| sertraline / Generic mfg. |
| Completed | N/A | | US | Sertraline, Hypericum perforatum (St. John's wort) | National Institute of Mental Health (NIMH), National Center for Complementary and Integrative Health (NCCIH) | Major Depression | | 07/01 | | |
NCT02231268: Observational Study to Assess a 6-months Treatment With Gladem |
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| Completed | N/A | 546 | Europe | Gladem | Boehringer Ingelheim | Depressive Disorder | 01/03 | | | |
NCT00602849: Bioequivalency Study of Sertraline Under Fasting Conditions |
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| Completed | N/A | 38 | Canada | Sertraline | Roxane Laboratories | Depression | 07/03 | 07/03 | | |
NCT00601588: Bioequivalency Study of Sertraline Under Fed Conditions |
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| Completed | N/A | 43 | Canada | Sertraline | Roxane Laboratories | Depression | 07/03 | 07/03 | | |
NCT01237275: Development of A Technique to Predict Antidepressant Responsiveness in Depressive Patients |
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| Unknown status | N/A | 300 | RoW | SSRI treated group, fluoxetine_Prozac, paroxetine_Paxil, Seroxat, sertraline_Zoloft | Samsung Medical Center | Depression, Continuous Antidepressant Abuse, Adverse Reaction to Drug | 12/03 | 12/16 | | |
NCT00325000: Interpersonal Psychotherapy for Severely Depressed Inpatients |
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| Terminated | N/A | | Europe | Interpersonal Psychotherapy, sertraline or amitriptyline | German Research Foundation | Major Depression | | 08/04 | | |
NCT00779350: Bioequivalence Study of Sertraline Hydrochloride 100mg Tablets Under Fasting Conditions |
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| Completed | N/A | 36 | US | sertraline 100 mg tablets | Ranbaxy Laboratories Limited | Healthy | 08/05 | 10/05 | | |
NCT00778973: Bioequivalence Study of Sertraline Hydrochloride 100mg Tablets Under Fed Conditions |
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| Completed | N/A | 36 | US | sertraline 100 mg tablets | Ranbaxy Laboratories Limited | Healthy | 09/05 | 10/05 | | |
| Completed | N/A | 100 | US | Sertraline | University of California, San Francisco | Menopause-Hot Flashes | | 01/06 | | |
NCT00263133: Modulation of Visually Evoked Potentials by an Antidepressant |
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| Completed | N/A | 12 | Europe | Sertraline | University Hospital Freiburg | Depression | | 01/06 | | |
NCT00339066: Effect of Brain Lesion Severity on Treatment Response in Late-Life Depression |
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| Completed | N/A | 131 | US | Sertraline | Duke University, National Institute of Mental Health (NIMH) | Depression | 03/06 | 03/06 | | |
| Completed | N/A | 208 | US | Sertraline, Zoloft | University of Pennsylvania, National Institute of Mental Health (NIMH), Duke University | Depressive Disorder, Depression | 04/06 | 04/06 | | |
NCT00057642: Improving Retention of Hispanics Receiving Antidepressant Therapy |
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| Completed | N/A | 50 | US | Sertraline, Venlafaxine Extended Release | New York State Psychiatric Institute, National Institute of Mental Health (NIMH) | Depression, Depressive Disorder | 08/06 | 08/06 | | |
NCT00284791: Lamotrigine in Treatment Resistant Depression in Adolescents |
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| Terminated | N/A | 50 | US | Lamotrigine (drug), Fluoxetine (drug), sertraline (drug) | MaineHealth, GlaxoSmithKline | Adolescent Depression | 02/07 | 02/07 | | |
NCT01352559: Prediction of Antidepressant Response Using Pharmacogenetics and Peripheral Lymphocytic Phenotype |
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| Unknown status | N/A | 1000 | RoW | responders, fluoxetine_Prozac, paroxetine_Paxil, Seroxat, sertraline_Zoloft, milnacipran, venlafaxine_Effexor, nortriptyline_Aventyl, Pamelor, Noritren, mirtazapine_Avanza, Zispin, Remeron, non-responders, SSRI nonresponders | Samsung Medical Center | Depression | 03/07 | 12/18 | | |
NCT00169988: Antidepressant and Antipsychotic to Treat Attenuated Positive and Negative Symptoms |
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| Completed | N/A | 8 | US | risperidone, sertraline-primary | Northwell Health, Stanley Medical Research Institute, Janssen Pharmaceutica N.V., Belgium, Pfizer | Prodromal Schizophrenia, Psychotic Disorders | | 04/07 | | |
NCT00406952: Study for Evaluating Different Methods of Measuring Depression Treatment Response |
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| Completed | N/A | 165 | US | electronic diary, Sertraline, Placebo, voice acoustics | Pfizer | Depressive Disorder, Major | | 08/07 | | |
NCT00208585: Sertraline vs. Placebo for Symptoms Following Traumatic Brain Injury |
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| Unknown status | N/A | 100 | US | sertraline | Walter Reed Army Medical Center, The Defense and Veterans Brain Injury Center, Minneapolis Veterans Affairs Medical Center, VA Palo Alto Health Care System, Hunter Holmes McGuire VA Medical Center, United States Naval Medical Center, San Diego, James A. Haley Veterans Administration Hospital, 59th Medical Wing | Traumatic Brain Injury | | 12/07 | | |
