| leflunomide / Generic mfg. |
| Ongoing | 4 | 315 | Europe | Methotrexate, Sulfasalazine, Leflunomide, Humira, N/A, Tablet, Injection, Methotrexate, Salazopyrin EN, Arava, Humira | University of Oxford, NIHR | Physical Inactivity , Poor dietary behaviour , Obesity , Overweight | | | | |
ACTRN12621001695897: A randomised controlled trial to compare drug dose reduction strategies in adults with rheumatoid arthritis and psoriatic arthritis for safer and more efficient drug use |
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| Recruiting | 4 | 324 | | | University of Sydney, Australian Government, Department of Health, National Health and Medical Research Council, Medical Research Future Fund (MRFF) | Rheumatoid arthritis, Psoriatic arthritis | | | | |
| Completed | 4 | 320 | | leflunomide 10mg,orally taken once daily for 24 weeks ;leflunomide 50mg, orally taken weekly for 24 weeks | People's Hospital, Peking University; Ministry of Science and Technology of China, National Key Technologies R&D Program | Rheumatoid arthritis | | | | |
ChiCTR-TRC-09000587: The intensive therapy of severe lupus nephritis: a multicenter, randomized, controlled prospective clinical trial. |
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| Completed | 4 | 360 | | NIH standard program (Induction period, follow-up once every four weeks; consolidation therapy: follow-up once every twelve weeks, maintaince therapy: follow-up once every twelve weeks ;Intensive group: mini-pulse of cyclophosphamid, hydroxycholoquin and another immunosupressive agent, such as mycophenolate, leflunomide, azathioprine or Methotrexate) | The department of Rheumotology and Immunology, People’s Hospital, Peking University.; People’s Hospital, Peking University, self supported | sever lupus nephritis | | | | |
ChiCTR-TRC-11001789: Effect of TGP combined with MTX and LEF on liver function in RA patients: Clinical study protocol |
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| Completed | 4 | 280 | | TGP capsules (TGP) + methotrexate (MTX) + leflunom ;methotrexate(MTX) + leflunomide (LEF) | Anhui Provincial Hospital Department of Rheumatism; Ningbo Lihua Pharmaceutical Company Limited, Ningbo Lihua Pharmaceutical Company Limited | Rheumatoid Arthritis | | | | |
ChiCTR-TRC-10000776: A Study on the Efficacy and Safety of Telmisartan, Clopidogrelin and Leflunomide in patients with IgA nephropathy |
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| Completed | 4 | 400 | | Telmisartan+ Clopidogrelin placebo + Leflunomide placebo ;Telmisartan + Clopidogrelin+ Leflunomide placebo ;Telmisartan + Clopidogrelin placebo + Leflunomide ;Telmisartan + Clopidogrelin + Leflunomide | Chinese General Hospital of PLA; Beijing Science and Technical Committee, Science and Technology fund of Beijing finance | lgA nephropathy | | | | |
ChiCTR-TRC-10000990: Mycophenolate Mofetil Versus Cyclophosphamide Versus Leflunomide for Maintenance Therapy in ANCA Associated Systemic Vasculitis with renal involvement in remission |
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| Completed | 4 | 60 | | CTX 10-15mg/kg, 2, 4, 6, 9, 12, 18, 24month ;MMF1.5-2.0g/d, reduced by 500mg every 3 months from ;Leflunomide 20mg/d, reduced by 10mg every 3 months | Shanghai Jiaotong University Affiliated Ruijin Hospital; Level of the institution：, Shanghai Jiaotong University Affiliated Ruijin Hospital | ANCA Associated Systemic Vasculitis with renal involvement in remission | | | | |
ChiCTR-IPR-14005368: Prospective trial of leflunomide in the treatment of immunoglobulin A nephropathy |
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| Not yet recruiting | 4 | 60 | | leflunomide 20mg/d ;Valsartan 80mg/d | West China Hospital of Sichuan University; Level of the institution：, Funding Opportunity | immunoglobulin A nephropathy | | | | |
2005-004582-41: Safety and efficacy of combination treatment with rituximab and leflunomide in patients with active rheumatoid arthritis |
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| Ongoing | 4 | 15 | Europe | Mabthera, Arava, Solu-Medrone 2mg, Rituximab, Leflunomide, Methylprednisolone, Mabthera, Arava, Solu-Medrone 2 Gram, Mabthera, Arava, Solu-Medrone 2 Gram | University of Leeds | Active Rheumatoid Arthritis | | | | |
2007-001190-28: Randomised controlled trial of tumour-necrosis-factor inhibitors against combination intensive therapy with conventional disease modifying anti-rheumatic drugs in established rheumatoid arthritis |
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| Ongoing | 4 | 190 | Europe | Methotrexate, Sulfasalazine, Hydroxychloroquine, Ciclosporin, Leflunomide, Sodium aurothiomalate (intramuscular gold), methylprednisolone, Prednisolone, Infliximab, Etanercept, Adalimumab, Azathioprine, Penicillamine, Methotrexate, Sulfasalazine, Hydroxychloroquine, Ciclosporin, Leflunomide, Sodium aurothiomalate (intramuscular gold), methylprednisolone, Prednisolone, Infliximab, Etanercept, Adalimumab, Azathioprine, Penicillamine, | King\'s College London | Rheumatoid Arthritis | | | | |
