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48 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
irinotecan / Generic mfg.
NCT00003955: Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Metastatic Rhabdomyosarcoma or Sarcoma

Completed
2
77
Europe, Canada, US, RoW
dactinomycin, filgrastim, pegfilgrastim, sargramostim, cyclophosphamide, irinotecan hydrochloride, vincristine sulfate, radiation therapy
Children's Oncology Group, National Cancer Institute (NCI)
Sarcoma
01/05
10/09
NCT00509860: Irinotecan (Camptosar) in Patients With Advanced Sarcomas

Completed
2
38
US
Irinotecan, Camptosar, CPT-11
M.D. Anderson Cancer Center
Sarcoma
08/07
01/12
NCT00004078: Irinotecan in Treating Children With Refractory Solid Tumors

Completed
2
181
US
irinotecan hydrochloride, Campto, Camptosar, CPT-11, irinotecan, U-101440E
Children's Oncology Group, National Cancer Institute (NCI)
Childhood Central Nervous System Germ Cell Tumor, Childhood Choroid Plexus Tumor, Childhood Craniopharyngioma, Childhood Grade I Meningioma, Childhood Grade II Meningioma, Childhood Grade III Meningioma, Childhood Infratentorial Ependymoma, Childhood Oligodendroglioma, Childhood Supratentorial Ependymoma, Previously Treated Childhood Rhabdomyosarcoma, Recurrent Childhood Cerebellar Astrocytoma, Recurrent Childhood Cerebral Astrocytoma, Recurrent Childhood Ependymoma, Recurrent Childhood Medulloblastoma, Recurrent Childhood Rhabdomyosarcoma, Recurrent Childhood Visual Pathway and Hypothalamic Glioma, Recurrent Childhood Visual Pathway Glioma, Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor, Recurrent Neuroblastoma, Recurrent Osteosarcoma, Unspecified Childhood Solid Tumor, Protocol Specific
10/07
 
NCT00025363: Comparison of Chemotherapy Regimens in Treating Children With Relapsed or Progressive Rhabdomyosarcoma

Completed
2
150
US
vincristine sulfate, leurocristine sulfate, VCR, Vincasar PFS, irinotecan hydrochloride, Campto, Camptosar, CPT-11, irinotecan, U-101440E, cyclophosphamide, CPM, CTX, Cytoxan, Endoxan, Endoxana, doxorubicin hydrochloride, ADM, ADR, Adria, Adriamycin PFS, Adriamycin RDF, ifosfamide, Cyfos, Holoxan, IFF, IFX, IPP, etoposide, EPEG, VP-16, VP-16-213, tirapazamine, SR 4233, Tirazone, WIN 59075, filgrastim, G-CSF, Neupogen, sargramostim, GM-CSF, Leukine, Prokine, pharmacological study, pharmacological studies, pharmacogenomic studies, Pharmacogenomic Study, laboratory biomarker analysis
National Cancer Institute (NCI)
Alveolar Childhood Rhabdomyosarcoma, Embryonal Childhood Rhabdomyosarcoma, Embryonal-botryoid Childhood Rhabdomyosarcoma, Previously Treated Childhood Rhabdomyosarcoma, Recurrent Childhood Rhabdomyosarcoma
10/07
 
NCT00276692: Irinotecan in Treating Patients With Newly Diagnosed Ewing's Sarcoma

Completed
2
35
Europe
irinotecan hydrochloride
Children's Cancer and Leukaemia Group
Sarcoma
09/08
07/09
NCT00613028: Ph II Bev + Either Temozolomide/Etoposide for GBM Pts Who Have Failed Bev + Irinotecan

Completed
2
23
US
Temo + Avastin, temozolomide, temodar, bevacizumab, VP-16 + Avastin, VP-16, etoposide, avastin
Duke University, Genentech, Inc.
Glioblastoma, Gliosarcoma
10/09
01/11
NCT00954876: Study of Capecitabine and Cetuximab as First-Line Therapy in Patients With Metastatic Wild Type Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Colorectal Cancer

Withdrawn
2
0
US
capecitabine and cetuximab
Translational Genomics Research Institute, Eli Lilly and Company
Metastatic Colorectal Cancer
01/10
01/10
NCT00433381: Bevacizumab and Irinotecan or Temozolomide in Treating Patients With Recurrent or Refractory Glioblastoma Multiforme or Gliosarcoma

