Nexletol (bempedoic acid) / Otsuka, Esperion Therap  >>  Phase 3
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6 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Nexletol (bempedoic acid) / Esperion Therap, Otsuka
CLEAR Tranquility, NCT03001076 / 2016-004084-39: Evaluation of the Efficacy and Safety of Bempedoic Acid (ETC-1002) as Add-on to Ezetimibe Therapy in Patients With Elevated LDL-C

Checkmark Association of Bempedoic Acid Administration With Atherogenic Lipid Levels in Phase 3 Randomized Clinical Trials of Patients With Hypercholesterolemia.
Checkmark Efficacy and safety of bempedoic acid added to ezetimibe in statin-intolerant patients with hypercholesterolemia: A randomized, placebo-controlled study.
Completed
3
269
US
Bempedoic acid, ETC-1002, Ezetimibe, Zetia, Placebo, placebo control
Esperion Therapeutics
Hypercholesterolemia, Atherosclerosis, Statin Adverse Reaction
01/18
02/18
CLEAR Harmony, NCT02666664 / 2015-004136-36: Evaluation of Long-Term Safety and Tolerability of ETC-1002 in High-Risk Patients With Hyperlipidemia and High CV Risk

Checkmark Association of Bempedoic Acid Administration With Atherogenic Lipid Levels in Phase 3 Randomized Clinical Trials of Patients With Hypercholesterolemia.
Checkmark [VIRTUAL] Long-term safety and efficacy of bempedoic acid in patients at high risk of atherosclerotic cardiovascular disease: results from the CLEAR Harmony open-label extension study
Checkmark Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol.
Checkmark From 1002-040 trial for hypercholesterolemia
Checkmark From CLEAR Harmony trial in hypercholesterolemia
Completed
3
2230
Europe, Canada, US
ETC-1002, bempedoic acid, Placebo
Esperion Therapeutics
Hypercholesterolemia, Atherosclerotic Cardiovascular Diseases
02/18
03/18
CLEAR Serenity, NCT02988115: Evaluation of the Efficacy and Safety of Bempedoic Acid (ETC-1002) in Patients With Hyperlipidemia and Statin Intolerant

Checkmark Association of Bempedoic Acid Administration With Atherogenic Lipid Levels in Phase 3 Randomized Clinical Trials of Patients With Hypercholesterolemia.
Checkmark From global pivotal Phase 3 CLEAR LDL-C lowering in hypercholesterolemia
Completed
3
345
Canada, US
bempedoic acid, ETC-1002, placebo, placebo control
Esperion Therapeutics
Hypercholesterolemia, Atherosclerotic Cardiovascular Disease, Statin Adverse Reaction
03/18
03/18
CLEAR Wisdom, NCT02991118 / 2016-003486-26: Evaluation of Long-Term Efficacy of Bempedoic Acid (ETC-1002) in Patients With Hyperlipidemia at High Cardiovascular Risk

Checkmark Association of Bempedoic Acid Administration With Atherogenic Lipid Levels in Phase 3 Randomized Clinical Trials of Patients With Hypercholesterolemia.
Checkmark Effect of Bempedoic Acid vs Placebo Added to Maximally Tolerated Statins on Low-Density Lipoprotein Cholesterol in Patients at High Risk for Cardiovascular Disease: The CLEAR Wisdom Randomized Clinical Trial.
Completed
3
779
US
bempedoic acid, ETC-1002, placebo, placebo control
Esperion Therapeutics
Hypercholesterolemia, Atherosclerotic Cardiovascular Disease
08/18
08/18
CLEAR Harmony OLE, NCT03067441 / 2016-004115-12: Assessment of the Long-Term Safety and Efficacy of Bempedoic Acid

Checkmark [VIRTUAL] Long-term safety and efficacy of bempedoic acid in patients at high risk of atherosclerotic cardiovascular disease: results from the CLEAR Harmony open-label extension study
Completed
3
1462
US
bempedoic acid, ETC-1002
Esperion Therapeutics, Inc.
Hypercholesterolemia, Atherosclerotic Cardiovascular Disease
11/19
11/19
CLEAR Outcomes, NCT02993406 / 2016-003485-11: Evaluation of Major Cardiovascular Events in Patients With, or at High Risk for, Cardiovascular Disease Who Are Statin Intolerant Treated With Bempedoic Acid (ETC-1002) or Placebo

Active, not recruiting
3
14014
Europe, Canada, US, RoW
Bempedoic acid 180 mg tablet, ETC-1002, Matching placebo tablet, placebo comparator
Esperion Therapeutics, Inc., The Cleveland Clinic
Cardiovascular Diseases, Statin Adverse Reaction
12/22
12/22

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