Completed

4

100

Europe

levosimendan, Placebo

University of Roma La Sapienza, University College London Hospitals

Myocardial Protection

02/07

02/07

Completed

4

200

Europe

levosimendan, placebo

Kuopio University Hospital

Heart Failure

12/08

12/08

Completed

4

20

Europe

Levosimendan (SIMDAX), Dopexamine (DOPACARD), n/a, Concentrate for solution for infusion, SIMDAX, Dopacard

Dr GED DEMPSEY, University Hospital Aintree

Septic Shock

 

 

Completed

4

61

US

levosimendan, Simdax, placebo,, placebo

Oslo University Hospital

Myocardial Infarction, Heart Failure, Cardiogenic Shock

09/11

03/12

Withdrawn

4

0

Europe

Levosimendan, Simdax, ATC-nr.: C01C X08, Placebo

Sykehuset i Vestfold HF, Orion Corporation, Orion Pharma

Heart Failure, Hip Fracture

12/12

12/12

Terminated

4

20

Europe

levosimendan, Simdax, placebo drug, Placebo

University of Aarhus

Diastolic Dysfunction, Left Ventricular Hypertrophy

03/13

03/13

Completed

4

70

Europe

Levosimendan, SIMDAX (trade mark), Placebo

Parc de Salut Mar

Heart Failure

10/13

11/15

Unknown status

4

40

Europe

Levosimendan, Dobutamine

Azienda Policlinico Umberto I

Cardiovascular Diseases

12/13

 

Completed

4

32

Europe

Levosimendan infusion, Placebo infusion

AHEPA University Hospital, Orion Corporation, Orion Pharma

Coronary Artery Disease

03/14

03/14

Completed

4

30

Europe

Levosimendan, Placebo

Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

Cardiac Surgery

11/14

11/14

Recruiting

4

180

 

Heart failure (routine therapy including positive inotropic drugs, diuretics and vasodilator, angiotensin converting enzyme inhibitors, beta-blockers, phosphodiesterase inhibitors, etc.) ;On the basis of routine therapy heart failure combined with creatine phosphate ;On the basis of routine therapy heart failure combined with Levosimendan ;On the basis of routine therapy heart failure combined with Recombinant Human Brain Natriuretic Peptideon

Qilu Hospital of Shandong University; Qilu Hospital of Shandong University, Science and technology projects of Shandong Province

chronic heart failure

 

 

Ongoing

4

20

Europe

Simdax, Simdax, Simdax

Tays/ anestesiayksikkö

Leikkaushoitoa vaativa elektiivinen aortta-aneyrymapotilas

 

 

Ongoing

4

20

Europe

Simdax, Simdax

University Medical Centre Ljubljana

advanced chronic heart failure

 

 

Ongoing

4

1000

Europe

SIMDAX, SIMDAX

FONDAZIONE CENTRO S. RAFFAELE DEL MONTE TABOR

high risk cardiac surgery affected by low cardiac output syndrome (LCOs)

 

 

Completed

4

1000

Europe, RoW

Levosimendan, simdax, placebo

Università Vita-Salute San Raffaele

Low Cardiac Output Syndrome

05/16

05/16

Completed

4

80

Europe

SIMDAX, Not applicable, Infusion, Simdax

Semmelweis University, Heart and Vascular Center, Semmelweis University

A total of 80 symptomatic patients with severe ischaemic or non-ischaemic cardiomyopathy will be enrolled in the study. Those, who were implanted a device and proved to be non-responders or low responders with ischaemic etiology would be separetly investigated. A vizsgálatba összesen 80 tünetes, előrehaladott szisztolés szívelégtelenségben (iszkémiás vagy nem iszkémiás cardiomyopathia) szenvedő beteg bevonását tervezzük. A korábban kardiális reszinkronizációs pacemaker/defibrillátor (CRT-P/CRT-D) beültetésen átesett non-responder vagy low-responder, iszkémiás cardiomyopathiában szenvedő betegeket külön csoportként kezeljük., Patients with severe heart failure symptoms and ischaemic or non-ischaemic etiology will be enrolled in the study. Előrehaladott szisztolés szívelégtelenségben (iszkémiás vagy nem iszkémiás cardiomyopathia) szenvedő betegek vizsgálatát tervezzük., Diseases [C] - Cardiovascular Diseases [C14]

 

 

Completed

4

40

Europe

Simdax (Levosimendan), Concentrate for solution for infusion, Simdax

Verein zur Förderung der Forschung auf dem Gebiet der Arteriosklerose, Thrombose und vaskulären Biologie (ATVB), Verein zur Förderung der Forschung auf dem Gebiet der Arteriosklerose, Thrombose und vaskulären Biologie (ATVB)

Advanced heart failure, Long time heart failure, Diseases [C] - Cardiovascular Diseases [C14]

 

 

Unknown status

4

30

Europe

Norepinephrine, Milrinone, Corotrope, Levosimendan, Simdax

Sahlgrenska University Hospital, Sweden

Septic Shock, Cardiomyopathy

01/19

01/19

Unknown status

4

60

RoW

Levosimendan, Milrinone

Assiut University

Hemodynamics

09/19

09/19

Not yet recruiting

4

12

 

Simendan ;Nil

Renji Hospital, Shanghai Jiao Tong University School of Medicine; Renji Hospital, Shanghai Jiao Tong University School of Medicine, None

cardiopulmonary resuscitation

 

 

Completed

4

30

Europe

Levosimendan, Simdax, Placebo

Sahlgrenska University Hospital, Sweden

Acute Kidney Injury, Renal Insufficiency, Acute

12/20

12/20

Recruiting

4

200

 