Completed
2
123
US
Bevacizumab, Anti-VEGF, Anti-VEGF Humanized Monoclonal Antibody, Anti-VEGF rhuMAb, Avastin, Bevacizumab Biosimilar BEVZ92, Bevacizumab Biosimilar BI 695502, Bevacizumab Biosimilar CBT 124, Bevacizumab Biosimilar FKB238, BEVACIZUMAB, LICENSE HOLDER UNSPECIFIED, Immunoglobulin G1 (Human-Mouse Monoclonal rhuMab-VEGF Gamma-Chain Anti-Human Vascular Endothelial Growth Factor), Disulfide With Human-Mouse Monoclonal rhuMab-VEGF Light Chain, Dimer, Recombinant Humanized Anti-VEGF Monoclonal Antibody, rhuMab-VEGF, Irinotecan Hydrochloride, Campto, Camptosar, Camptothecin 11, Camptothecin-11, CPT 11, CPT-11, Irinomedac, U-101440E, Temozolomide, CCRG-81045, Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, M & B 39831, M and B 39831, Methazolastone, RP-46161, SCH 52365, Temcad, Temodal, Temodar, Temomedac
National Cancer Institute (NCI), American College of Radiology Imaging Network, Radiation Therapy Oncology Group
Adult Glioblastoma, Adult Gliosarcoma, Recurrent Adult Brain Neoplasm
01/10
02/11
NCT00979017: Avastin/Temozolomide/Irinotecan for Unresectable/Multifocal Glioblastoma Multiforme

Completed
2
41
US
Avastin, Avastin (bevacizumab), Temozolomide, Temodar, Irinotecan, CPT-11, Camptosar
Katy Peters, Genentech, Inc.
Glioblastoma Multiforme, Gliosarcoma
02/11
01/13
NCT00735436: A Study of Gliadel Followed by Avastin + Irinotecan for Glioblastoma Multiforme (GBM)

Terminated
2
18
US
Gliadel/Avastin/CPT-11, bevacizumab, irinotecan
Duke University, Eisai Inc., Genentech, Inc.
Malignant Glioma, Glioblastoma Multiforme, Gliosarcoma
07/11
10/12
NCT00597402: Avastin in Combination With Radiation (XRT) & Temozolomide, Followed by Avastin, Temozolomide and Irinotecan for Glioblastoma (GBM) and Gliosarcomas

Completed
2
125
US
Avastin, Bevacizumab, Temozolomide, Temodar, Radiation Therapy (XRT), Irinotecan, CPT-11, Camptosar
Duke University, Genentech, Inc., Schering-Plough
Glioblastoma, Gliosarcoma, Brain Tumor
08/11
05/13
NCT00544778: Combination Chemotherapy and Dexrazoxane Followed by Surgery and Radiation Therapy in Treating Patients With Advanced Soft Tissue Sarcoma or Recurrent Bone Sarcoma

Terminated
2
7
US
filgrastim, dexrazoxane hydrochloride, doxorubicin hydrochloride, ifosfamide, irinotecan hydrochloride, protein expression analysis, immunoenzyme technique, adjuvant therapy, conventional surgery, neoadjuvant therapy, radiation therapy
City of Hope Medical Center, National Cancer Institute (NCI)
Sarcoma
11/11
 
NCT00003719: Irinotecan in Treating Patients With Stage IV or Recurrent Soft Tissue Sarcoma

Unknown status
2
27
US
irinotecan hydrochloride
Herbert Irving Comprehensive Cancer Center
Sarcoma
 
 
NCT01313884: Cyclophosphamide, Doxorubicin, Vincristine w/ Irinotecan and Temozolomide in Ewings Sarcoma

Terminated
2
3
US
Irinotecan, Camptosar, Campto, Vincristine, Oncovin, leurocristine, Temozolomide, Temodar, Temodal, Doxorubicin, Adriamycin, hydroxydaunorubicin, Cytoxan, Cyclophosphamide, Endoxan, Neosar, Procytox, Revimmune, cytophosphane, Pegfilgrastim, Neulasta
Stanford University, Amgen
Bone Cancer, Ewing's Sarcoma
07/14
07/14
NCT01380275: Trial of Docetaxel and Irinotecan (DI) for Recurrent or Refractory Bone and Soft Tissue Sarcomas.

