| lamivudine / Generic mfg. |
ChiCTR-OCH-12002141: Entecavir monotherapy versus de novo combination of lamivudine and adefovir for the treatment of naive HBeAg-positive chronic hepatitis B patients with High HBV viral load （the Climber study) |
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| Completed | 4 | 280 | | Lamivudine 100mg po qd, Adefovir Dipivoxil 10mg po qd, for 96 weeks ;Entecvir 0.5mg po qd, for 96 weeks | Departmen of infectious disease, Tongji Hospital, Tongji medical college, Huazhong university of science and technology; Departmen of infectious disease, Tongji hospital, Tongji medical college, Huazhong university of science and technology, Sino-American Shanghai Squibb Pharmaceuticals Ltd. | chronic hepatitis B | | | | |
ChiCTR-TRC-11001258: Efficacy of lamivudine and adefovir de-novo combination therapy or optimal therapy at week 48 in chronic hepatitis B patients |
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| Completed | 4 | 174 | | Adefovir 10mg/d,p.o.qd for 104 weeks or combination with Lamivudine 10mg/d,p.o.qd at 48 weeks.Total treatment time:104 weeks ;Lamivudine(LAM) 100mg/d,p.o.qd for 104 weeks or combination with Adefovir(ADV) 10mg/d,p.o.qd at 48 weeks.Total treatment time:104 weeks ;Lamivudine 100mg/d,p.o.qd +Adefovir 10mg/d,p.o.qd for 104 weeks | Department of Infectious Diseases, Guangdong General Hospital; Level of the institution：, self-financing | Chronic hepatitis B | | | | |
ChiCTR-TRC-08000219: Optimized antiviral therapy in chronic hepatitis B: A randomized, open-label, multicenter, controlled trial |
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| Completed | 4 | 300 | | Giving adefovir only ;Giving adefovir and lamivudine together ;Treated by Lamivudine for 16 weeks and combined with Adefovir when the HBV-DNA >1000 copies/ml | The First Affiliated Hospital of Wenzhou Medical College; GSK, GlaxoSmithKline (China) Investment Co. Ltd | Chronic Hepatitis B | | | | |
ChiCTR-ONRC-11001495: Lamivudine plus adefovir or telbivudine plus adefovir for chronic hepatitis B patients with suboptimal response to adefovir: a prospective controlled study |
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| Completed | 4 | 80 | | Telbivudine 600 mg/day , Adefovir 10 mg/day ;Lamivudine 100 mg/day , Adefovir 10 mg/day | Center of Infctious Diseases, West China Hospital of Sichuan University; Center of Infctious Diseases, West China Hospital of Sichuan University, self-funding | Chronic hepatitis B | | | | |
ChiCTR-TRC-12001980: Multiple-center clinical study of Antiviral Treatment with Nucleoside Analogues on Patients with HBV Associated Acute on Chronic Liver Failure among Multiple Center |
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| Completed | 4 | 800 | | entecavir ;lamivudine | Liver Failure Treatment and Research Center, 302 Military Hospital, Beijing, China; 302 Military Hospital, Beijing, China, The Military Key Clinical Program on the Traditional Chinese Medicine Research and Development; State | HBV associated acute on chronic liver failure | | | | |
ChiCTR-ONRC-12001924: Efficacy and safety of defovir dipivoxil in children with interferon therapy unresponsive and lamivudine- resistance chronic hepatitis B |
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| Completed | 4 | 30 | | Adefovir 0.25mg/kg/d,p.o.qd for three years.ADV dose is not to exceed 10 mg/day. | Affiliated Second Hospital, Southeast University, Nanjing; Affiliated Second Hospital, Southeast University, Nanjing, Self-finance | Chronic hepatitis B | | | | |