Levosimendan + standard inotropic medication ;standard inotropic medication

Cardiothoracic surgery ICU of the First Affiliated Hospital of Sun Yat-Sen University; The First Affiliated Hospital of Sun Yat-Sen University, Cardiovascular Multidisciplinary Integrated Thinking Research Fund，China International Medical foundation

Cardiac surgery-associated acute kidney injury

 

 

Not yet recruiting

4

200

 

levosimendan ;conventional therapy

Qingdao Municipal Hospital; Qingdao Municipal Hospital, China International Medical Foundation

Cardiovascular disease

 

 

Not yet recruiting

4

400

 

Levosimendan ;Vitamin C

First Affiliated Hospital, Zhejiang University School of Medicine; First Affiliated Hospital, Zhejiang University School of Medicine, Self finacing

Heart valve replacement

 

 

Not yet recruiting

4

600

 

Levosimendan ;Placebo

Shandong Provincial Hospital; Shandong Provincial Hospital, self-financing

Cardiovascular disease

 

 

Recruiting

4

40

 

Intravenous infusion of levosimendan ;Intravenous infusion of levosimendan

The First Affiliated Hospital, Sun Yat-sen University; The First Affiliated Hospital, Sun Yat-sen University, China Foundation for International Medical Exchange

Cardiac failure

 

 

Recruiting

4

136

RoW

levosimendan

Tongji Hospital

Heart Failure

06/22

06/22

Recruiting

4

1146

 

Levosimendan ;placebo

Fuwai Hospital; Fuwai Hospital, Sponsor funding

heart failure

 

 

Not yet recruiting

4

120

 

standard heart failure therapy ;standard heart failure therapy combined with levosimendan and dopamine

The First Affiliated Hospital of Sun Yat-Sen University; The First Affiliated Hospital of Sun Yat-Sen University, China International Medical Foundation

Heart failure

 

 

Ongoing

4

10

Europe

dobutamina, Levosimendan, Concentrate and solvent for concentrate for solution for infusion, Dobutamina, Simdax

Germans Trias i Pujol Health Research Institute, Germans Trias i Pujol Health Research Institute

Heart failure patients with depressed left ventricular ejection fraction Pacientes con insuficiencia cardiaca con fracción de eyección del ventrículo izquierdo deprimida, Heart failure patients with diminished cardiac function Pacientes con insuficiencia cardiaca reducida, Diseases [C] - Cardiovascular Diseases [C14]

 

 

Completed

4

40

RoW

Saline Solution, Nacl 0.9 %, Levosimendan, Magnesium Sulfate

Dalia Saad Abd-El Kader, Cairo University

Aortic Coarctation

03/23

04/23

Recruiting

4

108

 

Levosimendan ;Placebo

Qilu Hospital of Shandong University; Shandong University Qilu Hospital, Special funds and self-raised funds

Sarcopenia with heart failure with reduced ejection fraction

 

 

Recruiting

4

1000

RoW

protective ventilation, prone position ventilation, glucocorticoid therapy, Dexamethasone, Hydrocortisone, restrictive fluid resuscitation, Thymosin Alpha, Muscle relaxant therapy, Vecuronium Bromide, Succinylcholine, Integrated Chinese and Western Medicine Treatment, statin therapy, Simvastatin, Rosuvastatin, anti-infective treatment, Extracorporeal Membrane Oxygenation（ECMO）, stem cell therapy, Sedative analgesia/muscle relaxant therapy, Propofol, midazolam, dexmedetomidine, inotropes therapy, Dopamine, Olprinone, Levosimendan, Vasoactive drug therapy, Norepinephrine, epinephrine, metaraminol, isoproterenol

Second Affiliated Hospital, School of Medicine, Zhejiang University, Renmin Hospital of Wuhan University, The Second Affiliated Hospital of Harbin Medical University, West China Hospital, The First Affiliated Hospital of Zhengzhou University, Peking Union Medical College Hospital, Wuhan Union Hospital, China, Fudan University, Guangdong Provincial People's Hospital, Ningbo No. 1 Hospital, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University

Acute Respiratory Distress Syndrome

10/23

12/23

Recruiting

4

112

RoW

Levosimontane injection, wen，yue

Qilu Hospital of Shandong University

Heart Failure, Aortic Stenosis, Severe

01/25

02/25

Terminated

4

70

Europe

Levosimendan, Placebo

Medical University of Bialystok, Medical Research Agency, Poland, University of Opole, Medical University of Lodz, Poznan University of Medical Sciences, Nicolaus Copernicus University, National Institute of Cardiology, Warsaw, Poland, Azienda Ospedaliera dei Colli, John Paul II Specialist Hospital in Kraków

Heart Failure New York Heart Association Class III, Heart Failure New York Heart Association Class IV, Heart Failure, Systolic, Heart Failure With Reduced Ejection Fraction

02/24

08/24

Not yet recruiting

4

50

 

After completing the examination, the enrolled subjects were treated with levosimendan, with a starting dose of 0.1 μ G/kg/min, without limiting the side effects of speed (such as hypotension and tachycardia), the dosage can be increased to 0.2 after 2-4 hours μ G/kg/min, ensuring a total infusion time of 20-24 hours and a total dose of 12.5mg.; After completing the examination, the enrolled subjects were treated with dobutamine, with a starting dose of 5 μ G/kg/min, if MAP can be maintained at a normal level (MAP ≥ 65mmHg), maintain this infusion dose unchanged and continue infusion for 24 hours.

The First Affiliated Hospital of China Medical University; The First Affiliated Hospital of China Medical University, China International Medical Exchange Foundation

Septic cardiomyopathy

 

 

Recruiting

4

250

Europe

levosimendan, Soluvit, Standard care

Radboud University Medical Center

Mechanical Ventilation, Weaning Failure

08/27

08/28