| dabigatran etexilate / Generic mfg. |
2012-002263-96: dabigatran and rivaroxaban: prediction of anticoagulant effect Thrombin predict: Voorspellen van de mate van anticoagulante werking van twee orale anticoagulantia (dabigatran en rivaroxaban) |
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| Ongoing | 4 | 60 | Europe | Film-coated tablet, Capsule, hard, xarelto rivaroxaban, Pradaxa dabigatran | MUMC, MUMC | non valvular atrial fibrillation atriumfibrilleren zonder kleplijden, atrial fibrillation without cardiac valve abnormalities atriumfibrilleren zonder klepafwijkingen, Diseases [C] - Cardiovascular Diseases [C14] | | | | |
ChiCTR-TRC-13003739: dabigatran versus warfarin for intracardiac thrombus (mainly left atrial appendage thrombus) in patients with nonvalvular atrial fibrillation or atrial flutter |
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| Completed | 4 | 40 | | dabigatran 150mg BID p.o. ;maintain INR2-3 | Qilu Hospital, Shandong University; Qilu Hospital, Shandong University, Natural Science Foundation of China (81270238) and Scientific Research Foundation for the Doctoral Degree, State Education Ministry of China (20130131110065) | atrial fibrillation/atrial flutter | | | | |
2013-000474-30: Investigation into the possibilities of finding antidotes for the new oral anti blood clotting agents Suche nach Medikamenten zur Umkehr der Wirkung der neuen oralen Antikoagulantien (NOACs) und neuen Blutplättchen-Hemmer (NOPAIs) |
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| Ongoing | 4 | 120 | Europe | ELIQUIS, Pradaxa, Efient, Xarelto, Brilique, ELIQUIS, Pradaxa, Efient, Xarelto, Brilique | Medizinische Universität Innsbruck / Univ.-Klinik für Allg. u. Chirurg. Intensivmedizin, Medical University Innsbruck | blood coagulation disorders Blutgerinnungsstörungen | | | | |
2014-004357-13: Blod clotting in patients irregular heart rhythm: the effect of dabigatran Blodstørkningen hos personer med uregelmæssig hjerterytme: betydningen af dabigatran behandling |
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| Ongoing | 4 | 25 | Europe | Pradaxa, Pradaxa | Odense University Hospital, None | Atrial fibrillation Atrie flimmer | | | | |
2016-002105-18: Laboratory measurement of direct oral anticoagulants on patients with atrial fibrillation. |
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| Ongoing | 4 | 200 | Europe | Pradaxa, Xarelto, Eliquis, Lixiana, Capsule, Coated tablet, Pradaxa, Xarelto, Eliquis, Lixiana | Helsinki City Hospital Haartman, Helsinki University Hospital | Non-valvular atrial fibrillation, Atrial fibrillation, Diseases [C] - Cardiovascular Diseases [C14] | | | | |
2017-000393-11: Blood thinners for frail elderly with a heart rhythm disorder |
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| Ongoing | 4 | 2750 | Europe | Capsule, hard, Film-coated tablet, Tablet, Dabigatran ( Pradaxa), rivaroxaban (Xarelto), apixaban (Eliquis), edoxaban (Lixiana), acenocoumarol (Sintrom), fenprocumon (Marcoumar) | University Medical Center utrecht, ZonMw, Boehringer-Ingelheim, Bayer Healthcare, BMS Pfizer, Daiichi Sankyo | Atrial Fibrilation, heart rhythm disorder, Diseases [C] - Cardiovascular Diseases [C14] | | | | |
2017-003569-91: The effect of body weight on the medicine concentrations of dabigatran, edoxaban, apixaban and rivaroxaban in blood. |
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| Ongoing | 4 | 160 | Europe | Apixaban, Dabigatran, Edoxaban, Rivaroxaban, EU/1/11/691/001, EU/1/08/442/001, EU/1/15/993/001, EU/1/08/472/025, Coated tablet, Capsule, hard, Eliquis, Pradaxa, Lixiane, Xarelto | Hagaziekenhuis, Hagaziekenhuis | No medical condition will be investigated. This study will only investigate the effect of body weight on through concentrations of direct oral anticoagulants (DOACs), No medical condition will be investigated. This study will only investigate the effect of body weight on the medicine concentrations of dabigatran, edoxaban, apixaban and rivaroxaban in blood., Not possible to specify | | | | |