2014-000496-64: Viral suppression in Cerebrospinal Fluid in HIV-1 infected patients receiving Ritonavir-boosted Atazanavir plus lamivudine dual theraphy. SCALA study Supresión viral en el líquido cefalorraquídeo en pacientes con infección por VIH-1 que reciben tratamiento antirretroviral con atazanavir potenciado con ritonavir y lamivudina. Estudio SCALA |
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| Ongoing | 4 | 10 | Europe | REYATAZ, NORVIR, LAMIVUDINA EFG | Dr. Daniel Podzamczer Palter. Hospital Univesitari de Bellvitge. Unidad de VIH., Hospital Universitari de Bellvitge - Unidad de VIH | HIV-1 infection Infección por el virus VIH-1, HIV-1 infection Infección por el virus VIH-1, Diseases [C] - Virus Diseases [C02] | | | | |
2014-002281-70: Immune reconstitution in severely immunosuppressed antiretroviral-naive HIV-1?infected patients (<100 CD4+ T cells/?L) taking antiretroviral regimens based on dolutegravir or ritonavir-boosted darunavir (the AdvanZ-4 Trial). Reconstitución inmune en pacientes con infección por el VIH-1 no tratados previamente y con cifras de linfocitos CD4+ inferiores a 100 céls/mm3 que reciben un régimen de fármacos antirretrovirales basado en dolutegravir o darunavir/ritonavir. Estudio AdvanZ-4. |
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| Ongoing | 4 | 108 | Europe | CoatedTablet600 mg de abacavir ( sulfate) 300 mg de lamivudine, PREZISTA 300 mg comprimidos recubiertos con película darunavir, Norvir 100 mg soft tablets, Triumeq, Coated tablet, Capsule, soft, Tablet, KIVEXA( Abacavir 600 mg/ Lamivudine 300 mg) recovered tablets, PREZISTA 300 mg recovered Tablets, NORVIR 100 mg soft Tablets, TRIUMEQ®: Lamivudine(3TC) 300 mg+ Abacavir(ABC) 600 mg + dolutegravir(DGT) 50 mg : 1 comprimido | Fundació Clínic per a la Recerca Biomèdica, ViiV Healthcare UK Limited 980 Great West Road Brentford Middlesex TW8 9GS Reino Unido | tratement HIV infection tratamiento de la infección por HIV, HIV infection infección por HIV, Diseases [C] - Virus Diseases [C02] | | | | |
2015-000274-35: clinical trial to assess the safety, tolerability and efficacy of two dolutegravir-based simplification strategies in HIV-infected patients with prolonged virological suppression. ENSAYO CLÍNICO PARA EVALUAR LA SEGURIDAD, TOLERABILIDAD Y EFICACIA DE DOS ESTRATEGIAS DE SIMPLIFICACIÓN BASADAS EN DOLUTEGRAVIR EN PACIENTES INFECTADOS POR VIH CON SUPRESIÓN VIROLÓGICA SOSTENIDA. |
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| Ongoing | 4 | 450 | Europe | Lamivudine, Efavirenz, nevirapine, J05AX12, Coated tablet, Capsule, hard, Tablet, Prolonged-release tablet, Tivicay, Stribild, TRUVADA, KIVEXA, ZIAGEN, VIREAD, EMTRIVA, ATRIPLA, EVIPLERA, ISENTRESS, RAYATAZ, PREZISTA, KALETRA, NORVIR, INTELENCE, EDURANT, TRIUMEQ | Fundació Lluita contra la SIDA, Fundació Lluita contra la SIDA | Infection with human immunodeficiency virus (HIV). Infección por el virus de la inmunodeficiencia humana (VIH)., HIV infection Infección por VIH, Diseases [C] - Virus Diseases [C02] | | | | |
ChiCTR-ONRC-12002315: Contrast study of Entecavir monotherapy and the de novo combining Lamivudine with Adefovir therapy on HBeAg-positive CHB patients with high viral load |
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| Completed | 4 | 160 | | combination therapy of LAM with ADV ;therapy withETV | NanFang hospital; Xiangya secondary hospital, Guanghui foundation | chronic hepatitis B | | | | |
2004-002633-39: Prospective study of switch to 3TC monotherapy with evaluation of replication capacity in patients with virologic failure and 3TC resistance (a multicenter prospective clinical study within the SHCS) SHCS-Projekt Nr. 408 |
