| Cubicin (daptomycin) / Merck (MSD) |
2007-007640-10: Tissue pharmacokinetics of daptomycin measured by in vivo microdialysis in patients with diabetic foot infection |
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| Ongoing | 4 | 10 | Europe | Cubicin, Cubicin, Cubicin | PD Dr. med. K-H. Konz | A group of adult male or female patients with documented diabetes and bacterial soft tissue infection of the foot who must be subjected to undergo intravenous antimicrobial therapy with broad-spectrum antibiotics. | | | | |
2008-005965-69: Estudio piloto comparativo post-autorización de efectividad y seguridad, entre vancomicina y daptomicina, en las bacteriemias por Staphylococcus sp oxacilin-resistentes de los pacientes sometidos a hemodiálisis |
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| Ongoing | 4 | 120 | Europe | CUBICIN 350 mg polvo para concentrado para solución para perfusión, VANCOMICINA G.E.S. 1 g, POLVO PARA SOLUCIÓN INYECTABLE | Departamento de Microbiología. Hospital Clinico San Carlos | Estudio comparativo del comportamiento de daptimicina y vancomicina en las bacteriemias por staphylococcus oxacilin-resistentes de pacientes sometidos a hemodialisis. valorando el tiempo hasta la negativización del hemocultivo, el control clinico, loas complicaciones septicas a distancia, los efectos secundarios y los exitus en uno y otro grupo. | | | | |
2008-005960-14: Estudio piloto comparativo post-autorización de efectividad y seguridad, entre vancomicina y daptomicina, en las bacteriemias por Staphylococcus sp oxacilin-resistentes de los pacientes hematológicos. |
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| Ongoing | 4 | 120 | Europe | CUBICIN 350 mg polvo para concentrado para solución para perfusión, VANCOMICINA G.E.S. 1 g polvo para solución inyectable | Departamento de Microbiología. Hospital Clinico San Carlos | Comparar el comportamiento entre daptomicina y vancomicina en las bacteriemias por staphylococcus oxacilin-resistentes(negativización del hemocultivo, complicaciones y efectos secundarios) | | | | |
2007-005399-15: Penetration of Cubicin® and Fosfomycin® into skeletal muscle and subcutaneous adipose tissue of necrotizing soft tissue infections, measured by in-vivo microdialysis |
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| Ongoing | 4 | 12 | Europe | Cubicin (Daptomycin), Fosfomycin, Cubicin 350 mg powder for solution for injection or infusion, FOSFOMYCIN 8g i.v. Trockensubstanz zur Infusionsbereitung, Cubicin 350 mg powder for solution for injection or infusion, FOSFOMYCIN 8g i.v. Trockensubstanz zur Infusionsbereitung | Medizinische Universität Graz - Abteilung für Thorax- und Hyperbare Chirurgie | A group of adult male or female patients with documented necrotizing soft tissue infection who must be subjected to undergo intravenous antimicrobial therapy with broad spectrum antibiotics. | | | | |
ChiCTR1800019619: The cost-effectiveness study for daptomycin in the treatent of gram-positive bactermia and infective endocarditis |
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| Not yet recruiting | 4 | 60 | | Treated with daptomycin ;Treated with vancomycin | General Hospital of Shenyang military area region of PLA; General Hospital of Shenyang military area region of PLA, 无 | Gram-positive bacteremia and infective endocarditis | | | | |
2021-003891-15: Clinical trial to evaluate the safety and efficacy of a 7-day versus 14-day treatment for enterococcal infections. Ensayo clínico para evaluar la seguridad y eficacia de un tratamiento de 7 días frente a 14 días para infecciones por enterococos. |
