topotecan / Generic mfg.  >>  Phase 2
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11 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
topotecan / Generic mfg.
NCT02822157 / 2015-005838-22: Circulating Tumor DNA Guiding (Olaparib) Lynparza® Treatment in Ovarian Cancer

Active, not recruiting
2
160
Europe
Olaparib, Lynparza, carboplatin + gemcitabine or carboplatin + paclitaxel or carboplatin + liposomal doxorubicin or liposomal doxorubicin 4-weekly or topotecan or paclitaxel weekly
Universitaire Ziekenhuizen Leuven, AstraZeneca
Ovarian Epithelial Cancer
07/21
07/23
BEACON, NCT02308527 / 2012-000072-42: Activity Study of Bevacizumab With Temozolomide ± Irinotecan for Neuroblastoma in Children

Active, not recruiting
2
225
Europe
Bevacizumab, Avastin, Temozolomide, Temodal, Irinotecan, Campto, Topotecan, Dinutuximab Beta, Qarziba, Cyclophosphamide
University of Birmingham, Cancer Research UK, Roche Pharma AG, Imagine for Margo, EUSA Pharma, Inc.
Neuroblastoma
08/21
02/26
2021-004807-42: A Phase 2 Study of MORAb-202 in Platinum-resistant High-grade Serous Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Estudio en fase II de MORAb-202 en el cáncer seroso de alto grado resistente al platino, de ovario peritoneal primario o de trompas de Falopio

Not yet recruiting
2
150
Europe
MORAb-202, Paclitaxel, Pegylated Liposomal Doxorubicin, BMS-986445, L01C D01, L01DB01, Lyophilisate for solution for infusion, Concentrate for solution for infusion, Paclitaxel, Pegylated Liposomal Doxorubicin, topotecan
Bristol-Myers Squibb International Corporation, BRISTOL-MYERS SQUIBB INTERNATIONAL CORPORATION, Bristol -Myers Squibb International Corporation Belgium, Bristol-Myers Squibb International Corporation Belgium
Platinum-resistant High-grade Serous Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Cáncer seroso de alto grado resistente al platino, de ovario peritoneal primario o de trompas de Falopio, Ovarian Cancer, Primary Peritoneal Cancer or Fallopian Tube Cancer Cáncer de ovario, peritoneal primario o de trompas de Falopio, Diseases [C] - Cancer [C04]
 
 
DDRiver SCLC 250, NCT04768296 / 2020-004231-25: Berzosertib + Topotecan in Relapsed Platinum-Resistant Small-Cell Lung Cancer

Completed
2
76
Europe, Japan, US, RoW
Berzosertib, M6620, Topotecan
EMD Serono Research & Development Institute, Inc., Merck KGaA, Darmstadt, Germany
Small-cell Lung Cancer
07/23
07/23
CA116-001, NCT05613088: A Study of MORAb-202 Versus Investigator's Choice Chemotherapy in Female Participants With Platinum-resistant High-grade Serous (HGS) Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

Recruiting
2
90
Europe, Japan, US, RoW
MORAb-202, BMS-986445, Farletuzumab Ecteribulin, Paclitaxel, Bendalis, Pegylated Liposomal Doxorubicin (PLD), Caelyx, Topotecan, Hycamtin
Bristol-Myers Squibb, Eisai Inc.
Neoplasms, Ovarian
06/24
10/26
SJATRT, NCT02114229: Phase 2 Study of Alisertib Therapy for Rhabdoid Tumors

Active, not recruiting
2
125
US
alisertib, methotrexate, MTX, cisplatin, Platinol-AQ, carboplatin, paraplatin, cyclophosphamide, cytoxan, etoposide, VP-16, Vepesid, Etoposide phosphate (Etopophos), topotecan, Hycamtin, vincristine, Oncovin, Surgical resection, surgical management, Radiation therapy, Craniospinal irradiation (CSI), Radiotherapy
St. Jude Children's Research Hospital, Millennium Pharmaceuticals, Inc., Takeda Pharmaceuticals U.S.A., Inc.
Malignant Rhabdoid Tumor, Atypical Teratoid Rhabdoid Tumor
09/25
09/27
2021-005617-14: Study to assess safety and identify dose of ribociclib in combination of temozolomide and topotecan (TOTEM) in patients (12 months – 21 years old) with relapsed or refractory solid tumors (Phase I), and further assess efficacy and safety in patients (12 months – 21 years old) with relapsed or refractory neuroblastoma (Phase II) Estudio para evaluar la seguridad e identificar la dosis de ribociclib en combinación con temozolomida y topotecán (TOTEM) en pacientes (12 meses - 21 años) con tumores sólidos recidivantes o refractarios (Fase I) y evaluar la eficacia y seguridad en pacientes (12 meses - 21 años) con neuroblastoma recidivante o refractario (Fase II)

