Not yet recruiting

4

332

 

The University of Sydney, National Health and Medical Research Council (NHMRC)

Sciatica

 

 

Ongoing

4

300

Europe

Capsule, Cymbalta, Lyrica

Leiden University Medical Center, LUMC

chronic pain chronische pijn, chronic pain chronische pijn, Body processes [G] - Physiological processes [G07]

 

 

Ongoing

4

160

Europe

duloxetine, Cymbalta, Cymbalta, Cymbalta

Eli Lilly Nederland

Major depressive disorder (episode or recurrent), moderately severe as principal DSM-IV diagnosis.

 

 

Ongoing

4

219

Europe

duloxetine, Cymbalta, Cymbalta, Cymbalta

Eli Lilly Nederland, Eli Lilly Nederland BV, GGz Breburg, Arkin, GGz inGeest

Major depressive disorder (episode or recurrent), as principal DSM-IV diagnosis combined with (sub)chronic pain symptoms as defined bij score of >3 on BPI painlist for at least six weeks.

 

 

Completed

4

43

 

duloxetine with Oral administration of gabapentin, pregabalin and Mecobalamin ;Oral administration of gabapentin, pregabalin and Mecobalamin

Fujian Provincial Geriatric Hospital; None, self-funding

Subacute Herpes Zoster Neuralgia

 

 

Not yet recruiting

4

180

 

DULOXETINE ;SERTRALINE ;placebo

Department of Orthopaedic Surgery, West China Hospital, West China Medical School, Sichuan University; West China Hospital, Sichuan University, Ministry of Health Special Scientific Research Projects of China

Total knee arthroplasty

 

 

Recruiting

4

80

 

duloxetine sustained-release capsules ;none

Department of Psychology, The affiliated Drum Tower hospital of Nanjing university medical school; The affiliated Drum Tower hospital of Nanjing university medical school, Nanjing General course of medical science and technology development

persistent somatoform pain disorder

 

 

Recruiting

4

100

 

Duloxetine ;Placebo

West China Hospital of Sichuan University; West China Hospital of Sichuan University, Ministry of Health Special Scientific Research Projects of China

Total knee arthroplasty

 

 

Completed

4

150

RoW

Duloxetine, intra-articular injection of corticosteroid and hyaluronic acid

Beijing Tiantan Hospital

Osteoarthritis, Knee, Chronic Pain

06/21

12/21

Recruiting

4

100

 

duloxetine 60mg/day with standard analgesic regimen ;standard analgesic regimen

The Third People's Hospital of Chengdu; The Third People's Hospital of Chengdu, Self-financing

single-segment lumbar fusion

 

 

Recruiting

4

75

RoW

Pregabalin, Duloxetine

Cairo University

Postoperative Pain

08/21

09/21

Not yet recruiting

4

300

 

Use escitalopram or duloxetine ;Use Shu-Gan Jie-Yu capsule ;Use Shu-Gan Jie-Yu capsule combined with escitalopram or duloxetine

Shandong Mental Health Center; Shandong Mental Health Center, Shandong Province Integrated Traditional Chinese and Western Medicine Depression Prevention Project

Major depressive disorder

 

 

Not yet recruiting

4

84

 

200mg celecoxib b.i.d. (morning and night) p.o. for 4 weeks ;75mg pregabalin b.i.d. (morning and night) p.o. for 4 weeks ;30mg duloxetine b.i.d. (morning and night) p.o. for 4 weeks

West China Hopital of Sichuan University; West China Hopital of Sichuan University, 1.3.5 Project of West China Hospital [No. 2021YFQ0028]

Osteoarthritis

 

 

Recruiting

4

70

 

Duloxetine 60 mg daily for 7 days, starting on the day of surgery (2 hours before surgery) ;Placebo 60 mg daily for 7 days, starting on the day of surgery (2 hours before surgery)

West China Hospital, Sichuan University; West China Hospital, Sichuan University, 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University (ZYJC18039)

Total knee arthroplasty

 

 

Not yet recruiting

4

212

Europe

Cymbalta, Benztropine, Capsule, Tablet, Cymbalta, Benztropine

Aarhus University Hospital, The Research Clinic for Functional Disorders and Psychosomatics, The Tryg Foundation

Multiorgan Functional somatic disorders (FSD) / bodily disstress syndrome (BDS) multiorgan Funktionel lidelse, Functional somatic disorder Funktionel lidelse, Not possible to specify

 

 

Recruiting

4

90

RoW

Duloxetine, Gabapentin, Lacosamide

Tanta University

Oncology

09/23

09/24

Recruiting

4

40

US

Scrambler Therapy, Calmare Therapy, Standard Medication Management

Johns Hopkins University

Post Stroke Pain

12/25

12/25

Recruiting

4

424

Europe

Patient Education, Duloxetine, Cymbalta, SNRI, Benztropine Mesylate 0.5 MG and passive placebo RAP, Enhanced usual care

Aarhus University Hospital, Central Denmark Region, University of Aarhus, Vejle Hospital, Aalborg University Hospital, TrygFonden, Denmark, Independent Research Fund Denmark

