Sarcoma  >>  temozolomide  >>  Phase 2
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88 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
temozolomide / Generic mfg.
NCT02511132: A Two-part Phase IIb Trial of Vigil (Bi-shRNAfurin and GMCSF Augmented Autologous Tumor Cell Immunotherapy) in Ewing's Sarcoma

Completed
2b
22
US
Vigil, formerly known as FANG™, bi-shRNAfurin and GMCSF Autologous Tumor Cell Immunotherapy, Temozolomide, TEMODAR, Irinotecan, CAMPTOSAR, Gemcitabine, GEMZAR, Docetaxel, TAXOTERE
Gradalis, Inc.
Ewing's Sarcoma
11/18
12/20
NCT00005597: S9926 Temozolomide in Patients With Unresectable/Metastatic Gastrointestinal Stromal Tumors

Completed
2
25
US
temozolomide, NSC-362856
Southwest Oncology Group, National Cancer Institute (NCI)
Gastrointestinal Stromal Tumor
10/05
10/05
NCT00194766: Continuous Temozolomide in Patients With Advanced or Metastatic Soft Tissue Sarcoma or Metastatic Breast Cancer

Completed
2
35
US
Temozolomide
University of Washington, Schering-Plough
Breast Cancer, Soft Tissue Sarcoma
 
12/06
NCT00365222: Phase II Study of Temozolomide in Newly Diagnosed Glioblastoma

Terminated
2
1
US
Temozolomide, Temodar
H. Lee Moffitt Cancer Center and Research Institute, Schering-Plough
Glioblastoma, Gliosarcoma
06/07
06/07
NCT00039494: Erlotinib and Temozolomide With Radiation Therapy in Treating Patients With Glioblastoma Multiforme or Other Brain Tumors

Completed
2
171
US
erlotinib hydrochloride, CP-358,774, erlotinib, OSI-774, 3-dimensional conformal radiation therapy, 3D conformal radiation therapy, 3D-CRT, temozolomide, SCH 52365, Temodal, Temodar, TMZ
National Cancer Institute (NCI)
Adult Giant Cell Glioblastoma, Adult Glioblastoma, Adult Gliosarcoma
07/07
 
NCT00028795: Chemotherapy and Radiation Therapy After Surgery in Treating Children With Newly Diagnosed Astrocytoma, Glioblastoma Multiforme, Gliosarcoma, or Diffuse Intrinsic Pontine Glioma

Completed
2
170
US, Canada, Europe, RoW
temozolomide, adjuvant therapy, radiation therapy
Children's Oncology Group, National Cancer Institute (NCI)
Brain and Central Nervous System Tumors
09/07
03/12
NCT00084838: Chemotherapy Combined With Radiation Therapy for Newly Diagnosed CNS AT/RT

Completed
2
25
US
filgrastim, filgrastim XM02, G-CSF, cisplatin, CACP, cis-DDP, cis-diamminedichloro platinum (II), cis-diamminedichloroplatinum, Cis-dichloroammine Platinum (II), Cismaplat, Platinol, cyclophosphamide, Ciclofosfamida, Ciclofosfamide, Claphene, CP monohydrate, CPM, Cyclophospham, Cyclophosphamid monohydrate, Cyclophosphamidum, Cyclophosphan, Cyclophosphanum, Cytophosphane, Mitoxan, Syklofosfamid, Zytoxan, Clafen, Cytoxan, Neosar, cytarabine, arabinofuranosylcytosine, arabinosylcytosine, aracytidine, beta-cytosine arabinoside, cytarabine hydrochloride, cytarabinum, cytosine arabinoside, cytosine arabinosine hydrochloride, Cytosar-U, Tarabine PFS, dexrazoxane hydrochloride, Totect, Zinecard, doxorubicin hydrochloride, Adriamycin PFS, Adriamycin RDF, etoposide, VP-16, leucovorin calcium, folinate calcium, folinic acid, methotrexate, temozolomide, Temodar, Methazolastone, Temodal, TMZ, CCRG-81045, therapeutic hydrocortisone, vincristine sulfate, leurocristine sulfate, Vincasar PFS, radiation therapy, Dactinomycin, ACT-D, actinomycin C1, actinomycin D, actinomycin I1, actinomycin IV, actinomycin X 1, actinomycin-[thr-val-pro-sar-meval], AD, dactinomycine, meractinomycin
Dana-Farber Cancer Institute, National Cancer Institute (NCI)
Central Nervous System Tumor, Pediatric
02/08
03/13
NCT00613028: Ph II Bev + Either Temozolomide/Etoposide for GBM Pts Who Have Failed Bev + Irinotecan

Completed
2
23
US
Temo + Avastin, temozolomide, temodar, bevacizumab, VP-16 + Avastin, VP-16, etoposide, avastin
Duke University, Genentech, Inc.
Glioblastoma, Gliosarcoma
10/09
01/11
NCT00433381: Bevacizumab and Irinotecan or Temozolomide in Treating Patients With Recurrent or Refractory Glioblastoma Multiforme or Gliosarcoma

Completed
2
123
US
Bevacizumab, Anti-VEGF, Anti-VEGF Humanized Monoclonal Antibody, Anti-VEGF rhuMAb, Avastin, Bevacizumab Biosimilar BEVZ92, Bevacizumab Biosimilar BI 695502, Bevacizumab Biosimilar CBT 124, Bevacizumab Biosimilar FKB238, BEVACIZUMAB, LICENSE HOLDER UNSPECIFIED, Immunoglobulin G1 (Human-Mouse Monoclonal rhuMab-VEGF Gamma-Chain Anti-Human Vascular Endothelial Growth Factor), Disulfide With Human-Mouse Monoclonal rhuMab-VEGF Light Chain, Dimer, Recombinant Humanized Anti-VEGF Monoclonal Antibody, rhuMab-VEGF, Irinotecan Hydrochloride, Campto, Camptosar, Camptothecin 11, Camptothecin-11, CPT 11, CPT-11, Irinomedac, U-101440E, Temozolomide, CCRG-81045, Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, M & B 39831, M and B 39831, Methazolastone, RP-46161, SCH 52365, Temcad, Temodal, Temodar, Temomedac
National Cancer Institute (NCI), American College of Radiology Imaging Network, Radiation Therapy Oncology Group
Adult Glioblastoma, Adult Gliosarcoma, Recurrent Adult Brain Neoplasm
01/10
02/11
NCT00936052: Hyperbaric Hyperoxygenation With Radiotherapy and Temozolomide in Adults With Newly Diagnosed Glioblastoma

Unknown status
2
20
US
Hyperbaric Oxygen Therapy, Oxygenation, oxygen tank
Neurological Surgery, P.C.
Glioblastomas, Gliosarcoma
12/10
12/10
NCT00979017: Avastin/Temozolomide/Irinotecan for Unresectable/Multifocal Glioblastoma Multiforme

Completed
2
41
US
Avastin, Avastin (bevacizumab), Temozolomide, Temodar, Irinotecan, CPT-11, Camptosar
Katy Peters, Genentech, Inc.
Glioblastoma Multiforme, Gliosarcoma
02/11
01/13
NCT00187486: Safety and Efficacy Study of Tarceva, Temodar, and Radiation Therapy in Patients With Newly Diagnosed Brain Tumors

Completed
2
66
US
Tarceva, erlotinib, Temodar, temozolomide, Radiation Therapy
University of California, San Francisco, Genentech, Inc.
Glioblastoma Multiforme, Gliosarcoma
03/11
03/11
NCT00597402: Avastin in Combination With Radiation (XRT) & Temozolomide, Followed by Avastin, Temozolomide and Irinotecan for Glioblastoma (GBM) and Gliosarcomas