NCT00245557: Magnetic Resonance Imaging Study of Geriatric Depression |
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| Completed | N/A | 43 | US | Sertraline, Zoloft | Mclean Hospital, Pfizer, National Alliance for Research on Schizophrenia and Depression | Major Depressive Disorder | 08/08 | 08/08 | | |
NCT00585455: Vascular Effects of Sertraline in Heart Failure |
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| Terminated | N/A | 4 | US | sertraline | Yale University, Pfizer | Heart Failure, Depression | 07/09 | 07/09 | | |
| Terminated | N/A | 7 | Europe | ziprasidone, sertraline | Universitätsklinikum Hamburg-Eppendorf | Post-traumatic Stress Disorder | 08/09 | 06/10 | | |
AFADTRMDD, NCT01454635: Analisis of Facors Involved in Antidepressant Treatment Response of Major Depressive Disorder |
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| Completed | N/A | 96 | Japan | Sertraline, J Zoloft® | Showa University | Major Depressive Disorder | 03/10 | 03/10 | | |
NCT00944996: Assessment of Pituitary Adenylate Cyclase Activating Polypeptide-Brain Derived Neurotrophic Factor (PACAP-BDNF) Signaling System Involvement in Etiology and Treatment of Major Depression |
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| Completed | N/A | 100 | RoW | SSRI; SNRI; TCA, paroxetine, fluoxetine, sertraline, escitalopram, citalopram, mirtrazapine, venlafaxine, anafranil | Tirat Carmel Mental Health Center, University of Michigan, Ariel University, The Nazareth Hospital, Israel | Major Depression | 06/10 | 07/12 | | |
NCT01028482: Treatment of Postpartum Depression With Psychotherapy and Add-on Sertraline |
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| Completed | N/A | 42 | RoW | Sertraline, placebo, psychotherapy | Tel-Aviv Sourasky Medical Center | Postpartum Depression | 11/10 | 01/11 | | |
NCT00872131: Identifying Brain and Genetic Markers of Sertraline Treatment Response in People With Social Anxiety Disorder |
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| Completed | N/A | 200 | US | Sertraline, Zoloft | University of Michigan, National Institute of Mental Health (NIMH) | Anxiety Disorders | 05/11 | 08/11 | | |
NCT00421369: Augmentation of the Antidepressant Action of Sertraline With Triiodothyronine (T3)and Reboxetine: Clinical Efficacy, Adverse Effects and Predictors of Response. |
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| Completed | N/A | 35 | RoW | sertraline, triiodothyronine (T3), reboxetine | Hadassah Medical Organization | Major Depressive Disorder | | 08/11 | | |
NCT00605917: Special Investigation Of J Zoloft For Panic Disorder Patients |
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| Completed | N/A | 997 | NA | Sertraline hydrochloride, J Zoloft, Zoloft | Pfizer's Upjohn has merged with Mylan to form Viatris Inc. | Panic Disorder | 09/11 | 09/11 | | |
| Completed | N/A | 2272 | NA | Sertraline hydrochloride, J Zoloft, Zoloft | Pfizer's Upjohn has merged with Mylan to form Viatris Inc. | Panic Disorder, Depression | 09/11 | 09/11 | | |
NCT00605813: Special Investigation Of Long Term Use Of Sertraline. |
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| Completed | N/A | 542 | NA | Sertraline hydrochloride, J Zoloft, Zoloft | Pfizer's Upjohn has merged with Mylan to form Viatris Inc. | Depression, Panic Disorder | 09/11 | 09/11 | | |
NCT01032434: An 8-week, Open-label Study to Evaluate the Effect of Sertraline on Polysomnogram in Depressive Patients With Insomnia |
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| Completed | N/A | 31 | RoW | sertraline, zoloft | Guang Dong Provincial Mental Health Institute | Depression | 05/12 | 05/12 | | |
NCT01385709: The Influence of the Menstrual Cycle on Lithium and Sertraline Blood Levels |
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| Completed | N/A | 29 | US | | Weill Medical College of Cornell University | Bipolar Affective Disorders, Cyclothymic Disorder, Schizoaffective Disorder, Major Depressive Disorder, Dysthymic Disorder, Obsessive-Compulsive Disorder, Panic Disorder, Posttraumatic Stress Disorder, Premenstrual Dysphoric Disorder, Social Anxiety Disorder | 08/12 | 08/13 | | |
NCT01607593: A Retrospective And Multicenter Survey To Investigate The Dosage, Efficacy And Safety Of Sertraline In Posttraumatic Stress Disorder Patients |
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| Completed | N/A | 123 | Japan | sertraline (Zoloft) | Pfizer's Upjohn has merged with Mylan to form Viatris Inc. | Posttraumatic Stress Disorder | 10/12 | 10/12 | | |
NCT01437189: The Effects of Sertraline on Depression in Parkinson's Disease |
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| Completed | N/A | 35 | RoW | Sertraline, Zoloft | Zhejiang University | Depression, Parkinson's Disease | 08/13 | 11/13 | | |
NCT01467804: Randomized Double Blinding Controlled Study on" Jia Wei Xiao Yao Jiaonang" Treating Mild to Moderate Major Depressive Disorder |
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| Unknown status | N/A | 180 | RoW | Sertraline plus placebo of JWXYJN, JWXYJN plus placebo of Sertraline | Su Rui | Depressive Disorder | 11/12 | 12/12 | | |
NCT01488266: Aripiprazole Augmentation Versus Switching to Different Class of Antidepressants in Major Depressive Disorder |