Unknown status
2
35
RoW
Docetaxel (Taxotere), Taxotere, Irinotecan
National Cancer Center, Korea
Sarcoma
09/14
12/14
NCT01946529: Therapeutic Trial for Patients With Ewing Sarcoma Family of Tumor and Desmoplastic Small Round Cell Tumors

Active, not recruiting
2
24
US
vincristine, Oncovin(R), doxorubicin, Adriamycin(R), cyclophosphamide, Cytoxan(R), ifosfamide, Ifex(R), etoposide, VP-16, Vepesid(R), temozolomide, Temodar(R), temsirolimus, CCI-779, Torisel^TM, bevacizumab, rhumab VEGF, Avastin(R), sorafenib, BAY-43-9006, Nexavar(R), surgery, therapeutic conventional surgery, radiation, proton beam radiation therapy, external beam radiation therapy, brachytherapy
St. Jude Children's Research Hospital, University of Tennessee, University of Florida, Nemours Children's Clinic
Desmoplastic Small Round Cell Tumor, Ewing Sarcoma of Bone or Soft Tissue, Localized Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor, Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
08/15
07/26
AREN0321, NCT00335556: Combination Chemotherapy, Radiation Therapy, and/or Surgery in Treating Patients With High-Risk Kidney Tumors

Completed
2
291
US, Canada, RoW
Doxorubicin Hydrochloride, Irinotecan Hydrochloride, Conventional Surgery, surgery, conventional, Cyclophosphamide, Etoposide, Lastet, Carboplatin, Dactinomycin, Lyovac Cosmegen, Vincristine Sulfate, Kyocristine, Oncovin, VCR, Vincasar, Radiation Therapy, Cancer Radiotherapy, Irradiate, Irradiated, Irradiation, RT, Laboratory Biomarker Analysis
Children's Oncology Group, National Cancer Institute (NCI)
Childhood Renal Cell Carcinoma, Clear Cell Renal Cell Carcinoma, Clear Cell Sarcoma of the Kidney, Papillary Renal Cell Carcinoma, Rhabdoid Tumor of the Kidney, Stage I Renal Cell Cancer, Stage I Renal Wilms Tumor, Stage II Renal Cell Cancer, Stage II Renal Wilms Tumor, Stage III Renal Cell Cancer, Stage III Renal Wilms Tumor, Stage IV Renal Cell Cancer, Stage IV Renal Wilms Tumor
12/15
 
NCT01055314: Temozolomide, Cixutumumab, and Combination Chemotherapy in Treating Patients With Metastatic Rhabdomyosarcoma