2008-005727-28: BK viremi efter njurtransplantation: Screening, tidig diagnostik, tidig reduktion av immunhämning samt behandling med leflunomid (Arava®) |
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| Ongoing | 4 | 100 | Europe | Arava 20 mg filmdragerade tabletter, Arava 20 mg filmdragerade tabletter | Karolinska Universitetssjukhuset | BK Virusinfektion vid Njurtransplantation | | | | |
2018-002362-39: Methotrexate and leflunomide combination therapy in psoriatic arthritis. Methotrexaat en leflunomide combinatietherapie bij artritis psoriatica. |
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| Ongoing | 4 | 78 | Europe | Leflunomide, Methotrexate, Capsule, Injection, Leflunomide (Arava), Methotrexate (pharmachemie) | St Maartenskliniek, St Maartenskliniek | Adults diagnosed with Psoriatic Arthritis, Psoriatic arthritis, Diseases [C] - Immune System Diseases [C20] | | | | |
ChiCTR1900027627: Efficacy of leflunomide combined with prednisone for the treatment of PLA2R-associated primary membranous nephropathy |
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| Completed | 4 | 60 | | LEF combined with prednisone ;yclophosphamide (CTX) combined with prednisone | Department of Nephrology, The First Affiliated Hospital of Bengbu Medical College; The First Affiliated Hospital of Bengbu Medical College, Bengbu Medical College Natural Science Project | f PLA2R-associated primary membranous nephropathy | | | | |
| Not yet recruiting | 4 | 40 | | Kun-Xian Capsule ;Leflunomide | The First Affiliated Hospital of Chengdu Medical College; The First Affiliated Hospital of Chengdu Medical College, Project funds | IgA nephropathy | | | | |
NCT03739853: Severe Psoriatic Arthritis - Early intervEntion to Control Disease: the SPEED Trial |
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| Recruiting | 4 | 315 | Europe | Methotrexate, Sulfasalazine, Leflunomide, Adalimumab | University of Oxford | Psoriatic Arthritis | 08/24 | 02/25 | | |
ChiCTR2300072896: Cost-effectiveness of adalimumab "reduction strategies" in the treatment of rheumatoid arthritis: a multicenter, prospective, real-world observational study |
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| Not yet recruiting | 4 | 1000 | | None ;Adalimumab tapering combined with methotrexate therapy. The recommended dosage of adalimumab is as follows: Adalimumab, 40 mg/2 weeks, subcutaneous injection, reduce the dose after full dose treatment after reaching low disease activity. The dose reduction is carried out as follows: to extend the duration of administration and limiting the maximum duration of administration interval to 6 weeks (it is recommended to extend the duration of administration interval to 3, 4 or 6 weeks). The recommended dose of methotrexate is as follows: Methotrexate, taken orally, 10-30 mg once a week. ;triple therapy is applied. According to the patient's condition and willingness of patients, three traditional synthetic anti-rheumatic drug combination treatment could be applied, including but not limited to: methotrexate, leflunomide, sulfasalazine, hydroxychloroquine, etc. Recommended usage and dosage are as follows: Methotrexate, oral, 10-30 mg each time, once a week; Leflunomide, 10-20 mg once daily; Sulfasalazine, orally, 500 mg-1,000 mg each time, 3-4 times a day; Hydroxychloroquine, orally, 0.2 g to 0.4 g, once a day. | The First Affiliated Hospital of Chengdu Medical College; The First Affiliated Hospital of Chengdu Medical College, Self-funded | rheumatoid arthritis | | | | |
BIO3, NCT02714634: Clinical Trial Evaluating Methotrexate or Leflunomide + Targeted Therapy Versus Methotrexate or Leflunomide + Sulfasalazine + Hydroxychloroquine in Patients With Rheumatoid Arthritis and Insufficient Response to Methotrexate or Leflunomide |
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| Recruiting | 4 | 286 | Europe | Methotrexate + targeted therapy administration, methotrexate or leflunomide + sulfasalazine + hydroxychloroquine administration | University Hospital, Strasbourg, France | Rheumatoid Arthritis, Insufficient Response to Methotrexate or Leflunomide | 03/25 | 03/25 | | |
NCT05626348: The Clinical Efficacy of Immunomodulators in RA Patients |
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| Recruiting | 4 | 400 | RoW | Iguratimod, IGU, T-614, Methotrexate, MTX, Adalimumab Injection, adalimu, Leflunomide, LEF, Hydroxychloroquine, HCQ | Qilu Hospital of Shandong University | Arthritis, Rheumatoid | 06/25 | 12/26 | | |
ACTRN12623001342606: Steroid-Reducing Options for ReLapsING PolyMyalgia Rheumatica (STERLING PMR)Australian-specific protocol |
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| Not yet recruiting | 3 | 200 | | | the University of Adelaide, national health medical research council | polymyalgia rheumatica | | | | |
2014-003140-12: Leflunomide and Hydroxychloroquine combination therapy for primary Sjogren's Syndrome Leflunomide en Hydroxychloroquine combinatie therapie voor het primaire Syndroom van Sjogren |
