapy, radiation therapy | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, National Cancer Institute (NCI) | Esophageal Cancer | 03/13 | 03/13 | | |
NCT01360086: Fluorouracil, Cisplatin, Leucovorin Calcium, and Cetuximab in Treating Patients With Adenocarcinoma of the Stomach or Gastroesophageal Junction |
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| Completed | 2 | 65 | Europe | cetuximab, cisplatin, fluorouracil, leucovorin calcium, adjuvant therapy, neoadjuvant therapy, quality-of-life assessment, therapeutic conventional surgery | Federation Francophone de Cancerologie Digestive | Adenocarcinoma of the Gastroesophageal Junction, Gastric Cancer | 03/13 | 03/13 | | |
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NCT01123473 / 2009-011580-36: Epirubicin Hydrochloride, Cisplatin, and Fluorouracil or Capecitabine With or Without Lapatinib Ditosylate as First-Line Therapy in Treating Patients With Stomach Cancer or Gastroesophageal Junction Cancer |
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| Terminated | 2 | 29 | Europe | capecitabine, cisplatin, epirubicin hydrochloride, fluorouracil, lapatinib ditosylate | European Organisation for Research and Treatment of Cancer - EORTC | Adenocarcinoma of the Gastroesophageal Junction, Gastric Cancer | 08/13 | 09/14 | | |
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NCT01474642: Phase II Trial of XP Versus XG in Advanced Esophageal Squamous Cell Carcinoma |
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| Completed | 2 | 64 | RoW | Capecitabine/Cisplatin(XP), Capecitabine/Paditaxel(XG) | Samsung Medical Center | Advanced or Recurrent Esophageal Squamous Cell Carcinoma | 09/13 | 05/14 | | |
NCT01372202: CHFR Methylation Status Esophageal Cancer Study |
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| Terminated | 2 | 31 | US | Paclitaxel, Abraxane, Taxol, Cisplatin, Platinol, Oxaliplatin, Eloxatin, 5-Fluorouracil, 5-FU, Adrucil, Carac, Efudex, Fluorouracil, Radiotherapy, IMRT, Esophagectomy, Resection | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, National Cancer Institute (NCI) | Esophageal Cancer | 06/14 | 10/14 | | |
NCT02879227: Radiochemotherapy in Elderly Patients With Oesophagus Cancer |
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| Completed | 2 | 23 | Europe | Cisplatin, Arm Cisplatin, Oxaliplatin, Arm Oxaliplatin | Centre Hospitalier Universitaire de Besancon | Esophagus Cancer | 12/14 | 12/14 | | |
NCT00737438: Pre-operative Chemotherapy Plus Bevacizumab With Early Salvage Therapy Based on PET Assessment of Response in Patients With Locally Advanced But Resectable Gastric and GEJ Adenocarcinoma |
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| Completed | 2 | 22 | US | epirubicin, cisplatin, capecitabine, bevacizumab, docetaxel and irinotecan, Patients who have a poor PET response to cycle 1 of ECX plus bevacizumab, (eg. < 35% FDG reduction on the week 3 PET scan compared with baseline), will be switched to salvage therapy of docetaxel and irinotecan (DI)., This treatment will be administered on week 1 and 2 of a 3, week cycle for 2 cycles. Patients will receive bevacizumab for the 1st cycle, of salvage docetaxel/irinotecan only. There is again a planned 10-12 week time, interval (eg. 70-84 days) between the last bevacizumab treatment and surgery. | Memorial Sloan Kettering Cancer Center, Genentech, Inc., Weill Medical College of Cornell University | Esophageal Cancer, Gastric Cancer | 02/15 | 02/15 | | |
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NCT01830270: Preoperative Dose-dense Chemotherapy With Weekly Cisplatin, Epirubicin and Paclitaxel to Treat Patients With Locally Gastric Cancer |
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| Terminated | 2 | 30 | Europe | Epirubicin, Cisplatin, Paclitaxel, gastric surgery | Centre Hospitalier Universitaire de Besancon | Stomach Neoplasms, Oesophageal Junction Cancer, Lower Oesophagus Cancer | 04/15 | 07/16 | | |
NCT00354679: Irinotecan, Cisplatin, Bevacizumab, Radiation Therapy, and Surgery in Treating Patients With Locally Advanced Esophageal Cancer |
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| Completed | 2 | 34 | US | bevacizumab, cisplatin, irinotecan hydrochloride, proteomic profiling, diagnostic laboratory biomarker analysis, mass spectrometry, adjuvant therapy, neoadjuvant therapy, therapeutic conventional surgery, radiation therapy | Memorial Sloan Kettering Cancer Center, National Cancer Institute (NCI) | Esophageal Cancer | 06/15 | 06/15 | | |
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NCT01715233: Phase II Study Using CHFR Methylation Status in Patients With Metastatic Esophageal, Gastroesophageal, Gastric Cancer. |
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| Completed | 2 | 27 | US | Docetaxel, Modified DCF, Leucovorin, Fluorouracil, FU, Cisplatin, Carboplatin | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Metastatic Esophageal Cancer, Gastroesophageal Cancer, Gastric Cancer | 06/15 | 04/17 | | |