2018-000753-45: Vitreorretinal surgery with and without oral anticoagulants: results and complications. CirugÃa vitreorretiniana con y sin anticoagulantes orales: resultados y complicaciones |
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| Ongoing | 4 | 96 | Europe | Dabigatran, Apixaban, Rivaroxaban, Edoxaban, Acenocumarol, Enoxaparina, Capsule, hard, Coated tablet, Tablet, Solution for injection, PRADAXA, ELIQUIS, XARELTO, LIXIANA, SINTROM, CLEXANE | NAVARRBIOMED-FUNDACION MIGUEL SERVET, Navarrabiomed-Fundación Miguel Servet | Patients undergoing vitreoretinal surgery under treatment with oral anticoagulants Pacientes con indicación de cirugÃa vitreorretiniana y que estén en tratamiento con anticoagulantes orales, Patients undergoing vitreoretinal surgery under treatment with oral anticoagulants Pacientes con indicación de cirugÃa vitreorretiniana y que estén en tratamiento con anticoagulantes orales, Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Surgical Procedures, Operative [E04] | | | | |
2018-001443-31: DOAC concentrations in blood prior to surgery study: DALI study |
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| Not yet recruiting | 4 | 300 | Europe | Dabigatran, Rivaroxaban, Apixaban, EU/1/08/442/001, EU/1/08/472/025, EU/1/11/691/015, Capsule, hard, Coated tablet, Pradaxa, Xarelto, Eliquis | Leiden University Medical Center, Leiden University Medical Center | No medical condition will be investigated. This study will only investigate DOAC levels during surgery. Patients who use DOACs are patients with venous thrombosis and atrial fibrillation., No medical condition will be investigated. This study will only investigate DOAC levels during surgery. Patients who use DOACs are patients with venous thrombosis and atrial fibrillation., Not possible to specify | | | | |
ChiCTR-IPR-17011973: A Randomized Controlled Study on the Second - level Prevention of Dabigatran and Warfarin in Atrial Fibrillation Associated Ischemic Stroke / TIA Acute Phase |
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| Recruiting | 4 | 370 | | Dabigatran Etexilate 110mg ;Warfarin 1-3mg | The Department of Neurology, The Second Affiliated Clinical Hospital Of Harbin Medical University; The Second Affiliated Clinical Hospital Of Harbin Medical University, Nil | Atrial fibrillation ischemic stroke Atrial fibrillation associated transient ischemic attack | | | | |
2019-001336-62: Anticoagulation for Stroke Prevention In patients with Recent Episodes of perioperative Atrial Fibrillation after noncardiac surgery - The ASPIRE-AF trial |
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| Not yet recruiting | 4 | 2800 | Europe | ELIQUIS, PRADAXA, RIVAROXABAN, EDOXABAN TOSILATO, [B01AF02], [B01AE07], [B01AF01], [edoxaban], Tablet, Capsule, hard, Apixaban 2,5 mg filmovertrukne tabletter, Edoxaban 30 mg filmovertrukne tabletter, Apixaban 5 mg filmovertrukne tabletter, Edoxaban 60 mg filmovertrukne tabletter, Rivaroxaban 15 mg filmovertrukne tabletter, Rivaroxaban 20 mg filmovertrukne tabletter, Dabigatran 110 mg, hårde kapsler | Hamilton Health Sciences Corporation, Population Health Research Institute, Canadian Institute of Health Research, Population Health Reserarch Institute. | Perioperative atrial fibrillation after noncardiac surgery, Fast, irregular heartbeat after noncardiac surgery, Diseases [C] - Cardiovascular Diseases [C14] | | | | |
ChiCTR1800019890: Effect of gene polymorphism on the efficacy of direct oral anticoagulant therapy in patients with venous thromboembolism |