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| Ongoing | 4 | 5 | Europe | Epivir, 3TC, Epivir, Epivir | Prof. Dr. med. Milos Opravil, Universitätsspital Zürich | HIV patients with virological treatment failure due to multi-drug-resistant virus including 3TC resistance | | | | |
2017-004750-42: EFFICACY AND SAFETY OF A SIMPLIFICATION TREATMENT BASED ON DOLUTEGRAVIR AND DARUNAVIR / COBICISTAT VS USUAL TREATMENT IN SUPPRESSED HIV-1-INFECTED PATIENTS WITH MULTIDRUG RESISTANCE. Eficacia y seguridad de Dolutegravir más Darunavir/cobicistat como tratamiento de simplificación frente al tratamiento habitual en pacientes infectados por el VIH-1 virológicamente suprimidos y con resistencia a múltiples fármacos. |
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| Ongoing | 4 | 100 | Europe | lamivudine, Efavirenz, Nevirapine, Film-coated tablet, Coated tablet, Capsule, hard, Tablet, Rezolsta, Tivicay, Ziagen, EMTRIVA, VIREAD, kivexa, Truvada, Intelence, Edurant, Atripla, Eviplera, Reyataz, Prezista, Kaletra, Norvir, Evotaz, Isentress, Stribild, Triumeq, Genvoya, Celsentri, Descovy | FUNDACIÓ LLUITA CONTRA LA SIDA, ViiV Healthcare | HIV-1 VIH-1, HIV infection Infección por VIH, Diseases [C] - Virus Diseases [C02] | | | | |
2019-000199-41: A study to evaluate the impact of the change of antiretroviral treatment from dual therapy to triple therapy on inflammation in HIV+ patients. Estudio para evaluar el impacto del cambio de tratamiento antirretroviral de terapia dual a terapia triple sobre la inflamación en pacientes VIH + |
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| Not yet recruiting | 4 | 234 | Europe | Bictarvy, Tivicay, Epivir, Tablet, Bictarvy, Tivicay, Epivir | Fundación SEIMC-GESIDA, Gilead Sciences, S.L | HIV VIH, HIV VIH, Diseases [C] - Virus Diseases [C02] | | | | |
2019-002733-10: Exploratory, open-label, randomized clinical trial to assess the efficacy of first-line dual vs. triple antiretroviral therapy (art) in hiv-1 reservoir and in peripheral compartments in hiv-infected patients. Ensayo clínico abierto, aleatorizado para evaluar el efecto del tratamiento antirretroviral inicial doble vs.triple en el reservorio del VIH-1 y en tejidos periféricos en pacientes infectados por el VIH-1. |
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| Ongoing | 4 | 44 | Europe | Coated tablet, Tivicay, Descovy, Lamivudine | FUNDACIÓ LLUITA CONTRA LA SIDA, Viiv Healthcare | HIV infection Infección por VIH, HIV infection Infección por VIH, Diseases [C] - Virus Diseases [C02] | | | | |
ChiCTR1900027656: Analysis of the efficacy and safety of dotiapramib in the treatment of HIV infection |
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| Recruiting | 4 | 200 | | Dotiapramib tablets (contains 600 mg of abacavir sulfate, 300 mg of lamivudine and 50 mg of dotilavir sodium) | Chongqing Public Health Medical Treatment Center; Chongqing Public Health Medical Treatment Center, raise independently | AIDS | | | | |
ChiCTR1900020750: A prospective, randomized, non-inferior clinical trial for antiviral therapy optimization programs for AIDS patients |
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| Not yet recruiting | 4 | 200 | | Zidovudine 300mg twice daily / tenofovir 300mg once daily + lamivudine 300mg once daily + nevirapine 200mg twice daily / efavirenz 600mg once daily ;Lopinavir/ritonavir 500mg twice daily + lamivudine 300mg once daily | The Fifth Affilated Hosipital Of Sun Yat-sen University; The Fifth Affiliated Hosipital Of Sun Yat-sen University, Hospital funding and self-finacing | AIDS | | | | |