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| Not yet recruiting | 4 | 284 | Europe | Ciprofloxacin, ampicilin, vancomycin, linezolid, daptomycin, amoxicillin / clavulanic acid, piperacillin / tazobactam, amoxicilin, Film-coated tablet + pessary, Suspension for injection, Powder and solvent for solution for infusion, Solution for injection/infusion, Powder and solvent for solution for injection/infusion, Film-coated tablet, Tablet, Ciprofloxacin, ampicilin, vancomycin, linezolid, daptomycin, amoxicillin / clavulanic acid, piperacillin / tazobactam, amoxicilin | Fundación Pública Andaluza para la Gestión de la Investigación en Salud de Sevilla (FISEVI), Instituto de Salud Carlos III. Ministerio de Ciencia e Innovación | Adult patients with uncomplicated bacteremia caused by E. faecalis or E. faecium. Pacientes adultos con bacteriemias no complicadas causadas por E. Faecalis o E. faecium., Adult patients with infections that produce the passing of certainbacteria to the bloodstream. Pacientes adultos con infecciones que producen el paso de ciertasbacterias al torrente sanguíneo., Diseases [C] - Bacterial Infections and Mycoses [C01] | | | | |
2021-004108-16: Markers that indicate the drug concentration in the infection place in very ill patients |
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| Not yet recruiting | 4 | 60 | Europe | Daptomycin, Powder for solution for injection/infusion, Powder for solution for infusion, Solution for infusion, Powder for concentrate for solution for injection/infusion, Meropenem, Piperacillin/Tazobactam, ZYVOXID, Daptomycin | Medical University Vienna, Medical University of Vienna - Department of Clinical PHarmacology | All patients given standard of care intravenous therapy of the studied antibiotics will be screened against the inclusion criteria. Two groups are included: Group A (septic patients with organ dysfunction defined as SOFA >2) and Group B (control group of non-septic patients without organ dysfunction defined as SOFA <2)., Patients who receive the studied drugs., Diseases [C] - Bacterial Infections and Mycoses [C01] | | | | |
ChiCTR2100041991: The study of effectiveness and safety evaluation of high dose datoromycin in ICU patients |
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| Recruiting | 4 | 160 | | daptomycin 6 mg/kg Q24h ;daptomycin 10 mg/kg Q24h | The Second Affiliated Hospital of Harbin Medical University; The Second Affiliated Hospital of Harbin Medical University, China International Medical Foundation Young and middle-aged medical research special fund project | patients with suspected or confirmed severe infection caused by gram-positive cocci | | | | |
NCT03426761: Dalbavancin For The Treatment of Gram Positive Osteoarticular Infections |
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| Completed | 4 | 41 | US | Dalbavancin, Dalvance, Xydalba, Zevan, Vancomycin, Daptomycin, Nafcillin, Cefazolin | Infectious Diseases Physicians, Inc., Johns Hopkins University | Bone Infection, Osteomyelitis, Septic Arthritis, Joint Infection, Prosthetic Joint Infection | 12/22 | 12/22 | | |
ChiCTR2100041926: Study on the use of datomycin to prevent and treat DCD donor-derived infections due to gram positive bacteria in liver transplant recipients |
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| Recruiting | 4 | 140 | | daptomycin ;teicoplanin | Third Xiangya Hospital, Central South University; Third Xiangya Hospital, Central South University, Special Fund for young and middle-aged Medical Research of China International Medical Exchange Foundation | gram positive bacterial infections | | | | |
2022-001894-29: Accelerated treatment of heart valve infection Förkortad behandling vid hjärtklaffinfektion |
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| Ongoing | 4 | 750 | Europe | Doktacillin, Powder and solvent for solution for infusion, Powder and solution for solution for injection, Ceftriaxon, Doktacillin, Vancomycin, Cloxacillin, Cefotaxim, Bensylpenicillin, Daptomycin, Meropenem | Lund University, Region Skåne | Infectious endocarditis Infektiös endokardit, Bacterial infection of the heart valves Hjärtklaffsinfektion, Diseases [C] - Bacterial Infections and Mycoses [C01] | | | | |