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| Ongoing | 3 | 30 | Europe | Leflunomide mylan, Plaquenil, Capsule, Leflunomide Mylan, Plaquenil | UMC Utrecht, ZonMw | Sjogren's Syndrome Syndroom van Sjogren, Sjogren's Syndrome Syndroom van Sjogren, Diseases [C] - Immune System Diseases [C20] | | | | |
2007-004483-41: Effet de l’espacement des doses d’anti-TNF sur l’activité inflammatoire chez des polyarthrites rhumatoïdes en rémission ou en faible activité inflammatoire : essai randomisé contrôlé. |
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| Ongoing | 3 | 250 | Europe | ENBREL, HUMIRA, Methotrexate Bellon, ARAVA, ENBREL, HUMIRA, Methotrexate Bellon, ARAVA, ENBREL, HUMIRA, Methotrexate Bellon, ARAVA | ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP) | Polyarthrites rhumatoïdes en rémission. | | | | |
ChiCTR2000030058: A multicenter, randomized, double-blind, controlled clinical trial for leflunomide in the treatment of novel coronavirus pneumonia (COVID-19) |
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| Not yet recruiting | 3 | 200 | | Oral leflunomide ;Oral placebo | Renmin Hospital of Wuhan University; Renmin Hospital of Wuhan University, Science and technology department of Hubei province | Novel Coronavirus Pneumonia (COVID-19) | | | | |
2020-001899-14: An unblinded clinical Trial with random assignment to Treatment Groups in adult patients with psoriatic arthrits to evaluate how far immunosuppressive medication can be tapered without recurrence of symptoms |
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| Not yet recruiting | 3 | 270 | Europe | Prednisolone p.o., Sulfasalazine, Leflunomide, Methotrexate p.o., Methotrexate s.c., Etanercept, Adalimumab, Infliximab, Abatacept s.c., Abatacept i.v., Tablet, Coated tablet, , Solution for injection, Powder for concentrate for solution for infusion, Solution for injection in pre-filled pen, Solution for injection in pre-filled syringe, Solution for injection in dose-dispenser cartridge, Prolonged-release tablet, Xeljanz 5/10mg Filmtabletten, Otezla Filmtabletten, Simponi 50mg Injektionslösung Vorgefüllter Injektor/Fertigspritze, Cimzia 200mg Injektionslösung in einem Fertigpen, Orencia Injektionslösung in einer Fertigspritze, Orencia 250mg Pulver, Cosentyx 150mg Injektionslösung in einer Fertigspritze, Taltz, Cimzia 200mg Injektionslösung in einer Fertigspritze, Cimzia 200mg Injektionslösung in einer Patrone für ein Dosiergerät, Orencia 125mg Injektionslösung im Fertigpen, Cosentyx 150mg Injektionslösung in einem Fertigpen, Stelara 45mg/90mg Injektionslösung, Xeljanz 11mg Retardtablette, Rinvoq 15 mg Retardtablette, Tremfya 100mg Injektionslösung, Skyrizi 75/150mg Injektionslösung | Universitätsklinikum Erlangen, Universitätsklinikum Erlangen | Psoriatic arthritis Psoriasisarthritis, Psoriatic arthritis Gelenkbeteiligung bei Schuppenflechte, Diseases [C] - Immune System Diseases [C20] | | | | |
| Completed | 3 | 178 | Europe | leflunomide | Ashford and St. Peter's Hospitals NHS Trust | COVID-19 | 07/22 | 07/22 | | |
| Recruiting | 3 | 94 | Europe | Leflunomide 20 mg, Prednisolone | Elisabeth Brouwer, Dutch Arthritis Foundation Reuma Nederland | Polymyalgia Rheumatica | 11/22 | 11/22 | | |
ChiCTR2100051684: An open-label, randomized, controlled clinical trial of Leflunomide in the treatment of COVID-19 |
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| Recruiting | 3 | 60 | | Oral leflunomide + Symptomatic treatment ;Symptomatic treatment | Renmin Hospital of Wuhan University; Renmin Hospital of Wuhan University, self-raised | Novel Coronavirus Infected (COVID-19) | | | | |
NCT04610476: Impact of Tapering Immunosuppressants on Maintaining Minimal Disease Activity in Adult Subjects With Psoriatic Arthritis |
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| Recruiting | 3 | 270 | Europe | Prednisolone, Prednisolone generic drugs, Sulfasalazine, Azulfidine, Leflunomide, Arava, Methotrexate, Lantarel, Metex, Tofacitinib, Xeljanz, Apremilast, Otezla, Etanercept, Enbrel, Erelzi, Benepali, Adalimumab, Humira, Amgevita, Imraldi, Hyrimoz, Infliximab, Remicade, Zessly, Inflectra, Certolizumab pegol, Cimzia, Golimumab, Simponi, Abatacept, Orencia, Secukinumab, Cosentyx, Ixekizumab, Taltz, Ustekinumab, Stelara | University of Erlangen-Nürnberg Medical School | Psoriatic Arthritis, Withdrawal, Reduction | 10/24 | 10/25 | | |
| Recruiting | 3 | 220 | Europe, RoW | Abatacept (W12-W48), TNF Inhibitor (W12-W48), TNF Inhibitor (W0-W12) | University Hospital, Montpellier | Rheumatoid Arthritis | 11/24 | 11/25 | | |
NCT03414502: Treatment of Rheumatoid Arthritis With DMARDs: Predictors of Response |
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| Recruiting | 3 | 400 | US | Methotrexate, Methotrexate (MTX), Abatacept, Orencia, Adalimumab, Humira, Azathioprine, Imuran, Baricitinib, Olimuant, Certolizumab, Cimzia, Etanercept, Enbrel, Golimumab, Simponi, Hydroxychloroquine, Plaquenil, Infliximab, Remicade, Leflunomide, Arava, Minocycline, Minocin, Rituximab, Rituxin, Sarilumab, Kevzara, Sulfasalazine, Azulfidine, Tofacitinib, Xeljanz | University of Nebraska | Rheumatoid Arthritis | 03/26 | 03/28 | | |