Completed
2
125
US
Avastin, Bevacizumab, Temozolomide, Temodar, Radiation Therapy (XRT), Irinotecan, CPT-11, Camptosar
Duke University, Genentech, Inc., Schering-Plough
Glioblastoma, Gliosarcoma, Brain Tumor
08/11
05/13
NCT00657267: Dose-Intense Temozolomide in Recurrent Glioblastoma

Completed
2
58
US
Temozolomide, Temodar
Patrick Y. Wen, MD, Brigham and Women's Hospital, Massachusetts General Hospital, University of Pennsylvania, Wake Forest University Health Sciences, Tufts Medical Center, Dartmouth-Hitchcock Medical Center, Schering-Plough
Glioblastoma, Gliosarcoma
11/11
10/13
NCT00369590: VEGF Trap in Treating Patients With Recurrent Malignant Gliomas That Did Not Respond to Temozolomide

Completed
2
58
US
ziv-aflibercept, aflibercept, vascular endothelial growth factor trap, VEGF Trap, Zaltrap, pharmacological study, laboratory biomarker analysis
National Cancer Institute (NCI)
Adult Anaplastic Astrocytoma, Adult Anaplastic Oligodendroglioma, Adult Giant Cell Glioblastoma, Adult Gliosarcoma, Recurrent Adult Brain Tumor
12/11
10/12
NCT00612339: Avastin in Combination With Temozolomide for Unresectable or Multifocal GBMs and Gliosarcomas

Completed
2
41
US
Avastin and Temozolomide, Avastin - Bevacizumab, Temozolomide - Temodar
Duke University, Genentech, Inc., Schering-Plough
Glioblastoma, Gliosarcoma
05/12
05/12
NCT01004874: Avastin/Radiation (XRT)/Temozolomide (Temodar) Followed by Avastin/Temodar/Topotecan for Glioblastoma

Completed
2
80
US
Bevacizumab, Avastin, Temozolomide, Temodar, Radiation Therapy (XRT), Topotecan, Hycamtin
Duke University, Genentech, Inc., GlaxoSmithKline
Malignant Glioma, Glioblastoma, Gliosarcoma
07/12
11/21
NCT00100802: Radiation Therapy, Temozolomide, and Lomustine in Treating Young Patients With Newly Diagnosed Gliomas

Completed
2
118
US
Laboratory Biomarker Analysis, Lomustine, 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea, 1-Nitrosourea, 1-(2-chloroethyl)-3-cyclohexyl-, Belustin, Belustine, CCNU, Cecenu, CeeNU, Chloroethylcyclohexylnitrosourea, Citostal, Gleostine, Lomeblastin, Lomustinum, Lucostin, Lucostine, N-(2-Chloroethyl)-N'-cyclohexyl-N-nitrosourea, Prava, RB-1509, WR-139017, Radiation Therapy, Cancer Radiotherapy, ENERGY_TYPE, Irradiate, Irradiated, Irradiation, Radiation, Radiation Therapy, NOS, Radiotherapeutics, Radiotherapy, RT, Therapy, Radiation, Temozolomide, CCRG-81045, Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, M & B 39831, M and B 39831, Methazolastone, RP-46161, SCH 52365, Temcad, Temodal, Temodar, Temomedac, TMZ
Children's Oncology Group, National Cancer Institute (NCI)
Anaplastic Astrocytoma, Central Nervous System Neoplasm, Glioblastoma, Gliosarcoma, Spinal Cord Neoplasm
09/12
06/17
NCT00085254: Cilengitide, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

Completed
2
112
US
cilengitide, EMD 121974, temozolomide, SCH 52365, Temodal, Temodar, TMZ, radiation therapy, irradiation, radiotherapy, therapy, radiation, laboratory biomarker analysis, pharmacological study, pharmacological studies
National Cancer Institute (NCI)
Adult Giant Cell Glioblastoma, Adult Glioblastoma, Adult Gliosarcoma
11/12
11/12
NCT00881595: Proton Chemoradiotherapy for High-Risk Soft Tissue Sarcomas

Withdrawn
2
0
NA
Chemoradiotherapy Temozolomide, Temozolomide, Temodar, Proton therapy, Radiation therapy, Proton Chemoradiotherapy followed by surgery
University of Florida
Soft Tissue Sarcomas
11/12
11/12
NCT02599090: Phase II Sorafenib With Radiation and Temozolomide in Newly Diagnosed Glioblastoma or Gliosarcoma

Withdrawn
2
0
US
Temozolomide, Radiation, Radiotherapy, XRT, Sorafenib, BAY43-9006
M.D. Anderson Cancer Center, Bayer
Glioblastoma, Gliosarcoma
12/12
12/12
AVF4120s, NCT00525525: Study of Bevacizumab Plus Temodar and Tarceva in Patients With Glioblastoma or Gliosarcoma

Checkmark Radiation, temozolomide, erlotinib & bevacizumab for initial treatment of glioblastoma
Mar 2014 - Mar 2014: Radiation, temozolomide, erlotinib & bevacizumab for initial treatment of glioblastoma
Completed
2
74
US
Bevacizumab, Tarceva, Erlotonib, Temozolomide
University of California, San Francisco
Glioblastoma, Gliosarcoma
05/13
05/13
NCT01013285: Bevacizumab, Temozolomide, and External Beam Radiation Therapy as First-Line Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme or Gliosarcoma

Completed
2
70
US
bevacizumab, temozolomide, external beam radiation therapy
Jonsson Comprehensive Cancer Center
Brain and Central Nervous System Tumors
10/13
08/15
NCT00003718: Temozolomide in Treating Patients With Advanced Soft Tissue Sarcoma

Unknown status
2
25
US
temozolomide
Herbert Irving Comprehensive Cancer Center
Endometrial Cancer, Ovarian Cancer, Sarcoma
 
 
NCT00033709: Temozolomide and Thalidomide in Treating Patients With Metastatic, Locally Advanced, or Unresectable Leiomyosarcoma

Unknown status
2
US
temozolomide, thalidomide
Herbert Irving Comprehensive Cancer Center, National Cancer Institute (NCI)
Sarcoma
 
 
NCT01186406: Gliadel, XRT, Temodar, Avastin Followed by Avastin, Temodar for Newly Diagnosed Glioblastoma Multiforme (GBM)

Checkmark ASCO 2013
May 2013 - May 2013: ASCO 2013
Terminated
2
41
US
Gliadel, Gliadel (carmustine wafers), Radiation Therapy, Avastin, Avastin (bevacizumab), Temodar, Temodar (temozolomide)
Duke University, Genentech, Inc., Eisai Inc.
Glioblastoma Multiforme, Gliosarcoma
06/14
06/14
NCT00720356: Bevacizumab and Erlotinib After Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma Multiforme or Gliosarcoma

Checkmark ASCO 2013
May 2013 - May 2013: ASCO 2013
Checkmark P2 data-ASCO
Jun 2012 - Jun 2012: P2 data-ASCO
Completed
2
115
US
bevacizumab, Avastin, erlotinib hydrochloride, erlotinib, CP-358, 774, Tarceva
Northwestern University, M.D. Anderson Cancer Center
Brain and Central Nervous System Tumors
06/14
07/18
NCT01313884: Cyclophosphamide, Doxorubicin, Vincristine w/ Irinotecan and Temozolomide in Ewings Sarcoma

