Completed

4

60

 

Oral administration of donepezil, the first month ;Placebo 10mg / day.

Nanfang Hospital; Eisai china Inc, Eisai China Inc

Post-stroke patients with chronic non-fluent aphasia

 

 

Ongoing

4

20

Europe

ARICEPT, ARICEPT

FONDAZIONE SANTA LUCIA

Alzheimer, s Disease

 

 

Not yet recruiting

4

60

 

Shen Qi Yi Zhi Formula Granules ;Donepezil

Centre for Beijing Aging Brain Rejuvenation Initiative, Beijing Normal Univrsity; Centre for Beijing Aging Brain Rejuvenation Initiative, Beijing Normal Univrsity, The State Key Program of National Natural Science of China (Grant No.81430100)

Alzheimer’s disease

 

 

Recruiting

4

128

 

Shen zhi ling oral liquid ;Shen zhi ling oral liquid Mimetics ;Donepezil hydrochloride+Shen zhi ling oral liquid ;Donepezil hydrochloride+Shen zhi ling oral liquid Mimetics

Beijing Anzhen Hospital, Capital Medical University; Shandong?Wohua?Pharmaceutical?Co., Ltd., Self funded

Amnestic mild cognitive impairment (aMCI) and mild Alzheimer's disease (AD) (heart qi deficiency syndrome)

 

 

Not yet recruiting

4

32

RoW

Landex, Aricept, Dospelin, Donpethon, Tablet, , Landex, Aricept, Dospelin, Donpethon

Fakultní nemocnice Hradec Králové, Neurologická klinika Fakultní nemocnice Hradec Králové

Alzheimer's disease Alzheimerova choroba, Alzheimer's disease Alzheimerova choroba, Diseases [C] - Nervous System Diseases [C10]

 

 

Completed

4

89

US

donepezil HCL, Placebo

The Cleveland Clinic, National Institute on Aging (NIA)

Genetic Risk for Alzheimer's Disease

12/21

12/21

Not yet recruiting

4

30

 

Donepezil in combination with placebo ;donepezil in combination with modafinil and paracetamol

The Second Affiliated Hospital of Nanchang University; Guangzhou Century Clinical Research Co., Ltd, Xiangbei Welman pharmaceutical Co., Ltd.

Alzheimer's disease

 

 

Not yet recruiting

4

1205

Europe

cholinesterase inhibitors (CI) (donepezil, galantamine or rivastigmine)

University Hospital, Bordeaux

Alzheimer Disease, Cholinesterase Inhibitors

04/27

09/27

Ongoing

3

300

Europe

Aricept, Aricept

Stanmore Clinical Research Facility Ltd

Post-operative delirium.

 

 

Recruiting

3

240

Europe

Donepezil, Aricept

Assistance Publique - Hôpitaux de Paris, France Alzheimer

Alzheimer Disease, Early Onset

08/26

08/26

Not yet recruiting

2/3

200

US

Donepezil, Aricept ®

The University of Texas Health Science Center at San Antonio, National Institute on Aging (NIA)

Alzheimer's Disease (AD), Dementia, Cognitive Decline, Mild Cognitivie Impairment (MCI)

11/28

11/28

Ongoing

2

60

Europe

PR1, PR2, PR1, PR2, Aricept 5mg, Aricept 5mg (x2 tabs to give 10mg), Aricept 5mg, Aricept 5mg (x2 tabs to give 10mg)

Joint Sponsorship: University College London (UCL) & University College London Hospitals (UCLH)

Wernicke\'s aphasia caused by a stroke

 

 

Ongoing

2

30

Europe

ARICEPT, ARICEPT

OSPEDALE S. RAFFAELE

patients affected by multiple sclerosis

 

 

Ongoing

2

15

Europe

ARICEPT FLAS 10 mg, comprimidos bucodispersbles, ARICEPT FLAS 10 mg, comprimidos bucodispersbles

Marcelo L. Berthier Torres

Tratamiento de la Afasia crónica con DonepeziloTreatment of chronic aphasia with Donepecil

 

 

Recruiting

2

238

RoW

Donepezil Hydrochloride, Placebo

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Radiation Injuries, Cognitive Impairment

12/22

12/22

Recruiting

2

20

US

Donepezil, Placebo oral tablet, Topical Zinc Oxide

University of Maryland, Baltimore

Wound Heal

07/23

07/23

Terminated

2

7

US

Donepezil 5-10 Mg Oral Tablet, Placebo Oral Tablet

University of Maryland, Baltimore

Diabetes Mellitus, Type 2

09/23

09/23

Not yet recruiting

2

120

NA

Donepezil Hydrochloride, Placebo

Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

Parkinson Disease, Mild Cognitive Impairment

11/25

11/25

Recruiting

1

100

 

Yizhiannao Granule ;Donepezil

The First Affiliated Hospital of Anhui University of traditional Chinese Medicine; The First Affiliated Hospital of Anhui University of traditional Chinese Medicine, Beijing Afanty brain technology co. LTD

vascular cognitive impairment

 