Functional Disorder

11/27

11/29

Active, not recruiting

4

1014

US

Enhanced Self-Care (ESC), Acceptance and Commitment Therapy (ACT), Evidence-Based Exercise and Manual Therapy (EBEM), Duloxetine, Cymbalta

University of North Carolina, Chapel Hill, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Chronic Low-back Pain

11/24

11/24

Not yet recruiting

4

150

Canada

Duloxetine, Placebo

Sunnybrook Health Sciences Centre

Knee Osteoarthritis

07/26

12/26

Recruiting

4

60

US

Duloxetine, Cymbalta, Irenka, Escitalopram, Lexapro

University of Cincinnati

Anxiety, Depressive Symptoms

Not yet recruiting

4

120

 

Oral duloxetine 60 mg/dose once daily beginning two days before surgery and continuing through 14 days postoperatively; Oral pregabalin 150 mg/dose twice daily beginning two days before surgery and continuing through 14 days postoperatively; Oral duloxetine 60 mg/dose once a day and oral pregabalin 150 mg/dose twice a day starting two days prior to surgery and continuing until 14 days postoperatively; After the 6h postoperative fasting period, oral erixib tablets 0.1g, codeine 500mg, starting on the second postoperative day and up to 14 days postoperatively, oral erixib tablets 0.1g/dose, 2 times/day, oral codeine 500mg/dose, 2 times/day

Honghui Hospital, Xi'an Jiaotong University; Honghui Hospital, Xi'an Jiaotong University, self-finance

osteoarthritis of the knee

 

 

Recruiting

4

100

US

Duloxetine 30 mg, Common brands: Irenka, Cymbalta

Wake Forest University Health Sciences

Depression in Old Age, Fragility Fracture

02/25

02/25

Enrolling by invitation

4

3300

US

Listed for each disorder below, up to three drugs per disorder (too many characters to list in this field; see Intervention Description), (too many characters to list in this field; see Intervention Description)

NorthShore University HealthSystem

Brain Tumors, Epilepsy, Migraine, Mild Cognitive Impairment, Concussion, Multiple Sclerosis, Neuropathy, Parkinson's, Restless Legs Syndrome, Stroke

12/25

12/26

Not yet recruiting

4

800

 

Escitalopram oxalate; Paroxetine; Sertraline; Duloxetine; Mirtazapine; Shugan Jieyu capsule

Peking Union Medical College Hospital, Chinese Academy of Medical Sciences; Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Project of National Key R&D Program of China (2022YFC2504004)

irritable bowel syndrome

 

 

Recruiting

4

120

US

Naproxen, Duloxetine

Montefiore Medical Center

Back Pain, Low

09/26

09/26

Not yet recruiting

4

1200

 

All received 200 mg celecoxib as prophylactic pain control 2 hours before surgery, and all were given 1 mL of a 100-mL mixture containing 2,000 mg of fentanyl as needed after surgery using an intravenous patient-controlled anaesthesia (PCA) pump. After patients resumed oral intake, they were given 1 mg of oxycodone every 12 hours for 7 days, and 200 mg of celecoxib, 37.5 mg of tramadol, and 650 mg of acetaminophen every 12 hours for 6 weeks after surgry; During the initial 6-week treatment period, patients received 60 mg of duloxetine per day and thereafter, during the 6-week combination/high-dose treatment period, only non-responders (response rate assessed on the basis of a 30% reduction in mean 24-h pain on the BPI, or a score of 2) received 120 mg of duloxetine per day; During the initial 6-week treatment period, patients received 60 mg of duloxetine per day. Thereafter, during the 6-week combination/high-dose treatment period, only non-responders (response rate assessed on the basis of a 30% reduction in mean 24-h pain on the BPI or a score of 2) received the combination of 60 mg duloxetine daily and 300 mg pregabalin daily; During the initial 6-week treatment period, patients received 300 mg of pregabalin daily. Thereafter, during the 6-week combination/high-dose treatment period, only non-responders (response rate assessed on the basis of a 30% reduction in mean 24-h pain on the BPI or a score of 2) received the combination of 60 mg duloxetine daily and 300 mg pregabalin daily; During the initial 6-week treatment period, patients received 300 mg of pregabalin per day. Thereafter, during the 6-week combination/high-dose treatment period, only non-responders (response rate assessed on the basis of a 30 per cent reduction in mean 24-h pain on the BPI or a score of 2) received 600 mg of pregabalin per day; All received 200 mg celecoxib as prophylactic pain control 2 hours before surgery, and all were given 1 mL of a 100-mL mixture containing 2,000 mg of fentanyl as needed after surgery using an intravenous patient-controlled anaesthesia (PCA) pump. After patients resumed oral intake, they were given 1 mg of oxycodone every 12 hours for 7 days, and 200 mg of celecoxib, 37.5 mg of tramadol, and 650 mg of acetaminophen every 12 hours for 6 weeks after surgry

Honghui Hospital, Xi'an Jiaotong University; Honghui Hospital, Xi'an Jiaotong University, self-finance

osteoarthritis of the knee

 

 

Recruiting

3/4

146

 

Waitemata District Health Board, Health Research Council of New Zealand

Knee osteoarthritis