NCT01608464: Pre-op Chemo-RT w/CDDP/5FU vs Chemo w/ Docetaxel/Irinotecan in PET Non Responder Resectable Esophagus Cancer |
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| Terminated | 2 | 170 | RoW | irinotecan and docetaxel, Irinotecan, Docetaxel, Cisplatin, fluorouracil and concurrent radiation therapy, Cisplatin, 5-FU, Concurrent RT with CDDP and 5-FU | King Faisal Specialist Hospital & Research Center | Carcinoma of Esophagus | 09/15 | 09/15 | | |
NCT01854749: S1 Combined With Cisplatin in Treatment of Recurrence/Metastasis of ESCC Open-label Single Center Phase II Clinical Study |
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| Completed | 2 | 57 | RoW | S1 combined with cisplatin | Fudan University | Esophageal Squamous Cell Carcinoma | 12/15 | | | |
| Terminated | 2 | 105 | Europe | FU-CDDP, Fluoro-uracil+CisPlatin, LV5FU2-CDDP, Elvorin+Fluoro-uracil+CisPlatin, FOLFOX, Oxaliplatin+Fluoro-uracil+Elvorin, TPF, Docetaxel+CisPlatine+Fluoro-uracile, Best Supportive Care, antalgic treatment, nutritional support, ... | Centre Oscar Lambret, National Cancer Institute, France | Squamous Cell Carcinoma of Esophagus | 01/16 | 01/17 | | |
NCT02034968: Nimotuzumab Plus Nab-paclitaxel and Cisplatin in Treating Patients With Advanced Esophageal Carcinoma |
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| Withdrawn | 2 | 0 | RoW | Nimotuzumab, Anti epidermal growth factor receptor antibody h-R3 | Zhejiang University | Stage IV Esophageal Squamous Cell Carcinoma | 01/16 | 01/17 | | |
NCT02041819: Neoadjuvant Chemotherapy of Nimotuzumab Plus Nab-Paclitaxel in Squamous Cell Carcinoma of Esophagus |
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| Withdrawn | 2 | 0 | RoW | Nimotuzumab, nimo | Zhejiang University | Squamous Cell Carcinoma of Esophagus | 01/16 | 01/17 | | |
NCT00400114: Sutent Following Chemotherapy, Radiation and Surgery For Resectable Esophageal Cancer |
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| Completed | 2 | 36 | Canada | Irinotecan, Cisplatin, Radiation, Surgery, sunitinib (Sutent) | University Health Network, Toronto, Pfizer | Esophageal Cancer | 09/16 | 09/16 | | |
| Completed | 1b/2 | 130 | US, Canada, Europe, RoW | Capecitabine, Xeloda, Epirubicin, AMG 102, Cisplatin, Placebo | Amgen | Esophagogastric Junction Adenocarcinoma, Gastric Cancer, Esophageal Cancer | 11/10 | 06/13 | | |
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NCT00290719: Gefitinib, Cisplatin, Irinotecan, and Radiation Therapy Before Surgery in Treating Patients With Esophageal Cancer or Gastroesophageal Junction Cancer That Can Be Removed By Surgery |
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| Terminated | 1/2 | 6 | US | cisplatin, gefitinib, irinotecan hydrochloride, conventional surgery, neoadjuvant therapy, radiation therapy | University of California, San Francisco, National Cancer Institute (NCI) | Esophageal Cancer | 04/08 | 06/08 | | |
SAKK 75/06, NCT00445861: Cetuximab, Docetaxel, Cisplatin, and Radiation Therapy in Treating Patients With Locally Advanced Esophageal Cancer That Can Be Removed by Surgery |
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| Completed | 1/2 | 27 | Europe | cetuximab + docetaxel + cisplatin, Treatment level 1, Treatment level 2, conventional surgery | Swiss Group for Clinical Cancer Research | Esophageal Cancer | 11/08 | 11/08 | | |
NCT00209716: Phase I/II Study of Taxotere,CDDP and 5-FU(TPF) in Pre-treated Pts With Metastatic Esophageal Cancer. |
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| Completed | 1/2 | 30 | Japan | Taxotere, Docetaxel, 5-Fluorouracil, fluorouracil, Briplatin, Cisplatin | Hokkaido Gastrointestinal Cancer Study Group, Hokkaido University Hospital | Esophageal Cancer | 10/09 | 11/09 | | |
NCT00209690: Phase I/II Study of TPF as First-line Chemotherapy in Patients With Metastatic Esophageal Cancer. |
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| Completed | 1/2 | 30 | Japan | Taxotere, Docetaxel, 5-FU, 5-Fluorouracil, Briplatin, Cisplatin,CDDP | Hokkaido Gastrointestinal Cancer Study Group, Hokkaido University Hospital | Esophageal Cancer | 12/09 | 04/10 | | |
NCT00544362 / 2006-004770-27: Fluorouracil, Cisplatin, Cetuximab, and Radiation Therapy in Treating Patients With Esophageal Cancer That Can Be Removed by Surgery |
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| Completed | 1/2 | 33 | Europe | cetuximab, cisplatin, fluorouracil, conventional surgery | Federation Francophone de Cancerologie Digestive | Esophageal Cancer | 01/11 | 03/13 | | |
NCT02446574: Postoperative Chemoradiation in Patients With Node-positive Esophageal Squamous Cell Carcinoma |
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| Completed | 1/2 | 33 | RoW | Paclitaxel, taxel, Cisplatin, platimum, Radiation | Chinese Academy of Medical Sciences | Esophageal Neoplasms | 12/16 | 12/16 | | |
