lomustine / Generic mfg.  >>  Phase 2
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23 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
lomustine / Generic mfg.
R-2, NCT05898451: Effect of Refnot on Immunity in Cancer Patients

Completed
2
55
NA
Tumor necrosis factor-thymosin alfa 1 recombinant (TNF-T), Refnot, Tumor necrosis factor-thymosin alfa 1 recombinant, Tumor necrosis factor-thymosin alfa 1 recombinant (TNF-T) and chemotherapy, and Dacarbazine, Lomustine, Cisplatin
Refnot-Pharm Ltd
Solid Tumor
11/11
11/11
NCT01582269 / 2011-004418-40: A Study in Recurrent Glioblastoma (GB)

Active, not recruiting
2
180
Europe, Canada, US, RoW
LY2157299 monohydrate, LY2157299, Lomustine, Placebo, LY2157299 monohydrate-matched placebo
Eli Lilly and Company
Glioblastoma
07/14
09/24
2006-007083-28: Phase II study on the feasibility and efficacy of consolidation with 90Y-ibritumomab tiuxetan in patients with relapsed or refractory aggressive B-cell non-Hodgkin’s lymphoma having achieved partial or complete remission after induction with R-PECC chemotherapy.

Ongoing
2
60
Europe
prednisone, chlorambucil, etoposide, lomustine, 90Y-ibritumomab tiuxetan, A07EA03, Mabthera, Zevalin, Mabthera, Zevalin
HOVON foundation, KWF, Spectrum Pharmaceuticals
Aggressive B-cell NHL
 
 
2009-012186-63: Landelijke Werkgroep voor Neuro-Oncologie trial (LWNO 0901)Randomized phase II study of Bevacizumab versus Bevacizumab plus Lomustine in patients with recurrent Glioblastoma: the BELOB trial

Ongoing
2
86
Europe
Avastin, Belustine, Avastin, Belustine
Erasmus MC, more specifically for and on behalf of the department of Neurology/Neuro-Oncology
Patients with recurrent glioblastoma multiforme who failed combined chemo-irradiation with temozolomide.
 
 
2011-000900-16: A randomized phase II clinical trial on the efficacy of axitinib as a monotherapy or in combination with lomustine for the treatment of patients with recurrent glioblastoma

Ongoing
2
52
Europe
Axitinib, Lomustine, AG-013736, Cecenu (Lomustine), Cecenu (Lomustine)
UZ BRUSSEL, UZ Brussel
• Patients with recurrent central nervous system glioblastoma (histologically confirmed WHO grade IV glioma), at documented recurrence/progression following prior treatment with surgery, radiation therapy and alkylating chemotherapy. • No concomitant treatment with enzyme inducing anti-epileptic drugs (EIAED)
 
 
2019-004053-91: BRIOChe: A trial looking at re-irradiation and chemotherapy in patients with recurrent glioblastoma.

Not yet recruiting
2
70
Europe
Lomustine, Procarbazine, Vincristine, Capsule, Injection, Lomustine medac, Vincristine
University of Leeds, The Jon Moulton Charity Trust
Recurrent Glioblastoma, Brain tumour, Diseases [C] - Cancer [C04]
 
 
NCT03463265: Nab-sirolimus in Recurrent High Grade Glioma and Newly Diagnosed Glioblastoma

Completed
2
62
US
nab-sirolimus, nab-sirolimus + temozolomide, temozolomide, nab-sirolimus + bevacizumab, bevacizumab, nab-sirolimus + lomustine, lomustine (CCNU), nab-sirolimus + marizomib (MRZ), marizomib (MRZ), nab-sirolimus + temozolomide + radiotherapy, radiation
Aadi Bioscience, Inc.
High Grade Recurrent Glioma and Newly Diagnosed Glioblastoma
08/22
08/22
2020-005429-10: Romiplostim for thrombocytopenia induced by lomustine at first progression of MGMT promoter-methylated glioblastoma: a randomized phase II open label multicenter study Romiplostim para el tratamiento de los niveles bajos de plaquetas provocados la quimioterapia con lomustina en pacientes con la primera recurrencia (reaparición del crecimiento) de un tumor cerebral, glioblastoma con metilación de MGMT

