| sertraline / Generic mfg. |
| Not yet recruiting | 4 | 200 | | | Professor Jennifer Hudson, Australian Research Council, Macquarie University | Anxiety | | | | |
| Recruiting | 4 | 50 | | | Melbourne Health, Pfizer | Comorbidity of depression and substance use issues | | | | |
| Recruiting | 4 | 2688 | | | Brain Resource, Brain Resource | Major Depressive Disorder (MDD) | | | | |
ACTRN12613000442707: Reducing impulsivity in repeat violent offenders using a selective serotonin reuptake inhibitor (sertraline) |
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| Recruiting | 4 | 460 | | | University of NSW, NHMRC, NSW Department of Communities and Justice | Offending behaviour, Impulsivity, Anger, Aggression | | | | |
NCT00000378: Antidepressant Treatment of Melancholia in Late Life |
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| Completed | 4 | 110 | US | Sertraline, Nortriptyline, nortiptyline | New York State Psychiatric Institute, National Institute of Mental Health (NIMH) | Depression, Melancholia | 06/02 | 06/02 | | |
NCT01114100: The Effects of Treatment With Sertraline for Noncardiac Chest Pain |
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| Completed | 4 | 210 | Europe | sertraline, sertraline, zoloft, placebo | Maastricht University Medical Center, Pfizer | Panic Attacks, Chest Pain, Depression | 12/02 | 12/02 | | |
NCT00208702: Thyroid Medication and Antidepressants for Treating Major Depression |
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| Completed | 4 | 153 | US | Triiodothyronine, Cytomel, Placebo, Sertraline, Zoloft | Emory University, National Institute of Mental Health (NIMH) | Major Depression | 07/03 | 07/03 | | |
NCT00644982: A Comparison of Sertraline Versus Venlafaxine XR in the Treatment of Major Depression |
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| Completed | 4 | 163 | RoW | sertraline, Zoloft, venlafaxine XR | Pfizer's Upjohn has merged with Mylan to form Viatris Inc. | Depressive Disorder, Major | | 09/03 | | |
| Completed | 4 | 80 | US | sertraline | National Institute of Mental Health (NIMH) | Acute Traumatic Stress Disorders, Post-Traumatic Stress Disorders | | 02/04 | | |
NCT00118014: Sertraline and Habit Reversal in the Treatment of Patients With Trichotillomania |
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| Completed | 4 | 75 | US | Sertraline, Habit Reversal Training | Massachusetts General Hospital, Pfizer | Impulse Control Disorders | 04/04 | 08/04 | | |
| Completed | 4 | 262 | US | sertraline | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Major Depression, Diabetes | | 10/04 | | |
NCT00485862: Combination Therapy in Patients With Depression |
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| Completed | 4 | 214 | US | Atomoxetine Hydrochloride, Sertraline, Placebo | Eli Lilly and Company | Depressive Symptoms | | 01/05 | | |
NCT00004554: Sertraline for Alcohol Dependence and Depression |
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| Completed | 4 | 171 | US | naltrexone (Revia), sertraline (Zoloft), Placebo | University of Pennsylvania | Alcoholism, Depression | 08/05 | 02/06 | | |
NCT00229476: Study of Medication and Placebo Response in Major Depression |
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| Completed | 4 | 60 | US | sertraline (Zoloft) | University of California, Los Angeles, Eli Lilly and Company, Pfizer, Massachusetts General Hospital | Depressive Disorder, Major | 03/06 | | | |
| Completed | 4 | 26 | US | Placebo, Sertraline, Zoloft | Massachusetts General Hospital | Posttraumatic Stress Disorder, Depression | 07/06 | 07/06 | | |
NCT00157547: Quantitative EEG (QEEG) as a Predictor of Treatment Outcome in Depression |
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| Completed | 4 | 95 | US | Selective serotonin reuptake inhibitors (SSRI), fluoxetine, sertraline, paroxetine, fluvoxamine, citalopram, escitalopram, venlafaxine | Massachusetts General Hospital, Medtronic - MITG | Major Depressive Disorder | 08/06 | 08/06 | | |
NCT00021528: Sequenced Treatment Alternatives to Relieve Depression (STAR*D) |
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| Completed | 4 | 4000 | US | citalopram, BuproprionSR, buspirone, Lithium, mirtazapine, nortriptyline, sertraline, tranylcypromine, VenlafaxineXR, Cognitive Therapy, T3 (Triiodothyronine) | National Institute of Mental Health (NIMH) | Depression | | 09/06 | | |