Terminated
2
3
US
Irinotecan, Camptosar, Campto, Vincristine, Oncovin, leurocristine, Temozolomide, Temodar, Temodal, Doxorubicin, Adriamycin, hydroxydaunorubicin, Cytoxan, Cyclophosphamide, Endoxan, Neosar, Procytox, Revimmune, cytophosphane, Pegfilgrastim, Neulasta
Stanford University, Amgen
Bone Cancer, Ewing's Sarcoma
07/14
07/14
NCT00883298: Bi-weekly Temozolomide Plus Bevacizumab for Adult Patients With Recurrent Glioblastoma Multiforme

Completed
2
30
US
temozolomide and bevacizumab, Temodar, Avastin
Center for Neurosciences, Tucson, Genentech, Inc.
Recurrent Glioblastoma Multiforme, Recurrent Gliosarcoma
12/14
12/14
NCT01946529: Therapeutic Trial for Patients With Ewing Sarcoma Family of Tumor and Desmoplastic Small Round Cell Tumors

Active, not recruiting
2
24
US
vincristine, Oncovin(R), doxorubicin, Adriamycin(R), cyclophosphamide, Cytoxan(R), ifosfamide, Ifex(R), etoposide, VP-16, Vepesid(R), temozolomide, Temodar(R), temsirolimus, CCI-779, Torisel^TM, bevacizumab, rhumab VEGF, Avastin(R), sorafenib, BAY-43-9006, Nexavar(R), surgery, therapeutic conventional surgery, radiation, proton beam radiation therapy, external beam radiation therapy, brachytherapy
St. Jude Children's Research Hospital, University of Tennessee, University of Florida, Nemours Children's Clinic
Desmoplastic Small Round Cell Tumor, Ewing Sarcoma of Bone or Soft Tissue, Localized Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor, Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
08/15
07/26
NCT00003273: Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Brain Tumor

Withdrawn
2
0
US, Canada, RoW
filgrastim, carboplatin, cisplatin, cyclophosphamide, etoposide, leucovorin calcium, methotrexate, temozolomide, thiotepa, vincristine sulfate, autologous bone marrow transplantation, peripheral blood stem cell transplantation, radiation therapy
NYU Langone Health
Brain and Central Nervous System Tumors, Neuroblastoma, Retinoblastoma, Sarcoma
 
 
NCT01062425: Temozolomide and Radiation Therapy With or Without Cediranib Maleate in Treating Patients With Newly Diagnosed Glioblastoma

Checkmark P1/2 data-ASCO
Jun 2012 - Jun 2012: P1/2 data-ASCO
Completed
2
261
US
3-Dimensional Conformal Radiation Therapy, 3-dimensional radiation therapy, 3D Conformal, 3D CONFORMAL RADIATION THERAPY, 3D CRT, 3D-CRT, Conformal Therapy, Radiation Conformal Therapy, Radiation, 3D Conformal, Cediranib Maleate, AZD2171, AZD2171 Maleate, Recentin, Intensity-Modulated Radiation Therapy, IMRT, Intensity Modulated RT, Intensity-Modulated Radiotherapy, Radiation, Intensity-Modulated Radiotherapy, Laboratory Biomarker Analysis, Placebo Administration, Temozolomide, CCRG-81045, Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, M & B 39831, M and B 39831, Methazolastone, RP-46161, SCH 52365, Temcad, Temodal, Temodar, Temomedac, TMZ
National Cancer Institute (NCI), NRG Oncology, Radiation Therapy Oncology Group
Adult Glioblastoma, Adult Gliosarcoma
12/15
05/22
2006-005077-21: A Phase II study of concurrent radiation and Temozolomide followed by Temozolomide and Lomustine (CCNU) in the treatment of Children with High Grade Glioma

Completed
2
8
Europe
Temodal, Belustine, Temodal, Belustine, Temodal, Belustine
Dutch Childhood Oncology Group (DCOG)
High grade glioma: anaplastic astrocytoma, glioblastoma multiforme, gliosarcoma
 
 
NCT00998010: Bortezomib, Temozolomide, and Regional Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme or Gliosarcoma

Completed
2
24
US
bortezomib + temozolomide+ radiation therapy
Jonsson Comprehensive Cancer Center, Millennium Pharmaceuticals, Inc.
Brain and Central Nervous System Tumors
03/16
04/18
NCT01055314: Temozolomide, Cixutumumab, and Combination Chemotherapy in Treating Patients With Metastatic Rhabdomyosarcoma

Checkmark ASCO 2015
May 2015 - May 2015: ASCO 2015
Completed
2
175
US, Canada, RoW
Cixutumumab, Anti-IGF-1R Recombinant Monoclonal Antibody IMC-A12, IMC-A12, Cyclophosphamide, (-)-Cyclophosphamide, 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate, Carloxan, Ciclofosfamida, Ciclofosfamide, Cicloxal, Clafen, Claphene, CP monohydrate, CTX, CYCLO-cell, Cycloblastin, Cycloblastine, Cyclophospham, Cyclophosphamid monohydrate, Cyclophosphamidum, Cyclophosphan, Cyclophosphane, Cyclophosphanum, Cyclostin, Cyclostine, Cytophosphan, Cytophosphane, Cytoxan, Fosfaseron, Genoxal, Genuxal, Ledoxina, Mitoxan, Neosar, Revimmune, Syklofosfamid, WR- 138719, Dactinomycin, Actinomycin A IV, Actinomycin C1, ACTINOMYCIN D, Actinomycin I1, Actinomycin IV, Actinomycin X 1, Actinomycin-[thr-val-pro-sar-meval], Cosmegen, DACT, Dactinomycine, Lyovac Cosmegen, Meractinomycin, Doxorubicin Hydrochloride, 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8, 9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)- (9CI), ADM, Adriacin, Adriamycin, Adriamycin Hydrochloride, Adriamycin PFS, Adriamycin RDF, ADRIAMYCIN, HYDROCHLORIDE, Adriamycine, Adriblastina, Adriblastine, Adrimedac, Chloridrato de Doxorrubicina, DOX, DOXO-CELL, Doxolem, Doxorubicin.HCl, Doxorubin, Farmiblastina, FI 106, FI-106, hydroxydaunorubicin, Rubex, Etoposide, Demethyl Epipodophyllotoxin Ethylidine Glucoside, EPEG, Lastet, Toposar, Vepesid, VP 16-213, VP-16, VP-16-213, Ifosfamide, Asta Z 4942, Asta Z-4942, Cyfos, Holoxan, Holoxane, Ifex, IFO, IFO-Cell, Ifolem, Ifomida, Ifomide, Ifosfamidum, Ifoxan, IFX, Iphosphamid, Iphosphamide, Iso-Endoxan, Isoendoxan, Isophosphamide, Mitoxana, MJF 9325, MJF-9325, Naxamide, Seromida, Tronoxal, Z 4942, Z-4942, Irinotecan Hydrochloride, Campto, Camptosar, Camptothecin 11, Camptothecin-11, CPT 11, CPT-11, U-101440E, Laboratory Biomarker Analysis, Temozolomide, CCRG-81045, Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, M & B 39831, M and B 39831, Methazolastone, RP-46161, SCH 52365, Temodal, Temodar, Vincristine Sulfate Liposome, Marqibo
National Cancer Institute (NCI)
Adult Rhabdomyosarcoma, Childhood Alveolar Rhabdomyosarcoma, Childhood Embryonal Rhabdomyosarcoma, Metastatic Childhood Soft Tissue Sarcoma, Stage IV Adult Soft Tissue Sarcoma, Untreated Childhood Rhabdomyosarcoma
06/16
06/16
NCT00902577: MRI and PET/FMISO In Assessing Tumor Hypoxia in Patients With Newly Diagnosed Glioblastoma Multiforme