Not yet recruiting
2
100
Europe
romiplostim, [NA], Powder for solution for injection, Nplate
European Organisation for Research and Treatment of Cancer EORTC, EORTC AISBL/IVZW, Amgen Europe B.V., European Organisation for Research and Treatment of Cancer (EORTC)
thrombocytopenia caused by chemotherapy drug lomustine trombocitopenia inducida por lomustina, Low platelets due to bone marrow suppression caused by chemotherapy drug lomustine niveles bajos de plaquetas provocados la quimioterapia con lomustina, Diseases [C] - Blood and lymphatic diseases [C15]
 
 
RIGOLETTO, NCT04933942: Phase II Trial of Romiplostim for Thrombocytopenia Induced by Lomustine at First Progression of MGMT Promoter-meth Glioblastoma

Withdrawn
2
100
Europe
Lomustine, Romiplostim
European Organisation for Research and Treatment of Cancer - EORTC, Amgen
First Progression of MGMT Promoter-methylated Glioblastoma
12/22
12/22
ChiCTR2000035315: A Randomized, Open, Controlled, Multi-Centre, Phase II Clinical Study to Evaluate the Efficacy and Safety of ACT001 Monotherapy and the Combination of ACT001 with Temozolomide VS Temozolomide or Lomustine Alone in Patients with Recurrent Glioblastoma

Not yet recruiting
2
75
 
ACT001 alone ;ACT001 and TMZ combined group ;CCNU or TMZ control
General Hospital of Tianjin Medical University; General Hospital of Tianjin Medical University, funds raise by sponsor
Glioblastoma
 
 
GLIOSTELLA, NCT06336291: A Study With L19TNF in Combination With Lomustine in Patients With Glioblastoma at Progression or Recurrence

Not yet recruiting
2
90
US
L19TNF, onfekafusp alfa, Lomustine
Philogen S.p.A.
Glioblastoma
06/26
06/26
NCT06177964: Lerapolturev (PVSRIPO) in GBM

Not yet recruiting
2
92
US
Lerapolturev, Lomustine Pill
Darell Bigner, Istari Oncology, Inc.
Recurrent Supratentorial Glioblastoma
02/29
02/29
NCT06325683: Anti-Lag-3 (Relatlinib) and Anti-PD-1 Blockade (Nivolumab) Versus Standard of Care (Lomustine) for the Treatment of Patients With Recurrent Glioblastoma

Not yet recruiting
2
178
NA
Biopsy, BIOPSY_TYPE, Bx, Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Lomustine, 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea, 1-Nitrosourea, 1-(2-chloroethyl)-3-cyclohexyl-, Belustin, Belustine, CCNU, Cecenu, CeeNU, Chloroethylcyclohexylnitrosourea, Citostal, Gleostine, Lomeblastin, Lomustinum, Lucostin, Lucostine, N-(2-Chloroethyl)-N'-cyclohexyl-N-nitrosourea, Prava, RB-1509, WR-139017, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Nivolumab, ABP 206, BCD-263, BMS-936558, CMAB819, MDX-1106, NIVO, Nivolumab Biosimilar ABP 206, Nivolumab Biosimilar BCD-263, Nivolumab Biosimilar CMAB819, ONO-4538, Opdivo, Relatlimab, BMS 986016, BMS-986016, BMS986016, Immunoglobulin G4, Anti-(human Lymphocyte Activation Gene-3 Protein) (Human Heavy Chain), Disulfide with Human Light Chain, Dimer, Surgical Procedure, Operation, Surgery, Surgery Type, Surgery, NOS, Surgical, Surgical Intervention, Surgical Interventions, Surgical Procedures, Type of Surgery
National Cancer Institute (NCI)
Recurrent Glioblastoma
07/28
07/28
NCT04762069: A Study of Berubicin in Adult Subjects With Recurrent Glioblastoma Multiforme