Ongoing
1/2
230
Europe, RoW
ribociclib, temozolomida 5 mg cápsulas duras, topotecan, temozolomida 20 mg cápsulas duras, temozolomida 100 mg cápsulas duras, temozolomida 140 mg cápsulas duras, temozolomida 180 mg cápsulas duras, temozolomida 250 mg cápsulas duras, LEE011, Powder for oral solution, Capsule, hard, Concentrate for solution for infusion, Temozolomid SUN & Temozolomid Accord, Potactasol & Hycamtin
Novartis Farmacéutica, S.A., Novartis Pharma AG, Novartis Pharma AG
relapsed or refractory neuroblastoma and other solid tumors (including medulloblastoma, high grade glioma, malignant rhabdoid tumors, and rhabdomyosarcoma) in patients from 12 months to 21 years old neuroblastoma recidivante o refractario y otros tumores sólidos (incluyendo meduloblastoma, glioma de alto grado, tumores rabdoides malignos y rabdomiosarcoma) en pacientes con edades comprendidas entre los 12 meses y los 21 años, Recurrent solid tumors in patients from 12 months to 21 years old Tumores sólidos recurrentes en pacientes con edades comprendidas entre los 12 meses y los 21 años, Diseases [C] - Cancer [C04]
 
 
NCT03709680 / 2021-003444-25: Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors

Active, not recruiting
1/2
128
Europe, Canada, US, RoW
Palbociclib, Ibrance, Temozolomide, Temodar, Irinotecan, Campto, Topotecan, Hycamtin, Cyclophosphamide, Cytoxan
Pfizer, Children's Oncology Group (COG)
Ewing Sarcoma, Solid Tumors, Rhabdoid Tumor, Rhabdomyosarcoma, Neuroblastoma, Medulloblastoma, Diffuse Intrinsic Pontine Glioma
08/24
02/25
NCT05266196: A Rollover Protocol to Allow for Continued Access to the LSD1 Inhibitor Seclidemstat (SP-2577)

Enrolling by invitation
1/2
10
US
Seclidemstat, topotecan, cyclophosphamide
Salarius Pharmaceuticals, LLC
Ewing Sarcoma, Myxoid Liposarcoma, Desmoplastic Small Round Cell Tumor, Extraskeletal Myxoid Chondrosarcoma, Angiomatoid Fibrous Histiocytoma, Clear Cell Sarcoma, Myoepithelial Tumor, Low Grade Fibromyxoid Sarcoma, Sclerosing Epithelioid Fibrosarcoma
12/25
12/25
NCT04029688 / 2018-004579-11: A Study Evaluating the Safety, Tolerability, Pharmacokinetics and Preliminary Activity of Idasanutlin in Combination With Either Chemotherapy or Venetoclax in Treatment of Pediatric and Young Adult Participants With Relapsed/Refractory Acute Leukemias or Solid Tumors

Active, not recruiting
1/2
38
Europe, Canada, US
Idasanutlin, RG7388, Venetoclax, RG7601, GDC-0199, ABT-199, Cyclophosphamide, Topotecan, Fludarabine, Cytarabine, Intrathecal Chemotherapy
Hoffmann-La Roche
Acute Myeloid Leukemia (AML), Acute Lymphoblastic Leukemia (ALL), Neuroblastoma, Solid Tumors
06/24
12/25
NCT05429502 / 2021-005617-14: Study of Efficacy and Safety of Ribociclib (LEE011) in Combination With Topotecan and Temozolomide (TOTEM) in Pediatric Patients With Relapsed or Refractory Neuroblastoma and Other Solid Tumors

Recruiting
1/2
231
Europe, US, RoW
Topotecan, Hycamtin, Temozolomide, Temodar, Ribociclib, Kisqali, LEE011
Novartis Pharmaceuticals, Innovative Therapies For Children with Cancer Consortium
Neuroblastoma
10/28
01/29

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