Completed
2
50
US
FMISO, 18F-fluoromisonidazole, 18F-MISO, 18F-Misonidazole, MRI, Magnetic Resonance Imaging (MRI), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance, MRI Scan, NMR Imaging, Nuclear Magnetic Resonance Imaging (NMRI), Nuclear Magnetic Resonance Imaging, Medical Imaging, Nuclear Magnetic Resonance, Magnetic Resonance (MR), PET, Medical Imaging, Positron Emission Tomography, PET Scan, Positron Emission Tomography, Positron Emission Tomography Scan, Positron-Emission Tomography, proton magnetic resonance spectroscopic imaging, MRS, Magnetic Resonance Spectroscopy (MRS), Magnetic Resonance Imaging Spectroscopy (MRIS), Magnetic Resonance Spectroscopy Imaging (MRSI)
National Cancer Institute (NCI)
Adult Giant Cell Glioblastoma, Adult Glioblastoma, Adult Gliosarcoma
01/18
01/18
NCT01692496 / 2012-002745-38: Activity and Tolerability of Pazopanib in Advanced and/or Metastatic Liposarcoma. A Phase II Clinical Trial

Completed
2
52
Europe
Pazopanib
Grupo Espanol de Investigacion en Sarcomas, GlaxoSmithKline
Advanced and / or Metastatic Liposarcoma
03/18
03/18
NCT01355445 / 2010-023135-42: Vincristine and Irinotecan With or Without Temozolomide in Children and Adults With Refractory/Relapsed Rhabdomyosarcoma

Completed
2
120
Europe
Vincristine, Irinotecan, Vincristine-Irinotecan, Vincristine, Irinotecan, Temozolomide, Vincristine-Irinotecan-Temozolomide
Centre Oscar Lambret, SFCE
RHABDOMYOSARCOMA
06/18
05/19
NRG-BN001, NCT02163135: Dose-Escalated Photon IMRT or Proton Beam Radiation Therapy Versus Standard-Dose Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma

Not yet recruiting
2
576
US
3-dimensional conformal radiation therapy, 3D conformal radiation therapy, 3D-CRT, intensity-modulated radiation therapy, IMRT, photon beam radiation therapy, proton beam radiation therapy, temozolomide, SCH 52365, Temodal, Temodar, TMZ, laboratory biomarker analysis
Radiation Therapy Oncology Group, National Cancer Institute (NCI), NRG Oncology Foundation
Adult Giant Cell Glioblastoma, Adult Glioblastoma, Adult Gliosarcoma
05/19
 
GCC 1224, NCT01822275: Phase II Trial of Low-Dose Whole Brain Radiotherapy With Concurrent Temozolomide and Adjuvant Temozolomide in Patients With Newly-Diagnosed Glioblastoma Multiforme

Terminated
2
24
US
Chemotherapy with Temodar., Radiation therapy
University of Maryland, Baltimore
Histologically Proven Diagnosis of Glioblastoma or Gliosarcoma (WHO Grade IV)
09/19
09/19
NCI-2015-00694, NCT02455557: SurVaxM Vaccine Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma

Active, not recruiting
2
66
US
Laboratory Biomarker Analysis, Montanide ISA 51 VG, Sargramostim, 23-L-Leucinecolony-Stimulating Factor 2, DRG-0012, Leukine, Prokine, rhu GM-CFS, Sagramostim, Sargramostatin, SVN53-67/M57-KLH Peptide Vaccine, Temozolomide, CCRG-81045, Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, M & B 39831, M and B 39831, Methazolastone, RP-46161, SCH 52365, Temcad, Temodal, Temodar, Temomedac
Roswell Park Cancer Institute
Glioblastoma, Gliosarcoma
10/19
12/24
NCT01740258: Bevacizumab Beyond Progression (BBP)

Completed
2
68
US
Radiation Therapy, XRT, Temozolomide, temo, temodar, Bevacizumab, Avastin
Duke University, Genentech, Inc.
Malignant Glioma, Grade 4 Malignant Glioma, Glioblastoma, Gliosarcoma
11/19
11/19
NCT02689336: Erlotinib in Combination With Temozolomide in Treating Relapsed/Recurrent/Refractory Pediatric Solid Tumors

Withdrawn
2
0
NA
Erlotinib, Tarceva, Temozolomide, Temodar®
Washington University School of Medicine
Glioma, Rhabdomyosarcoma, Osteosarcoma, Medulloblastoma, Neuroectodermal Tumor, Ependymoma, Ewing's Sarcoma, Wilms Tumor
11/19
05/20
NCI protocol 10250, NCT03880019: A Phase II Clinical Trial Evaluating the Combination of Olaparib and Temozolomide for the Treatment of Advanced Uterine Leiomyosarcoma

Active, not recruiting
2
23
US
Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Core Biopsy, BIOPSY, CORE, CNB, Core Needle, Core Needle Biopsy, Needle Biopsy, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Olaparib, AZD 2281, AZD-2281, AZD2281, KU-0059436, Lynparza, Olanib, Olaparix, PARP Inhibitor AZD2281, Temozolomide, CCRG-81045, Gliotem, Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, M & B 39831, M and B 39831, Methazolastone, RP-46161, SCH 52365, Temcad, Temizole, Temodal, Temodar, Temomedac, TMZ
National Cancer Institute (NCI)
Stage III Uterine Corpus Leiomyosarcoma AJCC v8, Stage IV Uterine Corpus Leiomyosarcoma AJCC v8, Uterine Corpus Leiomyosarcoma
08/20
09/24
NCT02942264: Zotiraciclib (TG02) Plus Dose-Dense or Metronomic Temozolomide Followed by Randomized Phase II Trial of Zotiraciclib (TG02) Plus Temozolomide Versus Temozolomide Alone in Adults With Recurrent Anaplastic Astrocytoma and Glioblastoma

Completed
2
53
US
Zotiraciclib (TG02), TG02, Temozolomide (TMZ), Temodar
National Cancer Institute (NCI)
Brain Tumor, Astrocytoma, Astroglioma, Glioblastoma, Gliosarcoma
08/20
08/20
AIEOP EW-2, NCT02727387: Protocol for the Treatment of Metastatic Ewing Sarcoma

Completed
2
155
Europe
TEMIRI, Temozolomide + Irinotecan, ADM, Adriamycin, IFO, Ifosfamide, CYC, Cyclophosphamide, ETO, Etoposide, BUMEL, busulfan + melphalan, VIN, Vincristine
Italian Sarcoma Group
Ewing's Sarcoma (ES)
04/22
04/22
CombinaiR3, NCT03011528: First-line Treatment of Ewing Tumours With Primary Extrapulmonary Dissemination in Patients From 2 to 50 Years

Completed
2
45
Europe
VDC-IE x2, Intensified Induction VDC-IE x2, VDC-IE, Intensified Induction VDC-IE, TEMIRI, Intensified Induction TEMIRI, Consolidation BuMel, High dose Consolidation chemotherapy, Maintenance, 2 years maintenance, Local treatment by surgery, Surgery of primary tumour/metastatic sites, Local treatment by radiotherapy, Radiotherapy of primary tumour/metastatic sites
Institut Curie, UNICANCER
Ewing Sarcoma Family of Tumors
08/22
11/23
NCT03359005: Irinotecan and Temozolomide for Ewing Sarcoma