NCT00234312: Medications for the Treatment of Dysthymic Disorder and Double Depression |
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| Completed | 4 | 40 | US | escitalopram and sertraline | Oregon Health and Science University, Forest Laboratories | Depression, Dysthymia | 10/06 | 10/06 | | |
NCT00009191: The Depression in Alzheimer's Disease Study (DIADS) |
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| Completed | 4 | | US | Sertraline [Zoloft] | Johns Hopkins University, National Institute of Mental Health (NIMH) | Alzheimer Disease, Depression | 11/06 | 11/07 | | |
NCT00177996: Pharmacotherapy in Depression With Panic Spectrum |
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| Completed | 4 | 30 | US | sertraline hydrochloride, sertraline hydrochloride low versus high dose titration | University of Pittsburgh | Major Depression | 01/07 | 01/07 | | |
NCT00375843: Brain Activity Changes and Treatment Response in Depressed People Who Are Receiving Antidepressant Medication |
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| Completed | 4 | 118 | US | Escitalopram, Lexapro, Sertraline, Zoloft | National Institute of Mental Health (NIMH) | Depression | 06/07 | 03/08 | | |
| Terminated | 4 | 100 | | | Mood Research Foundation (WA) Inc, Mood Research Foundation (WA) Inc. | Heart disease | | | | |
| Completed | 4 | 93 | Canada | Sertraline, zoloft, placebo | Sunnybrook Health Sciences Centre, Medical Research Council | Depression | | | | |
NCT00198094: A Study of Sertraline and Early Alprazolam XR Administration Versus Sertraline Only in Panic Disorder Patients |
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| Completed | 4 | 150 | US | Sertraline and Alprazolam XR | Indiana University School of Medicine, Pfizer, University of Pennsylvania, University of South Florida | Panic Disorder | | 09/07 | | |
NCT00177424: Sertraline for Preventing Post-stroke Depression and Improving Rehabilitation Outcomes |
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| Terminated | 4 | 154 | US | sertraline, Placebo | University of Pittsburgh, National Institute of Mental Health (NIMH) | Cerebrovascular Accident, Depression | 10/07 | 10/07 | | |
NCT00318773: Short-Term Versus Long-Term Treatment for Severe Premenstrual Syndrome (PMS) |
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| Completed | 4 | 174 | US | sertraline | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Premenstrual Syndrome | 12/07 | 02/08 | | |
NCT00159965: Treatments for Psychogenic Nonepileptic Seizures (NES) |
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| Completed | 4 | 38 | US | sertraline, Zoloft, placebo | Rhode Island Hospital, National Institute of Neurological Disorders and Stroke (NINDS) | Convulsion, Non-Epileptic, Conversion Disorder, Depression, Stress Disorders, Post-Traumatic | 06/08 | 06/09 | | |
GCBTVF, NCT00680602: Group Cognitive Behavioral Therapy Versus Fluoxetine for Obsessive-Compulsive Disorder: a Practical Trial |
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| Completed | 4 | 158 | RoW | Group Cognitive Behavior Therapy, behavior therapy, CBT, group psychotherapy, SSRI (fluoxetine, sertraline, paroxetine, citalopram), Prozac, Zoloft, Paxil, Cipramil | University of Sao Paulo, Fundação de Amparo à Pesquisa do Estado de São Paulo | Obsessive Compulsive Disorder | 09/08 | 09/08 | | |
NCT00624013: Treatment of Diabetes and Depression in Hispanics and African Americans and Its Effect on A1c and Quality of Life. |
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| Completed | 4 | 89 | US | sertraline, Zoloft, Placebo | Charles Drew University of Medicine and Science | Diabetes, Depression | 10/08 | 10/08 | | |
TRY FIRST, NCT00666757: A Study Comparing Duloxetine to Other Antidepressants in the Treatment of Severe Depression |
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| Completed | 4 | 750 | US | duloxetine, LY248686, Cymbalta, fluoxetine, citalopram, paroxetine, sertraline | Eli Lilly and Company, Boehringer Ingelheim | Depression | 02/09 | 03/09 | | |
ACTRN12608000559314: Reducing impulsive behaviour in repeat violent offenders using a Selective Serotonin Reuptake Inhibitor (Sertraline) - Pilot study. |
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| Completed | 4 | 20 | | | NSW Justice Health, NSW Justice Health | Impulsivity