| Recruiting | 4 | 310 | Canada | Ceftriaxone, Rocephin, Usual Antibiotics (Cloxacillin, Cefazolin, Daptomycin), Cloxacillin, Cefazolin, Daptomycin, Ancef, Cubicin | Vancouver Island Health Authority | Staphylococcal Infections, Osteomyelitis, CNS Infection, Septic Arthritis, Diabetic Foot Infection, Vertebral Osteomyelitis, Abscess, Coagulase Negative Staphylococcal Infection | 07/23 | 03/24 | | |
| Enrolling by invitation | 4 | 135 | US | Amoxicillin, amoxicillin-clavulanate, cefadroxil, cefpodoxime, cefalexin, ciprofloxacin, delafloxacin, doxycycline, levofloxacin, linezolid, metronidazole, moxifloxacin, rifampin, trimethoprim-sulfamethoxazole, Ampicillin, ampicillin-sulbactam, cefazolin, cefepime, ceftaroline, ceftazidime, ceftazidime-avibactam, dalbavancin, daptomycin, ertapenem, meropenem, oritavancin, oxacillin, penicillin, piperacillin-tazobactam, tigecycline, vancomycin | West Virginia University | Endovascular Infection, Bone and Joint Infection, Skin and Soft Tissue Infection, Pulmonary Infection, Gastrointestinal Infection, Genitourinary Infection | 08/24 | 08/24 | | |
OPTIMAL, NCT05156437: Postoperative Antibiotic Management Duration Following Surgery for Intravenous Drug Abuse (IVDA) Endocarditis |
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| Enrolling by invitation | 4 | 20 | US | Amoxycillin, Cefalexin, Dicloxacillin, Linezolid, Levofloxacin, Rifampicin, Ampicillin, Oxacillin, Vancomycin, Daptomycin, Ceftriaxone, Cefepime, Ceftaroline | Vinay Badhwar | Endocarditis | 10/24 | 10/24 | | |
| Recruiting | 4 | 8000 | Europe, Canada, RoW | Cefazolin, Penicillin, Benzylpenicillin, Penicillin G, Clindamycin, Lincomycin, Vancomycin, Daptomycin, Effectiveness of early switch to oral antibiotics, Whole body FDG PET/CT Imaging | University of Melbourne, Berry Consultants, McGill University Health Centre/Research Institute of the McGill University Health Centre, Menzies School of Health Research, Aotearoa Clinical Trials, Queensland University of Technology, Sunnybrook Health Sciences Centre, Tan Tock Seng Hospital, Telethon Kids Institute, The Peter Doherty Institute for Infection and Immunity, The University of Queensland, UMC Utrecht, Radboud University Medical Center, King's College London, Rambam Health Care Campus, University College, London, Houston Medical Research Institute | Staphylococcus Aureus Bacteremia | 12/28 | 12/28 | | |
2005-001349-40: A Multicentre, Randomised, Assessor-Blind Study to Evaluate Efficacy and Safety of Daptomycin versus Vancomycin or Teicoplanin for Treatment of Complicated Skin and Soft Tissue Infections (cSSTI) |
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| | 3 | 130 | Europe | Daptomycin, Teicoplanin, Vancomycin hydrochloride, CB-109187, Cubicin, 350 mg powder for concentrate for solution for infusion, Targocid 400 mg, Vancomycin hydrochloride 500 mg, Cubicin, 350 mg powder for concentrate for solution for infusion, Targocid 400 mg, Vancomycin hydrochloride 500 mg | Novartis Pharma Services AG, Chiron Corporation Limited | Complicated Skin and Soft Tissue Infections (cSSTI) | | 05/08 | | |
2007-004990-24: Comparison of the concentrations of the antibiotic compound Daptomycin in serum, cartilage-, muscle and subcutaneous tissue after a preoperative intravenous administration (Klinische Studie zum Vergleich von Serum – und Gewebekonzentrationen in Subkutis, Muskel, Knorpel und Knochen des Antibiotikums Daptomycin nach präoperativer, intravenöser Applikation zur Infektionsprophylaxe bei orthopädischen Eingriffen) |
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| Ongoing | 3 | 18 | Europe | Cubicin, Cubicin | University Medical Center Freiburg | Elective orthopedic surgery | | | | |
