| Actemra IV (tocilizumab) / Roche, JW Pharma |
| Completed | 4 | 32 | Europe | tocilizumab [RoActemra/Actemra] | Hoffmann-La Roche | Rheumatoid Arthritis | 05/10 | 05/10 | | |
NCT02010216: A Study of RoActemra/Actemra (Tocilizumab) in Adult Patients With Rheumatoid Arthritis (SVOBODA Programme) |
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| Completed | 4 | 23 | RoW | tocilizumab [RoActemra/Actemra], RoActemra/Actemra | Hoffmann-La Roche | Rheumatoid Arthritis | 07/10 | 07/10 | | |
NCT00996203: A Study of Tocilizumab Added to DMARDs in Patients With Moderate to Severe Rheumatoid Arthritis and an Inadequate Response to DMARDs. |
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| Completed | 4 | 201 | RoW | tocilizumab [RoActemra/Actemra], DMARDs (disease-modifying antirheumatic drugs) | Hoffmann-La Roche | Rheumatoid Arthritis | 02/11 | 02/11 | | |
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NCT01034397 / 2009-012218-30: A Study of Tocilizumab Plus Non-biological DMARD in Patients With Moderate to Severe Rheumatoid Arthritis and an Inadequate Response to Non-biological DMARDs |
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| Completed | 4 | 54 | Europe | tocilizumab [RoActemra/Actemra], placebo, non-biological DMARDs | Hoffmann-La Roche | Rheumatoid Arthritis | 09/11 | 09/11 | | |
NCT01089023: A Study of Tocilizumab as Monotherapy or in Combination With DMARDs in Patients With Moderate to Severe Active Rheumatoid Arthritis |
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| Completed | 4 | 95 | RoW | tocilizumab [RoActemra/Actemra] | Hoffmann-La Roche | Rheumatoid Arthritis | 12/11 | 12/11 | | |
NCT01163747: A Study of the Effects of RoActemra/Actemra on Vaccination in Patients With Rheumatoid Arthritis on Background Methotrexate (VISARA) |
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| Completed | 4 | 91 | US | tocilizumab, RoActemra, Actemra, methotrexate, 23-Valent Pneumococcal Polysaccharide Vaccine, Pneumovax, Tetanus Toxoid Adsorbed Vaccine | Genentech, Inc. | Rheumatoid Arthritis | 12/11 | 06/12 | | |
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| Completed | 4 | 326 | US, Europe, RoW | Tocilizumab, RoActemra, Actemra, Adalimumab, Placebo to tocilizumab, Placebo to adalimumab | Hoffmann-La Roche | Rheumatoid Arthritis | 01/12 | 01/12 | | |
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NCT01195272 / 2010-018331-18: A Study of the Effects of RoActemra/Actemra (Tocilizumab) on Neutrophils in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to Biologic and/or Non-biologic DMARDs. |
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| Completed | 4 | 21 | Europe | tocilizumab [RoActemra/Actemra] | Hoffmann-La Roche | Rheumatoid Arthritis | 03/12 | 03/12 | | |
NCT01283971 / 2010-023587-40: A Study of RoActemra/Actemra (Tocilizumab) Versus Adalimumab in Combination With Methotrexate (MTX) in Patients With Moderate to Severe Active Rheumatoid Arthritis And an Inadequate Response to Treatment With Only One Tumor Necrosis Factor (TNF)-Inhibitor |
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| Terminated | 4 | 96 | US, Europe, RoW | tocilizumab [RoActemra/Actemra], RoActemra/Actemra, adalimumab, placebo to tocilizumab, placebo to adalimumab, methotrexate, folate | Hoffmann-La Roche | Rheumatoid Arthritis | 08/12 | 08/12 | | |
NCT01251120 / 2010-019935-37: A Study of RoActemra/Actemra (Tocilizumab) in Combination With DMARDs Versus Current Best Practice DMARD Therapy in Patients With Rheumatoid Arthritis |
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| Terminated | 4 | 2 | Europe | tocilizumab [RoActemra/Actemra], DMARD | Hoffmann-La Roche | Rheumatoid Arthritis | 01/13 | 01/13 | | |
NCT01219933 / 2010-019694-15: A Study of Glucocorticoid Use to Evaluate Systematic Methylprednisolone Reduction in Patients With Rheumatoid Arthritis on Background RoActemra/Actemra (Tocilizumab) (ACT-ALONE) |