| Ongoing | 2/3 | 178 | Europe | Leflunomide, Coated tablet, Leflunomide | Ashford and St Peter's Hospitals NHS Foundation Trust, LifeArc | Confirmed Covid-19 infection by RT-PCR, Typical symptoms of Coronavirus infection such as high temperature, cough, sore throat, headaches etc | | | | |
NCT05671497: The Effect of Cilostazol on Rheumatoid Arthritis Patients |
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| Recruiting | 2/3 | 70 | RoW | Cilostazol 100 MG, conventional synthetic antirheumatic drugs | Ain Shams University, Misr International University, Al-Azhar University | Rheumatoid Arthritis | 10/23 | 10/23 | | |
NCT05871086: Coenzyme Q10 in Juvenile Idiopathic Arthritis Patients |
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| Recruiting | 2/3 | 60 | RoW | Coenzyme Q10, Placebo, Standard Regimen | Nourhan Elsherif | Juvenile Idiopathic Arthritis | 12/23 | 12/23 | | |
| Completed | 2 | 240 | | Tu Fu Ling Tablets, 200mg Bid. Other: Placebo ;Tu Fu Ling Tablets, 100mg Tid. Other: Placebo. ;Leflunomide Tablets, 20mg Qd. Other: Placebo | The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine; Jingxiutang Pharmaceutical Company Ltd., Guangzhou, China., Jingxiutang Pharmaceutical Company Ltd., Guangzhou, China. | Rheumatoid Arthritis | | | | |
2020-001933-11: Leflunomide and Hydroxychloroquine combination therapy for primary Sjögren’s Syndrome |
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| Ongoing | 2 | 52 | Europe | Leflunomide, Hydroxychloroquine, Film-coated tablet, Tablet, Leflunomide, Plaquenil | University Medical Center Utrecht, ZonMw | Primary Sjogren Syndrome, Primary Sjogren Syndrome, Diseases [C] - Immune System Diseases [C20] | | | | |
2019-002470-32: Nuovi end-points clinici in pazienti con sindrome di Sjögren primaria (pSS): uno studio interventistico basato sulla stratificazione dei pazienti. NEw Clinical End-points in patients with primary Sjögren's Syndrome (pSS): an Interventional Trial based on stratifYing patients |
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| Ongoing | 2 | 300 | Europe | Leflunomide, mycophenolate mofetil, Hydroxychloroquine, [Leflunomide], [mycophenolate mofetil], [Hydroxychloroquine], Tablet, Arava, Mycophenolate mofetil TEVA, PLAQUENIL | ASSITANCE PUBLIQUE DES HOPITAUX DE PARIS, Innovative Medicines Initiative 2 | Primary Sjögren's syndrome (pSS) sindrome di Sjögren primaria (pSS), Primary Sjögren's syndrome (pSS) sindrome di Sjögren primaria (pSS), Body processes [G] - Immune system processes [G12] | | | | |
| Completed | 2 | 92 | RoW | Montelukast, Placebo, Conventional DMARDs | Noha Mansour | Rheumatoid Arthritis | 12/22 | 12/22 | | |
NCT04932564: Leflunomide for Musculoskeletal GVHD After Allogeneic Stem Cell Transplant |
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| Recruiting | 2 | 10 | RoW | Leflunomide tablet, Leflunomide | Tata Memorial Centre | Musculoskeletal Disease Other, GVHD, Chronic | 04/23 | 04/23 | | |
NCT04463615: Leflunomide for the Treatment of Relapsed or Refractory CD30+ Lymphoproliferative Disorders |
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| Completed | 2 | 1 | US | Leflunomide, Arava, SU101 | City of Hope Medical Center, National Cancer Institute (NCI) | Recurrent Lymphoproliferative Disorder, Refractory Lymphoproliferative Disorder | 07/21 | 07/21 | | |
NТО-RAS, NCT06229340: Leflunomide or Combination of MEK Inhibitor and Hydroxychloroquine for Refractory Patients With RAS Mutations |
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| Recruiting | 2 | 20 | RoW | Leflunomide, The combination of MEK inhibitor + hydroxychloroquine( plaquenil) ± bevacizumab | N.N. Petrov National Medical Research Center of Oncology | RAS Mutation, Ras (Kras or Nras) Gene Mutation, Colorectal Cancer Recurrent, Pancreas Cancer, Lung Cancer, Melanoma, Refractory Cancer | 10/26 | 10/26 | | |
| Recruiting | 2 | 300 | Europe | Hydroxychloroquine 400mg/d, Leflunomide 20mg/d, Mycophenolate mofetil 2000mg/d, Placebo of Hydroxychloroquine 400mg/d, Placebo of Leflunomide 20mg/d, Placebo of Mycophenolate mofetil 2000mg/d | Assistance Publique - Hôpitaux de Paris | Primary Sjögren's Syndrome (pSS) | 02/24 | 04/25 | | |
NCT04508790: Leflunomide, Pomalidomide, and Dexamethasone for the Treatment of Relapsed or Refractory Multiple Myeloma |