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| Unknown status | N/A | 90 | RoW | Aripiprazole, abilify, switching to different class of antidepressant, escitalopram, fluoxetine, paroxetine, sertraline, bupropion XL, mirtazapine, venlafaxine, milnacipran, duloxetine | Korea University, Korea OIAA, Taiwan Otsuka Pharm. Co., Ltd | Major Depressive Disorder | 01/13 | 03/13 | | |
| Withdrawn | N/A | 0 | US | Sertraline, Zoloft | Vanderbilt University | Depression | 08/13 | | | |
NCT01027559: fMRI Study of Treatment Changes in Major Depression |
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| Completed | N/A | 97 | US | Sertraline, SRT, Cognitive Behavioral Therapy, CBT | Washington University School of Medicine, National Institute of Mental Health (NIMH) | Major Depression, Treatment | 01/14 | 01/14 | | |
NCT00667121: Tamoxifen in Women With Breast Cancer and in Women at High-Risk of Breast Cancer Who Are Receiving Venlafaxine, Citalopram, Escitalopram, Gabapentin, or Sertraline |
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| Active, not recruiting | N/A | 85 | US | citalopram hydrobromide, escitalopram oxalate, gabapentin, sertraline hydrochloride, tamoxifen citrate, venlafaxine, molecular genetic technique, high performance liquid chromatography, laboratory biomarker analysis, pharmacological study, adjuvant therapy | Mayo Clinic, National Cancer Institute (NCI) | Breast Cancer, Depression, Hot Flashes, Psychosocial Effects of Cancer and Its Treatment | 05/14 | 12/24 | | |
NCT01896349: Interpersonal Psychotherapy for Treatment Resistant Depression |
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| Unknown status | N/A | 74 | RoW | IPT+ antidepressant drugs, Interpersonal Psychotherapy, Antidepressant drugs, fluoxetine, sertraline, paroxetine, Citalopram, escitalopram, fluvoxamine, Venlafaxine, Duloxetine, Bupropion, Lithium, Risperidone, tranylcypromine, Imipramine, amitriptyline, Clomipramine, nortriptyline, trazodone, Mirtazapine, sulpiride | Hospital de Clinicas de Porto Alegre | Treatment Resistant Depression | 08/14 | 11/14 | | |
| Completed | N/A | 3255526 | Canada | Duloxetine, Venlafaxine, Desvenlafaxine, Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline | Canadian Network for Observational Drug Effect Studies, CNODES, Drug Safety and Effectiveness Network, Canada, Canadian Institutes of Health Research (CIHR) | Depression, Acute Kidney Injury | 12/14 | 12/14 | | |
NCT01160588: Brain Markers of Anxiety Disorders and SSRI/CBT Treatment in Children and Adolescents |
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| Completed | N/A | 156 | US | Sertraline, Zoloft | University of Michigan, National Institute of Mental Health (NIMH) | Social Phobia, Generalized Anxiety Disorder, Separation Anxiety Disorder | 03/15 | 03/15 | | |
NCT02235064: Prophylactic Use of Postpartum Sertraline to Prevent Postpartum Depression |
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| Terminated | N/A | 2 | US | Sertraline, Zoloft, Placebo, Cellulose powder | The Cooper Health System | Depression, Postpartum | 07/15 | 07/15 | | |
NCT02285699: The Gut Microbiota in Obsessive-Compulsive Disorder |
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| Completed | N/A | 43 | Canada | SSRIs, Fluoxetine, Paroxetine, Fluvoxamine, Escitalopram, Citalopram, Sertraline | McMaster University, Hamilton Health Sciences Corporation | Obsessive-Compulsive Disorder | 03/16 | 03/16 | | |
NCT01943435: Study Comparing 3 Different Treatments for Arthritis of the Lower Back (Lumbar Spinal Stenosis) |
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| Completed | N/A | 259 | US | NSAIDs; adjunctive analgesics; adjunctive anti-depressants, ibuprofen, celecoxib, diclofenac, misoprostol, acetaminophen, tramadol, gabapentin, nortriptyline, duloxetine, sertraline, trazodone, mirtazapine, Lumbar epidural injection, Joint Mobilizations (spine, sacroiliac, hip), Individualized exercises: clinical setting, Group Exercise: community setting | Michael Schneider, DC, PhD, Patient-Centered Outcomes Research Institute | Lumbar Spinal Stenosis | 06/16 | 06/16 | | |
| Not yet recruiting | N/A | 80 | | Acupuncture group of patients will be treated 2 times a week, 30 minutes per time.We use Yintang and Baihui witch are verified to be effective in our previous study, and the match points are Taichong, Neiguan, Zusanli, Shenmen, Sanyinjiao. The parameter of electric acupuncture: frequency of 20Hz. The current intensity is based on the slightly shaking in the skin. ;We use SSRIs antidepressants including fluoxetine,Paroxetine, fluvoxamine, sertraline and citalopram. The dosage was follow the doctor's advice. | Peking University Sixth Hospital; Beijing University of Chinese Medicine, Self-raised funds | Depression | | | | |
PG, NCT00817011: Development of Pharmacogenomic Method to Predict Antidepressant Responsiveness |
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| Unknown status | N/A | 1000 | RoW | SSRI treated group, Other Names:, fluoxetine_Prozac, paroxetine_Paxil, Seroxat, sertraline_Zoloft, citalopram_Celexa, non-SSRI treated group, venlafaxine_Effexor, nortriptyline_Aventyl, Pamelor, Noritren, mirtazapine_Avanza, Zispin, Remeron, bupropion_amfebutamone, Wellbutrin, Zyban, duloxetine_Cymbalta, Yentreve, trazodone_Desyrel, Beneficat, Deprax | Samsung Medical Center | Depression, Antidepressant Drug Adverse Reaction | 12/16 | 03/18 | | |