2019-004884-32: COMPARAISON DU PROFIL PHARMACOCINETIQUE ET DE LA SECURITE DE LA DAPTOMYCINE ADMINISTREE PAR VOIE SOUS-CUTANEE PAR RAPPORT A LA VOIE INTRAVEINEUSE : ETUDE EN CROSS-OVER COMPARAISON DU PROFIL PHARMACOCINETIQUE ET DE LA SECURITE DE LA DAPTOMYCINE ADMINISTREE PAR VOIE SOUS-CUTANEE PAR RAPPORT A LA VOIE INTRAVEINEUSE : ETUDE EN CROSS-OVER |
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| Not yet recruiting | 3 | 12 | Europe | DAPTOMYCINE, Powder for injection, DAPTOMYCINE | CHU CAEN Normandie, CHU CAEN Normandie | Volontaire sain Volontaire sain, Volontaire sain Volontaire sain, Diseases [C] - Bacterial Infections and Mycoses [C01] | | | | |
2021-003914-38: Different antimicrobial durations for the treatment of infections associated with OsteosynthesisMaterial implanted after long bone fractures DIFERENTES DURACIONES DE TRATAMIENTO ANTIMICROBIANO DE INFECCIONES ASOCIADAS AL MATERIAL DE OSTEOSÍNTESIS TRAS FRACTURA DE HUESO LARGO |
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| Not yet recruiting | 3 | 378 | Europe | Ampicillim, amoxicillin/clavulanic, Cefazolin, Cefepime, Ceftazidime, CEFTRIAXONE, cloxacillin, daptomycin, Meropenem, Teicoplanin, Vancomycin, Amoxicillin, Amoxicillin / clavulanic acid, Ciprofloxacin, Levofloxacin, Linezolid, Moxifloxacin, Rifampicin, Powder and solvent for solution for infusion, Powder and solvent for solution for injection, Powder for solution for injection, Powder and solvent for suspension for injection, Powder for solution for injection/infusion, Tablet, , Capsule, Ampicillim, Amoxicillin/Clavulanic, Cefazolin, Cefepime, ceftazidime, CEFTRIAXONE, cloxacillin, daptomycin, Meropenem, Teicoplanin, Vancomycin, Amoxicillin, Amoxicillin / clavulanic acid, Ciprofloxacin, Clindamycin, Sulfametoxazol trimetoprim, Levofloxacin, Linezolid, Moxifloxacin, Rifampicin | Fundación Pública Andaluza para la Gestión de la Investigación, Instituto de Salud Carlos III. Ministerio de Ciencia e | Patients with long bone fractures who have had osteosynthesis material implanted to stabilize and assist fracturehealing and meet the criteria for Infections associated with osteosynthesis material Pacientes con fracturas de huesos largos a quienes se les ha implantado material de osteosíntesis para estabilizar y ayudar a la curación de la fractura y que cumplen con los criterios de Infecciones asociadas con el material de osteosíntesis., Patients with infections due to the implant used to stabilize a long bone fracture Pacientes con infecciones debidas al implante usado para estabilizar una fractura de hueso largo, Diseases [C] - Bacterial Infections and Mycoses [C01] | | | | |
| Not yet recruiting | 2 | 128 | Europe | Daptomycine, Powder for solution for injection/infusion, CUBICIN | CHU Dijon Bourgogne | méningite à pneumocoque, méningite bactérienne, Diseases [C] - Bacterial Infections and Mycoses [C01] | | | | |
NCT04775953: DOTS: Dalbavancin as an Option for Treatment of Staphylococcus Aureus Bacteremia |
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| Completed | 2 | 200 | Canada, US | Cefazolin, Dalbavancin, Daptomycin, Nafcillin, Oxacillin, Vancomycin | National Institute of Allergy and Infectious Diseases (NIAID) | Staphylococcal Bacteraemia | 10/23 | 12/23 | | |
NCT04983901: PHASE II SINGLE-CENTER, RANDOMIZED, OPEN-LABEL, PROSPECTIVE, STUDY TO DETERMINE THE IMPACT OF SERIAL PROCALCITONIN |
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| Completed | 2 | 100 | US | Imipenem/Cilastatin/Relebactam, RECARBRIO™, Cefepime, Meropenem, Meropenem Trihydrate, Merrem I.V., SM-7338, Piperacillin-Tazobactam, PIPER/TAZO, Piperacillin/Tazobactam, Zosyn, Vancomycin, Daptomycin, Cubicin, LY146032, Linezolid, Zyvox | M.D. Anderson Cancer Center, Merck Sharp & Dohme LLC | Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm | 10/23 | 10/23 | | |
