Recruiting

4

54

 

American University of Beirut, American University of Beirut

Polycystic ovary syndrome (PCOS)

 

 

Completed

4

25

 

collect blood sample

Institute of Clinical Pharmacology, Central South University; Level of the institution：, Self-funding

hyperlipemia

 

 

Completed

4

120

 

Rosuvastatin+Berberine ;Rosuvastatin

Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine; Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Traditional Chinese Medicine Development of the Three-year Action Plan

coronary heart disease

 

 

Ongoing

4

20

Europe

Crestor, Crestor, Crestor

Cardiff and Vale NHS Trust

New-onset diabetes after transplantation

 

 

Ongoing

4

24

Europe

Rosuvastatin, Crestor, Crestor

UMCN

Rosuvastatin is a proven cholesterol lowering medicine. Apart from it’s cholesterol lowering action, rosuvastatin may also increase tolerance against ischemia-reperfusion injury. We hypothesize that rosuvastatin increases tolerance against ischemia-reperfusion injury by induction of ecto-5’-nucleotidase and thereby increasing adenosine activity.This protective effect of rosuvastatin can be abbrogated by using the adenosine receptor antagonist caffeine.

 

 

Ongoing

4

8

Europe

caffeine, Crestor, Caffeine, Crestor, Caffeine

Department of Pharmacology-Toxicology

mechanism of influence of statins on human adaptive mechanisms in hypoxic circumstances

 

 

Ongoing

4

48

Europe

rosuvastatin, atorvastatin, rosuvastatin, lipitor, rosuvastatin, lipitor

RUNMC

ischemia and reperfusion injuryendothelial dysfunction

 

 

Recruiting

4

300

 

Atorvastatin calcium ;Atorvastatin calcium ;Rosuvastatin calcium ;Rosuvastatin calcium ;Pitavastatin calcium ;Pitavastatin calcium

Second Department of Cadre Ward, General Hospital of Jinan Military Region; General Hospital of Jinan Military Region, PLA GeneralLogistics Department of the Ministry of health care of special research projects(14BJZ27)

atherosclerotic cardiovascular disease

 

 

Recruiting

4

160

RoW

Pravastatin, Pravastatin (Mevalotin), Rosuvastatin, Crestor, Control, placebo

Taipei Veterans General Hospital, Taiwan

Diabetes

12/17

12/22

Not yet recruiting

4

300

 

rosuvastatin

Daping Hospital, Third Military Medical University; Daping Hospital, Externally Sponsored Scientific Research

Coronary heart disease (CHD).hyperlipidemia

 

 

Not yet recruiting

4

44

Europe

Rosuvastatin, Film-coated tablet, Crestor

Centro Hospitalar e Universitário de Coimbra, E.P.E., Astrazeneca-Produtos Farmacêuticos, Lda

Atherosclerosis, namely in the aorta, carotid and coronary arteries, Cardiovascular disease, Diseases [C] - Cardiovascular Diseases [C14]

 

 

Recruiting

4

80

RoW

Atorvastatin Oral Tablet, Rosuvastatin Oral Tablet

Postgraduate Institute of Medical Education and Research, Indian Council of Medical Research

Heart Failure With Reduced Ejection Fraction

06/22

08/22

Active, not recruiting

4

25

US

Rosuvastatin 20mg, Placebo

Minneapolis Heart Institute Foundation

Cardiovascular Risk Factor, Cardiovascular Diseases, Adverse Effect

12/22

12/22

Recruiting

4

48

RoW

The combinations of 10 µg midazolam, 375 µg dabigatran etexilate, 10 µg pitavastatin, 50 µg rosuvastatin, and 100 µg atorvastatin were administered to diabetic patients on an empty stomach.