ChiCTR1800017255: The Effect of The Integrated Traditional Chinese and Western Medicine in the Prevention and Control for Post-traumatic Stress Disorder |
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| Completed | N/A | 360 | | sertraline+fake acupoint stimulation control ;cognitive behavioural therapies ;acupoint stimulation control ;sertraline+acupoint stimulation control ;acupoint stimulation control ;ognitive behavioural therapies | Tongde Hospital of Zhejiang Province; Tongde Hospital of Zhejiang Province, Science and Technology Department of Zhejiang Province | post-traumatic stress disorder | | | | |
NCT02739061: The Study of the Pathogenesis and Cognitive Behavioral Group Therapy in Obsessive-Compulsive Disorder |
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| Completed | N/A | 142 | RoW | cognitive behavioral group therapy, sertraline, fluvoxamine, cognitive behavioral group therapy and drug therapy | Shanghai Mental Health Center | Obsessive-Compulsive Disorder | 03/17 | 07/17 | | |
NCT03126188: Study of the Effect of Antidepressant Drugs on Neurotrophic Factors in Patients With Depression |
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| Completed | N/A | 105 | RoW | Sertraline, Dosulepin, Venlafaxine | All India Institute of Medical Sciences, Bhubaneswar | Depressive Episode | 12/17 | 02/18 | | |
NCT01305889: The Effect of Problem Solving Therapy and Antidepressant Therapy on Cerebral Perfusion and Brain Derived Neurotropic Factor (BDNF) in Depressed Elders |
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| Completed | N/A | 19 | US | problem solving therapy, PST, Sertraline, SSRI | University of California, San Francisco, Leon J. Epstein Endowment | Major Depressive Disorder | 02/18 | 02/18 | | |
NCT02441387: Predictors of the Outcome of Late Life Depression |
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| Unknown status | N/A | 120 | RoW | Antidepressant, zoloft, lexapro, efexor, remeron, carbolithium, Psychoeducation, Treatment as usual (only pharmacological treatment). | University of Sao Paulo General Hospital, Fundação de Amparo à Pesquisa do Estado de São Paulo | Major Depression | 03/18 | 07/19 | | |
| Completed | N/A | 104 | NA | Sertraline or venlafaxine, Immune parameters | Kliniken Essen-Mitte, University of Bordeaux, IRCCS Centro San Giovanni di Dio Fatebenefratelli, Ruhr University of Bochum, National Research Agency, France, Créteil Hospital, German Federal Ministry of Education and Research, Ministry of Health, Italy | Depressive Disorder, Depression, Inflammation | 03/18 | 03/18 | | |
CODIACSQoL, NCT01993017: Comparison of Depression Identification After Acute Coronary Syndrome: Quality of Life and Cost Outcomes |
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| Completed | N/A | 1501 | US | Cognitive Behavioral Therapy (CBT), Problem Solving Therapy (PST), Antidepressant Medication, Sertraline, Bupropion, Standard Care, Depressive symptom screener, PHQ-8, No intervention | Columbia University, National Heart, Lung, and Blood Institute (NHLBI), Duke University, HealthPartners Institute, Kaiser Foundation Research Institute | Acute Coronary Syndrome, Depressive Symptoms | 07/18 | 07/19 | | |
NCT03179839: The Study of Mindfulness Based Cognitive Therapy and Obsessive-Compulsive Disorder |
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| Completed | N/A | 123 | RoW | Mindfulness-based Cognitive Therapy, Psycho-education Program, sertraline, fluvoxamine | Shanghai Mental Health Center | Obsessive-Compulsive Disorder | 11/18 | 07/19 | | |
NCT01352572: Effects of Antidepressant on Postsynaptic Signal Transduction in Serotonergic System of Depressed Patients |
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| Unknown status | N/A | 300 | RoW | antidepressant response, fluoxetine_Prozac, paroxetine_Paxil, Seroxat, sertraline_Zoloft, milnacipran, venlafaxine_Effexor, nortriptyline_Aventyl, Pamelor, Noritren, mirtazapine_Avanza, Zispin, Remeron, antidepressant non-response, fluoxetine, paroxetine, sertraline, milnacipran, venlafaxine, nortriptyline, mirtazapine | Samsung Medical Center | Depression | 12/18 | 12/18 | | |
NCT00817375: Pharmacogenomic Study to Predict Antidepressant Responsiveness in Depressed Patients |
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| Unknown status | N/A | 1000 | RoW | SSRI treated group, fluoxetine_Prozac, paroxetine_Paxil, Seroxat, sertraline_Zoloft, non-SSRI treated group, milnacipran, venlafaxine_Effexor, nortriptyline_Aventyl, Pamelor, Noritren, mirtazapine_Avanza, Zispin, Remeron | Samsung Medical Center | Depression, Adverse Reaction to Drug | 12/18 | 12/18 | | |
NCT01228357: Predict Antidepressant Responsiveness Using Pharmacogenomics |
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| Unknown status | N/A | 1000 | RoW | SSRI treated group, fluoxetine_Prozac, paroxetine_Paxil, Seroxat, sertraline_Zoloft, non-SSRI treated group, milnacipran, venlafaxine_Effexor, nortriptyline_Aventyl, Pamelor, Noritren, mirtazapine_Avanza, Zispin, Remeron | Samsung Medical Center | Depression, Depressive Symptoms | 12/18 | 12/18 | | |
NCT04076371: The Treatment Efficacy of Combination Atypical Antipsychotics With Sertraline in Patients With Schizophrenia |