Recruiting
2
60
RoW
Vincristine, VCR, Temozolomide, Temodar
Peking University People's Hospital
Ewing Sarcoma
11/22
02/25
NCT04200443: Cabozantinib and Temozolomide for the Treatment of Unresectable or Metastatic Leiomyosarcoma or Other Soft Tissue Sarcoma

Active, not recruiting
2
72
US
Cabozantinib, Quality-of-Life Assessment, Quality of Life Assessment, Questionnaire Administration, Temozolomide, CCRG-81045, Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, M & B 39831, M and B 39831, Methazolastone, RP-46161, SCH 52365, Temcad, Temodal, Temodar, Temomedac, TMZ
City of Hope Medical Center, National Cancer Institute (NCI)
Metastatic Leiomyosarcoma, Metastatic Soft Tissue Sarcoma, Stage III Uterine Corpus Leiomyosarcoma AJCC v8, Stage IIIA Uterine Corpus Leiomyosarcoma AJCC v8, Stage IIIB Uterine Corpus Leiomyosarcoma AJCC v8, Stage IIIC Uterine Corpus Leiomyosarcoma AJCC v8, Stage IV Uterine Corpus Leiomyosarcoma AJCC v8, Stage IVA Uterine Corpus Leiomyosarcoma AJCC v8, Stage IVB Uterine Corpus Leiomyosarcoma AJCC v8, Unresectable Leiomyosarcoma, Unresectable Soft Tissue Sarcoma
06/24
06/24
NCT03137888: Spectroscopic MRI-Guided Radiation Therapy Planning in Glioblastoma

Active, not recruiting
2
34
US
Dose-Escalated Radiation Therapy, RT, Radiation Therapy, Spectroscopic Magnetic Resonance Imaging, sMRI, MRSI, Magnetic Resonance Spectroscopic Imaging, Temozolomide, Methazolastone, Temcad, Temodal, Temodar, Temomedac, TMZ
Emory University, Johns Hopkins University, University of Miami, National Cancer Institute (NCI), National Institutes of Health (NIH)
Glioblastoma, Gliosarcoma
01/25
01/25
NCT03746080: Whole Brain Radiation Therapy With Standard Temozolomide Chemo-Radiotherapy and Plerixafor in Treating Patients With Glioblastoma

Active, not recruiting
2
21
US
Plerixafor, AMD 3100, JM-3100, Mozobil, SDZ SID 791, Temozolomide, CCRG-81045, Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, M & B 39831, M and B 39831, Methazolastone, RP-46161, SCH 52365, Temcad, Temodal, Temodar, Temomedac, Whole-Brain Radiotherapy (WBRT), WBRT, whole-brain radiation therapy, whole-brain radiotherapy, Radiation Therapy, XRT, RT
Lawrence D Recht, Sanofi
Glioblastoma, Glioblastoma With Primitive Neuronal Component, Gliosarcoma, Malignant Glioma, Oligodendroglial Component Present
05/22
07/27
NCT01149850: Bevacizumab and Temozolomide in Treating Older Patients With Newly-Diagnosed Glioblastoma Multiforme or Gliosarcoma

Completed
2
50
US
bevacizumab, anti-VEGF humanized monoclonal antibody, anti-VEGF monoclonal antibody, anti-VEGF rhuMAb, Avastin, recombinant humanized anti-VEGF monoclonal antibody, rhuMAb VEGF, temozolomide, CCRG-81045, M & B 39831, SCH 52365, Temodal, Temodar, TMZ, laboratory biomarker analysis, immunohistochemistry staining method, immunohistochemistry, microarray analysis, gene expression profiling, DNA methylation analysis
Jonsson Comprehensive Cancer Center, Genentech, Inc.
Giant Cell Glioblastoma, Glioblastoma, Gliosarcoma
12/23
12/23
NRG-BN001, NCT02179086: Dose-Escalated Photon IMRT or Proton Beam Radiation Therapy Versus Standard-Dose Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma

Active, not recruiting
2
624
Canada, US
3-dimensional conformal radiation therapy, 3D conformal radiation therapy, 3D-CRT, intensity-modulated radiation therapy, IMRT, photon beam radiation therapy, proton beam radiation therapy, temozolomide, SCH 52365, Temodal, Temodar, TMZ, laboratory biomarker analysis
NRG Oncology, National Cancer Institute (NCI), Radiation Therapy Oncology Group
Adult Giant Cell Glioblastoma, Adult Glioblastoma, Adult Gliosarcoma
05/24
05/26
NCT03556384: Temozolomide (TMZ) In Advanced Succinate Dehydrogenase (SDH)-Mutant/Deficient Gastrointestinal Stromal Tumor (GIST)

Active, not recruiting
2
23
US
Temozolomide, TEMODAR®
Adam Burgoyne, MD, PhD
Gastrointestinal Stromal Tumors, Sdh, GIST, Cancer
06/24
06/25
hSTAR GBM, NCT05052957: (Hematopoetic Stem Cell (HPC) Rescue for GBM)

Recruiting
2
16
US
P140K-MGMT, O6-benzylguanine, BG, Photon Based Radiotherapy, temozolomide, TMZ, Filgrastim, G-CSF,Granulocyte-Colony Stimulating Factor, carmustine, BCNU,bis-chloronitrosourea
Leland Metheny, National Cancer Institute (NCI)
Glioblastoma Multiforme, Glioblastoma Multiforme, Adult, Supratentorial Glioblastoma, Supratentorial Gliosarcoma
06/24
12/24
NCT03197506: Pembrolizumab and Standard Therapy in Treating Patients With Glioblastoma

Suspended
2
52
US
External Beam Radiation Therapy, Definitive Radiation Therapy, EBRT, External Beam Radiation, External Beam Radiotherapy, External Beam RT, external radiation, External Radiation Therapy, external-beam radiation, Radiation, External Beam, Teleradiotherapy, Teletherapy, Teletherapy Radiation, Laboratory Biomarker Analysis, Pembrolizumab, Keytruda, Lambrolizumab, MK-3475, SCH 900475, Radiation Therapy, Cancer Radiotherapy, ENERGY_TYPE, Irradiate, Irradiated, Irradiation, Radiation, Radiation Therapy, NOS, Radiotherapeutics, Radiotherapy, RT, Therapy, Radiation, Temozolomide, CCRG-81045, Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, M & B 39831, M and B 39831, Methazolastone, RP-46161, SCH 52365, Temcad, Temodal, Temodar, Temomedac, TMZ, Therapeutic Conventional Surgery
Mayo Clinic, National Cancer Institute (NCI)
Glioblastoma, Gliosarcoma, Supratentorial Glioblastoma
08/24
08/24
NCT04817254: Association of Peripheral Blood Immunologic Response to Therapeutic Response to Adjuvant Treatment With Immune Checkpoint Inhibition (ICI) in Patients With Newly Diagnosed Glioblastoma or Gliosarcoma

Recruiting
2
73
US
TMZ, ipilimumab 3mg/kg, Nivolumab, ipilimumab 1mg/kg
National Cancer Institute (NCI)
Glioblastoma, Gliosarcoma, Malignant Glioma
11/25
12/26
NCT05457829: Doxorubicin Hydrochloride Liposome Combined With Irinotecan Versus VIT Regimen in the Treatment of Pediatric Rhabdomyosarcoma

Not yet recruiting
2
88
NA
Doxorubicin Hydrochloride Liposome+Irinotecan, Temozolomide+Irinotecan+Vincristine
Sun Yat-sen University, CSPC Ouyi Pharmaceutical Co., Ltd.
Rhabdomyosarcoma, Child
06/26
07/26
GIST, NCT05661643: The Efficacy and Safety of Temozolomide in SDH-deficient