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| Not yet recruiting | 4 | 200 | | Dabigatran ;Rivaroxaban | Shanghai Pulmonary Hospital; Shanghai Pulmonary Hospital, shanghai pulmonary hospital | venous thromboembolism | | | | |
ChiCTR2000029015: A randomized controlled trial of indobufen versus aspirin plus dabigatran after stable coronary artery disease in atrial fibrillation |
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| Not yet recruiting | 4 | 80 | | Indobufen 200mg bid for 6 monh ;Aspirin 100mg qd, and Dabigatran 110mg bid for 6 months | The First Affiliated Hospital of Nanjing Medical University; The First Affiliated Hospital of Nanjing Medical University, Hangzhou Zhongmei Huadong Pharmaceutical Co. Ltd. | Coronary artery disease | | | | |
| Recruiting | 4 | 200 | RoW | Dabigatran Etexilate, Pradaxa | Irina Ermolaeva | Atrial Fibrillation, T2DM (Type 2 Diabetes Mellitus), Chronic Kidney Diseases | 07/21 | 05/22 | | |
2021-005022-18: Preventing formation of blood clots due to atrial fibrillation, a cardiac arrhythmia that first occurred after coronary bypass surgery, with the help of anticoagulant medications. Vorbeugung der Bildung von Blutgerinnseln durch Vorhofflimmern, einer Herzrhythmusstörungen, die nach einer koronaren Bypass-Operation erstmalig aufgetreten ist, mit Hilfe von gerinnungshemmenden Medikatmenten. |
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| Not yet recruiting | 4 | 3200 | Europe | Marcumar, Dabigatran, Xarelto, Apixaban, Edoxaban, Aspirin, Brilique, Clopidogrel, B01AC04, Tablet, Capsule, hard, Marcumar, Pradaxa, Xarelto, Eliquis, Lixiana, Aspirin, Brilique, Clopidogrel | Icahn School of Medicine at Mount Sinai, NIH/NHLBI | New-Onset Post-Operative Atrial Fibrillation afterCABG Neu auftretendes postoperatives Vorhofflimmernnach CABG, New-Onset Post-Operative Atrial Fibrillation aftercoronary artery bypass graft (bridging of constrictions in coronary vessels) Neu aufgetretenes Vorhofflimmern nach einerkoronaren Bypassoperation (Überbrückung von Engstellen in Herzkranzgefäßen), Diseases [C] - Cardiovascular Diseases [C14] | | | | |
2019-002138-35: Heavy menstrual bleeding in premenopausal women treated with direct oral anticoagulants - the MEDEA study |
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| Not yet recruiting | 4 | 120 | Europe | Pradaxa, Cyklokapron, EU/1/08/442, RVG 05574, Capsule, hard, Film-coated tablet, Pradaxa / Dabigatran etexilate, Cyklokapron / Tranexamic acid | Amsterdam University Medical Centers - location AMC, Boehringer Ingelheim International GmBH | Heavy menstrual bleeding associated with direct oral anticoagulants in premenopausal women., Heavy menstrual bleeding associated with direct oral anticoagulants in premenopausal women., Diseases [C] - Female diseases of the urinary and reproductive systems and pregancy complications [C13] | | | | |
2017-000236-34: Early versus Late initiation of direct oral Anticoagulants in post-ischaemic stroke patients with atrial fibrillatioN (ELAN): an international, multicentre, randomised-controlled, two-arm, assessor-blinded trial |
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| Not yet recruiting | 4 | 2000 | Europe | ELIQUIS 5 MG COMPRESSE RIVESTITE CON FILM, PRADAXA 150 MG CAPSULE RIGIDE, XARELTO 20 MG COMPRESSE RIVESTITE CON FILM, LIXIANA 60 MG COMPRESSE RIVESTITE CON FILM, [041225145], [038451100], [038744189], [044315188], Film-coated tablet, Capsule, hard, Xarelto 20 mg film-coated tablets, Pradaxa 150 mg hard capsules, Lixiana 60 mg film-coated tablets, Eliquis 5 mg film-coated tablets | Inselspital (University Hospital) Bern, Insel Gruppe AG, Bern University Hospital, Department of Neurology, Swiss National Science Foundation, Swiss Heart Foundation, Stroke Association | Recurrent strokes in patients with atrial fibrillation who suffered an ischaemic stroke, Recurrent strokes in patients with atrial fibrillation who suffered an ischaemic stroke, Diseases [C] - Cardiovascular Diseases [C14] | | | | |