| Recruiting | 2 | 128 | Europe | Daptomycin | Centre Hospitalier Universitaire Dijon | Pneumococcal Meningitis | 06/24 | 09/24 | | |
2009-018212-26: Etude de la diffusion de la daptomycinedans le tissu osseux et le liquide synovialchez le volontaire sain après injection unique |
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| Ongoing | 1/2 | 21 | Europe | CUBICIN, CUBICIN | Centre Hospitalier Universitaire de Besançon | La condition mpédicale étudiée est la diffusion osseuse de la daptomycine. Pour l\'étudier, nous avons choisi de faire une étude interventionnelle prospective monocentrique de phase 1 chez le volontaire sain. | | | | |
NCT04414137: Description of Eosinophilic Pneumonia in BJI/PJI Treated by Daptomycin |
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| Recruiting | N/A | 20 | Europe | Description of eosinophilic pneumonia due to daptomycine | Hospices Civils de Lyon | Dactinomycin Adverse Reaction, Bone and Joint Infection | 01/21 | 09/21 | | |
ChiCTR2100052422: Daptomycin Pharmacokinetics in Critically Ill Patients undergoing Extracorporeal Membrane Oxygenation |
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| Completed | N/A | 34 | | Nil ;Nil | Zhongda Hospital Affiliated to Southeast University; Zhongda Hospital Affiliated to Southeast University, Wu Jieping Medical Foundation | Bloodstream infection | | | | |
TANDEM, NCT04132115: Optimized Antibiotic Therapy in Patients With Subarachnoid Haemorrhage (ES) and Cerebral Haemorrhage (EC) |
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| Recruiting | N/A | 104 | Europe | Piperacillin/tazobactam, Meropenem, Daptomycin, Ceftobiprole, Linezolid, Vancomycin, Fluconazol, Acyclovir, Gentamicins, Amikacin, Ganciclovir | Azienda Sanitaria-Universitaria Integrata di Udine | Therapeutic Drug Monitoring, Subarachnoid Hemorrhage, Intracerebral Hemorrhage | 10/21 | 10/21 | | |
| Recruiting | N/A | 1130 | Europe | patients having had BJI or PJI treated with daptomycin | Hospices Civils de Lyon | Dactinomycin Adverse Reaction, Bone and Joint Infection | 03/22 | 07/22 | | |
NCT04277143: A Pharmacokinetics Study of Daptomycin in Critically Ill Patients and Effects of Daptomycin on Kidney |
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| Not yet recruiting | N/A | 120 | RoW | Daptomycin | Zhongnan Hospital | Outcome, Fatal, Infection | 07/22 | 12/22 | | |
NCT04546815: The Efficacy and Safety of Daptomycin in the Treatment of Gram-positive Bacterial Infection. |
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| Recruiting | N/A | 2000 | RoW | Daptomycin | Jiangsu Hengrui Pharmaceutical Co., Ltd. | Antibiotic | 08/22 | 08/22 | | |
NCT04033029: Antibiotic Plasma Concentrations During Continuous Renal Replacement Therapy With a High Adsorption Membrane (oXiris®) |
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| Completed | N/A | 20 | Europe | Continuous venovenous hemodiafiltration with high adsorption membrane (oXiris®), Antibiotics, Piperacillin/tazobactam, Ceftazidime, Cefepime, Daptomycin, Ceftolozane/tazobactam | Hospital Universitari de Bellvitge, Baxter Healthcare Corporation | Hemodiafiltration, Sepsis, Acute Kidney Injury | 06/23 | 06/23 | | |
NCT06189885: Preoperative Daptomycin Prophylaxis in Two-Stage Exchange Arthroplasty: A Prospective, Randomized, Double-Blinded Trial |
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| Not yet recruiting | N/A | 184 | RoW | Cefazolin with Daptomycin, Cefazolin with vancomycin | Chang Gung Memorial Hospital | Periprosthetic Joint Infection | 07/26 | 07/26 | | |
NCT05224687: Utility Assessment of a Pharmacy-to-Dose Daptomycin |
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| Enrolling by invitation | N/A | 100 | US | Retroactive review of patient data of those receiving a dose of daptomycin | Methodist Health System | Antibiotics Causing Adverse Effects in Therapeutic Use | 12/22 | 12/22 | | |