| Soliris (eculizumab) / AstraZeneca |
NCT02946463 / 2016-002025-11: ALXN1210 (Ravulizumab) Versus Eculizumab in Complement Inhibitor Treatment-Naïve Adult Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) |
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| Completed | 3 | 272 | Europe, Canada, Japan, US, RoW | Ravulizumab, Eculizumab | Alexion Pharmaceuticals, Inc. | Paroxysmal Nocturnal Hemoglobinuria (PNH) | 02/23 | 02/23 | | |
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NCT03748823 / 2017-002370-39: Ravulizumab Subcutaneous (SC) Versus Ravulizumab Intravenous (IV) in Adults With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Eculizumab |
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| Completed | 3 | 139 | Europe, Canada, US, RoW | Ravulizumab OBDS, Ravulizumab, ALXN1210 | Alexion Pharmaceuticals, Inc. | Paroxysmal Nocturnal Hemoglobinuria | 02/21 | 08/23 | | |
2020-003565-19: Espacement personnalisé des perfusions d’eculizumab basé sur un suivi thérapeutique pharmacologique : évaluation médicoéconomique prospective multicentrique chez les patients en rémission atteints d’un syndrome hémolytique et urémique atypique nécessitant un traitement au long cours. Espacement personnalisé des perfusions d’eculizumab basé sur un suivi thérapeutique pharmacologique : évaluation médicoéconomique prospective multicentrique chez les patients en rémission atteints d’un syndrome hémolytique et urémique atypique nécessitant un traitement au long cours. |
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| Not yet recruiting | 3 | 80 | Europe | SOLIRIS, L04AA25, Solution for injection, SOLIRIS | CHRU DE TOURS, CHRU DE TOURS | Patients en rémission atteints d’un syndrome hémolytique et urémique atypique nécessitant un traitement au long cours par eculizumab Patients en rémission atteints d’un syndrome hémolytique et urémique atypique nécessitant un traitement au long cours par eculizumab, Patients en rémission atteints d’un syndrome hémolytique et urémique atypique nécessitant un traitement au long cours par eculizumab Patients en rémission atteints d’un syndrome hémolytique et urémique atypique nécessitant un traitement au long cours par eculizumab, Not possible to specify | | | | |
NCT03759366 / 2016-001384-37: A Phase 3 Open-Label Study of Eculizumab in Pediatric Participants With Refractory Generalized Myasthenia Gravis (gMG) |
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| Completed | 3 | 11 | Europe, Japan, US | Eculizumab | Alexion Pharmaceuticals, Inc. | Myasthenia Gravis, Myasthenia Gravis, Juvenile Form, Myasthenia Gravis, Generalized | 01/22 | 11/23 | | |
ALPHA, NCT04469465 / 2019-003829-18: Danicopan as Add-on Therapy to a C5 Inhibitor in Paroxysmal Nocturnal Hemoglobinuria (PNH) Participants Who Have Clinically Evident Extravascular Hemolysis (EVH) |
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| Completed | 3 | 86 | Europe, Canada, Japan, US, RoW | Danicopan, ALXN2040, Placebo, C5 Inhibitor | Alexion Pharmaceuticals, Inc. | Paroxysmal Nocturnal Hemoglobinuria | 06/22 | 01/24 | | |
EspacECU, NCT04859608: Personalized Spacing of Eculizumab Infusions Based on Therapeutic Pharmacological Monitoring |
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| Active, not recruiting | 3 | 40 | Europe | Spacing of Eculizumab infusions | University Hospital, Tours, Centre Hospitalier Universitaire, Amiens, University Hospital, Angers, Centre Hospitalier Universitaire de Besancon, University Hospital, Caen, Centre Hospitalier of Chartres, Nantes University Hospital, University of Nancy, Poitiers University Hospital, Rennes University Hospital, University Hospital, Rouen, University Hospital, Strasbourg, France, Centre Hospitalier Universitaire de Nice, Hôpital Necker-Enfants Malades, Tenon Hospital, Paris, University Hospital, Lille, Reims University Hospital, University Hospital, Clermont-Ferrand, Assistance Publique Hopitaux De Marseille, Hospices Civils de Lyon | Hemolytic-Uremic Syndrome, Atypical | 12/23 | 06/24 | | |
| Completed | 3 | 97 | Europe, Japan, US, RoW | LNP023, iptacopan, Eculizumab, Ravulizumab | Novartis Pharmaceuticals | Paroxysmal Nocturnal Hemoglobinuria (PNH) | 09/22 | 03/23 | | |
COMMODORE 2, NCT04434092 / 2019-004931-21: A Phase III Study Evaluating the Efficacy and Safety of Crovalimab Versus Eculizumab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Not Previously Treated With Complement Inhibitors. |
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| Active, not recruiting | 3 | 204 | Europe, Japan, RoW | Crovalimab, Eculizumab | Hoffmann-La Roche, Chugai Pharmaceutical | Paroxysmal Nocturnal Hemoglobinuria | 11/22 | 06/28 | | |