Recruiting
2
29
RoW
Temozolomide capsule
Asan Medical Center
Gastrointestinal Stromal Tumors
12/26
12/27
NCT05440786 / 2021-004734-11: CAMPFIRE: A Study of Abemaciclib (LY2835219) in Participants With Ewing's Sarcoma

Recruiting
2
45
Europe, Japan, US, RoW
Abemaciclib, LY2835219, Irinotecan, Temozolomide
Eli Lilly and Company
Sarcoma, Ewing, Neoplasm Metastasis
02/27
09/28
NCT01864109: Irinotecan and Temozolomide in Combination With Existing High Dose Alkylator Based Chemotherapy for Treatment of Patients With Newly Diagnosed Ewing Sarcoma

Active, not recruiting
2
83
US
Cyclophosphamide, Doxorubicin, Vincristine, Ifosfamide, Etoposide, Surgery, Radiation Therapy*, Temozolomide, Irinotecan, Mesna, Dexrazoxane, G-CSF
Memorial Sloan Kettering Cancer Center
Newly Diagnosed Ewing Sarcoma
 
 
NCT00005952: Temozolomide Plus Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Malignant Glioma or Recurrent CNS or Other Solid Tumors

Completed
1/2
30
US
filgrastim, temozolomide, peripheral blood stem cell transplantation
Duke University, National Cancer Institute (NCI)
Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor, Head and Neck Cancer, Kidney Cancer, Neuroblastoma, Ovarian Cancer, Sarcoma, Testicular Germ Cell Tumor
11/05
11/05
NCT00492141: Aerosol L9-NC and Temozolomide in Ewing's Sarcoma

Completed
1/2
10
US
Temozolomide, Temodar, L9-NC, 9-Nitro-20(S)-Camptothecin, Aerosol L9-NC
M.D. Anderson Cancer Center
Ewing's Sarcoma
05/07
09/09
NCT00541840 / 2007-002176-34: Phase I-II Trial of Sorafenib in Combination With Ifosfamide in Soft Tissue Sarcoma

Unknown status
1/2
24
Europe
Sorafenib, BAY 43-9006
Grupo Espanol de Investigacion en Sarcomas
Soft Tissue Sarcoma
04/09
04/10
NCT00402116: Phase 1/2 Study of Enzastaurin in Newly Diagnosed Glioblastoma Multiforme (GBM) and Gliosarcoma (GS) Patients

Completed
1/2
72
US
enzastaurin, LY317615, temozolomide, radiation therapy
Eli Lilly and Company, University of California, San Francisco
Glioblastoma, Glioblastoma Multiforme, Gliosarcoma
12/09
12/09
NCT00305864: Motexafin Gadolinium, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme or Gliosarcoma

Completed
1/2
118
US
3-Dimensional Conformal Radiation Therapy, 3-dimensional radiation therapy, 3D CONFORMAL RADIATION THERAPY, 3D CRT, 3D-CRT, Conformal Therapy, Radiation Conformal Therapy, Motexafin Gadolinium, API-GP3, gadolinium texaphyrin, Gd (III) Texaphryin, Gd-Tex, PCI-0120, Xcytrin, Temozolomide, CCRG-81045, Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, M & B 39831, M and B 39831, Methazolastone, RP-46161, SCH 52365, Temcad, Temodal, Temodar, Temomedac
National Cancer Institute (NCI), Radiation Therapy Oncology Group
Adult Giant Cell Glioblastoma, Adult Glioblastoma, Adult Gliosarcoma
02/11
03/11
NCT00734526: Phase I Portion of Phase I/II Sorafenib With Radiation and Temozolomide in Newly Diagnosed Glioblastoma or Gliosarcoma

Terminated
1/2
18
US
Temozolomide, Radiation, Radiotherapy, XRT, Sorafenib, BAY43-9006
M.D. Anderson Cancer Center, Bayer
Glioblastoma, Gliosarcoma
12/12
12/12
Zactima, NCT00441142: With Temodar During Radiation Treatment for Newly Diagnosed Stage IV Brain Tumors

Checkmark P1/2 data
May 2011 - May 2011: P1/2 data
Completed
1/2
119
US
ZD6474, Vandetanib, Zactima, temozolomide, Temodar, Radiation Therapy, RT, XRT
Patrick Y. Wen, MD, Dana-Farber Cancer Institute, Beth Israel Deaconess Medical Center, Massachusetts General Hospital, University of Virginia, Memorial Sloan Kettering Cancer Center, Henry Ford Hospital
Glioblastoma Multiforme, Gliosarcoma
08/13
10/17
NCT00731731: Vorinostat, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

Completed
1/2
125
US
3-Dimensional Conformal Radiation Therapy, 3-dimensional radiation therapy, 3D Conformal, 3D CONFORMAL RADIATION THERAPY, 3D CRT, 3D-CRT, Conformal Therapy, Radiation Conformal Therapy, Radiation, 3D Conformal, Cognitive Assessment, Laboratory Biomarker Analysis, Temozolomide, CCRG-81045, Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, M & B 39831, M and B 39831, Methazolastone, RP-46161, SCH 52365, Temcad, Temodal, Temodar, Temomedac, TMZ, Vorinostat, L-001079038, MSK-390, SAHA, Suberanilohydroxamic Acid, Suberoylanilide Hydroxamic Acid, Zolinza
National Cancer Institute (NCI)
Adult Giant Cell Glioblastoma, Adult Glioblastoma, Adult Gliosarcoma
02/14
11/19
NCT00662506: Cediranib, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma

Completed
1/2
46
US
Cediranib Maleate, AZD2171, AZD2171 Maleate, Recentin, Diffusion Tensor Imaging, DTI, Diffusion Weighted Imaging, Diffusion Weighted MRI, Diffusion-Weighted Magnetic Resonance Imaging, Diffusion-Weighted MR Imaging, Diffusion-Weighted MRI, DWI, DWI MRI, DWI-MRI, MR Diffusion-Weighted Imaging, Dynamic Contrast-Enhanced Magnetic Resonance Imaging, DCE MRI, DCE-MRI, DYNAMIC CONTRAST ENHANCED MRI, Fludeoxyglucose F-18, 18FDG, FDG, fludeoxyglucose F 18, Fludeoxyglucose F18, Fluorine-18 2-Fluoro-2-deoxy-D-Glucose, Fluorodeoxyglucose F18, Intensity-Modulated Radiation Therapy, IMRT, Intensity Modulated RT, Intensity-Modulated Radiotherapy, Laboratory Biomarker Analysis, Perfusion Magnetic Resonance Imaging, magnetic resonance perfusion imaging, Positron Emission Tomography, Medical Imaging, Positron Emission Tomography, PET, PET SCAN, Positron Emission Tomography Scan, Positron-Emission Tomography, proton magnetic resonance spectroscopic imaging, Temozolomide, CCRG-81045, Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, M & B 39831, M and B 39831, Methazolastone, RP-46161, SCH 52365, Temcad, Temodal, Temodar, Temomedac
National Cancer Institute (NCI)
Adult Giant Cell Glioblastoma, Adult Glioblastoma, Adult Gliosarcoma
04/14
04/14
NCT01977677: Plerixafor After Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed High Grade Glioma