Checkmark ASCO 2015
May 2015 - May 2015: ASCO 2015
Completed
2
175
US, Canada, RoW
Cixutumumab, Anti-IGF-1R Recombinant Monoclonal Antibody IMC-A12, IMC-A12, Cyclophosphamide, (-)-Cyclophosphamide, 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate, Carloxan, Ciclofosfamida, Ciclofosfamide, Cicloxal, Clafen, Claphene, CP monohydrate, CTX, CYCLO-cell, Cycloblastin, Cycloblastine, Cyclophospham, Cyclophosphamid monohydrate, Cyclophosphamidum, Cyclophosphan, Cyclophosphane, Cyclophosphanum, Cyclostin, Cyclostine, Cytophosphan, Cytophosphane, Cytoxan, Fosfaseron, Genoxal, Genuxal, Ledoxina, Mitoxan, Neosar, Revimmune, Syklofosfamid, WR- 138719, Dactinomycin, Actinomycin A IV, Actinomycin C1, ACTINOMYCIN D, Actinomycin I1, Actinomycin IV, Actinomycin X 1, Actinomycin-[thr-val-pro-sar-meval], Cosmegen, DACT, Dactinomycine, Lyovac Cosmegen, Meractinomycin, Doxorubicin Hydrochloride, 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8, 9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)- (9CI), ADM, Adriacin, Adriamycin, Adriamycin Hydrochloride, Adriamycin PFS, Adriamycin RDF, ADRIAMYCIN, HYDROCHLORIDE, Adriamycine, Adriblastina, Adriblastine, Adrimedac, Chloridrato de Doxorrubicina, DOX, DOXO-CELL, Doxolem, Doxorubicin.HCl, Doxorubin, Farmiblastina, FI 106, FI-106, hydroxydaunorubicin, Rubex, Etoposide, Demethyl Epipodophyllotoxin Ethylidine Glucoside, EPEG, Lastet, Toposar, Vepesid, VP 16-213, VP-16, VP-16-213, Ifosfamide, Asta Z 4942, Asta Z-4942, Cyfos, Holoxan, Holoxane, Ifex, IFO, IFO-Cell, Ifolem, Ifomida, Ifomide, Ifosfamidum, Ifoxan, IFX, Iphosphamid, Iphosphamide, Iso-Endoxan, Isoendoxan, Isophosphamide, Mitoxana, MJF 9325, MJF-9325, Naxamide, Seromida, Tronoxal, Z 4942, Z-4942, Irinotecan Hydrochloride, Campto, Camptosar, Camptothecin 11, Camptothecin-11, CPT 11, CPT-11, U-101440E, Laboratory Biomarker Analysis, Temozolomide, CCRG-81045, Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, M & B 39831, M and B 39831, Methazolastone, RP-46161, SCH 52365, Temodal, Temodar, Vincristine Sulfate Liposome, Marqibo
National Cancer Institute (NCI)
Adult Rhabdomyosarcoma, Childhood Alveolar Rhabdomyosarcoma, Childhood Embryonal Rhabdomyosarcoma, Metastatic Childhood Soft Tissue Sarcoma, Stage IV Adult Soft Tissue Sarcoma, Untreated Childhood Rhabdomyosarcoma
06/16
06/16
NCT01355445 / 2010-023135-42: Vincristine and Irinotecan With or Without Temozolomide in Children and Adults With Refractory/Relapsed Rhabdomyosarcoma

Completed
2
120
Europe
Vincristine, Irinotecan, Vincristine-Irinotecan, Vincristine, Irinotecan, Temozolomide, Vincristine-Irinotecan-Temozolomide
Centre Oscar Lambret, SFCE
RHABDOMYOSARCOMA
06/18
05/19
NCT01814501: Panitumumab and Chemotherapy in Patients With Advanced Colorectal Cancer After Prior Therapy With Bevacizumab

Unknown status
2
16
US
panitumumab, ABX-EGF, MOAB ABX-EGF, monoclonal antibody ABX-EGF, Vectibix, irinotecan hydrochloride, Campto, Camptosar, CPT-11, irinotecan, U-101440E, fluorouracil, 5-fluorouracil, 5-Fluracil, 5-FU, leucovorin calcium, CF, CFR, LV
John Hays, Amgen
Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum, Recurrent Colon Cancer, Recurrent Rectal Cancer, Signet Ring Adenocarcinoma of the Colon, Signet Ring Adenocarcinoma of the Rectum, Stage IV Colon Cancer, Stage IV Rectal Cancer
12/19
12/19
AIEOP EW-2, NCT02727387: Protocol for the Treatment of Metastatic Ewing Sarcoma

Completed
2
155
Europe
TEMIRI, Temozolomide + Irinotecan, ADM, Adriamycin, IFO, Ifosfamide, CYC, Cyclophosphamide, ETO, Etoposide, BUMEL, busulfan + melphalan, VIN, Vincristine
Italian Sarcoma Group
Ewing's Sarcoma (ES)
04/22
04/22
CombinaiR3, NCT03011528: First-line Treatment of Ewing Tumours With Primary Extrapulmonary Dissemination in Patients From 2 to 50 Years

Completed
2
45
Europe
VDC-IE x2, Intensified Induction VDC-IE x2, VDC-IE, Intensified Induction VDC-IE, TEMIRI, Intensified Induction TEMIRI, Consolidation BuMel, High dose Consolidation chemotherapy, Maintenance, 2 years maintenance, Local treatment by surgery, Surgery of primary tumour/metastatic sites, Local treatment by radiotherapy, Radiotherapy of primary tumour/metastatic sites
Institut Curie, UNICANCER
Ewing Sarcoma Family of Tumors
08/22
11/23
NCT03359005: Irinotecan and Temozolomide for Ewing Sarcoma