Violence | | | | |
NCT01477268: Cognitive Correlates of Antidepressant Treatment Response in Elders |
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| Completed | 4 | 30 | Canada | Zoloft (antidepressant), Sertraline | Unity Health Toronto | Depression | 04/09 | 10/09 | | |
NCT00368550: Sertraline Pharmacotherapy for Alcoholism Subtypes |
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| Completed | 4 | 134 | US | Sertraline, Zoloft, Placebo | UConn Health, National Institute on Alcohol Abuse and Alcoholism (NIAAA) | Alcoholism | 06/09 | 12/09 | | |
NCT00391430: Cognitive Behavioral Therapy Versus Sertraline in the Treatment of Post-Traumatic Stress Disorder |
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| Terminated | 4 | 39 | US | Sertraline, Cognitive behavioral therapy (CBT) | NYU Langone Health, National Institute of Mental Health (NIMH) | Post-Traumatic Stress Disorder | 07/09 | 07/09 | | |
| Completed | 4 | 42 | US | sertraline 50 mg daily, zoloft 50 mg daily, sertraline 100 mg daily, zoloft 100mg daily, Placebo 50 or 100 mg, 50mg or 100mg matching placebo | VA Office of Research and Development | Generalized Anxiety Disorder | 07/09 | 09/09 | | |
NCT00969852: Pharmacokinetics and Pharmacodynamics of Sertraline After Low Dose Administration |
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| Completed | 4 | 10 | RoW | Sertraline, Zoloft(Pfizer) | Seoul National University Hospital, Ministry of Health, Welfare and Family Affairs, Korea National Enterprise for Clinical Trials | Healthy | 08/09 | 03/10 | | |
NCT00677352: A Study Of Sertraline Compared With Paroxetine In The Treatment Of Panic Disorder |
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| Completed | 4 | 321 | Japan | sertraline, Zoloft, JZoloft, Paroxetine, Paxil | Pfizer's Upjohn has merged with Mylan to form Viatris Inc. | Panic Disorder | 01/10 | 02/10 | | |
NCT00519012: Benefits of Switching Antidepressants Following Early Nonresponse |
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| Unknown status | 4 | 200 | Japan | Sertraline to Paroxetine, Paroxetine to Sertraline | Oizumi Hospital | Depression | 12/10 | 12/10 | | |
| Completed | 4 | 149 | Europe | Risperidone, ATC code N05AX 08, Escitalopram, ATC code N06AB 10, Citalopram, ATC code N06AB 04, Sertraline, ATC code N06AB 06, Paroxetine, ATC code N06AB 05 | Sykehuset Innlandet HF, Ullevaal University Hospital, Eikertun Nursing Home, University of Bergen, Innlandet Hospital Trust, Sanderud, Innlandet Hospital Trust, Reinsvoll, Diakonhjemmet Hospital, Sykehuset Telemark, The Nordmøre and Romsdal Hospital Trust, Songdalstunet Nursing Home, Sykehuset Buskerud HF, Kroken Nursing Home, Tromsø, Kløveråsen, Bodø, Bjørgene Omsorgssenter, Haugesund, Alesund Hospital | Dementia | 12/10 | 12/10 | | |
NCT00382291: Effectiveness of Sertraline and Cognitive Behavioral Therapy in Treating Pediatric Obsessive-Compulsive Disorder |
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| Completed | 4 | 56 | US | Regular Titration, Placebo, Slow Titration | University of Florida, National Institute of Mental Health (NIMH) | Obsessive-Compulsive Disorder | 02/11 | 02/11 | | |
ChiCTR-TRC-11001732: short-term Deanxit in combination with Sertraline treats somatic disease accompanied with depressive disorder |
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| Completed | 4 | 68 | | Sertraline and Deanxit ;Sertraline | Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University; Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Natural Science Foundations of Guangdong province (No. 8151008901000027) | somatic disease accompanied with depressive disorder | | | | |
NCT00282828: Improving Treatment Outcomes in Pharmacotherapy of Generalized Social Anxiety Disorder |
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| Completed | 4 | 397 | US, Canada | Sertraline, Venlafaxine, Placebo, Clonazepam | Massachusetts General Hospital, National Institute of Mental Health (NIMH) | Social Phobia | 12/11 | 12/11 | | |
NCT00536198: Evaluating the Effectiveness of Sertraline in Treating Women With Premenstrual Dysphoric Disorder |
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| Completed | 4 | 252 | US | Sertraline, Zoloft, Placebo, Placebo, sugar pill | Yale University, National Institute of Mental Health (NIMH) | Premenstrual Dysphoric Disorder | 02/12 | 02/12 | | |