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| Completed | 4 | 68 | Europe | methylprednisolone, tocilizumab [RoActemra/Actemra] | Hoffmann-La Roche | Rheumatoid Arthritis | 03/13 | 03/13 | | |
NCT01399697 / 2011-001626-15: A Study of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate Versus RoActemra/Actemra Monotherapy in Patients With Rheumatoid Arthritis and an Inadequate Response to Methotrexate |
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| Completed | 4 | 261 | Europe | methotrexate, placebo, tocilizumab [RoActemra/Actemra] | Hoffmann-La Roche | Rheumatoid Arthritis | 05/14 | 05/14 | | |
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NCT01149057: A Study of RoActemra/Actemra (Tocilizumab) in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to Current Non-Biologic and/or Biologic DMARDS |
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| Completed | 4 | 145 | RoW | tocilizumab [RoActemra/Actemra] | Hoffmann-La Roche, Clalit Health Services | Rheumatoid Arthritis | 07/14 | 07/14 | | |
SURPRISE, NCT01120366: Success of Tocilizumab in RA Patients With Remission Induction and Sustained Efficacy After Discontinuation |
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| Completed | 4 | 233 | Japan | Tocilizumab plus methotrexate, Actemra, Methotrexate, Tocilizumab | SURPRISE Study Group | Rheumatoid Arthritis | 12/14 | 12/14 | | |
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NCT01661140 / 2011-005260-20: A Study of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate in Patients With Severe Active Rheumatoid Arthritis, Comparing Tapering Versus Maintaining the Methotrexate Dosage |
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| Terminated | 4 | 427 | Europe | Methotrexate (stable dose), Tocilizumab, RoActemra/Actemra, Methotrexate (tapering dose) | Hoffmann-La Roche | Rheumatoid Arthritis | 02/15 | 02/15 | | |
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NCT01878318: A Study of The Effect of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate on Articular Damage in The Hand in Patients With Moderate to Severe Rheumatoid Arthritis Who Have an Inadequate Response to Non-Biological DMARDs |
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| Withdrawn | 4 | 0 | RoW | methotrexate, tocilizumab [RoActemra/Actemra] | Hoffmann-La Roche | Rheumatoid Arthritis | 06/15 | 06/15 | | |
NCT01331837 / 2010-020065-24: A Study of Tocilizumab in Comparison to Etanercept in Participants With Rheumatoid Arthritis and Cardiovascular Disease Risk Factors |
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| Completed | 4 | 3080 | Europe, Canada, US, RoW | Etanercept, Tocilizumab, Actemra | Hoffmann-La Roche | Rheumatoid Arthritis | 03/16 | 03/16 | | |
RITACT, NCT01715831: A Long-term Safety Extension Study of Tocilizumab in Brazilian Participants With Rheumatoid Arthritis (RA) Who Completed the Studies ML21530 and MA21488 |
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| Completed | 4 | 26 | RoW | DMARDs, Tocilizumab, RoActemra; Actemra | Hoffmann-La Roche | Arthritis, Rheumatoid | 06/16 | 06/16 | | |
ADIPRAT, NCT02843789: Evolution of Adipokines and Body Composition in Rheumatoid Arthritis Patients Receiving Tocilizumab Therapy |
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| Completed | 4 | 109 | Europe | Tocilizumab | Centre Hospitalier Universitaire de Besancon | Arthritis, Rheumatoid | 11/17 | 11/17 | | |
NCT01638715 / 2012-000139-21: A Randomized, Multi-Center Biomarker Trial to Predict Therapeutic Responses of Patients With Rheumatoid Arthritis to a Specific Biologic Mode of Action |
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| Completed | 4 | 115 | Europe, RoW | Remicade, Orencia, Ro-Actemra, Mabthera | Medical University of Vienna | Rheumatoid Arthritis | 08/18 | 08/18 | | |