Recruiting
2
60
RoW
Vincristine, VCR, Temozolomide, Temodar
Peking University People's Hospital
Ewing Sarcoma
11/22
02/25
Pan-MSI-ACSE, NCT06333314: Dostarlimab for Locally Advanced or Metastatic Cancer (Non-colorectal/Non-endometrial) With Tumor dMMR/MSI

Not yet recruiting
2
120
Europe
Dostarlimab, Chemotherapy
UNICANCER, National Cancer Institute, France, GlaxoSmithKline
Pancreatic Adenocarcinoma, Ampulla of Vater Carcinoma, Adrenocortical Carcinoma, Neuroendocrine Carcinoma, Soft Tissue Sarcoma, Small Bowel Adenocarcinoma, Duodenum Adenocarcinoma, Gastric Adenocarcinoma
10/28
09/30
NCT04554836: MoLiMoR - A Study With FOLFIRI-based First-line Therapy With or Without Intermittent Cetuximab

Active, not recruiting
2
144
Europe
Cetuximab, FOLFIRI
TheraOp
Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum
07/24
10/24
NCT00077285: Irinotecan and Carboplatin as Upfront Window Therapy in Treating Patients With Newly Diagnosed Intermediate-Risk or High-Risk Rhabdomyosarcoma

Active, not recruiting
2
65
US
filgrastim, carboplatin, cyclophosphamide, dexrazoxane hydrochloride, doxorubicin hydrochloride, etoposide, ifosfamide, irinotecan hydrochloride, vincristine sulfate, conventional surgery, radiation therapy
Memorial Sloan Kettering Cancer Center, National Cancer Institute (NCI)
Sarcoma
10/24
10/24
Actuate 1801, NCT03678883: 9-ING-41 in Patients With Advanced Cancers

Active, not recruiting
2
350
Europe, Canada, US
9-ING-41, Gemcitabine - 21 day cycle, Gemzar, Doxorubicin., Doxil, Adriamycin, Lomustine, CCNU, Gleostine, Carboplatin., Paraplatin, Nab paclitaxel., Abraxane, Protein-bound paclitaxel, Nanoparticle albumin-bound paclitaxel, Paclitaxel., Taxol, Gemcitabine - 28 day cycle, Irinotecan, Camptosar
Actuate Therapeutics Inc.
Cancer, Pancreatic Cancer, Sarcoma, Renal Cancer, Refractory Cancer, Refractory Neoplasm, Refractory Non-Hodgkin Lymphoma, Pancreatic Adenocarcinoma, Resistant Cancer, Neoplasm Metastasis, Neoplasm of Bone, Neoplasm, Breast, Neoplasm of Lung, Neoplasms,Colorectal, Neoplasms Pancreatic, Malignant Glioma, Malignancies, Malignancies Multiple, Bone Metastases, Bone Neoplasm, Bone Cancer, Pancreas Cancer, Pancreatic Neoplasms, Breast Neoplasms, Acute T Cell Leukemia Lymphoma
11/24
11/25
RMS13, NCT01871766: Risk-Adapted Focal Proton Beam Radiation and/or Surgery in Patients With Low, Intermediate and High Risk Rhabdomyosarcoma Receiving Standard or Intensified Chemotherapy

Active, not recruiting
2
98
US
Vincristine, Oncovin®, Dactinomycin, Actinomycin-D, Cosmegen®, Cyclophosphamide, Cytoxan(R), Surgical Resection, Surgery, Radiation, Proton Beam Radiation, External Beam Radiation, Brachytherapy, Bevacizumab, rhuMab, VEGF, Avastin®, Sorafenib, Nexavar®, Myeloid Growth Factor, G-CSF, Filgrastim, Pegfilgrastim, Lymph Node Sampling, Irinotecan, Camptosar ®, Ifosfamide, Ifex ®, Etoposide, VP-16, Vepesid®, Etoposide Phosphate, Etopophos®, Doxorubicin, Adriamycin®, Dexrazoxane, Zinecard, ^1^1C-methionine, Contrast Media
St. Jude Children's Research Hospital
Rhabdomyosarcoma
07/25
06/30
ONSEMBLE, NCT05593328: Study of Onvansertib in Combination With FOLFIRI and Bevacizumab Versus FOLFIRI and Bevacizumab for Second Line Treatment of Metastatic Colorectal Cancer in Participants With a Kirsten Rat Sarcoma Virus Gene (KRAS) or Neuroblastoma-RAS (NRAS) Mutation

