Delirium, Dementia, Amnestic, Cognitive Disorders  >>  donepezil  >>  Phase 1
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11 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
donepezil / Generic mfg.
NCT01406145: A Study of the Safety and Tolerability of ASP0777 in Subjects With Alzheimer's Disease (AD) Taking a Stable Dose of Donepezil

Completed
1b
60
US
ASP0777, Placebo
Astellas Pharma Inc
Alzheimer's Disease
11/11
11/11
NCT01181310: Placebo-Controlled Crossover Study to Evaluate Donepezil and MK-3134 for Reversal of Cognitive Impairment Associated With Scopolamine Administration (3134-005)(COMPLETED)

Completed
1
31
Europe
A: Placebo to match Donepezil and MK-3134 + Placebo to match Scopolamine, B: Placebo to match Donepezil and MK-3134 + Scopolamine 0.5 mg, C: MK-3134 25 mg + Scopolamine 0.5 mg, D: Donepezil 10 mg + Scopolamine 0.5 mg, Aricept (donepezil), E: Combo: Donepezil 10 mg + MK-3134 25 mg + Scopolamine 0.5 mg
Merck Sharp & Dohme LLC
Dementia
10/07
10/07
NCT00713765: Pharmacokinetic Interaction Between AZD3480 and Donepezil

Terminated
1
33
Europe
AZD3480, Donepezil
AstraZeneca
Alzheimer's Disease
12/08
12/08
NCT00874939: A Study to Evaluate the Effects of MK-0249 and an Alzheimer's Disease Medication on Cognitive Function in Adults With Alzheimer's Disease (MK-0249-023)

Terminated
1
4
NA
MK-0249 7.5 mg, MK-0249 25 mg, Donepezil 5mg, Aricept, Placebo to MK-0249, Placebo to Donepezil
Merck Sharp & Dohme LLC
Alzheimer's Disease, Dementia
04/09
04/09
NCT00777608 / 2008-003377-41: A Study to Test the Performance of the CogState Computerized Neuropsychological Battery in Patients With Alzheimer's Disease (0000-086)(COMPLETED)

Completed
1
106
Europe
Comparator: Placebo 5mg (run in), Donepezil 5 - 10 mg, Comparator: Placebo 5-10 mg, Donepezil 10 mg
Merck Sharp & Dohme LLC
Alzheimer's Disease
10/09
04/10
NCT01042314: Drug-Drug Interaction Study With AriceptĀ® (Donepezil)

Checkmark P1 data (AAICAD 2012)
Jul 2012 - Jul 2012: P1 data (AAICAD 2012)
Completed
1
18
US
Donepezil, AriceptĀ®, BMS-708163
Bristol-Myers Squibb
Alzheimer Disease
04/10
04/10
NCT01028911: A Study to Evaluate the Safety, Tolerability, and Blood Levels of PF-03654746 in Subjects With Mild to Moderate Alzheimer's Disease

Terminated
1
9
US
PF-03654746, Placebo
Pfizer
Alzheimer's Disease
05/10
05/10
NCT01024660: The Effect of Cognitive Function as Measured by Repeated Cognitive Measures After 12 Weeks Treatment With Donepezil

Completed
1
155
Canada, Europe, RoW
Donepezil, Aricept, Placebo to match Aricept
AstraZeneca
Alzheimer's Disease
01/11
01/11
NCT00750529: Alzheimer and Sleep

Completed
1
15
Europe
Galantamine and Donepezil
University Hospital, Clermont-Ferrand, Janssen-Cilag Farmaceutica Ltda.
Alzheimer's Disease
09/13
09/13
NCT01903824: Pharmacokinetics and Pharmacodynamics (PK/PD) of CEP-26401 in Healthy Subjects

Completed
1
40
Europe
CEP-26401, Irdabisant, donepezil hydrochloride, Aricept, modafinil, Provigil, Placebo
Teva Branded Pharmaceutical Products R&D, Inc.
Cognitive Impairment
10/13
12/13
NCT02051335: Roflumilast and Donepezil to Reverse Scopolamine Induced Cognitive Deficits in Healthy Adults

Completed
1
27
Europe
Roflumilast, Daxas, Roflumilast placebo, Donepezil, Aricept, Donepezil placebo, Scopolamine, Hyoscine hydrobromide
AstraZeneca
Memory Impairment, Alzheimer's Disease
05/14
05/14

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