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| Completed | N/A | 1640 | NA | olanzapine-sertraline combination, olanzapine-sertraline, only olanzapine, risperidone-sertraline combination, risperidone-sertraline, only risperidone, paliperidone-sertraline combination, paliperidone-sertraline, only paliperidone, ziprasidone-sertraline combination, ziprasidone-sertraline, only ziprasidone | Beijing HuiLongGuan Hospital | Schizophrenia | 12/18 | 12/18 | | |
| Terminated | N/A | 15 | US | Sertraline, Placebo | Duke University | COPD, Anxiety, Depression, Stress, Interstitial Lung Disease | 02/19 | 02/19 | | |
NCT02893371: Longitudinal Comparative Effectiveness of Bipolar Disorder Therapies |
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| Terminated | N/A | 1037352 | US | Lithium Carbonate, Lithobid, Lamotrigine, Lamictal, Valproic Acid, Depakote, Valproate, Oxcarbazepine, Trileptal, Carbamazepine, Equetro, Ziprasidone, Geodon, Risperidone, Risperdal, Quetiapine, Seroquel, Olanzapine, Zyprexa, Aripiprazole, Abilify, Fluoxetine / Olanzapine, Symbyax, Haloperidol, Haldol Decanoate, Perphenazine, Trilafon, Clozapine, Clozaril, Asenapine, Saphris, Lurasidone, Latuda, Paliperidone, Invega, Mirtazapine, Remeron, Remeronsoltab, Bupropion, Zyban, Aplenzin, Wellbutrin, Desvenlafaxine, Pristiq, Desfax, Duloxetine, Cymbalta, Irenka, Venlafaxine, Effexor XR, Citalopram, Celexa, Escitalopram, Lexapro, Fluoxetine, Prozac, Sarafem, Fluvoxamine, Faverin, Fevarin, Floxyfral, Dumyrox, Luvox, Paroxetine, Paxil, Seroxat, Sertraline, Zoloft, Vilazodone, Viibryd, Doxepin, Sinequan, Silenor | University of New Mexico, Patient-Centered Outcomes Research Institute, Montana State University, National Alliance on Mental Illness Montana, CGStat LLC, Risk Benefit Statistics LLC, National Alliance on Mental Illness New Mexico, National Alliance on Mental Illness Westside Los Angeles | Bipolar Disorder | 06/19 | 06/19 | | |
TSOS6, NCT02655354: A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and Comorbidity |
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| Completed | N/A | 635 | US | Motivational Interviewing, Cognitive Behavioral Therapy Elements, Care Management, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Citalopram, Venlafaxine, Duloxetine, Mirtazapine, Diphenhydramine, Trazodone, Prazosin | University of Washington, National Institutes of Health (NIH), National Institute of Mental Health (NIMH), National Institute on Alcohol Abuse and Alcoholism (NIAAA) | Posttraumatic Stress Disorder, Depression, Alcohol-Related Disorders, Suicidal Ideation, Substance-Related Disorders, Mild Cognitive Impairment, Quality of Life, Pain, Wounds and Injury, Brain Injuries, Chronic Disease | 11/19 | 11/19 | | |
NCT02189213: Treatment of Pediatric Anxiety Disorders by Predicting Treatment Response Through Biocellular Markers and Sleep |
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| Terminated | N/A | 14 | US | Sertraline, Zoloft | New York State Psychiatric Institute, Columbia University | Generalized Anxiety Disorder, Separation Anxiety Disorder, Social Phobia | 12/19 | 12/19 | | |
ChiCTR-ROB-17013747: Identification of miRNAs as serum markers for the treatment effect of panic disorder |
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| Not yet recruiting | N/A | 100 | | treatment with sertraline | the People's Hospital of Sichuan Province; the People's Hospital of Sichuan Province, Supported by the Western psychiatry association fund projects | panic disorder | | | | |
ChiCTR2000036464: Study on pain-related potentials and event-related potentials of recurrent transcranial magnetic stimulation combined with sertraline hydrochloride in the treatment for depressive disorder with somatic pain |
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| Completed | N/A | 120 | | rTMS ;Sertraline (75mg/d) ;Nil | West China Hospital of Sichuan University; West China Hospital, Sichuan University, raise independently | Major disorder depressive | | | | |
ChiCTR1800014277: The cohort study on the auricular electro-acupuncture treating the Treatment-resistant depression |
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| Recruiting | N/A | 88 | | Auricular electro-acupuncture plus Sertraline versus Sertraline alone | Guang An Men Hospital of China Academy of Chinese Medical Sciences; Guang An Men Hospital of China Academy of Chinese Medical Sciences, National Natural Science Foundation of China | Treatment-resistant depression | | | | |
NCT02955719: CAMH - McMaster Collaborative Care Initiative For Mental Health Risk Factors In Dementia |
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| Completed | N/A | 145 | Canada | Sertraline, zoloft, Venlafaxine, effexor, CBT/Psychological Therapy, Psychiatric Consultation, Lifestyle Intervention Resources | Centre for Addiction and Mental Health, McMaster University | Depression, Anxiety, Mild Cognitive Impairment | 07/20 | 07/20 | | |
| Completed | N/A | 941 | US | sertraline, psychotherapy | Pfizer's Upjohn has merged with Mylan to form Viatris Inc. | Obsessive Compulsive Disorder | 09/20 | 09/20 | | |
NCT04430556: Brain Hippocampal Volume Relationship With Anxious Symptoms in Major Depressive Patients |