Active, not recruiting
2
23
US
Onvansertib, FOLFIRI, Bevacizumab
Cardiff Oncology
Colorectal Cancer, Metastatic Colorectal Cancer
11/25
04/26
NCT05457829: Doxorubicin Hydrochloride Liposome Combined With Irinotecan Versus VIT Regimen in the Treatment of Pediatric Rhabdomyosarcoma

Not yet recruiting
2
88
NA
Doxorubicin Hydrochloride Liposome+Irinotecan, Temozolomide+Irinotecan+Vincristine
Sun Yat-sen University, CSPC Ouyi Pharmaceutical Co., Ltd.
Rhabdomyosarcoma, Child
06/26
07/26
NCT04388839: Evolutionary Therapy for Rhabdomyosarcoma

Recruiting
2
28
US
Vincristine, Cyclophosphamide, Vinorelbine, Navelbine, Actinomycin D, Cosmegen, Cyclophosphamide Pill
H. Lee Moffitt Cancer Center and Research Institute, National Pediatric Cancer Foundation
Rhabdomyosarcoma
12/26
12/27
NCT01864109: Irinotecan and Temozolomide in Combination With Existing High Dose Alkylator Based Chemotherapy for Treatment of Patients With Newly Diagnosed Ewing Sarcoma

Active, not recruiting
2
83
US
Cyclophosphamide, Doxorubicin, Vincristine, Ifosfamide, Etoposide, Surgery, Radiation Therapy*, Temozolomide, Irinotecan, Mesna, Dexrazoxane, G-CSF
Memorial Sloan Kettering Cancer Center
Newly Diagnosed Ewing Sarcoma
 
 
I-SPY 2, NCT01042379: I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer

Hourglass Jan 2023 - Dec 2023 : From P2 I-SPY 2 trial for invasive breast cancer
Checkmark Presentation of data from I-SPY trial for HR+/HER2- and TNBC breast cancer at SABCS 2022
Dec 2022 - Dec 2022: Presentation of data from I-SPY trial for HR+/HER2- and TNBC breast cancer at SABCS 2022
Checkmark Data from trial evaluating T-DM1+pertuzumab in the adjuvant setting
Nov 2018 - Nov 2018: Data from trial evaluating T-DM1+pertuzumab in the adjuvant setting
More
Recruiting
2
5000
US
Standard Therapy, Paclitaxel (Taxol); Doxorubicin (Adriamycin), AMG 386 with or without Trastuzumab, AMG 386 (Trebananib); (Trastuzumab) Herceptin, AMG 479 (Ganitumab) plus Metformin, Ganitumab, MK-2206 with or without Trastuzumab, (Trastuzumab) Herceptin, AMG 386 and Trastuzumab, AMG 386 (Trebananib); Trastuzumab (Herceptin), T-DM1 and Pertuzumab, T-DM1 (Trastuzumab emtansine); Pertuzumab (Perjeta), Pertuzumab and Trastuzumab, Pertuzumab (Perjeta); Trastuzumab (Herceptin), Ganetespib, ABT-888, Veliparib, Neratinib, PLX3397, Pembrolizumab - 4 cycle, Talazoparib plus Irinotecan, Patritumab and Trastuzumab, Pembrolizumab - 8 cycle, SGN-LIV1A, Durvalumab plus Olaparib, SD-101 + Pembrolizumab, Tucatinib plus trastuzumab and pertuzumab, Cemiplimab, Cemiplimab plus REGN3767, Trilaciclib with or without trastuzumab + pertuzumab, Trilaciclib (G1T28); Pertuzumab (Perjeta); Trastuzumab (Herceptin), SYD985 ([vic-]trastuzumab duocarmazine), Oral Paclitaxel + Encequidar + Dostarlimab (TSR-042) + Carboplatin with or without trastuzumab, Oral Paclitaxel + Encequidar (Oraxol); Dostarlimab (TSR-042); Trastuzumab (Herceptin), Oral Paclitaxel + Encequidar + Dostarlimab (TSR-042) with or without trastuzumab, Amcenestrant, SAR439859, Amcenestrant + Abemaciclib, Amcenestrant (SAR439859), Abemaciclib (Verzenio), Amcenestrant + Letrozole, Amcenestrant (SAR439859), Letrozole (Femara), ARX788, ARX788 + Cemiplimab, VV1 + Cemiplimab, VOYAGER V1™, VSV-IFNβ-NIS, Datopotamab deruxtecan, Dato-DXd, Datopotamab deruxtecan + Durvalumab, Zanidatamab, Lasofoxifene, Z-endoxifen, ARV-471, ARV-471 + Letrozole
QuantumLeap Healthcare Collaborative
Breast Neoplasms, Breast Cancer, Breast Tumors, Angiosarcoma, TNBC - Triple-Negative Breast Cancer, HER2-positive Breast Cancer, HER2-negative Breast Cancer, Hormone Receptor Positive Tumor, Hormone Receptor Negative Tumor, Early-stage Breast Cancer, Locally Advanced Breast Cancer
12/30
12/31
NCT05042934: Lurbinectedin With or Without Irinotecan in Treating Patients With Relapsed or High Risk Metastatic Ewing Sarcoma