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| Recruiting | 2 | 29 | US | Dexamethasone, Aacidexam, Adexone, Aknichthol Dexa, Alba-Dex, Alin, Alin Depot, Alin Oftalmico, Amplidermis, Anemul mono, Auricularum, Auxiloson, Baycadron, Baycuten, Baycuten N, Cortidexason, Cortisumman, Decacort, Decadrol, Decadron, Decadron DP, Decalix, Decameth, Decasone R.p., Dectancyl, Dekacort, Deltafluorene, Deronil, Desamethasone, Desameton, Dexa-Mamallet, Dexa-Rhinosan, Dexa-Scheroson, Dexa-sine, Dexacortal, Dexacortin, Dexafarma, Dexafluorene, Dexalocal, Dexamecortin, Dexameth, Dexamethasone Intensol, Dexamethasonum, Dexamonozon, Dexapos, Dexinoral, Dexone, Dinormon, Fluorodelta, Fortecortin, Gammacorten, Hexadecadrol, Hexadrol, Lokalison-F, Loverine, Methylfluorprednisolone, Millicorten, Mymethasone, Orgadrone, Spersadex, TaperDex, Visumetazone, ZoDex, Leflunomide, Arava, SU101, Pomalidomide, 4-Aminothalidomide, Actimid, CC-4047, Imnovid, Pomalyst | City of Hope Medical Center, National Cancer Institute (NCI) | Recurrent Plasma Cell Myeloma, Refractory Plasma Cell Myeloma | 06/24 | 06/24 | | |
NCT05014646: Leflunomide for the Treatment of High-Risk Smoldering Multiple Myeloma in African-American and European-American Patients |
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| Recruiting | 2 | 56 | US | Cholestyramine, Cholybar, Colestyramine, Duolite AP143 Resin, Questran, Questran Light, Leflunomide, Arava, SU101 | City of Hope Medical Center, National Cancer Institute (NCI) | Smoldering Plasma Cell Myeloma | 12/25 | 12/25 | | |
| Completed | 1/2 | 240 | | 2 pieces of Tong Luo Hua Shi Capsules. Votalin and Leflunomide Tablets when necessary ;3 pieces of Tong Luo Hua Shi Capsules. Votalin and Leflunomide Tablets when necessary ;4 pieces of Tong Luo Hua Shi Capsules. Votalin and Leflunomide Tablets when necessary ;4 pieces placebo | The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine; Lanzhou Heshengtang Pharmaceutical Co., Ltd, Lanzhou Heshengtang Pharmaceutical Co.,Ltd | Rheumatoid arthritis | | | | |
NCT02509052: Leflunomide in Treating Patients With Relapsed or Refractory Multiple Myeloma |
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| Completed | 1/2 | 12 | US | Laboratory Biomarker Analysis, Leflunomide, Arava, SU101, Pharmacological Study | City of Hope Medical Center, National Cancer Institute (NCI) | Recurrent Plasma Cell Myeloma, Refractory Plasma Cell Myeloma | 09/18 | 06/22 | | |
NCT04532372: Leflunomide for the Treatment of Severe COVID-19 in Patients With a Concurrent Malignancy |
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| Terminated | 1/2 | 2 | US | Best Practice, standard of care, standard therapy, Leflunomide, Arava, SU101, Placebo Administration | City of Hope Medical Center, National Cancer Institute (NCI) | Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm, Symptomatic COVID-19 Infection Laboratory-Confirmed | 06/23 | 06/23 | | |
NCT03709446: Leflunomide in Previously Treated Metastatic Triple Negative Cancers |
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| Recruiting | 1/2 | 54 | US | Leflunomide, Arava | Joseph Sparano | Breast Neoplasms, Breast Diseases, Metastatic Triple Negative Breast Cancer | 10/25 | 10/26 | | |
| Recruiting | 1/2 | 34 | RoW | Leflunomide, Steroid Drug | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | Idiopathic Pulmonary Hemosiderosis, Leflunomide | 12/26 | 12/26 | | |
ChiCTR-TRC-10001014: Randomized Controlled Study to Evaluate the Clinical Outcomes of Rheumatoid Arthritis Treated with Method of Activating Blood Circulation by Removing Blood Stasis |
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| Completed | 1 | 120 | | observation group: Leflunomide Tablets, from the first day to the third day, 50mg, qd, po, then 20mg, qd, po. Ligustrazine Powder-Needle, 0.12g, solubling in 5% GS/NS 100ml, qd, iv, in 30 to 60 minutes. ;control group: Leflunomide Tablets, from the first day to the third day, 50mg, qd, po, then 20mg, qd, po. | Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences; Level of the institution：, Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences | Rheumatoid Arthritis | | | | |
| Terminated | 1 | 11 | US | Leflunomide | University of Chicago | COVID-19 | 01/22 | 01/22 | | |
NCT05247203: Telitacicept Study in Chinese Subjects With Systemic Lupus Erythematosus |
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| Completed | 1 | 92 | RoW | Telitacicept, RC18, standard therapy | RemeGen Co., Ltd. | Systemic Lupus Erythematosus | 10/23 | 11/23 | | |
NCT04370483: Leflunomide for the Treatment of High-Risk Smoldering Multiple Myeloma |
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| Active, not recruiting | 1 | 1 | US | Leflunomide, Arava, SU101, Quality-of-Life Assessment, Quality of Life Assessment | City of Hope Medical Center, National Cancer Institute (NCI) | Smoldering Plasma Cell Myeloma | 12/24 | 12/24 | | |
NCT06228443: Bioequivalence Study of Generic Leflunomide 20 mg Film-coated Tablets and Reference Product Under Fasting Conditions |
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| Not yet recruiting | 1 | 48 | NA | Leflunomide 20 mg Film-coated Tablet, ARAVA® 20 mg Film-coated Tablet | International Bio service | Healthy Volunteer | 04/24 | 04/24 | | |
NCT06454383: Gemcitabine and Leflunomide in Patients With Advanced Unresectable Pancreatic Cancer |