Peking University Third Hospital

Diabetes

12/25

12/25

Not yet recruiting

4

100

 

receive medium-dose statin daily(atorvastatin 20mg qn or rosuvastatin 10mg qn) ;receive medium-dose statin daily(atorvastatin 20mg qn or rosuvastatin 10mg qn)+once a month, subcutaneous injection of 1 injection of PCSK9 inhibitor each time ;receive medium-dose statin daily(atorvastatin 20mg qn or rosuvastatin 10mg qn)+twice a month, subcutaneous injection of 1 injection of PCSK9 inhibitor each time

The First Affiliated Hospital of Nanjing Medical University; Jiangsu Provincial People's Hospital, Self-funded

acute coronary syndrome

 

 

Recruiting

4

100

 

PCSK9iatorvastatin calcium 20mg/ rosuvastatin calcium 10mg; atorvastatin calcium 20mg/ rosuvastatin calcium 10mg

The Second Affiliated Hospital of the Army Medical University; The Second Affiliated Hospital of the Army Medical University, The patient's normal medical treatment process, examination fees and drug costs shall be borne by themself.

Cerebral vascular disease

 

 

Active, not recruiting

4

2476

US

High dose potent statin, atorvastatin or rosuvastatin, ACE-I (lisinopril) or ARB (losartan), ACE-I or ARB, Aspirin, Lifestyle Counseling, PACE Lifestyle Intervention, Quality of Life Questionnaires, QOL

University of Florida, United States Department of Defense

Coronary Artery Disease

09/24

12/24

Recruiting

4

112

RoW

Rosuvastatin Immediate-Release Tablet (IRT) 10mg, Rosuvastatin orally disintegrating tablet (SUVARO®ODT) 10mg

Yonsei University

Dyslipidemia

07/24

08/24

Recruiting

4

170

 

On the basis of conventional statin therapy, use Repatha subcutaneous injection to treat 1 vial of Q2W ;Atorvastatin 20mg/day or rosuvastatin 10mg/day

Tianjin Medical University General Hospital; Tianjin Medical University General Hospital, Suzhou Industrial Park Xinxin Cardiovascular Health Foundation

Coronary atherosclerosis

 

 

Not yet recruiting

4

216

Europe

Preemptive pharmacogenetic atorvastatin dose based on CPIC guidelines, Preemptive pharmacogenetic simvastatin dose based on CPIC guidelines, Preemptive pharmacogenetic pitavastatin dose based on CPIC guidelines, Preemptive pharmacogenetic rosuvastatin dose based on CPIC guidelines, Preemptive pharmacogenetic pravastatin dose based on CPIC guidelines, Preemptive pharmacogenetic lovastatin dose based on CPIC guidelines, Preemptive pharmacogenetic fluvastatin dose based on CPIC guidelines, Standard of Care (SoC) dosing of atorvastatin, Standard of Care (SoC) dosing of simvastatin, Standard of Care (SoC) dosing of pitavastatin, Standard of Care (SoC) dosing of rosuvastatin, Standard of Care (SoC) dosing of prasavastatin, Standard of Care (SoC) dosing of lovastatin, Standard of Care (SoC) dosing of fluvastatin

Instituto de Investigación Hospital Universitario La Paz, Instituto de Salud Carlos III

Cardiovascular Diseases, Dyslipidemias, Statin Adverse Reaction, Pharmacogenic Myopathy

02/25

03/25

Recruiting

4

60

RoW

Midazolam, dabigatran etexilate, pitavastatin, rosuvastatin and atorvastatin

Peking University Third Hospital

Chronic Kidney Disease

06/24

12/24

Recruiting

4

200

US

Rosuvastatin, Colchicine, Placebo

Massachusetts General Hospital, National Heart, Lung, and Blood Institute (NHLBI)

Coronary Artery Disease

07/26

07/27

Ongoing

3

120

Europe

Tablet

AZIENDA SANITARIA LOCALE DI BARI

Patients with Acute coronary syndrome without up-leveling of ST line.

 

 

Not yet recruiting

3

400

Europe

rosuvastatin, Tablet, Rosuvastatine EG

UZ Leuven, Fonds Wetenschappelijk Onderzoek - Vlaanderen (FWO), Vlaamse Instituut Biotechnologie

There are two population groups, 20 healthy volunteers and at least 165 individuals diagnosed with IBD. Either with remission to mild/moderate active ulcerative colitis or remission to mild Crohn's disease., A bowel disease that are characterized by inflammation with ulcer formation in the lining of large intestine (UC) and/or rest of intestines (CD). Characterized by diarrhea and abdominal cramps., Diseases [C] - Digestive System Diseases [C06]