Withdrawn
1b/2
0
US
Fine-Needle Aspiration, Aspirate, Fine Needle, Fine Needle Aspiration, Fine Needle Biopsy, fine-needle aspiration biopsy, FNA, FNA biopsy, Irinotecan, Irinotecan Hydrochloride, Campto, Camptosar, Camptothecin 11, Camptothecin-11, CPT 11, CPT-11, Irinomedac, Irinotecan Hydrochloride Trihydrate, Irinotecan Monohydrochloride Trihydrate, U-101440E, Lurbinectedin, PM01183, Zepzelca
M.D. Anderson Cancer Center, National Cancer Institute (NCI)
Metastatic Ewing Sarcoma, Recurrent Ewing Sarcoma
08/22
08/22
NCT00996346: Phase I/II Study of Irinotecan and Temsirolimus in Patients With Refractory Sarcomas

Checkmark In combination with irinotecan for metastatic sarcoma
Nov 2013 - Nov 2013: In combination with irinotecan for metastatic sarcoma
Terminated
1/2
17
US
Irinotecan&Temsirolimus:Arm1, Level 1, Irinotecan = Camptosar, Campto, or CPT-11, Temsirolimus = Toricel or CCI-779, Irinotecan&Temsirolimus:Arm 1, Level 2, Irinotecan&Temsirolimus:Arm 2, Level 1
New Mexico Cancer Care Alliance, Wyeth is now a wholly owned subsidiary of Pfizer
Sarcoma
11/11
11/13
NCT01086345: Radiosurgery Plus Bevacizumab in Glioblastoma

Terminated
1/2
9
US
radiosurgery, Radiation Surgery, bevacizumab, anti-VEGF humanized monoclonal antibody, anti-VEGF monoclonal antibody, anti-VEGF rhuMAb, Avastin, recombinant humanized anti-VEGF monoclonal antibody, rhuMAb VEGF, irinotecan hydrochloride, Campto, Camptosar, camptothecin-11, CPT-11, irinotecan, U-101440E
Case Comprehensive Cancer Center
Glioblastoma, Gliosarcoma, Brain Tumor
12/14
12/14
NCT03009058 / 2016-001459-28: Study of IMM 101 in Combination With Standard of Care in Patients With Metastatic or Unresectable Cancer

Terminated
1/2
2
Europe
IMM-101, Heat killed M. obuense (NCTC) 13365), Gemcitabine, GEMZAR, Nabpaclitaxel, Abraxane, Capecitabine, Folinic Acid, Leucovorin, Fluorouracil, 5FU, Irinotecan, Campto, Camptosar, Oxaliplatin, Eloxatin, cetuximab, Erbitux, Anti-PD1, pembrolizumab (KEYTRUDA),, nivolumab (OPDIVO), Ipilimumab, YERVOY, Cyclophosphamide, cytophosphane
Immodulon Therapeutics Ltd
Metastatic Cancer
08/17
08/17
PembroPlus, NCT02331251: Study of Pembrolizumab Plus Chemotherapy in Patients With Advanced Cancer