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| Unknown status | N/A | 30 | RoW | Sertraline | Hospital Universitario Dr. Jose E. Gonzalez, Instituto de Información e Investigación en Salud Mental A. C. | Major Depressive Disorder, Anxiety Disorders | 12/20 | 12/20 | | |
NCT03841474: The Recovery of Cardiovascular Patients With Depression |
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| Recruiting | N/A | 150 | RoW | Psychiatric treatment with sertraline, Intervention I, Psychiatric treatment with escitalopram, Intervention II | KliniÄki BolniÄki Centar Zagreb | Coronary Artery Disease, Depression, Cardiovascular Diseases | 06/21 | 11/21 | | |
NCT04962841: Nutraceuticals and Drug Treatment in Frail Older Adults |
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| Recruiting | N/A | 485 | Europe | Nutraceuticals, empaglifozin, nebivolol, sertraline, rivastigmine, metformin, ramipril, amlodipine | University of Campania "Luigi Vanvitelli" | Frailty | 07/21 | 04/23 | | |
ChiCTR2100048534: Early effects of repetitive transcranial magnetic stimulation in combination with sertraline in adolescent patients with first-episode major depressive disorder |
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| Not yet recruiting | N/A | 77 | | repetitive transcranial magnetic stimulation ;sertraline | The First Clinical Medical College of Zhejiang University of Traditional Chinese Medicine; Hangzhou Seventh People's Hospital, clinical research project | adolescent depression | | | | |
ChiCTR2000031610: Clinical study for the improvement of the onset delay of SSRIs antidepressants by ''Shu-Gan Tiao-Shen'' remedy of Acupuncture |
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| Not yet recruiting | N/A | 70 | | Oral sertraline and ''Shugan Tiaoshen'' remedy of Acupuncture ;Oral sertraline and sham acupuncture | The Second Affiliated Hospital of Guangzhou University of traditional Chinese medicine (Guangdong Hospital of traditional Chinese Medicine); The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Sanming Project of Medicine in Shenzhen, SZSM201806077 | Moderate Depression | | | | |
ChiCTR2100051613: Clinical validation of multidimensional intervention treatment and management model of generalized anxiety disorder in general hospital |
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| Not yet recruiting | N/A | 120 | | Sertraline ;Group interpersonal therapy ;Biofeedback therapy | Renji Hospital, Shanghai Jiao Tong University School of Medicine; Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai municipal health commission | Generalized Anxiety Disorder | | | | |
NCT04977544: Virtual Reality Exposure Therapy in the Intensive Treatment of Social Anxiety Disorder |
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| Recruiting | N/A | 200 | RoW | vert, Sertraline | Second Affiliated Hospital, School of Medicine, Zhejiang University | Phobia | 09/22 | 09/22 | | |
ChiCTR2200058710: Dynamic clinical study of brain imaging and epigenetics in antidepressant treatment of depression |
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| Recruiting | N/A | 180 | | Sertraline tablet or Duloxetine enteric-coated capsules ;No | University City Hospital of Chongqing Medical University; University City Hospital of Chongqing Medical University, Self-raised | Major depressive disorder | | | | |
CAR-BIG, NCT04446039: Non-interventional, Retrospective Cohort Study to Explore Antidepressant Treatment in Korea |
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| Completed | N/A | 405349 | RoW | Escitalopram, Paroxetine, Fluoxetine, Mirtazapine, Duloxetine, Sertraline, Venlafaxine, Tianeptine, Vortioxetine, Desvenlafaxine, Bupropion | Pfizer | Major Depression | 11/22 | 11/22 | | |
| Not yet recruiting | N/A | 318 | | Western medicine (Sertraline) ;Western medicine (Sertraline) and Non-invasive TCM(Herbal medicine and auricular acupressure) ;Western medicine (Sertraline) and Comprehensive TCM (Herbal medicine, auricular acupressure, and acupuncture) | Wushan County Hospital of Traditional Chinese Medicine; Wushan County Hospital of Traditional Chinese Medicine, hospital | Major Depressive Disorder | | | | |
ChiCTR2300067298: Efficacy of omega-3 fatty acid adjunctive with sertraline in nonsuicidal self-injury behavior of child and adolescents with major depressive disorder |
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| Not yet recruiting | N/A | 60 | | Sertraline + fish oil capsules ;Sertraline | Chaohu Hospital Affiliated to Anhui Medical University; Chaohu Hospital Affiliated to Anhui Medical University, at my own expense | depression | | | | |
ChiCTR2200055834: Clinical efficacy of self-designed Chaihu Guizhi Decoction on patients with liver Qi stagnation depression and its effect on tryptophan metabolism pathway and intestinal microflora induced by inflammatory factors |
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| Not yet recruiting | N/A | 66 | | Self-made Chaihu Guizhi decoction combined with sertraline hydrochloride ;Sertraline hydrochloride | The First Affiliated Hospital of Guangxi University of Chinese Medicine; The First Affiliated Hospital of Guangxi University of Chinese Medicine, Financial appropriation of Guangxi Department of Health | Depression | | | | |
| Recruiting | N/A | 1000 | | Antidepressants (sertraline, esitalopram, venlafaxine) ;None | Fudan University; The Second Xiangya Hospital of Central South University, Shanghai Municipal Science and Technology Major Project | Major depressive disorder | | | | |
