Neoplasms, Connective and Soft Tissue  >>  topotecan  >>  Phase 2
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7 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
topotecan / Generic mfg.
NCT00001335: New Therapeutic Strategies for Patients With Ewing's Sarcoma Family of Tumors, High Risk Rhabdomyosarcoma, and Neuroblastoma

Completed
2
90
US
ADR-529, Topotecan, G-CSF
National Cancer Institute (NCI)
Ewing's Sarcoma, Neuroblastoma, Rhabdomyosarcoma
 
01/02
NCT00002643: Combination Chemotherapy in Treating Patients With Newly Diagnosed Metastatic Ewing's Sarcoma or Primitive Neuroectodermal Tumor

Completed
2
130
US, Canada, Europe, RoW
filgrastim, amifostine trihydrate, cyclophosphamide, doxorubicin hydrochloride, etoposide, ifosfamide, topotecan hydrochloride, vincristine sulfate, conventional surgery, low-LET cobalt-60 gamma ray therapy, low-LET electron therapy, low-LET photon therapy
National Cancer Institute (NCI), Children's Cancer Group
Neutropenia, Sarcoma
06/03
 
NCT00003745: Chemotherapy in Treating Children With Recurrent or Refractory Sarcomas

Completed
2
125
US, Canada, Europe, RoW
topotecan hydrochloride
National Cancer Institute (NCI)
Sarcoma
06/03
 
NCT00002515: Combination Chemotherapy Followed by Bone Marrow Transplantation in Treating Patients With Rare Cancer

Completed
2
US
filgrastim, carboplatin, thiotepa, topotecan hydrochloride, autologous bone marrow transplantation, bone marrow ablation with stem cell support, in vitro-treated bone marrow transplantation
Memorial Sloan Kettering Cancer Center
Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor, Head and Neck Cancer, Kidney Cancer, Liver Cancer, Lymphoma, Neuroblastoma, Ovarian Cancer, Retinoblastoma, Sarcoma, Testicular Germ Cell Tumor
04/05
04/05
NCT00003156: Topotecan in Treating Patients With Recurrent or Refractory Cancer of the Uterus

Terminated
2
US, Canada
topotecan hydrochloride
Gynecologic Oncology Group, National Cancer Institute (NCI)
Sarcoma
10/05
 
NCT00130858: a Multicenter Clinical Trial for the Treatment of Children and Adolescents With Soft Tissue Sarcoma Stage 4

Completed
2
90
Europe
Topotecan, Carboplatin
Cooperative Weichteilsarkom Study Group, Deutsche Krebshilfe e.V., Bonn (Germany)
Sarcoma, Soft Tissue
12/07
03/09
NCT00516295: Vincristine Sulfate, Topotecan Hydrochloride, and Cyclophosphamide With or Without Bevacizumab in Treating Young Patients With Refractory or First Recurrent Extracranial Ewing Sarcoma

Completed
2
7
US
topotecan hydrochloride, hycamptamine, Hycamtin, SKF S-104864-A, TOPO, vincristine sulfate, leurocristine sulfate, VCR, Vincasar PFS, cyclophosphamide, CPM, CTX, Cytoxan, Endoxan, Endoxana, bevacizumab, anti-VEGF humanized monoclonal antibody, anti-VEGF monoclonal antibody, Avastin, rhuMAb VEGF
National Cancer Institute (NCI)
Ewing Sarcoma of Bone, Extraosseous Ewing Sarcoma, Peripheral Primitive Neuroectodermal Tumor, Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
08/09
01/10

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