Completed
1/2
30
US
radiation therapy, irradiation, radiotherapy, therapy, radiation, temozolomide, SCH 52365, Temodal, Temodar, TMZ, plerixafor, AMD 3100, Mozobil, laboratory biomarker analysis, pharmacological study, pharmacological studies
Lawrence Recht, National Cancer Institute (NCI)
Adult Ependymoblastoma, Adult Giant Cell Glioblastoma, Adult Glioblastoma, Adult Gliosarcoma, Adult Medulloblastoma, Adult Mixed Glioma, Adult Oligodendroglial Tumors, Adult Pineoblastoma, Adult Supratentorial Primitive Neuroectodermal Tumor (PNET)
11/17
09/18
NCT01514201: Veliparib, Radiation Therapy, and Temozolomide in Treating Younger Patients With Newly Diagnosed Diffuse Pontine Gliomas

Checkmark ASCO 2015
May 2015 - May 2015: ASCO 2015
Completed
1/2
66
US
3-Dimensional Conformal Radiation Therapy, 3-dimensional radiation therapy, 3D CONFORMAL RADIATION THERAPY, 3D CRT, 3D-CRT, Conformal Therapy, Radiation Conformal Therapy, Intensity-Modulated Radiation Therapy, IMRT, Intensity Modulated RT, Intensity-Modulated Radiotherapy, Laboratory Biomarker Analysis, Pharmacological Study, Temozolomide, CCRG-81045, Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, M & B 39831, M and B 39831, Methazolastone, RP-46161, SCH 52365, Temcad, Temodal, Temodar, Temomedac, Veliparib, ABT-888, PARP-1 inhibitor ABT-888
National Cancer Institute (NCI)
Anaplastic Astrocytoma, Brain Stem Glioma, Childhood Mixed Glioma, Fibrillary Astrocytoma, Giant Cell Glioblastoma, Glioblastoma, Gliosarcoma, Untreated Childhood Anaplastic Astrocytoma, Untreated Childhood Brain Stem Glioma, Untreated Childhood Fibrillary Astrocytoma, Untreated Childhood Giant Cell Glioblastoma, Untreated Childhood Glioblastoma, Untreated Childhood Gliosarcoma
03/18
03/18
NCT02052648: Study of IDO Inhibitor and Temozolomide for Adult Patients With Primary Malignant Brain Tumors

Hourglass Jan 2019 - Jun 2019 : Updated data from P1b trial for recurrent pediatric brain tumors
Checkmark In combination with temozolomide for malignant brain tumors at SNO 2015
Nov 2015 - Nov 2015: In combination with temozolomide for malignant brain tumors at SNO 2015
Checkmark Top-line data from P1b portion of P1b/2 trial in temozolomide-refractory primary malignant brain tumors at ASCO 2015
May 2015 - Jun 2015: Top-line data from P1b portion of P1b/2 trial in temozolomide-refractory primary malignant brain tumors at ASCO 2015
More
Completed
1/2
160
US
Indoximod, 1-methyl-D-tryptophan, D-1MT, Temozolomide, Temodar, Methazolastone, Bevacizumab, Avastin, Stereotactic Radiation, SRS or SRT
NewLink Genetics Corporation
Glioblastoma Multiforme, Glioma, Gliosarcoma, Malignant Brain Tumor
04/18
06/19
NCI-2013-00701, NCT00669669: O6-Benzylguanine-Mediated Tumor Sensitization With Chemoprotected Autologous Stem Cell in Treating Patients With Malignant Gliomas

Terminated
1/2
12
US
3-Dimensional Conformal Radiation Therapy, 3-dimensional radiation therapy, 3D CONFORMAL RADIATION THERAPY, 3D CRT, 3D-CRT, Conformal Therapy, Radiation Conformal Therapy, Autologous Hematopoietic Stem Cell Transplantation, Autologous Stem Cell Transplantation, Carmustine, BCNU, Becenum, Becenun, BiCNU, Bis(chloroethyl) Nitrosourea, Bis-Chloronitrosourea, Carmubris, Carmustin, Carmustinum, FDA 0345, Gliadel, N,N'-Bis(2-chloroethyl)-N-nitrosourea, Nitrourean, Nitrumon, SK 27702, SRI 1720, WR-139021, Filgrastim, Filgrastim XM02, G-CSF, Neupogen, r-metHuG-CSF, Recombinant Methionyl Human Granulocyte Colony Stimulating Factor, rG-CSF, Tbo-filgrastim, Tevagrastim, In Vitro-Treated Peripheral Blood Stem Cell Transplantation, in vitro-treated PBPC transplantation, in vitro-treated peripheral blood progenitor cell transplantation, Intensity-Modulated Radiation Therapy, IMRT, Intensity Modulated RT, Intensity-Modulated Radiotherapy, Laboratory Biomarker Analysis, O6-Benzylguanine, 6-O-BENZYLGUANINE, O(6)-Benzylguanine, Plerixafor, AMD 3100, JM-3100, Mozobil, SDZ SID 791, Proton Beam Radiation Therapy, Temozolomide, CCRG-81045, Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, M & B 39831, M and B 39831, Methazolastone, RP-46161, SCH 52365, Temcad, Temodal, Temodar, Temomedac
Fred Hutchinson Cancer Center
Glioblastoma, Gliosarcoma
07/18
01/21
NCT02116777: Talazoparib and Temozolomide in Treating Younger Patients With Refractory or Recurrent Malignancies

Completed
1/2
40
US
Laboratory Biomarker Analysis, Pharmacological Study, Talazoparib, BMN 673, BMN-673, Temozolomide, CCRG-81045, Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, M & B 39831, M and B 39831, Methazolastone, RP-46161, SCH 52365, Temcad, Temodal, Temodar, Temomedac, TMZ
National Cancer Institute (NCI)
Adult Solid Neoplasm, Childhood Solid Neoplasm, Recurrent Childhood Central Nervous System Neoplasm, Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor, Recurrent Malignant Solid Neoplasm, Refractory Central Nervous System Neoplasm
12/18
12/18
NCT02661282: Autologous CMV-Specific Cytotoxic T Cells and Temozolomide in Treating Patients With Glioblastoma

Completed
1/2
65
US
Autologous Cytomegalovirus-specific Cytotoxic T-lymphocytes, Autologous CMV-specific CTLs, Laboratory Biomarker Analysis, Temozolomide, CCRG-81045, Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, M & B 39831, M and B 39831, Methazolastone, RP-46161, SCH 52365, Temcad, Temodal, Temodar, Temomedac, TMZ, Therapeutic Conventional Surgery
M.D. Anderson Cancer Center, National Cancer Institute (NCI)
Cytomegalovirus Positive, Glioblastoma, Gliosarcoma, Malignant Glioma, Recurrent Brain Neoplasm, Recurrent Glioblastoma
02/22
02/22
2021-005617-14: Study to assess safety and identify dose of ribociclib in combination of temozolomide and topotecan (TOTEM) in patients (12 months – 21 years old) with relapsed or refractory solid tumors (Phase I), and further assess efficacy and safety in patients (12 months – 21 years old) with relapsed or refractory neuroblastoma (Phase II) Estudio para evaluar la seguridad e identificar la dosis de ribociclib en combinación con temozolomida y topotecán (TOTEM) en pacientes (12 meses - 21 años) con tumores sólidos recidivantes o refractarios (Fase I) y evaluar la eficacia y seguridad en pacientes (12 meses - 21 años) con neuroblastoma recidivante o refractario (Fase II)

