| phenytoin / Generic mfg. |
2014-002188-13: Emergency treatment with levetiracetam or phenytoin in status epilepticus in children (EcLiPSE) - a randomsied unblinded controlled trial |
|
|
| Ongoing | 4 | 308 | Europe | Levetiracetam, Phenytoin, Concentrate for solution for infusion, Keppra, Epanutin | University of Liverpool, Alder Hey Children's NHS Foundation Trust, National Institute Health Research Health Technology Assessment (NETSCC), ational Institute Health Research Health Technology Assessment (NETSCC) | Convulsive Status Epilepticus, A convulsive seizure which continues for a prolonged period (longer than five minutes), or when convulsive seizures occur one after the other with no recovery between., Diseases [C] - Nervous System Diseases [C10] | | | | |
2016-003325-41: PREemptive Pharmacogenomic testing for Preventing Adverse drug REactions (PREPARE) |
|
|
| Ongoing | 4 | 450 | Europe | Syrup, Tablet, Capsule, hard, Powder for injection, Capsule, Solution for injection, Concentrate for solution for infusion, Powder for solution for infusion, Codeine, Acenocoumarol, Amitriptyline, Aripiprazole, Atomoxetine, Atorvastatine, Azathioprine, Capecitabine, Carbamazepine, Citalopram, Clomipramine, Clopidogrel, Clozapine, Efavirenz, Escitalopram, Flecainide, Flucloxacillin, Fluorouracil, Haloperidol, Irinotecan, Mercaptopurine, Metoprolol, Oxycodone, Paroxetine, Phenprocoumon, Phenytoin, ORAP 1 mg Tabletten, Propafenone, Sertraline, Simvastatin, Tacrolimus, Tamoxifen, Tegafur, Tioguanine, Tramadol, Venlafaxine, Voriconazole, Zuclopenthixol, Ethinylestradiol, ORAP 4 mg Tabletten | Leiden University Medical Center, Leiden University Medical Center | Adverse drug reactions, Side-effects, Not possible to specify | | | | |
NCT04829838: Comparison of Efficacy of Phenytoin With Levetireacetam for the Management of Children With Status Epilepticus |
|
|
| Recruiting | 4 | 244 | RoW | intravenous levetireacetam | ayesha tariq, King Edward Medical University | Status Epilepticus | 07/21 | 07/21 | | |
NCT05697614: The Benefit and Safety of Older Generation Anti-Epileptic Drugs (AEDs) in Drug-Resistant Epilepsy Children |
|
|
| Recruiting | 4 | 100 | RoW | Valproic acid, sodium divalproex, depaken, Carbamazepin, tegretol, bamgetol, Phenytoin, kutoine, Lamotrigine, lamictal, Clobazam, frisium, Oxcarbazepine, trileptal | Dr Cipto Mangunkusumo General Hospital | Drug Resistant Epilepsy | 05/23 | 06/23 | | |
| Not yet recruiting | 3 | 1649 | NA | Phenytoin Sodium, Levetiracetam, Keppra | Cambridge University Hospitals NHS Foundation Trust, University of Cambridge | Traumatic Brain Injury, Post Traumatic Seizures | 03/26 | 03/28 | | |
| Completed | 2/3 | 81 | Europe | phenytoin cream, Placebo cream | David J. Kopsky, Princess Beatrix Muscle Foundation, Dr. C.J. Vaillant Fonds | Chronic Idiopathic Axonal Polyneuropathy | 06/23 | 06/23 | | |
ACTRN12614000747628: A Within-Subject Randomized Controlled Trial on the Effects of Phenytoin on Social Cognition and Behaviour in Males aged 16 Years and Older with Autism Spectrum Disorders |
|
|
| Recruiting | 2 | 20 | | | University of Sydney, Autres PTYLD | Autism Spectrum Disorder | | | | |
2004-004787-74: A double blind, prospective, randomised, controlled clinical trial to evaluate the effect of topical phenytoin, on healing, in diabetic foot ulcers. |
|
|
| Ongoing | 2 | 144 | Europe | | Royal Group of Hospitals Trust | Diabetes Mellitus and associated diabetic foot ulceration | | | | |