2012-000547-27: A Pilot Randomised Controlled Trial of Drug Treatment for Depression in Patients undergoing Haemodialysis |
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| Ongoing | 4 | 60 | Europe | Sertraline, Capsule, Sertralin - 1 A Pharma® 50 mg Filmtabletten | East and North Hertfordshire NHS Trust, University of Hertfordshire, National Institute of Health Research, | Major Depressive Disorder in Patients with End Stage Renal Disease, Depression in patients with kidney disease, Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
| Completed | 4 | 38 | US | sertraline, Zoloft, CBT-ip, Combined (sertraline + CBT-ip), Standard Care, TAU, standard care | Rhode Island Hospital, American Epilepsy Society, Epilepsy Foundation, University of Cincinnati, Stanford University | Convulsion, Non-Epileptic, Conversion Disorder, Depression, Stress Disorders, Post-Traumatic, Dissociative Disorders | 12/12 | 06/13 | | |
NCT01309074: Does Pregabalin Improve Symptoms of Anxiety in Patients With Epilepsy? A Comparison With Sertraline |
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| Withdrawn | 4 | 0 | US | Pregabalin-Lyrica, Lyrica., Sertraline, Zoloft. | Rush University Medical Center | Epilepsy, Anxiety | 12/12 | 12/12 | | |
NCT00955474: Seroquel Alone Versus Seroquel With an SSRI for Depression With Psychotic Symptoms |
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| Terminated | 4 | 32 | US | Quetiapine, Quetiapine (generic name): Seroquel (brand name), escitalopram, Lexapro, Sertraline, Zoloft (brand name), Citalopram, Celexa | Massachusetts General Hospital | Major Depressive Disorder With Psychotic Features | 01/13 | 01/13 | | |
NCT00178828: Dynamic Measures of Neurochemistry in Mood Disorders |
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| Completed | 4 | 42 | US | sertraline, bupropion | Vanderbilt University Medical Center | Depression | 04/13 | 04/13 | | |
NCT00834652: Adding an Insulin-Sensitizing Medication to Depression Treatment for People Who Are Depressed and Overweight |
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| Completed | 4 | 206 | US | Sertraline, Zoloft, Metformin | Washington University School of Medicine, National Institute of Mental Health (NIMH) | Depression | 05/13 | 05/13 | | |
| Terminated | 4 | 85 | US | Transdermal Estradiol, Vivelle dot, Climara, Sertraline, Zoloft, Placebo | Northwestern University | Postpartum Depression | 09/13 | 09/13 | | |
| Ongoing | 4 | 60 | Europe | Sertraline, Generic sertraline, Tablet, Sertraline | Hertfordshire Partnership University NHS Foundation Trust, University of Hertfordshire, National Institute of Health Research, Hertfordshire Partnership University Foundation NHS Trust, South West London and St Georges Mental Health NHS Trust, Southern Health NHS Foundation Trust | Obsessive Compulsive Disorder, Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
DCM, NCT01287494: Depression Care Management for Depressed Elders in China Primary Care |
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| Unknown status | 4 | 320 | RoW | Sertraline, Zoloft | Zhejiang University | Depression | 02/14 | 07/14 | | |
| Completed | 4 | 280 | Europe | Sertraline, trauma-focused cognitive behavioural therapy | Caecilie Buhmann | Post-Traumatic Stress Disorder | 04/14 | 04/14 | | |
NCT01178671: Combined Mirtazapine and SSRI Treatment of PTSD: A Placebo-Controlled Trial |
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| Completed | 4 | 38 | US | Mirtazapine, Remeron, Sertraline, Zoloft, Sugar pill, placebo | Research Foundation for Mental Hygiene, Inc., National Institute of Mental Health (NIMH) | Posttraumatic Stress Disorder | 05/14 | 06/14 | | |
| Terminated | 4 | 104 | Europe | C-ECT, Thrymatron System IV device (Somatics, LLC, ISO 13485:2003)., Pharmacotherapy:, Antidepressants:, - Venlafaxine 75-225 mg/d. N06AX16, - Duloxetine 60-120 mg/d. N06AX21, - Imipramine 100-300 mg/d. N06AA02, - Clomipramine 75-225 mg/d. N06AA04, - Nortriptyline 75-200 mg/d. 906AA10, - Sertraline 50-200 mg/d. N06AB06, -Fluoxetine 20-40 mg/d. N06AB03, - Citalopram 20-60 mg/d. N06AB04, - Paroxetine 20-40 mg/d. N06AB05, - Escitalopram 10-20 mg/d. N06AB10, - Mirtazapine 15-45 mg/d. N06AX11, - Mianserin 10-60 mg/d. 906AX03, - Trazadone 50-200 mg/d. 906AX05, - Reboxetin 2-12 mg/d. N06AX18, Antipsychotic drugs, - Olanzapine 2'5-20 mg/d. N05AH03, - Risperidone 0'5-9 mg/d. N05AX08, - Quetiapine 50-600 mg/d. N05AH04, - Aripiprazole 5-30 mg/d. N05AX12, Lithium: 200-1200 mg/d. 905AN01, Anxyiolitics:, - Diazepam 2'5-50 mg/d. N05BA01, - Clorazepate 5-50 mg/d. N05BA05, - Lorazepam 1-10 mg/d. N05BA06, PHARMACOTHERAPY | Hospital Universitari de Bellvitge | Depression | 07/14 | 07/14 | | |