Ongoing
1/2
230
Europe, RoW
ribociclib, temozolomida 5 mg cápsulas duras, topotecan, temozolomida 20 mg cápsulas duras, temozolomida 100 mg cápsulas duras, temozolomida 140 mg cápsulas duras, temozolomida 180 mg cápsulas duras, temozolomida 250 mg cápsulas duras, LEE011, Powder for oral solution, Capsule, hard, Concentrate for solution for infusion, Temozolomid SUN & Temozolomid Accord, Potactasol & Hycamtin
Novartis Farmacéutica, S.A., Novartis Pharma AG, Novartis Pharma AG
relapsed or refractory neuroblastoma and other solid tumors (including medulloblastoma, high grade glioma, malignant rhabdoid tumors, and rhabdomyosarcoma) in patients from 12 months to 21 years old neuroblastoma recidivante o refractario y otros tumores sólidos (incluyendo meduloblastoma, glioma de alto grado, tumores rabdoides malignos y rabdomiosarcoma) en pacientes con edades comprendidas entre los 12 meses y los 21 años, Recurrent solid tumors in patients from 12 months to 21 years old Tumores sólidos recurrentes en pacientes con edades comprendidas entre los 12 meses y los 21 años, Diseases [C] - Cancer [C04]
 
 
NCT01837862: A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas

Recruiting
1/2
36
US
Mebendazole, Vermox, Vincristine, Oncovin, Carboplatin, Paraplatin, Temozolomide, Temodar, Bevacizumab, Avastin, Irinotecan, CPT-11, Camptosar
Julie Krystal, Janssen Pharmaceuticals
Pilomyxoid Astrocytoma, Pilocytic Astrocytoma, Glioma, Astrocytic, Optic Nerve Glioma, Pleomorphic Xanthoastrocytoma, Glioblastoma Multiforme, Anaplastic Astrocytoma, Gliosarcoma, Diffuse Intrinsic Pontine Glioma, DIPG, Low-grade Glioma, Brainstem Glioma
04/24
04/25
NCT03709680 / 2021-003444-25: Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors

Active, not recruiting
1/2
128
Europe, Canada, US, RoW
Palbociclib, Ibrance, Temozolomide, Temodar, Irinotecan, Campto, Topotecan, Hycamtin, Cyclophosphamide, Cytoxan
Pfizer, Children's Oncology Group (COG)
Ewing Sarcoma, Solid Tumors, Rhabdoid Tumor, Rhabdomyosarcoma, Neuroblastoma, Medulloblastoma, Diffuse Intrinsic Pontine Glioma
08/24
02/25
NCT04095221: A Study of the Drugs Prexasertib, Irinotecan, and Temozolomide in People With Desmoplastic Small Round Cell Tumor and Rhabdomyosarcoma

Active, not recruiting
1/2
21
US
Prexasertib, Irinotecan
Memorial Sloan Kettering Cancer Center
Desmoplastic Small Round Cell Tumor, Rhabdomyosarcoma
09/24
09/24
ChiCTR2200062822: An open, single-arm, single center phase I/II clinical study of fluzoparib combined with temozolomide in the treatment of patients with advanced soft tissue sarcoma

Not yet recruiting
1/2
41
 
Fluzoparib combined with temozolomide
Department of Orthopaedic Oncology, First Affiliated Hospital of Sun Yat-sen University; The First Affiliated Hospital of Sun Yat-sen University, Self-funded
Advanced soft tissue sarcoma
 
 
NCT04796012: VITAS: Atezolizumab in Combination With Chemotherapy for Pediatric Relapsed/Refractory Solid Tumors

Recruiting
1/2
23
US
Atezolizumab, Tecentriq, Vincristine, Vincristine Sulfate Injection, Oncovin, Vincasar PES, Vincrex, Irinotecan, Irinotecan Hydrochloride Injection, Campto, Temozolomide, Temozolomide Capsules, Temodar
University of Texas Southwestern Medical Center
Solid Tumor, Rhabdomyosarcoma
01/25
01/25
NCT03174197: Atezolizumab in Combination With Temozolomide and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma

Active, not recruiting
1/2
80
US
Atezolizumab, MPDL 3280A, MPDL 328OA, MPDL-3280A, MPDL3280A, MPDL328OA, RG7446, RO5541267, Tecentriq, Radiation Therapy, Cancer Radiotherapy, Irradiate, Irradiated, irradiation, Radiation, Radiotherapeutics, RADIOTHERAPY, RT, Therapy, Radiation, Temozolomide, CCRG-81045, Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, M & B 39831, M and B 39831, Methazolastone, RP-46161, SCH 52365, Temcad, Temodal, Temodar, Temomedac
M.D. Anderson Cancer Center, National Cancer Institute (NCI)
Glioblastoma, Gliosarcoma
06/25
06/25
NCT04901702 / 2021-003570-31: Study of Onivyde With Talazoparib or Temozolomide in Children With Recurrent Solid Tumors and Ewing Sarcoma

Active, not recruiting
1/2
46
Canada, US
Onivyde, Nanoliposomal irinotecan, Talazoparib, BMN 673, Talzenna, Temozolomide, Temodar, Temodal
St. Jude Children's Research Hospital, Pfizer, Ipsen
Recurrent Solid Tumor, Recurrent Ewing Sarcoma, Recurrent Hepatoblastoma, Recurrent Malignant Germ Cell Tumor, Recurrent Malignant Solid Neoplasm, Recurrent Neuroblastoma, Recurrent Osteosarcoma, Recurrent Peripheral Primitive Neuroectodermal Tumor, Recurrent Rhabdoid Tumor, Recurrent Rhabdomyosarcoma, Recurrent Soft Tissue Sarcoma, Recurrent Wilms Tumor, Refractory Ewing Sarcoma, Refractory Hepatoblastoma, Refractory Malignant Germ Cell Tumor, Refractory Malignant Solid Neoplasm, Refractory Neuroblastoma, Refractory Osteosarcoma, Refractory Peripheral Primitive Neuroectodermal Tumor, Refractory Rhabdoid Tumor, Refractory Rhabdomyosarcoma, Refractory Soft Tissue Sarcoma
12/25
12/25
NCT04890093: Vincristine and Temozolomide in Combination With PEN-866 for Adolescents and Young Adults With Relapsed or Refractory Solid Tumors

Not yet recruiting
1/2
64
US
PEN-866, Vincristine, Temozolomide
National Cancer Institute (NCI)
Sarcoma, Ewing, Rhabdomyosarcoma
02/26
12/26
NCT06006273: A Phase Ib Trial of Eribulin in Combination With Irinotecan and Temozolamide in Children With Relapsed or Refractory Solid Tumors

Recruiting
1/2
48
US
Eribulin, Irinotecan, Temozolomide
M.D. Anderson Cancer Center
Refractory Solid Tumors
12/26
12/28
FaR-RMS, NCT04625907 / 2018-000515-24: An Overarching Study for Children and Adults With Frontline and Relapsed RhabdoMyoSarcoma

Recruiting
1/2
1672
Europe, RoW
Irinotecan, Actinomycin D, Dactinomycin, Doxorubicin, Ifosfamide, Vincristine, Vinorelbine, Cyclophosphamide, Temozolomide, radiotherapy, Regorafenib
University of Birmingham
Rhabdomyosarcoma
06/30
06/30
NCT06023641: Treatment of Newly Diagnosed Rhabdomyosarcoma Using Molecular Risk Stratification and Liposomal Irinotecan Based Therapy in Children With Intermediate and High Risk Disease

Recruiting
1/2
100
US
Vincristine, Oncovin, Dactinomycin, (actinomycin-D), Cyclophosphamide, Cytoxan®., Surgical Resection, Proton beam radiation or external beam radiation or brachytherapy, Liposomal irinotecan, (Onivyde®), Vinorelbine, Navelbine, Temozolomide, Temodar, Filgrastim, peg-filgrastim, Neupogen
St. Jude Children's Research Hospital
Rhabdomyosarcoma
10/34
10/37

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