Hourglass Jan 2023 - Jun 2023 : Data from trial for glioblastoma
Hourglass Jul 2022 - Dec 2022 : Interim analysis data from trial for glioblastoma in adults
Active, not recruiting
2
210
Europe, US
Berubicin, Berubicin Hydrochloride, Lomustine, Lomustine Capsules, CCNU, CeeNU, Gleostine
CNS Pharmaceuticals, Inc., Worldwide Clinical Trials
Glioblastoma Multiforme, Adult
12/24
03/25
NCT04863950: Investigator-Initiated Study of Imipramine Hydrochloride and Lomustine in Recurrent Glioblastoma

Recruiting
2
25
US
Lomustine, Gleostine, Imipramine Hydrochloride, Trofranil
The University of Texas Health Science Center at San Antonio
Glioblastoma
09/24
09/25
Actuate 1801, NCT03678883: 9-ING-41 in Patients With Advanced Cancers

Active, not recruiting
2
350
Europe, Canada, US
9-ING-41, Gemcitabine - 21 day cycle, Gemzar, Doxorubicin., Doxil, Adriamycin, Lomustine, CCNU, Gleostine, Carboplatin., Paraplatin, Nab paclitaxel., Abraxane, Protein-bound paclitaxel, Nanoparticle albumin-bound paclitaxel, Paclitaxel., Taxol, Gemcitabine - 28 day cycle, Irinotecan, Camptosar
Actuate Therapeutics Inc.
Cancer, Pancreatic Cancer, Sarcoma, Renal Cancer, Refractory Cancer, Refractory Neoplasm, Refractory Non-Hodgkin Lymphoma, Pancreatic Adenocarcinoma, Resistant Cancer, Neoplasm Metastasis, Neoplasm of Bone, Neoplasm, Breast, Neoplasm of Lung, Neoplasms,Colorectal, Neoplasms Pancreatic, Malignant Glioma, Malignancies, Malignancies Multiple, Bone Metastases, Bone Neoplasm, Bone Cancer, Pancreas Cancer, Pancreatic Neoplasms, Breast Neoplasms, Acute T Cell Leukemia Lymphoma
11/24
11/25
LEAHRN, NCT02724579: Reduced Craniospinal Radiation Therapy and Chemotherapy in Treating Younger Patients With Newly Diagnosed WNT-Driven Medulloblastoma