ChiCTR1900027640: A real world study for a simplified regimen of dolutegravir combined with lamivudine in the treatment of newly infected HIV patients |
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| Not yet recruiting | 4 | 30 | | DTG 50mg +3TC 300mg once a day | The Fifth Affiliated Hosipital Of Sun Yat-sen University; The Fifth Affiliated Hosipital Of Sun Yat-sen University, Hospital funding and self-finacing | HIV/AIDS | | | | |
2021-005347-79: Exposure to Doravirine in people with HIV undergoing weight loss surgery Blootstelling aan doravirine bij mensen met hiv die een operatie voor gewichtsverlies ondergaan |
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| Ongoing | 4 | 8 | Europe | Film-coated tablet, Pifeltro® (100 mg doravirine), Delstrigo® (100 mg doravirine/ 300 mg Lamivudine/ 245 mg Tenofovir Disoproxil Fumarate) | Radboud University Medical Center, Radboud University Medical Center | HIV plus bariatric surgery, HIV and weight loss surgery, Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Surgical Procedures, Operative [E04] | | | | |
ChiCTR2100047490: Rapid initiation of antiviral therapy in newly diagnosed HIV-infected patients based on the simplified protocol of dotiravir / lamivudine |
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| Recruiting | 4 | 100 | | Lamivudine / dotiravir | The First Affiliated Hospital of China Medical University; The First Affiliated Hospital of China Medical University, Study on the optimization and application of AIDS comprehensive treatment plan; AIDS Health Foundation (AHF) | AIDS | | | | |
ChiCTR2300072308: Study on the efficacy and safety of Dolutegravir combined with Lamivudine in the treatment of HIV infections |
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| Completed | 4 | 72 | | None ;None | Chest Hospital of Guangxi Zhuang Autonomous Region (Longtan Hospital of Guangxi Zhuang Autonomous Region); Chest Hospital of Guangxi Zhuang Autonomous Region (Longtan Hospital of Guangxi Zhuang Autonomous Region), Scientific and technological funds provided by Guangxi Liuzhou Science and Technology Bureau, self-owned funds of Chest Hospital of Guangxi Zhuang Autonomous Region (Longtan Hospital) | Acquired immune deficiency syndrome | | | | |
| Active, not recruiting | 4 | 155 | RoW | Darunavir (DRV) 800 milligram (MG) Oral Tablet, Prezista, Ritonavir 100 MG Oral Tablet, Norvir, RTV, N(t)RTIs, Nucleoside/nucleotide reverse transcriptase inhibitors [N(t)RTIs], Dolutegravir 50 MG Oral Tablet, Tivicay, DTG, TDF 300 MG Oral Tablet, tenofovir disoproxil fumarate, Viread, 3TC 300 MG Oral Tablet, lamivudine, FTC 200 MG Oral Cap, Emtriva, emtricitabine | Kirby Institute | HIV Infections | 01/24 | 01/24 | | |
| Active, not recruiting | 4 | 100 | RoW | TLD - Tenofovir Disoproxil Fumarate / Lamivudine / Dolutegravir, Acriptega | University of Witwatersrand, South Africa, Bill and Melinda Gates Foundation | HIV Prevention | 06/26 | 08/26 | | |
NCT06503796: Antiviral Therapy in Infants With HBV Infection |
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| Not yet recruiting | 4 | 60 | RoW | Lamivudine, Interferon | Beijing 302 Hospital | HBV | 11/25 | 11/26 | | |
ChiCTR2300069528: A randomized, open-label, controlled clinical trial of lamivudine in the treatment of adults with ultra-early novel coronavirus infection |
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| Suspended | 4 | 1000 | | Symptomatic treatment+lamivudine 10mg qd*5 days ;Symptomatic treatment+azvudine 5mg qd*5 days | Emergency Department of Rongxian People's Hospital; Rongxian People's Hospital, Self-financing | 2019 novel coronavirus infection | | | | |