ChiCTR-ONC-12002609: Observation of the efficacy and safety of Sertraline in the treatment of depressive patients comorbid with CHD |
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| Completed | 4 | 200 | | zloft treatment | Beijing Anzhen Hospital of Capital Medical University; Beijing Anzhen Hospital of Capital Medical University, Pfizer Inc | depressive patients comorbid with CHD | | | | |
| Completed | 4 | 207 | Europe | Venlafaxine, Efexor, Sertraline | Charlotte Sonne, Psychiatric Center Ballerup | Post Traumatic Stress Disorder, Depression | 10/14 | 10/14 | | |
| Unknown status | 4 | 1080 | RoW | Escitalopram, Lexapro, Mirtazapine, Remeron, modified electroconvulsive therapy, mECT, repetitive transcranial magnetic stimulation, rTMS, Fluoxetine, Citalopram, Paroxetine, Sertraline, Fluvoxamine, Venlafaxine, Duloxetine, Bupropion, Trazodone | Shanghai Mental Health Center | Major Depressive Disorder | 10/14 | 12/14 | | |
NCT02901249: Cost- Effectiveness and Quality of Life Assessment in Major Depression Disorder |
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| Completed | 4 | 68 | NA | sertraline, Cloridrate of sertraline, Nortriptyline, Cloridrate of nortrytyline, Lithium, Lithium Carbonate | Federal University of Rio Grande do Sul | Depression | 11/14 | 09/15 | | |
NCT02918097: Cost- Effectiveness and Quality of Life Assessment in Bipolar Disorder Depressive Episode |
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| Completed | 4 | 78 | NA | Lithium Carbonate, Carbolitium, Sertraline, Zoloft, Nortriptyline, Pamelor, Risperidone, Risperdal | Federal University of Rio Grande do Sul | Bipolar Disorder | 11/14 | 09/15 | | |
| Unknown status | 4 | 80 | Europe | Paroxetine, Sertraline, Citalopram, Venlafaxine, Amitriptyline, Escitalopram, Amitriptylinoxide, Nortriptyline, Trimipramine | HolsboerMaschmeyer NeuroChemie GmbH, Max-Planck-Institute of Psychiatry | Major Depression | 12/14 | 12/14 | | |
NCT01460212: Magnetic Resonance Imaging Study of Cognitive-Behavior Therapy for Major Depressive Disorder |
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| Unknown status | 4 | 80 | RoW | SSRI antidepressants, fluoxetine (Prozac), sertraline (Zoloft), paroxetine (Paxil), citalopram (Celexa), escitalopram (Lexapro), fluvoxamine (Luvox), Cognitive-Behavior Therapy, cognitive behavioural therapy（CBT） | Nanjing Medical University | Major Depressive Disorder | 12/14 | 10/15 | | |
TMSFOS, NCT02042573: Preliminary Study to Investigate the Effect of rTMS and SSRI Antidepressants on Leukocyte Expression of the C-FOS and DUSP1 Genes in Patients Treated for Depression |
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| Terminated | 4 | 10 | Europe | rTMS, SSRI (SEROPLEX ou ZOLOFT), Genetic samples | Centre Hospitalier Universitaire Dijon | Depression | 06/18 | | | |
NCT01794455: Effects of Cerebral Hypoperfusion and Its Reversal on Late-Life Depression |
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| Terminated | 4 | 1 | US | Sertraline, Zoloft, Candesartan, Atacand | Vanderbilt University | Depression, Hypertension | 03/15 | 03/15 | | |
| Completed | 4 | 2011 | Japan | Sertraline, Mirtazapine | Kyoto University, National Center of Neurology and Psychiatry, Japan | Unipolar Major Depressive Episode | 09/15 | 12/15 | | |
NCT01916824: Effects of Treatment on Decision-making in Major Depression |
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| Completed | 4 | 53 | US | Any FDA Approved Antidepressant, Sertraline, Zoloft, Citalopram, Celexa, Escitalopram, Lexapro, Paroxetine, Paxil, Fluoxetine, Prozac, Vilazodone, Viibryd, Venlafaxine XR, Effexor XR, Desvenlafaxine, Pristiq, Duloxetine, Cymbalta, Bupropion, Wellbutrin, Mirtazapine, Remeron | Emory University | Major Depressive Disorder, Healthy Controls | 12/15 | 12/15 | | |
2006-000105-38: A definitive multi-centre pragmatic randomised controlled double-blind trial of the clinical and cost effectiveness of mirtazapine and sertraline versus placebo for the treatment of depression in dementia presenting in secondary care |