Active, not recruiting
2
45
Canada, US, RoW
Cisplatin, Abiplatin, Blastolem, Briplatin, CDDP, Cis-diammine-dichloroplatinum, Cis-diamminedichloridoplatinum, Cis-diamminedichloro Platinum (II), Cis-diamminedichloroplatinum, Cis-dichloroammine Platinum (II), Cis-platinous Diamine Dichloride, Cis-platinum, Cis-platinum II, Cis-platinum II Diamine Dichloride, Cismaplat, Cisplatina, Cisplatinum, Cisplatyl, Citoplatino, Citosin, Cysplatyna, DDP, Lederplatin, Metaplatin, Neoplatin, Peyrone's Chloride, Peyrone's Salt, Placis, Plastistil, Platamine, Platiblastin, Platiblastin-S, Platinex, Platinol, Platinol- AQ, Platinol-AQ, Platinol-AQ VHA Plus, Platinoxan, Platinum, Platinum Diamminodichloride, Platiran, Platistin, Platosin, Cyclophosphamide, (-)-Cyclophosphamide, 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate, Asta B 518, B-518, Carloxan, Ciclofosfamida, Ciclofosfamide, Cicloxal, Clafen, Claphene, CP monohydrate, CTX, CYCLO-cell, Cycloblastin, Cycloblastine, Cyclophospham, Cyclophosphamid monohydrate, Cyclophosphamide Monohydrate, Cyclophosphamidum, Cyclophosphan, Cyclophosphane, Cyclophosphanum, Cyclostin, Cyclostine, Cytophosphan, Cytophosphane, Cytoxan, Fosfaseron, Genoxal, Genuxal, Ledoxina, Mitoxan, Neosar, Revimmune, Syklofosfamid, WR- 138719, WR-138719, Laboratory Biomarker Analysis, Lomustine, 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea, 1-Nitrosourea, 1-(2-chloroethyl)-3-cyclohexyl-, Belustin, Belustine, CCNU, Cecenu, CeeNU, Chloroethylcyclohexylnitrosourea, Citostal, Gleostine, Lomeblastin, Lomustinum, Lucostin, Lucostine, N-(2-Chloroethyl)-N'-cyclohexyl-N-nitrosourea, Prava, RB-1509, WR-139017, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Radiation Therapy, Cancer Radiotherapy, Energy Type, ENERGY_TYPE, Irradiate, Irradiated, Irradiation, Radiation, Radiation Therapy, NOS, Radiotherapeutics, Radiotherapy, RT, Therapy, Radiation, Vincristine, LCR, Leurocristine, VCR, Vincrystine, Vincristine Sulfate, Kyocristine, Leurocristine Sulfate, Leurocristine, sulfate, Oncovin, Vincasar, Vincosid, Vincrex, Vincristine, sulfate
Children's Oncology Group, National Cancer Institute (NCI)
Medulloblastoma
06/27
06/27
NCT04049669: Pediatric Trial of Indoximod With Chemotherapy and Radiation for Relapsed Brain Tumors or Newly Diagnosed DIPG

Recruiting
2
140
US
Indoximod, Partial Radiation, Full-dose Radiation, Temozolomide, Cyclophosphamide, Etoposide, Lomustine
Theodore S. Johnson, National Cancer Institute (NCI), Augusta University, Emory University
Glioblastoma, Medulloblastoma, Ependymoma, Diffuse Intrinsic Pontine Glioma
10/25
10/27
PersoMed-I, NCT04402073 / 2020-003063-26: Personalized Risk-Adapted Therapy in Post-Pubertal Patients With Newly-Diagnosed Medulloblastoma

Recruiting
2
205
Europe, RoW
Sonidegib, Cisplatin, Lomustine, Vincristine, radiotherapy
European Organisation for Research and Treatment of Cancer - EORTC, EORTC-BTG, Sunpharmaceuticals
Medulloblastoma
03/30
03/30
XPORT-GBM-029, NCT04421378: A Study of Selinexor in Combination With Standard of Care Therapy for Newly Diagnosed or Recurrent Glioblastoma

Terminated
1/2
74
Canada, US
Selinexor, KPT-330, XPOVIO, Temozolomide (TMZ), Temodar, Lomustine (CCNU), Standard Fractionated Radiation therapy (RT), Bevacizumab, TTField, Carmustine
Karyopharm Therapeutics Inc
Glioblastoma Multiforme
07/23
07/23
GLIOSTAR, NCT04573192: A Study to Evaluate Safety and Efficacy of L19TNF Plus Lomustine in Patients With Glioblastoma at First Progression

Recruiting
1/2
142
Europe
L19TNF, onfekafusp alfa, Lomustine
Philogen S.p.A.
Glioblastoma
03/25
12/25
NCT04910022: Ph I/II Study of NMS-03305293+TMZ in Adult Patients With Recurrent Glioblastoma

Recruiting
1/2
150
Europe, US
NMS-03305293, Temozolomide
Nerviano Medical Sciences
Glioblastoma, Diffuse Glioma
06/25
11/25
NCT03382977: Study to Evaluate Safety, Tolerability, and Optimal Dose of Candidate GBM Vaccine VBI-1901 in Recurrent GBM Subjects

Recruiting
1/2
98
US
VBI-1901, Carmustine, BiCNU, Lomustine, Gleostine
VBI Vaccines Inc.
Glioblastoma Multiforme
07/25
08/25

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