Cubicin (daptomycin) / Merck (MSD)  >>  Phase 4
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15 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Cubicin (daptomycin) / Merck (MSD)
2007-007640-10: Tissue pharmacokinetics of daptomycin measured by in vivo microdialysis in patients with diabetic foot infection

Ongoing
4
10
Europe
Cubicin, Cubicin, Cubicin
PD Dr. med. K-H. Konz
A group of adult male or female patients with documented diabetes and bacterial soft tissue infection of the foot who must be subjected to undergo intravenous antimicrobial therapy with broad-spectrum antibiotics.
 
 
2008-005965-69: Estudio piloto comparativo post-autorización de efectividad y seguridad, entre vancomicina y daptomicina, en las bacteriemias por Staphylococcus sp oxacilin-resistentes de los pacientes sometidos a hemodiálisis

Ongoing
4
120
Europe
CUBICIN 350 mg polvo para concentrado para solución para perfusión, VANCOMICINA G.E.S. 1 g, POLVO PARA SOLUCIÓN INYECTABLE
Departamento de Microbiología. Hospital Clinico San Carlos
Estudio comparativo del comportamiento de daptimicina y vancomicina en las bacteriemias por staphylococcus oxacilin-resistentes de pacientes sometidos a hemodialisis. valorando el tiempo hasta la negativización del hemocultivo, el control clinico, loas complicaciones septicas a distancia, los efectos secundarios y los exitus en uno y otro grupo.
 
 
2008-005960-14: Estudio piloto comparativo post-autorización de efectividad y seguridad, entre vancomicina y daptomicina, en las bacteriemias por Staphylococcus sp oxacilin-resistentes de los pacientes hematológicos.

Ongoing
4
120
Europe
CUBICIN 350 mg polvo para concentrado para solución para perfusión, VANCOMICINA G.E.S. 1 g polvo para solución inyectable
Departamento de Microbiología. Hospital Clinico San Carlos
Comparar el comportamiento entre daptomicina y vancomicina en las bacteriemias por staphylococcus oxacilin-resistentes(negativización del hemocultivo, complicaciones y efectos secundarios)
 
 
2007-005399-15: Penetration of Cubicin® and Fosfomycin® into skeletal muscle and subcutaneous adipose tissue of necrotizing soft tissue infections, measured by in-vivo microdialysis

Ongoing
4
12
Europe
Cubicin (Daptomycin), Fosfomycin, Cubicin 350 mg powder for solution for injection or infusion, FOSFOMYCIN 8g i.v. Trockensubstanz zur Infusionsbereitung, Cubicin 350 mg powder for solution for injection or infusion, FOSFOMYCIN 8g i.v. Trockensubstanz zur Infusionsbereitung
Medizinische Universität Graz - Abteilung für Thorax- und Hyperbare Chirurgie
A group of adult male or female patients with documented necrotizing soft tissue infection who must be subjected to undergo intravenous antimicrobial therapy with broad spectrum antibiotics.
 
 
ChiCTR1800019619: The cost-effectiveness study for daptomycin in the treatent of gram-positive bactermia and infective endocarditis

Not yet recruiting
4
60
 
Treated with daptomycin ;Treated with vancomycin
General Hospital of Shenyang military area region of PLA; General Hospital of Shenyang military area region of PLA, 无
Gram-positive bacteremia and infective endocarditis
 
 
2021-003891-15: Clinical trial to evaluate the safety and efficacy of a 7-day versus 14-day treatment for enterococcal infections. Ensayo clínico para evaluar la seguridad y eficacia de un tratamiento de 7 días frente a 14 días para infecciones por enterococos.

Not yet recruiting
4
284
Europe
Ciprofloxacin, ampicilin, vancomycin, linezolid, daptomycin, amoxicillin / clavulanic acid, piperacillin / tazobactam, amoxicilin, Film-coated tablet + pessary, Suspension for injection, Powder and solvent for solution for infusion, Solution for injection/infusion, Powder and solvent for solution for injection/infusion, Film-coated tablet, Tablet, Ciprofloxacin, ampicilin, vancomycin, linezolid, daptomycin, amoxicillin / clavulanic acid, piperacillin / tazobactam, amoxicilin
Fundación Pública Andaluza para la Gestión de la Investigación en Salud de Sevilla (FISEVI), Instituto de Salud Carlos III. Ministerio de Ciencia e Innovación
Adult patients with uncomplicated bacteremia caused by E. faecalis or E. faecium. Pacientes adultos con bacteriemias no complicadas causadas por E. Faecalis o E. faecium., Adult patients with infections that produce the passing of certainbacteria to the bloodstream. Pacientes adultos con infecciones que producen el paso de ciertasbacterias al torrente sanguíneo., Diseases [C] - Bacterial Infections and Mycoses [C01]
 
 
2021-004108-16: Markers that indicate the drug concentration in the infection place in very ill patients

Not yet recruiting
4
60
Europe
Daptomycin, Powder for solution for injection/infusion, Powder for solution for infusion, Solution for infusion, Powder for concentrate for solution for injection/infusion, Meropenem, Piperacillin/Tazobactam, ZYVOXID, Daptomycin
Medical University Vienna, Medical University of Vienna - Department of Clinical PHarmacology
All patients given standard of care intravenous therapy of the studied antibiotics will be screened against the inclusion criteria. Two groups are included: Group A (septic patients with organ dysfunction defined as SOFA >2) and Group B (control group of non-septic patients without organ dysfunction defined as SOFA <2)., Patients who receive the studied drugs., Diseases [C] - Bacterial Infections and Mycoses [C01]
 