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| Ongoing | 4 | 507 | Europe | Sertraline 50mg, Mirtazapine 15mg tablet, Sertraline 50mg tablet, Mirtazapine 15mg tablet, Sertraline 50mg tablet, Mirtazapine 15mg tablet | King\'s College London (IOP) | Depression in dementia | | | | |
2007-004613-34: Nordic Longterm OCD treatment Study: A Nordic Multicenter treatment study evaluating a stepped care model based on the \"Expert Clinical Guidelines\". The study is performed with no sponsor from pharmaceutical firms. |
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| Ongoing | 4 | 120 | Europe | Sertraline, Zoloft or generic Sertralin preparations, Zoloft or generic Sertralin preparations | The Centre for Child and Adolescent Mental Health, Eastern and Southern Norway (R.BUP) | Obsessive Compulsive Disorder | | | | |
| Ongoing | 4 | 50 | Europe | Paroxetine, Amitriptyline, Clomipramine, Imipramine, Nortriptyline, escitalopram, Citalopram, Fluoxetine, Fluvoxamine, Sertraline, Duloxetine, venlafaxine, EU/1/04/296/002, Seroxat, Tryptizol, Anafranil, Imipramine, Nortrilen, Lexapro, Cipramil, prozac, Fevarin, Zoloft, Cymbalta, Efexor, Seroxat, Tryptizol, Anafranil, Imipramine, Nortrilen, Lexapro, Cipramil, prozac, Fevarin, Zoloft, Cymbalta, Efexor | Isala Klinieken | Pregnant women with psychiatric morbidity and an strong indication for using antidepressants | | | | |
2013-003440-22: What are the indications for Prescribing ANtiDepressAnts that lead to a clinical benefit? PANDA |
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| Ongoing | 4 | 547 | Europe | Sertraline, Sertraline, Sertraline | University College London | depression | | | | |
| Terminated | 4 | 5 | Europe | Sertraline, SSRI, Cognitive Behavioural Therapy, CBT | University College, London, NHS Health Technology Assessment Programme, National Institute for Health Research, United Kingdom | Generalised Anxiety Disorder | 02/16 | 02/16 | | |
ANDROS, NCT02463110: Acute Myocardial Necrosis and Depression: Antiplatelet Effect of Reuptake Inhibition of Serotonin |
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| Terminated | 4 | 2 | Europe | Sertraline, No treatment, Placebo, Placebo one capsule, which can be increased up to 4 capsules per day (maximum dose) for 6 months. | Assistance Publique - Hôpitaux de Paris, Action Research Group | Depression, Coronary Artery Disease | 02/16 | 02/16 | | |
2005-004525-26: Cognitive behavioural therapy vs. sertraline in patients with depression and poorly controlled diabetes mellitus: A randomized controlled trial |
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| Completed | 4 | 350 | Europe | Sertralin-Hexal 50mg Filmtabletten, Sertralin-Hexal 50mg Filmtabletten | Ruhr Universität Bochum | Patients with insulin-treated type 1 or type 2 diabetes mellitus with depression and HbA1c-value >7,5% ICD E14.90 with F32 | | 09/10 | | |
NCT01856127: Does Vilazodone Help With Antidepressant-associated Sexual Dysfunction? |
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| Terminated | 4 | 4 | US | Vilazodone, Viibryd, Sertraline, Zoloft | Thomas Jefferson University, Forest Laboratories | Sexual Dysfunction, Major Depressive Disorder | 06/16 | 06/16 | | |
NCT01896934: Frontal Hypoperfusion Effects on Antidepressant Outcomes in Late-Life Depression |
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| Completed | 4 | 31 | US | Sertraline, Zoloft | Vanderbilt University, National Institute of Mental Health (NIMH) | Major Depressive Disorder | 06/16 | 06/16 | | |
NCT02228005: The Effect of a Selective Serotonin Reuptake Inhibitor on Gait, Balance, and Bone Metabolism in Older Adults |
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| Completed | 4 | 25 | Canada | Sertraline, Zoloft | University Health Network, Toronto | Depression | 07/16 | 07/16 | | |
NCT02504931: Serotonin Selective Reuptake Inhibitor Treatment of Dual Diagnosis Post-traumatic Stress Disorder and Alcohol Problems |
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| Completed | 4 | 49 | US | Sertraline, Zoloft, Placebo, Placebo Control | The University of Texas Health Science Center at San Antonio, STRONG STAR Multidisciplinary PTSD Research Consortium, South Texas Veterans Health Care System, U.S. Army Medical Research and Development Command, United States Department of Defense | PTSD, Alcohol Use Disorder | 08/16 | 12/16 | | |