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| Recruiting | 1 | 19 | US | Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Cholestyramine, Cholybar, Colestyramine, Duolite AP143 Resin, Questran, Questran Light, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Diagnostic Imaging, Medical Imaging, Gemcitabine, dFdC, dFdCyd, Difluorodeoxycytidine, Leflunomide, Arava, SU101, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI | City of Hope Medical Center, National Cancer Institute (NCI) | Advanced Pancreatic Adenocarcinoma, Stage III Pancreatic Cancer AJCC v8, Stage IV Pancreatic Cancer AJCC v8, Unresectable Pancreatic Ductal Adenocarcinoma | 11/26 | 11/26 | | |
NCT04212416: Leflunomide in Treating Patients With Steroid Dependent Chronic Graft Versus Host Disease |
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| Active, not recruiting | 1 | 18 | US | Leflunomide, Arava, SU101 | City of Hope Medical Center, National Cancer Institute (NCI) | Chronic Graft Versus Host Disease, Steroid Refractory Graft Versus Host Disease | 08/24 | 08/24 | | |
NCT05443425: Leflunomide in Combination With Steroids for the Treatment of Acute Graft-versus-Host Disease After Donor Stem Cell Transplant for Hematologic Malignancies |
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| Recruiting | 1 | 18 | US | Cholestyramine, Cholybar, Colestyramine, Duolite AP143 Resin, Questran, Questran Light, Leflunomide, Arava, SU101, Steroid Therapy | City of Hope Medical Center, National Cancer Institute (NCI) | Acute Graft Versus Host Disease, Hematopoietic and Lymphoid System Neoplasm | 07/25 | 07/25 | | |
NCT04997993: Leflunomide in Patients With PTEN-Altered Advanced Solid Malignancies |
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| Recruiting | 1 | 24 | US | Leflunomide | Deborah Doroshow | PTEN-null Advanced Solid Tumors | 09/26 | 09/26 | | |
ChiCTR2000039729: The clinical efficacy and safety of tofacitinib tablets combined with methotrexate tablets in the treatment of psoriatic arthritis |
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| Recruiting | N/A | 30 | | Tofacitinib 5mg twice a day and Methotrexate 10mg once a week ;Leflunomide 20mg once a day and Methotrexate 10mg once a week | Yuyao People's Hospital; Yuyao People's Hospital, salf-paying | psoriatic arthritis | | | | |
ChiCTR-TRC-12001859: Treatment of coronary heart disease in rheumatoid arthritis with leflunomide combined with ligustrazine in clinical research |
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| Completed | N/A | 60 | | leflunomide combined with ligustrazine ;leflunomide combined with placebo | Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences; Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Self-financing | coronary heart disease in rheumatoid arthritis | | | | |
ChiCTR-TRC-13003948: The evaluation of clinical curative effect of 'supplying of shen and nourishing sui' law of electroacupuncture combined with ZeLing joint swelling mixture in the treatment of rheumatoid arthritis with yin-deficiency of liver and kidney pattern |
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| Completed | N/A | 120 | | Methotrexate 10mg qw PO + Leflunomide 10mg qd PO ;M+L+SEA+ZJSM | Institute of Acupuncture-Moxibustion and Meridian, Shanghai University of Traditional Chinese Medicine; Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Development of Chinese medicine in Shanghai three-year action plan | rheumatoid arthritis | | | | |
ChiCTR-ROC-16009278: IL-22-producing CD4+T cells in the treatment response of rheumatoid arthritis to combination therapy with methotrexate and leflunomide |
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| Completed | N/A | 80 | | null ;null | the First Hospital of Jilin University; the First Hospital of Jilin University, The National Natural Science Foundation of China (No. 81501343) | Rheumatoid Arthritis | | | | |
ChiCTR-INR-17011495: Canceled by the investigator The efficacy and safety of metformin hydrochloride combined with atorvastatin in the treatment of primary mild to moderate systemic sy |
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| Recruiting | N/A | 90 | | The level of SELSNA-SLEDAI was evaluated at week 4, week 12 and week 24, the BILAG table, the SLE lesion index, and the SLE damage index were measured at 4 weeks, 12 weeks and 24 weeks. The levels of Th17, Treg and Th17 / Treg were measured. ;Leflunomide tablets 10m, 1 times / day, orally. The SELSNA-SLEDAI score table, BILAG worksheet, SLE damage index score were assessed at week 4, week 12 and week 24, and serum Th17, Treg and Th17 / Treg ratios were measured. ;0 weeks to give prednisone acetate tablets 0.5-1mg / kg.d (or patients can choose to take the same dose of methylprednisolone tablets), 4 weeks after the beginning of the dose by 2 weeks to reduce the regular dose of 10% Reduction to prednisone acetate tablets 10mg / day to maintain. ;All patients without contraindications plus hydroxychloroquine tablets 0.2,2 / day, orally; and according to the condition plus calcium (800-1200mg / day), vitamin D (200-800IU / day) and other treatment. | The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology; The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Self-raised | Primary mild to moderate systemic systemic lupus erythematosus | | | | |