 

Completed

1

62

RoW

Jiedu Yizhi Formula, Donepezil Hydrochloride Tablets

Changchun University of Chinese Medicine

Ensure the Legality and Compliance of the Testing Process

12/23

04/24

Recruiting

1

108

RoW

Donepezil, Usual care

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Urinary Retention After Procedure

05/23

07/23

Recruiting

1

US

MK-1167, Donepezil, Placebo

Merck Sharp & Dohme LLC

Alzheimer's Disease

08/24

08/24

Recruiting

1

76

 

On the basis of routine treatment and nursing, combined with EEG biofeedback adjuvant therapy, once a day, 30 minutes each time, 5 times a week, a total of 10 times (intervention for 4 weeks).; Routine treatment includes: controlling blood pressure, regulating blood sugar, regulating lipid metabolism, nourishing nerves, and improving circulation, while administering drugs that improve cognitive function such as ibuprofen soft capsules, piracetam capsules, and donepezil hydrochloride Routine care: such as admission guidance, dietary care, medication guidance, primary rehabilitation gymnastics guidance, psychological care, and discharge rehabilitation guidance.

Affiliated Hospital of North Sichuan Medical College; Affiliated Hospital of North Sichuan Medical College, Hospital provide their own supplies

vascular cognitive impairment no dementia

 

 

Recruiting

1

50

US

Donepezil, Aricept, Placebo

Vanderbilt University Medical Center

Bilateral Sensorineural Hearing Loss

09/25

09/25

Completed

N/A

144

 

Bushenyisui formulas ;Hydrochloride donepezil

The second hospital affiliated toTianjin university of traditional Chinese medicine; The second hospital affiliated toTianjin university of traditional Chinese medicine, Ministry of Science and Technology of China

Alzheimer's disease

 

 

Recruiting

N/A

100

 

metformin and donepezil, ;acarbose and donepezil

Tianjin First Center Hospital; Tianjin First Center Hospital, department of neurology

vascular cognitive impairment

 

 

Recruiting

N/A

75

 

Nimodipine 30mg 3 times/day, even served 24 weeks ;The next day 1, 3 times a week, 4 weeks for a period of treatment, a total of 6 courses of treatment, 72 times ;Foundation treatment +Donepezil oral treatment

The First Affiliated Hospital of Anhui Medical University; The First Affiliated Hospital of Anhui Medical University, The national natural science foundation of China

subcortical ischemia vascular dementia

 

 

Completed

N/A

45

 

Oral Placebo ;Oral levothyroxine tablets ;Oral levothyroxine tablets and donepezil

Anhui Medical University; The First Affiliated Hospital of Anhui Medical University, China national natural science foundation

Hypothyroidism

 

 

Recruiting

N/A

232

 

''San-Cai Yi-Zhi'' moxibustion ;Multisensory stimulation + Simultaneous multi-tasking ;''San-Cai Yi-Zhi'' moxibustion + multi-sensory stimulation + body movement ;Oral donepezil hydrochloride

Chengdu University of Traditional Chinese Medicine; Chengdu University of Traditional Chinese Medicine, Provincial-level special funds for science and technology

Mild Cognitive Impairment, MCI

 

 

Recruiting

N/A

40

 

Donepezil and/or Menantine treatment for more than 3 months ;acer truncatum bunge seed oil 3ml/day oral 3 months

Shenzhen Luohu People's Hospital; Shenzhen Luohu People's Hospital, Corporate Sponsorship

Senile dementia

 

 

Recruiting

N/A

128

 

Shenqiyizhi Keli, Pro, Bid ;Aricept (donepezil hydrochloride), Pro, Qd

Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medicine; Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medicine, National key research and development plan

Preclinical Alzheimer Disease

 

 

Not yet recruiting

N/A

360

 

no ;no ;no ;no ;no ;no ;Hengqing II prescription ;placebo ;Aricept

Shanghai Sixth People's Hospital; Shanghai sixth people's hospital, Shanghai Shenkang Group

Azheimer's disease

 

 

Recruiting

N/A

600

 

Bushenkaiqiao granules+Donepezil Hydrochloride ;Donepezil Hydrochloride

Shanghai Municipal Hospital of Traditional Chinese Medicine; Level of the institution：, National key R & D plan 2018yfc2002500

Alzheimer's disease

 

 

Recruiting

N/A

102

 

Electropuncture (3 times/w) + donepezil (5mg, Qd) ;Sham Electropuncture (3 times/w) + donepezil (5mg, Qd)

Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine; Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Special Project for Intergrated Traditional Chinese Medicine and Western Medicine

Alzheimer's disease

 

 

Recruiting

N/A

480

 

Donepezil Hydrochloride ;placebo ;Donepezil Hydrochloride ;Liuwei Dihuang pill

Traditional Chinese Pharmacological Laboratory, School of Traditional Chinese Medicine, Southern Medical University; TCM-Integrated Hospital of Southern Medical University, National Key Research and Development Project 2018YFC1704404

Alzheimer disease

 