NCT02520726: PTSD Prevention Study Examining the Efficacy of Sertraline in Burn Victims |
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| Terminated | 4 | 5 | US | Sertraline, Zoloft, Placebo oral capsule | University of Utah | Post-traumatic Stress Disorder | 09/16 | 09/16 | | |
| Ongoing | 4 | 479 | Europe | Mirtazapine Hexal, Sertralin Hexal, Citalopram Hexal, Fluoxetin EG, Tablet, Film-coated tablet, Capsule, Mirtazapine Hexal, Sertralin Hexal, Citalopram Hexal, Fluoxetin EG | PRIMENT Clinical Trials Unit, UCL, National Institute of Health Research | Depression, Depression, Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
| Completed | 4 | 223 | US | Sertraline, Zoloft, Prolonged Exposure Therapy | VA Ann Arbor Healthcare System, U.S. Army Medical Research and Development Command | Posttraumatic Stress Disorder | 12/16 | 05/17 | | |
| Unknown status | 4 | 500 | Europe | SSRI/SNRI, citalopram, duloxetine, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, venlafaxine | Centre Hospitalier Universitaire Vaudois, University Hospital, Geneva, Hospices Civils de Lyon, Central Hospital, Nancy, France | Depressive Disorder, Lactation | 12/16 | 12/18 | | |
| Unknown status | 4 | 100 | RoW | Sertraline, Early Improvement | University of Sao Paulo | Major Depressive Disorder | 01/17 | 01/17 | | |
2016-003325-41: PREemptive Pharmacogenomic testing for Preventing Adverse drug REactions (PREPARE) |
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| Ongoing | 4 | 450 | Europe | Syrup, Tablet, Capsule, hard, Powder for injection, Capsule, Solution for injection, Concentrate for solution for infusion, Powder for solution for infusion, Codeine, Acenocoumarol, Amitriptyline, Aripiprazole, Atomoxetine, Atorvastatine, Azathioprine, Capecitabine, Carbamazepine, Citalopram, Clomipramine, Clopidogrel, Clozapine, Efavirenz, Escitalopram, Flecainide, Flucloxacillin, Fluorouracil, Haloperidol, Irinotecan, Mercaptopurine, Metoprolol, Oxycodone, Paroxetine, Phenprocoumon, Phenytoin, ORAP 1 mg Tabletten, Propafenone, Sertraline, Simvastatin, Tacrolimus, Tamoxifen, Tegafur, Tioguanine, Tramadol, Venlafaxine, Voriconazole, Zuclopenthixol, Ethinylestradiol, ORAP 4 mg Tabletten | Leiden University Medical Center, Leiden University Medical Center | Adverse drug reactions, Side-effects, Not possible to specify | | | | |
| Completed | 4 | 21 | NA | Vortioxetine, Brintellix, Sertraline, zoloft | Universidad Juárez Autónoma de Tabasco | Depression, Type 2 Diabetes Mellitus | 06/17 | 06/18 | | |
NCT02022709: Efficacy of Exposure and Response Prevention(ERP) and SSRIs in Chinese OCD Patients |
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| Completed | 4 | 78 | RoW | Fluoxetine, Prozac, Sertraline, Zoloft, Paroxetine, Seroxat, Citalopram, Cipramil, Fluvoxamine, Luvox, Exposure and Response Prevention, Exposure and Rituals Prevention | Shanghai Mental Health Center, Shanghai Municipal Science and Technology Commission, Shanghai Jiao Tong University School of Medicine | Obsessive-Compulsive Disorder, Anxiety Disorders, Mental Disorders | 11/17 | 03/18 | | |
| Completed | 4 | 269 | Canada, US | Sertraline + Olanzapine, Zyprexa, Sertraline + Placebo, Placebo | Weill Medical College of Cornell University, University of Toronto, University of Massachusetts, Worcester, University of Pittsburgh | Psychotic Depression | 11/17 | 11/17 | | |
| Not yet recruiting | 4 | 80 | | sertraline, 50mg/time, q.d. ;sertraline 50mg/time, q.d.; xiaoyao pill 9g/time, b.i.d. | School of Traditional Chinese Medicine, Southern Medical University; Level of the institution：, Key research project supported by National Natural Science Foundation | depression | | | | |
NCT00182533: Sertraline in Generalized Social Phobia With Co-Occurring Anxiety and Mood Disorders |
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| Terminated | 4 | 170 | Canada | Sertraline, Zoloft, Placebo | Hamilton Health Sciences Corporation, Pfizer | Phobia, Social, Panic Disorder, Agoraphobia, Obsessive-Compulsive Disorder, Anxiety Disorders, Major Depressive Disorder | 01/18 | 01/18 | | |
ATRAX, NCT02641652: A Randomized Controlled Trial of Sertraline in Paroxysmal Arterial Hypertension |