ChiCTR2000033372: Efficacy and safety of leflunomide for Refractory novel coronavirus pneumonia (COVID-19): A non-Randomized Controlled Study |
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| Completed | N/A | 30 | | Standard treatment plus Oral leflunomide ;Standard treatment | Shandong University Qilu Hospital; Shandong University Qilu Hospital, Shandong University | Novel Coronavirus Pneumonia (COVID-19) | | | | |
ChiCTR-INR-17013574: Clinical Study on Treating Ankylosing Spondylitis with Chinese Herbal Decoction Zhitongzhu Decoction |
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| Not yet recruiting | N/A | 80 | | Leflunomide ;Chinese herbalshentongzhuyudecoction | The First Affiliated Hospital of Heilongjiang Chinese Medicine Colledge; The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Self sponsored and department sponsored | Ankylosing spondylitis | | | | |
ChiCTR2100041847: Clinical observation on the treatment of joint swelling and pain due to the Fengtabuzu syndrome of RA by Dai medicine Longmengshahousan |
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| Recruiting | N/A | 72 | | Longmengshahousan, Methotrexate tablets and Leflunomide tablets ;Longmengshahousan simulation agent, Methotrexate tablets and Leflunomide tablets | Yunnan Hospital of Traditional Chinese Medicine; Yunnan Hospital of Traditional Chinese Medicine, Science and Technology Department of Yunnan Province | RA | | | | |
ChiCTR2100041894: Observation on the clinical effect of external application of Yi medicine SISE ointment in the treatment of rheumatoid arthritis (wind cold dampness syndrome) joint swelling and pain |
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| Recruiting | N/A | 72 | | Yiyisise ointment, Methotrexate, Leflunomide tablets and Folic acid tablets ;Yiyisise ointment simulant, Methotrexate, Leflunomide tablets and Folic acid tablets | Yunnan Hospital of Traditional Chinese Medicine; Yunnan Provincial Hospital of Traditional Chinese Medicine/The First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, Science and Technology Department of Yunnan Province | Rheumatoid arthritis | | | | |
ChiCTR2100041821: Observation on the clinical curative effect of external application of Rebi ointment in treating rheumatoid arthritis (damp-heat syndrome) joint pain |
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| Recruiting | N/A | 72 | | Rebi ointment, Methotrexate tablets, Leflunomide tablets, and Folic acid tablets ;Rebi cream simulant, Methotrexate tablets, Leflunomide tablets, and Folic acid tablets | Yunnan Provincial Hospital of Traditional Chinese Medicine/The First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine; Yunnan Provincial Hospital of Traditional Chinese Medicine/The First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, Science and Technology Department of Yunnan Province | Rheumatoid Arthritis | | | | |
ChiCTR2100041819: Clinical study of Hanbi ointment in the treatment of rheumatoid arthritis |
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| Recruiting | N/A | 72 | | Hanbi ointment + Methotrexate + Leflunomide Tablets + Folic Acid Tablets ;Hanbi ointment simulant+ Methotrexate + Leflunomide Tablets + Folic Acid Tablets | The First Affiliated Hospital of Yunnan University of traditional Chinese Medicine; The First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, Department of science and technology of Yunnan Province | Rheumatoid arthritis | | | | |
ChiCTR2100041909: Clinical study on Yupingfengguizhi solution assisted hormone Withdrawal and reduction in rheumatoid arthritis (Wind-Cold-Dampness Arthralgia Syndrome) |
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| Recruiting | N/A | 93 | | Yupingfengguizhi solution, Prednisone Acetate Tablets, Methotrexate, Leflunomide ;Prednisone Acetate Tablets, Methotrexate, Leflunomide | Yunnan Traditional Chinese Medicine Hospital; Medical Ethics Committee of Yunnan Traditional Chinese Medicine Hospital, Science and Technology Department of Yunnan Province | Rheumatoid arthritis | | | | |
ChiCTR2100041777: Clinical study on Juanbi granule in adjuvant hormone withdrawal of rheumatoid arthritis |
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| Recruiting | N/A | 93 | | Juanbi granule, Prednisone Acetate Tablets, Methotrexate and Leflunomide ;Prednisone Acetate Tablets, Methotrexate and Leflunomide | Yunnan Hospital of Traditional Chinese Medicine /The First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine; Medical Ethics Committee of Yunnan Traditional Chinese Medicine Hospital, Science and Technology Department of Yunnan Province | rheumatoid arthritis | | | | |
| Recruiting | N/A | 116 | RoW | Leflunomide 10mg Tab, Prednisone Acetate, Placebos | Jiang lindi | Takayasu Arteritis | 12/22 | 12/22 | | |