ACCESS 2, NCT05131204 / 2020-002761-33: Efficacy and Safety of the Combination of Pozelimab and Cemdisiran Versus Continued Eculizumab or Ravulizumab Treatment in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria |
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| Terminated | 3 | 2 | US | Cemdisiran, ALN-CC5, Eculizumab, Soliris, Pozelimab, REGN3918, Ravulizumab, ALXN1210, Ultomiris | Regeneron Pharmaceuticals | Paroxysmal Nocturnal Hemoglobinuria | 07/23 | 07/23 | | |
ConfIdeS, NCT04935177: Renal Function in Highly Sensitized Patients 1 Year After Desensitization With Imlifidase Prior to DD Kidney Tx |
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| Recruiting | 3 | 64 | US | Imlifidase, IdeS, HMED-IdeS, PLEX, Plasma exchange, PE, IVIg, Intravenous immunoglobulin, Anti-CD20 antibodies, Rituximab, Eculizumab, Soliris, Remain on wait list | Hansa Biopharma AB | Kidney Transplantation in Highly Sensitized Patients | 06/25 | 06/25 | | |
NCT06449001: Study of Danicopan as Add-on Treatment to Ravulizumab or Eculizumab in Pediatric Participants With PNH Who Have Clinically Significant Extravascular Hemolysis |
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| Not yet recruiting | 3 | 6 | NA | Danicopan | Alexion Pharmaceuticals, Inc. | Paroxysmal Nocturnal Hemoglobinuria, PNH, Extravascular Hemolysis | 01/27 | 01/28 | | |
Soliris, NCT05886244: Eculizumab in Adult Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) in China |
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| Active, not recruiting | 3 | 15 | RoW | Eculizumab | Alexion Pharmaceuticals, Inc., AstraZeneca | Paroxysmal Nocturnal Hemoglobinuria | 06/25 | 06/25 | | |
GEMECULI, NCT05702996: Multicenter, Uncontrolled Pilot Study Evaluating the Efficacy of Eculizumab in the Treatment of Gemcitabine-induced Thrombotic Microangiopathies |
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| Not yet recruiting | 3 | 10 | Europe | Eculizumab administration | University Hospital, Rouen | Thrombotic Microangiopathies | 09/25 | 09/25 | | |
Soliris, NCT05876351: Eculizumab in Pediatric and Adult Participants With Atypical Hemolytic Uremic Syndrome (aHUS) in China |
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| Recruiting | 3 | 25 | RoW | Eculizumab | Alexion Pharmaceuticals, Inc., AstraZeneca | Atypical Hemolytic Uremic | 03/26 | 03/26 | | |
| Recruiting | 3 | 66 | Europe | Soliris®, Eculizumab, Renin angiotensin system blockers | Assistance Publique - Hôpitaux de Paris | Hypertensive Emergency-associated Hemolytic Uremic Syndrome | 05/26 | 11/27 | | |
ACCESS-1, NCT05133531 / 2020-004486-40: A Study to Evaluate How Safe Pozelimab + Cemdisiran Combination Therapy is and How Well it Works in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) Who Have Not Recently Received or Have Not Received Complement Inhibitor Treatment |
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| Recruiting | 3 | 190 | Europe, Canada, Japan, US, RoW | Ravulizumab, ALXN1210, Ultomiris, Pozelimab, REGN3918, Cemdisiran, ALN-CC5, Eculizumab, Soliris | Regeneron Pharmaceuticals | Paroxysmal Nocturnal Hemoglobinuria | 03/27 | 03/27 | | |
COMMODORE 1, NCT04432584 / 2020-000597-26: A Study Evaluating The Safety, Pharmacokinetics, and Efficacy Of Crovalimab Versus Eculizumab In Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Complement Inhibitors |
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| Recruiting | 3 | 190 | Europe, Canada, Japan, US, RoW | Crovalimab, Eculizumab | Hoffmann-La Roche, Chugai Pharmaceutical | Paroxysmal Nocturnal Hemoglobinuria | 09/29 | 09/29 | | |
2019-001829-26: A Trial to Evaluate the Safety and Activity of Eculizumab in PediatricPatients with Relapsing Neuromyelitis Optica Spectrum Disorder (NMOSD) Ensayo para evaluar la seguridad y actividad de eculizumab en pacientes pediátricos con trastorno del espectro de la neuromielitis óptica recidivante |
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| Not yet recruiting | 2/3 | 15 | Europe | Soliris, Soliris, Concentrate for solution for infusion, Soliris | Alexion Pharmaceuticals Inc., ALEXION PHARMACEUTICALS INCORPORATED, Alexion Pharmaceuticals Inc, Alexion Pharmaceuticals Inc. | Neuromyelitis Optica Spectrum Disorder (NMOSD) Trastorno del espectro de la neuromielitis óptica (TENMO), Neuromyelitis Optica Spectrum Disorder (NMOSD) Trastorno del espectro de la neuromielitis óptica (TENMO), Diseases [C] - Nervous System Diseases [C10] | | | | |
ECU-NMO-303, NCT04155424: A Study of the Safety and Activity of Eculizumab in Pediatric Participants With Relapsing Neuromyelitis Optica Spectrum Disorder |
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| Terminated | 2/3 | 5 | Europe, Canada, Japan, US, RoW | Eculizumab, Soliris | Alexion Pharmaceuticals, Inc. | Neuromyelitis Optica, Neuromyelitis Optica Spectrum Disorder | 07/23 | 07/23 | | |