 

 

Not yet recruiting

3

320

NA

ART, Atorvastatin, Atovastatin adjunct therapy, ART, Rosuvastatin, Rosuvastatin adjunct therapy, ART, No statin, No statin adjunct therapy, Healthy-HIV-negative, HIV-negative controls

Makerere University, University of Oxford, Case Western Reserve University

HIV Infection

06/22

12/22

Recruiting

3

298

RoW

Cipros 10 association, EMS association, Crestor 10 mg, Rosuvastatin 10 mg

EMS

Hypertriglyceridemia, Dyslipidemia

06/24

02/25

Completed

3

50

RoW

Rosuvastatin 20mg

Tanta University

Chemotherapy-induced Cardiotoxicity, Breast Cancer

09/23

09/23

Not yet recruiting

3

46

NA

Rosuvastatin 20 Mg Oral Tablet, Coenzyme Q10 100 MG Oral Capsule

Tanta University

Nonalcoholic Steatohepatitis

02/24

04/24

Recruiting

3

600

RoW

Atorvastatin 40 Mg Oral Tablet, group A, Rosuvastatin 20mg, group B

Kafrelsheikh University

Ischemic Stroke

04/25

05/25

Not yet recruiting

3

240

NA

BERLIM 25/10 association, EMPAGLIFLOZIN, ROSUVASTATIN CALCIUM, BERLIM 25/10 ASSOCIATION PLACEBO, EMPAGLIFLOZIN PLACEBO, ROSUVASTATIN CALCIUM PLACEBO

EMS

Type 2 Diabetes Mellitus, Dyslipidemia

04/25

08/25

Recruiting

3

2700

Europe, Canada

Rosuvastatin Calcium, Rosuvastatin, Placebo Oral Tablet, Placebo

Ottawa Hospital Research Institute

Venous Thromboembolism, Blood Clot, Post Thrombotic Syndrome

01/26

01/27

Recruiting

2/3

80

RoW

Propranolol, Carvedilol, Rosuvastatin, Placebo

Universidade Federal do Rio de Janeiro

Cirrhosis, Portal Hypertension, Variceal Hemorrhage

12/20

12/22

Recruiting

2/3

220

Europe

Rosuvastatin 10mg

Universitaire Ziekenhuizen KU Leuven, Vlaams Instituut Biotechnologie (VIB)

Ulcerative Colitis

11/23

12/23

Ongoing

2

130

Europe

Film-coated tablet

AZIENDA OSPEDALIERO-UNIVERSITARIA PISANA, DIPARTIMENTO CARDIOTORACICO E VASCOLARE UNIVERSITA' DI PISA

Asymptomatic carotid stenosis >80% in patients with baseline LDL cholesterol >120 mg/dL. Stenosi carotidea >80% asintomatica in pazienti con colesterolemia LDL >120 mg/dL., Carotid stenosis Stenosi carotidea, Diseases [C] - Cardiovascular Diseases [C14]

 

 

Ongoing

2

25

Europe

Tritace, Tablet, Film-coated tablet, Capsule, Januvia, Cialis, Lipitor, Zestril, Crestor, Zocor, Coversyl, Tritace, Atacand, Nebilet

European Commission FP7 Health 2010, European Commission FP7 Health 2010

HFpEF patients over 18 years old and concomitant arterial hypertension, overweight or obesity and pulmonary hypertension. Patiënten met HFpEF die ouder zijn dan 18 jaar en tevens lijden aan arteriële hypertensie, overgewicht of obesitas en pulmonale hypertensie., Heart Failure with preserved Ejection Fraction in combination with a high blood pressure, high pulmonary blood pressure and overweight or obesity. Hartfalen met een bewaarde ejectiefractie met daarnaast een hoge bloeddruk, hoge longbloeddruk en overgewicht of zwaarlijvigheid., Diseases [C] - Cardiovascular Diseases [C14]

 

 

Recruiting

2

65

RoW

Rosuvastatin 10mg

Cairo University, German University in Cairo

Cisplatin Adverse Reaction

08/21

08/21

Active, not recruiting

2

8

Canada, US

Rosuvastatin Calcium, Placebo Oral Tablet, Coenzyme Q10, Calcium Carbonate, Vitamin D