LEFAZAREM, NCT04737343: Comparison of the Efficacy of Leflunomide and Azathioprine for the Maintenance Therapy of ANCA Associated Vasculitis |
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| Recruiting | N/A | 114 | RoW | Leflunomide, Tuoshu for commericial name, Azathioprine Tablets | Chinese SLE Treatment And Research Group, Shanghai Zhongshan Hospital, Affiliated Hospital of Jilin University, Changchun,China, Second Affiliated Hospital of Nanchang University, The First Affiliated Hospital of Anhui Medical University, Beijing Shijitan Hospital, Capital Medical University, The Affiliated Hospital of Inner Mongolia Medical University, The First Affiliated Hospital of Kunming Medical College, Sichuan Province People's Hospital, Second Affiliated Hospital, School of Medicine, Zhejiang University | ANCA Associated Vasculitis, Maintenance Therapy | 11/24 | 12/24 | | |
NCT05789017: Treatment Strategies for IgG4-RD Patients With Internal Organ Involvement |
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| Recruiting | N/A | 60 | RoW | Prednisone and Mycophenolate Mofetil, Mycophenolate Mofetil, Leflunomide | Peking Union Medical College Hospital | Autoimmune Diseases | 12/24 | 12/24 | | |
NCT05789030: Treatment Strategies for IgG4-RD Patients With Superficial Organ Involvement |
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| Recruiting | N/A | 90 | RoW | Diprospan plus iguratimod, Diprospan plus leflunomide, Prednisone plus leflunomide | Peking Union Medical College Hospital | Autoimmune Diseases | 12/24 | 12/24 | | |
ChiCTR2300071123: Effect of Yuping Fengguizhi Granules on intestinal flora in patients with RA (wind-cold-dampness Bi syndrome) exposed to hormones |
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| Recruiting | N/A | 60 | | Prednisone acetate, Methotrexate, Leflunomide, Yupingfeng cassia branch granules ;Prednisone acetate, Leflunomide, Methotrexate | The First Affiliated Hospital of Yunnan University of Chinese Medicine; Yunnan Hospital of Traditional Chinese Medicine, Research fund | Rheumatoid arthritis | | | | |
ChiCTR2300067676: A Clinical trial of glucocorticoids tapering and discontinuation by combining traditional Chinese herb and DMARDs on rheumatoid arthritis |
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| Not yet recruiting | N/A | 231 | | Prednisone Acetate Tablets, Methotrexate, Leflunomide ;Prednisone Acetate Tablets, Methotrexate, Leflunomide and combined with formula No.1 of chinese medicine ;Prednisone Acetate Tablets, Methotrexate, Leflunomide and combined with formula No.2 of chinese medicine | Yunnan Provincial Hospital of Traditional Chinese Medicine / The No.1 Affiliated Hospital of Yunnan University of Traditional Chinese Medicine; Yunnan Hospital of Traditional Chinese Medicine, Science and Technology Department of Yunnan Province | Rheumatoid arthritis | | | | |
| Recruiting | N/A | 15 | Europe | Leflunomide 20 mg | University Hospital, Basel, Switzerland | MEN1 Gene Mutation | 01/25 | 01/25 | | |
ELF, NCT04542733: The Efficacy of Everolimus With Reduced-dose Tacrolimus Versus Reduced-dose Tacrolimus in Treatment of BK Virus Infection in Kidney Transplantation Recipient |
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| Recruiting | N/A | 50 | RoW | Everolimus, reduced dose tacrolimus | King Chulalongkorn Memorial Hospital | Kidney Transplant Infection, BK Virus Infection | 09/25 | 09/25 | | |
NCT03893136: The Registry Study of Takayasu Arteritis in East China |
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| Recruiting | N/A | 1000 | RoW | Tocilizumab, IL-6R antibody, Leflunomide, Arava | Shanghai Zhongshan Hospital | Takayasu Arteritis, Mechanisms, Defense, Pregnancy Related, Treatment Refusal, Outcome | 05/26 | 05/26 | | |
| Recruiting | N/A | 36 | RoW | Leflunomide | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | Henoch-Schonlein Purpura | 06/27 | 06/27 | | |
| Recruiting | N/A | 2000 | US | Methotrexate, Sulfasalazine, Leflunomide, Pamidronate, Zoledronic acid, Etanercept, Adalimumab, Certolizumab, Infliximab, Golimumab, NSAID | Seattle Children's Hospital, Boston Children's Hospital, Boston, MA, USA, Hospital for Special Surgery, New York City, NY, USA, Joseph M Sanzari Children's Hospital, Hackensack University Medical Center, Hackensack, NJ, USA, Riley Children's Hospital, Indianapolis, IN, USA, University of North Carolina, Chapel Hill, NC, USA, Royal Children's Hospital, Melbourne, Australia, Hacettepe University, Ankara, Turkey, Bambino Gesù Children's Hospital, Rome, Italy, University of British Columbia, Vancouver, BC, Canada, Meyer Children's Hospital, Florence, Italy, Mansoura University | Chronic Nonbacterial Osteomyelitis, Chronic Recurrent Multifocal Osteomyelitis | 08/28 | 08/50 | | |
| Recruiting | N/A | 500 | RoW | YISAIPU® ( An etanercept biosimilar), a recombinant tumor necrosis factor receptor-Fc fusion protein, rhTNFR:Fc, csDMARDs | The First Affiliated Hospital of Xiamen University | Rheumatoid Arthritis | 06/25 | 12/25 | | |