| Simdax (levosimendan IV) / AbbVie |
NCT00130871: Levosimendan Pretreatment for Weaning Patients From Cardio-Pulmonary Bypass |
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| Completed | 2 | 60 | Europe | levosimendan | Orion Corporation, Orion Pharma | Coronary Heart Disease | | 01/06 | | |
| Unknown status | 2 | 40 | Europe | Levosimendan, Milrinone | Ludwig Boltzmann Gesellschaft | Low Cardiac Output Syndrome | | | | |
NCT00800306: Effects of Levosimendan on Microcirculation in Septic Shock |
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| Completed | 2 | 40 | Europe | Levosimendan, dobutamine | University of Roma La Sapienza | Septic Shock | 02/08 | 04/09 | | |
| Completed | 2 | 10 | US | levosimendan, Simdax | University of Utah | Heart Failure | 12/08 | 12/08 | | |
NCT01120106: Levosimendan Administration in Neonates With Transposition of the Great Arteries |
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| Completed | 2 | 63 | Europe | levosimendan, simdax, placebo, saline | Bambino Gesù Hospital and Research Institute | Low Cardiac Output Syndrome | 12/10 | 09/11 | | |
| Terminated | 2 | 116 | Europe | Levosimendan, Conventional intensified inotropic treatment | Jose Luis Vazquez Martinez | Acute Heart Failure | 02/12 | 02/12 | | |
2012-004979-39: In patients with acute failure of kidney function, levosimendan will be given to help attenuate the course of kdiney failure and aid patients to recover faster. |
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| Ongoing | 2 | 68 | Europe | Levosimendan, Concentrate and solvent for solution for infusion | VieCuri Medical Center, Orion Pharma | Acute Kidney Injury (AKI) in adult ICU patients, Acute Kidney Injury (acute renal failure) in patients admitted to the Intensive Care Unit (ICU), Diseases [C] - Symptoms and general pathology [C23] | | | | |
2012-003012-31: Cardiovascular effects of esmolol alone and in combination with levosimendan during septic shock Effets cardiovasculaires associés à l'administration d'esmolol seul et en association au lévosimendan chez le patient en choc septique |
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| Ongoing | 2 | 10 | Europe | Solution for injection, BREVIBLOC, SIMDAX | DIRECTION CENTRALE DU SERVICE DE SANTE DES ARMEES, Direction Centrale Du Service de Sante des Armées | Évaluation de la tolérance hemodynamique, Patients avec un choc septique récent, Diseases [C] - Cardiovascular Diseases [C14] | | | | |
2009-010404-28: PREVENCIÓN DEL SÍNDROME DE BAJO GASTO POSTOPERATORIO EN RECIÉN NACIDOS SOMETIDOS A CIRUGÍA CARDIOVASCULAR: ESTUDIO PILOTO SOBRE LA FARMACOCINÉTICA Y FARMACODINAMIA DOSIS-DEPENDIENTE DE DOS INODILATADORESPREVENTION OF LOW CARDIAC OUTPUT SINDROME IN NEWBORNS UNDERGOING CARDIAC SURGERY: A PILOT STUDY ABOUT DOSE-DEPENDENT PHARMACOKINETICS AND PHARMACODYNAMICS OF 2 INODILATORS |
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| Ongoing | 2 | 20 | Europe | COROTROPE, Levosimendan, COROTROPE solución inyectable, SIMDAX 2,5 mg/ml concentrado para solución para perfusión, COROTROPE solución inyectable, SIMDAX 2,5 mg/ml concentrado para solución para perfusión | Fundación de Investigación Biomédica del Hospital Universitario La Paz, Madrid | Este estudio evaluará la eficacia de dos inodilatadores (IND) en el tratamiento del síndrome de bajo gasto postoperatorio (SBGP) en recién nacidos sometidos a cirugía cardiovascular (CCV) | | | | |
| Completed | 2 | 72 | Europe | Levosimendan, Simdax, Milrinone, Corotrop | Göteborg University, Helsinki University Central Hospital | Congenital Heart Defects | 04/17 | 04/17 | | |
NCT03557255: Levosimendan for Cardiac Patients Undergoing Major Abdominal Cancer Surgeries |
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| Completed | 2 | 60 | RoW | Levosimendan, drug group, Saline, control group | National Cancer Institute, Egypt | Heart Failure | 02/18 | 04/18 | | |
NCT03541603: Hemodynamic Evaluation of Levosimendan in Patients With PH-HFpEF |
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| Completed | 2 | 44 | US | Levosimendan, Levosimendan 2.5 mg/mL Injectable Solution, Matching Placebo, Placebo | Tenax Therapeutics, Inc. | Hypertension Pulmonary Secondary, Heart Failure, Right Sided, Heart Failure With Normal Ejection Fraction | 04/20 | 04/20 | | |
NCT05063370: Levosimendan in Patients With Impaired Right Ventricular Function Undergoing Cardiac Surgery |
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| Active, not recruiting | 2 | 40 | RoW | Levosimendan, Standard Care | Ain Shams University | Right Heart Failure, Open-heart Surgery | 12/21 | 01/22 | | |
2021-001702-30: Use of Levosimendan as treatment of aneurysmal Hemorrhage Utilisation du Levosimendan dans la prise en charge des hémorragies anévrysmales» |
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| Not yet recruiting | 2 | 30 | Europe | ZIMINO 12,5 mg, Solution for infusion, ZIMINO 2,5 mg/ml (Levosimendan) | APHP, Laboratoire ORION corporation | subarachnoid hemorrhages of aneurysmal origin (HSAa) hémorragies sous-arachnoïdiennes d’origine anévrysmales (HSAa), subarachnoid hemorrhages of aneurysmal origin (HSAa) hémorragies sous-arachnoïdiennes d’origine anévrysmales (HSAa), Body processes [G] - Physiological processes [G07] | | | | |
NCT03624010: Open-Label Rollover Study of Levosimendan in PH-HFpEF Patients |
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| Completed | 2 | 20 | US | Levosimendan 2.5 mg/ml Injectable Solution | Tenax Therapeutics, Inc. | Hypertension Pulmonary Secondary Heart Failure, Right Sided Heart Failure With Normal Ejection Fraction, Heart Failure With Normal Ejection Fraction | 02/24 | 02/24 | | |
| Recruiting | 2 | 6 | Europe | Levosimendan 2.5 milligram/milliliter Injectable Solutiondose Inhaled, Levosimendan 2.5 milligram/milliliter Injectable Solutiondose Intravenous | Universitair Ziekenhuis Brussel | Left Ventricular Dysfunction | 11/24 | 01/25 | | |
| Recruiting | 2 | 30 | Europe | Levosimendan, Placebo | Assistance Publique - Hôpitaux de Paris, Orion Corporation, Orion Pharma | Sub-arachnoid Haemorrhage | 04/26 | 04/26 | | |
| Completed | 1/2 | 20 | Europe | Milrinone, cronotrope, Levosimendan, Simdax | Fundacion para la Investigacion Biomedica del Hospital Universitario la Paz, Hospital Universitario La Paz, Fondo de Investigacion Sanitaria | Low Cardiac Output Syndrome | 11/10 | 11/10 | | |