Dr. B. Catharine. Craven, The Craig H. Neilsen Foundation, Toronto Rehabilitation Institute, University Health Network, Toronto, University of Miami, Rick Hansen Institute

Spinal Cord Injuries, Osteoporosis, Metabolic Syndrome

12/22

12/22

Recruiting

2

48

RoW

Megestrol Acetate, Rosuvastatin

Fudan University

Endometrial Carcinoma Stage I

08/25

08/25

Recruiting

2

424

RoW

Clopidogrel, Aspirin, Atorvastatin, Rosuvastatin

Chang Gung Memorial Hospital

Acute Stroke, Dual Antiplatelet Therapy, Statin

02/24

07/26

Recruiting

2

256

US

Rosuvastatin, Rosuvastatin 20 mg, Rosuvastatin 10 mg

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), The Cleveland Clinic, Columbia University, Weill Medical College of Cornell University, Duke University, Mayo Clinic, University of Miami, University of Michigan, University of California, San Diego, University of California, San Francisco, LAC+USC Medical Center, Virginia Commonwealth University, National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Cancer Institute (NCI), University of Southern California

Cirrhosis, Cirrhosis, Liver, Cirrhosis Early, Cirrhosis Due to Hepatitis B, Cirrhosis Advanced, Cirrhosis Infectious, Cirrhosis Alcoholic, Cirrhosis, Biliary, Cirrhosis Cryptogenic, Cirrhosis Due to Hepatitis C, Cirrhosis Due to Primary Sclerosing Cholangitis

11/26

11/26

Recruiting

1/2

130

RoW

YN001, Placebo for YN001, Placebo, rosuvastatin calcium tablets, Crestor®

Beijing Inno Medicine Co., Ltd.

Atherosclerotic Cardiovascular Disease

10/24

11/24

Not yet recruiting

1

32

 

Gilead Sciences, Gilead Sciences

Inflammatory Diseases

 

 

Recruiting

1

20

 

rosuvastatin (10mg/d) * 52 weeks

Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences; Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, AstraZeneca Investment (China) Co., Ltd

Nonalcoholic fatty liver disease(NAFLD)

 

 

Completed

1

64

 

Retrospective analysis of pharmacokinetics data and collect 5ml blood for genotying ;Retrospective analysis of pharmacokinetics data and collect 5ml blood for genotying ;Retrospective analysis of pharmacokinetics data and collect 5ml blood for genotying ;Retrospective analysis of pharmacokinetics data and collect 5ml blood for genotying

The 2nd Affiliated Hospital, School of Medicine, Zhejiang University; The Second Affiliated Hospital， School of Medicine，Zhejiang University, Division of Clinical Pharmacology, The 2nd Affiliated Hospital, School of Medicine, Zhejiang University

not disease-related

 

 

Completed

1

24

 

rosuvastatin

Institute of Clinical Pharmacology, Central South University; Institute of Clinical Pharmacology, Central South University, National Natural Science Foundation of China

Hyperlipidemia

 

 

Recruiting

1

20

Europe, RoW

JNJ 56021927, Drug Cocktail, Pioglitazone, Rosuvastatin

Aragon Pharmaceuticals, Inc.

Prostatic Neoplasms, Castration-Resistant

11/16

12/24

Active, not recruiting

1

56

Europe, Canada, US

losartan, dextromethorphan, caffeine, omeprazole, midazolam, rosuvastatin, bupropion immediate release (IR), encorafenib, binimetinib, modafinil

Pfizer, Pierre Fabre Laboratories

Advanced Solid Tumors, Metastatic Melanoma

07/22

06/23

Completed

1

24

US

CC-92480, BMS-986348, Rifampin, Itraconazole, Digoxin, Rosuvastatin

Bristol-Myers Squibb

Healthy Volunteers

11/22

11/22

Recruiting

1

10

Europe

Placebo, Ticagrelor, Rosuvastatin

Helsinki University Central Hospital, University of Helsinki

Pharmacokinetics

12/22

12/22

Completed

1

20

US

Rosuvastatin, ALXN2040

Alexion

Healthy Participants

03/23

04/23