ChiCTR2000033145: Study on the correlation between protein C system-related protein expression level and the anticoagulant effect of rivaroxaban and dabigatran |
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| Not yet recruiting | 4 | 100 | | 无 ;无 | The Fifth People's Hospital of Shanghai; The Fifth People's Hospital of Shanghai, Scientific Research Project funded by The Fifth People's Hospital of Shanghai | Atrial fibrillation | | | | |
RE-DUAL PCI, NCT04688723: Dual Therapy With Dabigatran/Ticagrelor Versus Dual Therapy With Dabigatran/Clopidogrel in ACS Patients With Indication for NOAC Undergoing PCI |
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| Recruiting | 4 | 1000 | Europe | Dabigatran + Ticagrelor, Dabigatran + clopidogrel | Zuyderland Medisch Centrum, Boehringer Ingelheim | Coronary Artery Disease, Myocardial Ischemia, Myocardial Infarction, Atrial Fibrillation | 12/22 | 07/23 | | |
NCT06273215: Evaluation of the Pharmacokinetics of Microdose Midazolam, Dabigatran, Pitavastatin, Atorvastatin and Rosuvastatin in Diabetic Patients |
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| Recruiting | 4 | 48 | RoW | The combinations of 10 µg midazolam, 375 µg dabigatran etexilate, 10 µg pitavastatin, 50 µg rosuvastatin, and 100 µg atorvastatin were administered to diabetic patients on an empty stomach. | Peking University Third Hospital | Diabetes | 12/25 | 12/25 | | |
ChiCTR2200062928: Effects of oral dronedarone hydrochloride tablets on NOACs concentrations in patients with paroxysmal or persistent atrial fibrillation: a randomized, controlled, single-center clinical study |
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| Not yet recruiting | 4 | 75 | | Amiodarone 200mg qd combined with dabigatran 110mg bid for 1 month ;Dronedarone 400mg bid plus dabigatran 110mg bid for 1 month ;Dabigatran 150mg bid for 1 month ;Amiodarone 200mg qd combined with rivaroxaban 15mg qd for 1 month ;Dronedarone 400mg bid combined with rivaroxaban 15mg qd for 1 month ;Rivaroxaban 20mg qd for 1 month | The First Hospital of China Medical University; The First Hospital of China Medical University, The CSPC Ouyi Pharmaceutical Co., Ltd | Atrial fibrillation | | | | |
| Recruiting | 4 | 1512 | Europe | CE-mark approved LAA closure devices, Acetylsalicylic acid, ASS, Clopidogrel, Dabigatran, Pradaxa®, Rivaroxaban, Xarelto®, Apixaban, Eliquis®, Edoxaban, LIXIANA®, Phenprocoumon, Marcumar®, Warfarin, Coumadin® | Charite University, Berlin, Germany, Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), Atrial Fibrillation Network, Stiftung Institut fuer Herzinfarktforschung | Atrial Fibrillation | 09/23 | 03/25 | | |
NCT04045093: Dabigatran for Mitral Stenosis Atrial Fibrillation |
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| Recruiting | 4 | 370 | RoW | Dabigatran etexilate, Pradaxa, Warfarin | The University of Hong Kong | Atrial Fibrillation, Mitral Stenosis | 09/26 | 09/27 | | |
ANDES, NCT03568890: Short-Term Anticoagulation Versus Antiplatelet Therapy for Preventing Device Thrombosis Following Left Atrial Appendage Closure |
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| Recruiting | 4 | 510 | Canada | Rivaroxaban, dabigatran, apixaban, or edoxaban, Clopidogrel -75 mg/day, Low dose aspirin -80 to 125 mg/day- | Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec | Left Atrial Appendage Closure, Thrombosis, Stroke, TIA, Bleeding | 12/25 | 09/26 | | |
DEA-LAA, NCT03539055: Efficacy of Short Term Dabigatran Etexilate Followed by Aspirin Monotherapy After LAA (Left Atrial Appendage) Device Closure (the Study). |