 

Not yet recruiting

N/A

140

 

Donepezil ;Transcranial magnetic stimulation ;Transcranial direct current stimulation ;Transcranial magnetic stimulation combined with donepezil ;Transcranial direct current stimulation combined with donepezil

Lanzhou University Second Hospital; Lanzhou University Second Hospital, Gansu Youth Science and Technology Fund Program

Traumatic brain injury;cognitive impairment

 

 

Not yet recruiting

N/A

150

 

Zhinao capsule (0.4g/ pill, orally, 3 capsules per time, 3 times a day) + Donepezil tablets (5mg/ pill, orally, 1 tablet per time, taken before going to bed at night, the dose was maintained for 4 weeks and increased to 2 tablets before going to bed at night), the course of treatment was 24 weeks. ;Zhinao capsule simulator (oral, 3 capsules a time, 3 times a day) + Donepezil tablets (5mg/ tablet, orally, 1 tablet a time, before going to bed at night, the dose maintained for 4 weeks and increased to 2 tablets before going to bed at night), the course of treatment was 24 weeks.

The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine; The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Major Science and Technology Project of Anhui Province (No.201903a07020016)

Alzheimer's disease (AD)

 

 

Recruiting

N/A

100

RoW

Detection of cytof in peripheral PBMC, Donepezil for patients with AD and DLB

First Affiliated Hospital of Zhejiang University

Alzheimer Disease, Lewy Body Disease, Neurodegenerative Diseases

12/23

12/23

Not yet recruiting

N/A

176

RoW

Acupuncture, Sham Acupuncture, Donepezil

Shanghai University of Traditional Chinese Medicine, Shanghai Minimally Invasive Surgery Center

Alzheimer Disease, Cognitive Impairment

11/26

11/26

Not yet recruiting

N/A

30

 

Donepezil + placebo ;Donepezil + dL-3-n-Butylphthalide

Affiliated Taihe Hospital of Hubei University of Medicine; Affiliated Taihe Hospital of Hubei University of Medicine, China International Medical Foundation, CIMF

Post-stroke cognitive impairment (PSCI)

 

 

Recruiting

N/A

94

 

Regulating Heart and Kidney Formula; Donepezil

Shanghai Geriatric Institute of Chinese Medicine; Shanghai Geriatric Institute of Chinese Medicine, Budgeted Projects of Shanghai University of Traditional Chinese Medicine (Natural Sciences Category)

Alzheimer‘s Disease

 

 

Recruiting

N/A

240

RoW

Active acupuncture, Sham acupuncture, Donepezil Hydrochloride

Shanghai Institute of Acupuncture, Moxibustion and Meridian

Alzheimer Disease 1

12/25

12/25

Recruiting

N/A

60

 

Administration of donepezil ;Fecal transplantation is given on top of conventional treatment

Affiliated Hospital of Guangdong Medical University; Affiliated Hospital of Guangdong Medical University, Affiliated Hospital of Guangdong Medical University

Cognitive impairment

 

 

Not yet recruiting

N/A

110

 

Besides the control group, Tongdu Tiaoshen acupuncture was also given.once a day, for 2 months.; Donepezil 5 mg orally, once a day, for 2 months.

The Second Affiliated Hospital of Anhui University of Chinese Medicine; The Second Affiliated Hospital of Anhui University of Chinese Medicine, Health Commission of Anhui Province (Provincial Financial Support Project/Youth Project)

vascular cognitive impairment

 

 

Recruiting

N/A

1176

 

Donepezil 5mg is taken orally every evening in combination with placebo, which is taken orally three times a day with a dosage of 300mg per administration.; Donepezil 5mg is taken orally every evening in combination with phosphatidylcholine capsules, which are taken orally three times a day with a dosage of 300mg per administration.; Donepezil 5mg is taken orally every evening in combination with placebo, which is taken orally three times a day with a dosage of 100mg per administration, and phosphatidylcholine capsules, which are taken orally three times a day with a dosage of 200mg per administration.; NA

Shandong First Medical University; Shandong Provincial Hospital Affiliated to Shandong First Medical University, Ministry of Science and Technology of China

Alzheimer's disease

 

 

Recruiting

N/A

75

 

The dose of Donepezil was increased to 10mg/d for 12 weeks. If the patient has insomnia, change to morning medication; High frequency rTMS true stimulus (stimulus parameters are as follows: the stimulus frequency is 20Hz; The stimulation duration was 2s and the interval was 28s. Each target stimulated 15 sequences with 600 pulses, a total of 60 sequences with 2400 pulses, a total treatment time of 30 minutes) +5mg/d Donepezil; High frequency rTMS sham stimulus +5mg/d Donepezil

Shandong First Medical University; Shandong First Medical University, National Natural Science Foundation of China；Talent Fund Project of Shandong First Medical University

Alzheimer

 

 

Not yet recruiting

N/A

150

NA

Donepezil, GV-971

First Affiliated Hospital Xi'an Jiaotong University

Alzheimer Disease

12/23

12/24