NCT05952713: Comparative Responses to 15 Different Antidepressants in Major Depressive Disorder |
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| Completed | N/A | 73336 | Europe | Antidepressant, sertraline, citalopram, fluoxetine, paroxetine, escitalopram, reboxetine, venlafaxine, duloxetine, mirtazapine, vortioxetine, agomelatine, amitriptyline, imipramine | Mental Health Services in the Capital Region, Denmark, University of Copenhagen | Major Depressive Disorder | 07/23 | 07/23 | | |
NCT05588102: Electronic Training of Elderly Depression With Cognitive Impairment |
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| Recruiting | N/A | 128 | RoW | Selective Serotonin Reuptake Inhibitor（SSRIs，Fluoxetine, paroxetine, fluvoxamine, sertraline, citalopram, escitalopram）, Electronic cognitive training | Capital Medical University | Geriatric Depression, Cognitive Impairment | 01/24 | 01/24 | | |
| Recruiting | N/A | 148 | RoW | Sertraline, Zoloft, Lustral | University of Belgrade, Clinical Centre of Serbia, Institute of Mental Health, Serbia, Military Medical Academy, Belgrade, Serbia | Depressive Disorder, Major | 09/23 | 11/23 | | |
NCT05930912: Psychiatric Orders in Psychoanalytic Treatment of ASD |
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| Active, not recruiting | N/A | 1 | RoW | Psychoanalysis, Psychodynamic analysis, sertraline 50mg, SSRI, Duloxetine 20 MG, SNRI, Cognitive Behavioral Therapy, CBT | Yang I. Pachankis, PhD, S for Science | PTSD, Autism Spectrum Disorder High-Functioning, OCD, Agoraphobia With Panic Attacks, Depression, Unipolar, Depression, Anxiety, Depression and Suicide, Depression, Reactive, Depression; Psychoneurotic, Depression Anxiety Disorder, Panic Disorder With Agoraphobia, Severe Agoraphobic Avoidance and Mild Panic Attacks, Anxiety Disorders, ADHD - Combined Type, Borderline Personality Disorder, Social Anxiety Disorder, Avoidant Personality Disorder, Stockholm Syndrome, Grief, Separation Insecurity | 09/23 | 12/23 | | |
NCT02890212: Selenium as Augmentation Treatment for Sertraline Resistant Major Depression |
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| Suspended | N/A | 60 | RoW | selenium supplementation, placebo | University of Sao Paulo General Hospital | Major Depression | 12/25 | 12/25 | | |
ChiCTR2200056814: Effect of N-acetylcysteine on obsessive-compulsive disorder (OCD) and its effect on SLC1A1 gene polymorphism |
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| Not yet recruiting | N/A | 92 | | Sertraline + acetylcysteine ;Sertraline | Huzhou Third People's Hospital; Huzhou Third People's Hospital, self-funded | obsessive-compulsive disorder | | | | |
| Recruiting | N/A | 1000 | | Antidepressants (fluoxetine, paroxetine, sertraline, fluvoxamine, citalopram, esitalopram, venlafaxine) ;None | West China Hospital, Sichuan University ; West China Hospital of Sichuan University, National Natural Science Foundation of China | depression | | | | |
NCT05544071: the Safety and Effectiveness of Precise rTMS Based on Neuroimaging in the Treatment of Adolescent Depression With Anhedoniadepression With Anhedonia |
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| Recruiting | N/A | 88 | RoW | Transcranial Magnetic Stimulation (TMS), TMS, Sertraline | Xijing Hospital | Major Depressive Disorder, Repetitive Transcranial Magnetic Stimulation | 12/23 | 12/24 | | |
ChiCTR2100042841: A randomized controlled trial for Shugan Tiaoshen integrated program of acupuncture and moxibustion in the treatment of moderate depressive disorder |
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| Recruiting | N/A | 592 | | Acupuncture, Moxibustion, Auricular acupuncture, Sertraline ;sham acupuncture, sham Moxibustion, sham Auricular acupuncture, placebo ;Acupuncture, Moxibustion, Auricular acupuncture, placebo ;sham acupuncture, sham Moxibustion, sham Auricular acupuncture, sertraline | Guangdong Hospital of traditional Chinese Medicine; The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Province Key Field R&D Program——Modernization of Lingnan Traditional Chinese Medicine | Depressive disorder | | | | |
NCT05833399: Correlation of Genetic Variations With Clinical Response in Substance Use Disorder |
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| Recruiting | N/A | 200 | RoW | Quetiapine, olanzapine, mirtazapine, carbamazepine, sertraline, amitriptyline, chlorpromazine and risperidone, Seroquel, Olapex, Remeron, Tegretol, Moodapex, Tryptizol, Neurazine and Apexidone. | Alexandria University | Substance Use Disorders, Substance Dependence | 03/24 | 12/24 | | |
ChiCTR2000030506: Effectiveness of Electro-Acupuncture on treating MDD: a Randomized Controlled Trial |
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| Not yet recruiting | N/A | 240 | | Electroacupuncture (EA) and Placebo pill ;Sham EA and Sertraline ;Sham EA and Placebo pill | Shanghai Seventh People's Hospital, Shanghai University of TCM; Shanghai Seventh People's Hospital, Shanghai University of TCM, Government Sponsor | Major Depressive Disorder | | | | |
LYMPHODEP, NCT06337539: Precision Psychiatry for Depression: Immune Response and Affective Symptoms as Predictors of Response to Antidepressants |