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| Completed | 4 | 100 | US | Dabigatran Etexilate Oral Capsule, Pradaxa | Vanderbilt University Medical Center, Boehringer Ingelheim | Atrial Fibrillation, Device Related Thrombus, Left Atrial Appendage Thrombosis, Watchman LAA Closure Device | 12/23 | 02/24 | | |
ADONIS-PCI, NCT04695106: Dual Antithrombotic Therapy With Dabigatran and Ticagrelor in Patients With ACS and Non-valvular AF Undergoing PCI |
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| Recruiting | 4 | 2230 | Europe | Ticagrelor, Brilique, Dabigatran Etexilate, Pradaxa, Aspirin, Clopidogrel | Medical University of Gdansk, Medical University of Warsaw, Nicolaus Copernicus University, Institute of Cardiology, Warsaw, Poland, Military Institute of Medicine, Poland, Bielanski Hospital, Medical University of Silesia, Poznan University of Medical Sciences, University of Opole, Poland, Medical University of Łódź, Voivodeship Hospital, Kielce, Poland, Voivode Specialist Hospital in Olsztyn, Poland, Medical University of Lublin, Pomeranian Medical University Szczecin, Central Clinical Hospital of the Ministry of Internal Affairs and Administration, Warsaw, Poland | Atrial Fibrillation, Antithrombotic Therapy, Acute Coronary Syndrome, Percutaneous Coronary Interventions | 03/24 | 03/26 | | |
NCT05747768: A Clinical Study to Evaluate the Pharmacokinetics of Microdose Midazolam, Dabigatran, Pitavastatin, Atorvastatin and Rosuvastatin in Healthy Volunteers and Renal Impairment Patients |
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| Recruiting | 4 | 60 | RoW | Midazolam, dabigatran etexilate, pitavastatin, rosuvastatin and atorvastatin | Peking University Third Hospital | Chronic Kidney Disease | 06/24 | 12/24 | | |
DaRe2THINK, NCT04700826: Preventing Stroke, Premature Death and Cognitive Decline in a Broader Community of Patients With Atrial Fibrillation |
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| Recruiting | 4 | 3000 | Europe | Direct Oral Anticoagulants, apixaban, dabigatran, edoxaban or rivaroxaban | University of Birmingham, Clinical Practice Research Datalink, University Hospital Birmingham NHS Foundation Trust, University of Oxford, London School of Economics and Political Science, Aston University | Atrial Fibrillation | 01/26 | 01/31 | | |
| Recruiting | 4 | 6660 | Europe | Dalteparin Sodium, Tinzaparin Sodium, Enoxaparin Sodium, Rivaroxaban, Apixaban, Dabigatran Etexilate | Imperial College London | Venous Thromboembolism, Varicose Veins | 06/26 | 12/26 | | |
ASPIRE-AF, NCT03968393: Anticoagulation for Stroke Prevention In Patients With Recent Episodes of Perioperative AF After Noncardiac Surgery |
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| Recruiting | 4 | 2270 | Europe, Canada, RoW | Non-vitamin K oral anticoagulant (NOAC), Apixaban, Dabigatran, Edoxaban, Rivaroxaban | Population Health Research Institute, Hamilton Health Sciences Corporation | Stroke, Atrial Fibrillation | 12/26 | 12/28 | | |
DANNOAC-VTE, NCT03129555: The Danish Non-vitamin K Antagonist Oral Anticoagulation Study in Patients With Venous Thromboembolism |
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| Recruiting | 4 | 5000 | Europe | Dabigatran Etexilate Oral Capsule, Rivaroxaban Oral Tablet, Edoxaban Oral Tablet, Apixaban Oral Tablet | Herlev and Gentofte Hospital, Danish Society of Cardiology | Deep Vein Thrombosis, Pulmonary Embolism | 03/27 | 03/29 | | |
DANNOAC-AF, NCT03129490: The Danish Non-vitamin K Antagonist Oral Anticoagulation Study in Patients With Atrial Fibrillation |
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| Recruiting | 4 | 11000 | Europe | Dabigatran Etexilate Oral Capsule, Rivaroxaban Oral Tablet, Edoxaban Oral Tablet, Apixaban Oral Tablet | Herlev and Gentofte Hospital, Danish Society of Cardiology | Atrial Fibrillation, Atrial Flutter | 10/27 | 10/27 | | |