2004-005046-12: A double blind prospective randomised controlled trial to evaluate the effect of topical phenytoin on the healing of venous leg ulcers |
|
|
| Ongoing | 2 | 146 | Europe | PR1, | Ulster Community & Hospitals Trust | Venous Leg Ulceration | | | | |
2016-001611-20: Cause-based treatment of patients with therapy resistant early onset epilepsy |
|
|
| Ongoing | 2 | 25 | Europe | Phenytoin, Vimpat, Suspension for use in drinking water, Syrup, Vimpat Syrup | University of Tübingen, University of Tübingen | patients with epileptic encephalopathies Patienten mit epileptischen Enzephalopathien, patients with early onset diffucult to treat epilepsies Patienten mit früh beginnender schwer zu behandelnden Epilepsien, Diseases [C] - Nervous System Diseases [C10] | | | | |
HopES, NCT03778996: SM-88 Maintenance Therapy for Advanced Ewing's Sarcoma and as Salvage Therapy for Sarcoma |
|
|
| Active, not recruiting | 2 | 31 | US | Combination metyrosine-derivative, low-dose methoxsalen, phenytoin and sirolimus (MPS), SM-88 | Sarcoma Oncology Research Center, LLC, Tyme, Inc | Sarcoma, Ewing, Sarcoma | 12/24 | 03/25 | | |
2020-001340-25: Clinical study with phenytoin cream for the treatment of painful chronic idiopathic axonal polyneuropathy |
|
|
| Not yet recruiting | 2 | 72 | Europe | phenytoin 10% cream, phenytoin 20% cream, Cream | University Medical Center Utrecht, Prinses Beatrix Spier Fonds | Painful chronic idiopathic axonal polyneuropathy, Peripheral nerve pain without known cause, Diseases [C] - Nervous System Diseases [C10] | | | | |
NCT05637086: Clinical Study Evaluating Safety of Pentoxifylline in Patients With Grand-Mal Epilepsy Treated by Phenytoin Monotherapy |
|
|
| Recruiting | 2 | 60 | RoW | Phenytoin, Pentoxifylline 400 MG | Mostafa Bahaa, Sahar El-Haggar, Prof Clinical pharmacy Department- Tanta University, Principal Investigator Maha Ahmed Younis, PhD Pharmacy Practice Department- Horus University, Tarek Mohamed Mostafa, Prof Clinical pharmacy Department- Tanta University | Epilepsy | 12/26 | 11/27 | | |
| Not yet recruiting | 1 | 105 | | | University of Newcastle, John Hunter Hospital | Heart failure with reduced ejection fraction (HFrEF); Arrhythmia; Cardiomyopathy | | | | |
ACTRN12619000730101: Antiarrhythmic effects of phenytoin or dantrolene in patients with cardiomyopathy. |
|
|
| Not yet recruiting | 1 | 105 | | | University of Newcastle, John Hunter Hospital | Heart failure with reduced ejection fraction (HFrEF), Arrhythmia, Cardiomyopathy | | | | |
NCT05901714: A Study to Assess the Effect of Phenytoin on the Drug Levels of Afimetoran and the Effect of Afimetoran on the Drug Levels of Midazolam |
|
|
| Recruiting | 1 | 50 | US | Afimetoran, BMS-986256, Phenytoin, Midazolam | Bristol-Myers Squibb | Healthy Participants | 10/23 | 10/23 | | |
NCT05995249: A Study of the Interaction of TAK-279 With Substances That Have an Impact on Metabolism in Healthy Adults |
|
|
| Completed | 1 | 172 | US | TAK-279, Erythromycin, Phenytoin, Efavirenz | Takeda | Healthy Volunteers | 12/23 | 12/23 | | |
NCT06379958: Drug-Drug Interaction (DDI) Study of Leramistat in Healthy Adult Subjects |
|
|
| Recruiting | 1 | 36 | Europe | leramistat 40mg, Itraconazole 200 mg, Phenytoin 100 Mg Oral Capsule, Simvastatin 40mg | Modern Biosciences Ltd | Pharmacokinetics | 05/24 | 09/24 | | |
NCT06466473: A Study to Learn How Different Forms of The Study Medicine Called Phenytoin Are Taken up Into the Blood in Healthy Adults |
|
|
| Not yet recruiting | 1 | 34 | NA | Phenytoin (Ascoli), Phenytoin (Vega Baja) | Pfizer | Healthy | 11/24 | 11/24 | | |