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| Not yet recruiting | N/A | 50 | Europe | SSRI, Sertraline, Citalopram, Escitalopram, Fluoxetine, Paroxetine, Fluvoxamine | Germans Trias i Pujol Hospital | Depression, Inflammation, Antidepressants, Immunity | 12/26 | 07/27 | | |
POPS or POP02, NCT04278404: Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS) |
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| Recruiting | N/A | 5000 | Canada, US | The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:, Aminocaproic acid, Amiodarone, Bosentan, Budesonide, Cefdinir, Cefepime, Ceftazidime, Clindamycin, Clobazam, Dexamethasone, Dexmedetomidine, Dextroamphetamine/Amphetamine, Fosfomycin, Furosemide, Gabapentin, Guanfacine, Hydrocortisone, Labetalol, Meropenem, Metformin, Milrinone, Nalbuphine, Nicardipine, Nifedipine, Oseltamivir, Oxycodone, Risperidone, Sertraline, Sevelamer Carbonate / Sevelamer Hydrochloride, Spironolactone, Terbutaline, Tranexamic acid, Voriconazole, Zolpidem, Azithromycin, Lopinavir/Ritonavir, Ribavirin, Tocilizumab, Anakinra, Aspirin, Canakinumab, Colchicine, Interferon, Remdesivir, Ruxolitinib, Sarilumab, Abatacept, Infliximab | Duke University, The Emmes Company, LLC, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension, Urinary Tract Infections in Children, Hypertension, Pain, Hyperphosphatemia, Primary Hyperaldosteronism, Edema, Hypokalemia, Heart Failure, Hemophilia, Menorrhagia, Insomnia, Pneumonia, Skin Infection, Arrythmia, Asthma in Children, Bronchopulmonary Dysplasia, Adrenal Insufficiency, Fibrinolysis; Hemorrhage, Attention Deficit Hyperactivity Disorder, Multisystem Inflammatory Syndrome in Children (MIS-C), Kawasaki Disease, Coagulation Disorder, Down Syndrome | 09/26 | 09/27 | | |
| Not yet recruiting | N/A | 296 | RoW | Friendship Bench intervention, Antidepressants -Fluoxetine, Antidepressants-Sertraline | University of Bern, University of Zimbabwe, Swiss National Science Foundation | Major Depressive Disorder, Severe Depressive Episode Without Psychotic Symptoms | 12/26 | 02/27 | | |
ChiCTR2200056949: Clinical efficacy of SSRIs in patients with first-episode depression based on serum c-reactive protein levels |
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| Not yet recruiting | N/A | 120 | | Sertraline ;Sertraline ;bupropion | Xiamen Xianyue Hospital; Xiamen Xianyue Hospital, Xiamen Science and Technology Plan Project | depression disorder | | | | |
NCT03511118: Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants |
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| Recruiting | N/A | 1600 | Canada, US | Tranexamic acid (TXA), labetalol, metformin, nifedipine, clindamycin, oxycodone, azithromycin, escitalopram, sertraline, ondansetron, Ciprofloxacin, Doxycycline, Levofloxacin, Methylphenidate, Sumatriptan, Citalopram, Cyclobenzaprine, Furosemide, Gabapentin, Hydrochlorothiazide, Hydroxyurea, Rosuvastatin, Topiramate, Trazodone, Valganciclovir, Venlafaxine, Verapamil, Remdesivir, Anakinra, Tocilizumab, Fluvoxamine, Amoxicillin, Bupropion, Duloxetine, Hydrocodone, Levetiracetam, Paroxetine, Buprenorphine | Duke University, The Emmes Company, LLC, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Lactating Women on Select DOI, Breastfed Infants of Mothers on Select DOI | 09/24 | 09/24 | | |
NCT05923021: Moderate Depressive Disorder With Cheek Acupuncture |
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| Not yet recruiting | N/A | 126 | NA | cheek acupuncture, Sertraline Hydrochloride Tablets | The First Affiliated Hospital of Zhejiang Chinese Medical University | Acupuncture, Depression | 12/24 | 12/24 | | |
ChiCTR2000038013: Study on the clinical effect and mechanism of Jianpi Jieyu Decoction on depressive episode |
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| Recruiting | N/A | 240 | | sertraline ;Jianpi Jieyu decoction ;Sertraline combined with Jianpi Jieyu decoction | Zhejiang Tongde hospital; Tongde Hospital of Zhejiang Province, Pilot project of cooperation between Chinese and Western medicine for national major and difficult diseases | Depressive disorder | | | | |
ChiCTR2100042762: Clinical and Cognitive Neural Mechanism of ''Shugan Tiaoshen'' Integrated Acupuncture and Moxibustion Therapy in the Treatment of Major Depressive Disorder |
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| Recruiting | N/A | 190 | | active integrated Acupuncture and Moxibustion+placebo 50mg/qd ;active integrated Acupuncture and Moxibustion+Sertraline 50mg/qd ;sham integrated Acupuncture and Moxibustion+Sertraline 50mg/qd ;sham integrated Acupuncture and Moxibustion+placebo 50mg/qd ;None ;acupuncture | The Second Affiliated Hospital of Guangzhou University of Chinese Medicine; The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Province Key Field R&D Program—Modernization of Lingnan Traditional Chinese Medicine | Major Depressive Disorder | | | | |
ChiCTR2100053117: Comparative study on clinical characteristics, biomarkers and treatment outcome of mixed major depressive disorder and bipolar II disorder |
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| Recruiting | N/A | 120 | | Sertraline+lithium carbonate ;Sertraline+lithium carbonate | Huzhou Third People's Hospital; Huzhou Third People's Hospital, Self-raised | Affective disorder | | | | |