 
ChiCTR2100041991: The study of effectiveness and safety evaluation of high dose datoromycin in ICU patients

Recruiting
4
160
 
daptomycin 6 mg/kg Q24h ;daptomycin 10 mg/kg Q24h
The Second Affiliated Hospital of Harbin Medical University; The Second Affiliated Hospital of Harbin Medical University, China International Medical Foundation Young and middle-aged medical research special fund project
patients with suspected or confirmed severe infection caused by gram-positive cocci
 
 
NCT03426761: Dalbavancin For The Treatment of Gram Positive Osteoarticular Infections

Completed
4
41
US
Dalbavancin, Dalvance, Xydalba, Zevan, Vancomycin, Daptomycin, Nafcillin, Cefazolin
Infectious Diseases Physicians, Inc., Johns Hopkins University
Bone Infection, Osteomyelitis, Septic Arthritis, Joint Infection, Prosthetic Joint Infection
12/22
12/22
ChiCTR2100041926: Study on the use of datomycin to prevent and treat DCD donor-derived infections due to gram positive bacteria in liver transplant recipients

Recruiting
4
140
 
daptomycin ;teicoplanin
Third Xiangya Hospital, Central South University; Third Xiangya Hospital, Central South University, Special Fund for young and middle-aged Medical Research of China International Medical Exchange Foundation
gram positive bacterial infections
 
 
2022-001894-29: Accelerated treatment of heart valve infection Förkortad behandling vid hjärtklaffinfektion

Ongoing
4
750
Europe
Doktacillin, Powder and solvent for solution for infusion, Powder and solution for solution for injection, Ceftriaxon, Doktacillin, Vancomycin, Cloxacillin, Cefotaxim, Bensylpenicillin, Daptomycin, Meropenem
Lund University, Region Skåne
Infectious endocarditis Infektiös endokardit, Bacterial infection of the heart valves Hjärtklaffsinfektion, Diseases [C] - Bacterial Infections and Mycoses [C01]
 
 
NCT04141787: Ceftriaxone as Home IV for Staph Infections

Recruiting
4
310
Canada
Ceftriaxone, Rocephin, Usual Antibiotics (Cloxacillin, Cefazolin, Daptomycin), Cloxacillin, Cefazolin, Daptomycin, Ancef, Cubicin
Vancouver Island Health Authority
Staphylococcal Infections, Osteomyelitis, CNS Infection, Septic Arthritis, Diabetic Foot Infection, Vertebral Osteomyelitis, Abscess, Coagulase Negative Staphylococcal Infection
07/23
03/24
COPAT, NCT05977868: Comparing Oral Versus Parenteral Antimicrobial Therapy

Enrolling by invitation
4
135
US
Amoxicillin, amoxicillin-clavulanate, cefadroxil, cefpodoxime, cefalexin, ciprofloxacin, delafloxacin, doxycycline, levofloxacin, linezolid, metronidazole, moxifloxacin, rifampin, trimethoprim-sulfamethoxazole, Ampicillin, ampicillin-sulbactam, cefazolin, cefepime, ceftaroline, ceftazidime, ceftazidime-avibactam, dalbavancin, daptomycin, ertapenem, meropenem, oritavancin, oxacillin, penicillin, piperacillin-tazobactam, tigecycline, vancomycin
West Virginia University
Endovascular Infection, Bone and Joint Infection, Skin and Soft Tissue Infection, Pulmonary Infection, Gastrointestinal Infection, Genitourinary Infection
08/24
08/24
OPTIMAL, NCT05156437: Postoperative Antibiotic Management Duration Following Surgery for Intravenous Drug Abuse (IVDA) Endocarditis

Enrolling by invitation
4
20
US
Amoxycillin, Cefalexin, Dicloxacillin, Linezolid, Levofloxacin, Rifampicin, Ampicillin, Oxacillin, Vancomycin, Daptomycin, Ceftriaxone, Cefepime, Ceftaroline
Vinay Badhwar
Endocarditis
10/24
10/24
SNAP, NCT05137119: Staphylococcus Aureus Network Adaptive Platform Trial

Recruiting
4
8000
Europe, Canada, RoW
Cefazolin, Penicillin, Benzylpenicillin, Penicillin G, Clindamycin, Lincomycin, Vancomycin, Daptomycin, Effectiveness of early switch to oral antibiotics, Whole body FDG PET/CT Imaging
University of Melbourne, Berry Consultants, McGill University Health Centre/Research Institute of the McGill University Health Centre, Menzies School of Health Research, Aotearoa Clinical Trials, Queensland University of Technology, Sunnybrook Health Sciences Centre, Tan Tock Seng Hospital, Telethon Kids Institute, The Peter Doherty Institute for Infection and Immunity, The University of Queensland, UMC Utrecht, Radboud University Medical Center, King's College London, Rambam Health Care Campus, University College, London, Houston Medical Research Institute
Staphylococcus Aureus Bacteremia
12/28
12/28

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