NCT06067412: Efficacy of Phenytoin vs Levetiracetam in Status Epilepticus at Institute of Child Health,Faisalabad |
|
|
| Completed | N/A | 70 | RoW | Levetiracetam, Phenytoin | Shaheed Zulfiqar Ali Bhutto Medical University | Status Epilepticus | 01/23 | 01/23 | | |
NCT05542589: Efficacy of Phenytoin Phonophoresis on Pressure Ulcer Healing |
|
|
| Completed | N/A | 40 | RoW | Phenytoin phonophoresis, Sham phenytoin phonophoresis | Cairo University | Pressure Ulcer | 02/23 | 02/23 | | |
| Recruiting | N/A | 80 | Europe | Ketamine, Perampanel, Any anti-epileptic and anesthetic therapy, excluding Ketamine and Perampanel, Levetiracetam, Valproate, Phenytoin, Lacosamide, Topiramate, Propofol, Midazolam, Thiopental | University of Milano Bicocca, Azienda Ospedaliera San Gerardo di Monza, Azienda Ospedaliero-Universitaria di Modena, Azienda Ospedaliera Universitaria Integrata Verona, Ospedale Centrale Bolzano, Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia, Azienda Ospedaliero-Universitaria Careggi, Azienda Ospedaliero-Universitaria di Parma, Santa Chiara Hospital, Ospedale M. Bufalini Cesena, Azienda Ospedaliera Brotzu, Istituto Di Ricerche Farmacologiche Mario Negri | Status Epilepticus, Cardiac Arrest | 06/24 | 09/24 | | |
NCT06312254: Pharmacological Modulation of Peripheral Nerve Excitability |
|
|
| Not yet recruiting | N/A | 20 | Europe | Topical lidocaine 5%, Topical Phenytoin 10%, Topical Mepyramine 2%, Topical Placebo | Aalborg University | Peripheral Neuropathy | 02/25 | 08/25 | | |
| Recruiting | N/A | 1000 | Europe | Valproic acid, carbamazepine, phenobarbital, phenytoin, levetiracetam, lamotrigine, topiramate, oxcarbazepine, stiripentol, clobazam, brivaracétam, felbamate, lacosamide, rufinamide, gabapentine, pregabaline, sultiame, tiagabine, vigabatrine, mesuximide, primidone, perampanel, ethosuximide, zonisamide, cannabidiol, genetic polymorphisms | Assistance Publique - Hôpitaux de Paris | Epilepsy | 06/26 | 06/26 | | |
| Recruiting | N/A | 10400 | | carbamazepine ;sodium valproate ;lamotrigine ;topiramate ;oxcarbazepine ;levetiracetam ;gabapentin ;phenytoin ;phenobarbital ;clonazepam ;The antiepileptic drug 1 which will obtain marketing authorization in China in the future ;The antiepileptic drug 2 which will obtain marketing authorization in China in the future ;The antiepileptic drug 3 which will obtain marketing authorization in China in the future | The Department of Neurology, the First Affiliated Hospital of Wenzhou Medical University; The First Affiliated Hospital of Wenzhou Medical University, Wenzhou Medical Association | epilepsy | | | | |
ACTRN12607000182493: Comparison of the safety, tolerability, and efficacy, of levetiracetam versus phenytoin when administered intravenously to an inpatient population at risk for seizures. |
|
|
| Not yet recruiting | N/A | 80 | | | Professor Mark Cook, Professor Mark Cook, UCB Pharma | Seizures | | | | |
ACTRN12622000470796:
EFFICACY AND SAFETY OF levetiracetam versus phenytoin for neonatal seizures.A randomized controlled trial. |
|
|
| Not yet recruiting | N/A | 184 | | | DR KHWAJA KAMRAN WAJID, DR KHAWAJA KAMRAN WAJID | neonatal seizures | | | | |
ACTRN12615000129583: Convulsive Status Epilepticus Paediatric Trial (ConSEPT): A PREDICT study comparing levetiracetam versus phenytoin for management of convulsive status epilepticus in children.
|
|
|
| Recruiting | N/A | 200 | | | Starship Children's Hospital, Health Research Council of New Zealand, A+ Charitable Trust
| Paediatric Status Epilepticus | | | | |