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| Unknown status | 4 | 136 | NA | Sertraline, Placebo | University Hospital Olomouc, Brno University Hospital, St. Anne, University Hospital Ostrava, Tomas Bata Hospital, Czech Republic, Prerov Hospital, Valasske Mezirici Hospital, Thomayer University Hospital, Vsetin Hospital | Hypertension | 06/18 | 12/18 | | |
2012-002817-20: Etude sur l’effet de la stimulation magnétique et des antidépresseurs sur l’expression des gènes C-FOS et DUSP1 des patients traités pour un état dépressif |
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| Not yet recruiting | 4 | 60 | Europe | Capsule, Tablet, ZOLOFT, SEROPLEX | CHU Dijon, DIRC Est | troubles dépressifs majeurs, dépression, Psychiatry and Psychology [F] - Psychological processes [F02] | | | | |
NCT03711708: Relative Bioavailability Study of Zoloft Oral Solution to Zoloft Tablets |
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| Completed | 4 | 36 | RoW | Zoloft Oral Solution, Zoloft tablets | Pfizer's Upjohn has merged with Mylan to form Viatris Inc. | Healthy | 02/19 | 02/19 | | |
| Completed | 4 | 77 | US | Selective serotonin re-uptake inhibitor, Escitalopram or Sertraline, SSRI, Antidepressant medication, Depression treatment, Cognitive Behavioral Therapy, CBT, Depression Treatment, Talk therapy, Combination treatment (SSRI + CBT), Crossover treatment, escitalopram, depression treatment, antidepressant, talk therapy, depression trial | Emory University, National Institute of Mental Health (NIMH) | Depression | 10/19 | 10/19 | | |
| Terminated | 4 | 17 | Europe | Zoloft, ICBT | Katarina Wide | Pregnancy, Moderate Depression | 11/19 | 11/19 | | |
| Unknown status | 4 | 2688 | Europe, US, RoW | Escitalopram, Lexapro, Sertraline, Zoloft, Venlafaxine-XR, Effexor | BRC Operations Pty. Ltd. | Major Depressive Disorder | 12/19 | 12/19 | | |
FEARCON, NCT03068429: Fear Conditioned Response in Healthy Subjects and in OCD Patients Pre and Post Treatment With Sertraline. |
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| Completed | 4 | 69 | RoW | Sertraline Hydrochloride, sertraline 50mg, zoloft | University of Sao Paulo | Obsessive-Compulsive Disorder | 12/19 | 07/20 | | |
ChiCTR1900027004: Role of SERTRALINE (SSRI) Versus DULOXETINE (SSNRI) among depressed total knee arthroplasty candidates: a prospective, randomized, patient selective, double blind study |
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| Not yet recruiting | 4 | 180 | | DULOXETINE ;SERTRALINE ;placebo | Department of Orthopaedic Surgery, West China Hospital, West China Medical School, Sichuan University; West China Hospital, Sichuan University, Ministry of Health Special Scientific Research Projects of China | Total knee arthroplasty | | | | |
ChiCTR1900027005: Compare the effect of DULOXETINE Versus SERTRALINE in THA patients with anxiety and depression: a prospective, randomized, double-blinded study |
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| Recruiting | 4 | 180 | | DULOXETINE ;SERTRALINE ;placebo | West China Hospital, Sichuan University; West China Hospital, Sichuan University, Ministry of Health Special Scientific Research Projects of China | THA | | | | |
NCT04094870: A Pilot Trial of Perinatal Depression Treatment in HIV Infected Women |
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| Completed | 4 | 80 | RoW | Sertraline, SSRI, Interpersonal therapy | University of North Carolina, Chapel Hill, National Institute of Mental Health (NIMH) | Perinatal Depression, HIV-1-infection | 10/20 | 10/20 | | |
ChiCTR1900022904: The influnce of anxiety traits and compulsive beliefs in parents of patients with obsessive-compulsive disorder at different age of onset on treatment |
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| Not yet recruiting | 4 | 40 | | therapeutic dose of sertraline ;therapeutic dose of sertraline | The Second Affiliated Hospital of Guangxi Medical University; The Second Affiliated Hospital of Guangxi Medical University, The Self-financing research project of Guangxi Zhuang Autonomous Region Health and Family Planning Commission | obsessive-compulsive disorder | | | | |
ChiCTR1800020182: A control study for sertraline and agomelatine on insomnia symptoms in patients with depression |
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| Recruiting | 4 | 80 | | agomelatine 25-75mg per day before sleep ;sertraline 50-200mg per day before sleep | Kangci Hospital of Jiaxing; Level of the institution：, Subject funds of Tongxiang | Dpression | | | | |