Checkmark AACR-NCI-EORTC 2015
Oct 2015 - Oct 2015: AACR-NCI-EORTC 2015
Checkmark IASLC-WCLC 2015
Aug 2015 - Aug 2015: IASLC-WCLC 2015
Terminated
1/2
81
US
Pembrolizumab, Keytruda, Gemcitabine, Gemzar, Docetaxel, Taxotere, Nab-paclitaxel, Abraxane, Vinorelbine, Navelbine, Irinotecan, Camptosar, Liposomal Doxorubicin, Doxil
Western Regional Medical Center
Advanced Cancer, Breast Cancer, Sarcoma, Pancreatic Cancer, Small Cell Lung Cancer, Ovarian
01/18
01/18
NCT03416517: Anlotinib and Irinotecan for Ewing Sarcoma

Unknown status
1/2
47
RoW
Anlotinib, AL3818, Irinotecan, Camptosar
Peking University People's Hospital
Ewing's Tumor Metastatic
02/20
12/20
NCT03245450 / 2016-003352-67: Study Evaluating the Safety and Efficacy of Eribulin Mesilate in Combination With Irinotecan Hydrochloride in Children With Refractory or Recurrent Solid Tumors

Completed
1/2
40
Europe
Eribulin mesilate, E7389, Irinotecan hydrochloride, (S)-4,11-diethyl-39 3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]-indolizino[1,2-b]quinolin-9-4-yl-[1,4'-bipiperidine]-1'-carboxylate, monohydrochloride, trihydrate
Eisai Inc.
Refractory or Recurrent Solid Tumors, Rhabdomyosarcoma, Non-Rhabdomyosarcoma Soft Tissue Sarcoma, Ewing Sarcoma
05/21
05/21
PM1183-A-014-15, NCT02611024: Pharmacokinetic Study of Lurbinectedin in Combination With Irinotecan in Patients With Selected Solid Tumors

Recruiting
1/2
320
Europe, US
Lurbinectedin, PM01183, Irinotecan
PharmaMar
Advanced Solid Tumors, Glioblastoma, Soft Tissue Sarcoma (Excluding GIST), Endometrial Carcinoma, Epithelial Ovarian Carcinoma, Mesothelioma, Gastroenteropancreatic Neuroendocrine Tumor, SCLC, Gastric Carcinoma, Pancreatic Adenocarcinoma, Colorectal Carcinoma, Neuroendocrine Tumors
03/26
03/26
NCT01837862: A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas

Recruiting
1/2
36
US
Mebendazole, Vermox, Vincristine, Oncovin, Carboplatin, Paraplatin, Temozolomide, Temodar, Bevacizumab, Avastin, Irinotecan, CPT-11, Camptosar
Julie Krystal, Janssen Pharmaceuticals
Pilomyxoid Astrocytoma, Pilocytic Astrocytoma, Glioma, Astrocytic, Optic Nerve Glioma, Pleomorphic Xanthoastrocytoma, Glioblastoma Multiforme, Anaplastic Astrocytoma, Gliosarcoma, Diffuse Intrinsic Pontine Glioma, DIPG, Low-grade Glioma, Brainstem Glioma
04/24
04/25
SARC037, NCT04067115: A Phase I/II Study to Evaluate the Safety of Trabectedin in Combination With Irinotecan in Ewing Sarcoma Patients

Active, not recruiting
1/2
48
US
Trabectedin 1 MG [Yondelis], Irinotecan, tumor biopsy, 3'-Deoxy-3'-18F Fluorothymidine (18F-FLT) Imaging, 18F-FLT Imaging
Sarcoma Alliance for Research through Collaboration, Janssen Scientific Affairs, LLC, National Institutes of Health (NIH), National Cancer Institute (NCI)
Ewing Sarcoma
06/24
06/24
NCT03709680 / 2021-003444-25: Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors

Active, not recruiting
1/2
128
Europe, Canada, US, RoW
Palbociclib, Ibrance, Temozolomide, Temodar, Irinotecan, Campto, Topotecan, Hycamtin, Cyclophosphamide, Cytoxan
Pfizer, Children's Oncology Group (COG)
Ewing Sarcoma, Solid Tumors, Rhabdoid Tumor, Rhabdomyosarcoma, Neuroblastoma, Medulloblastoma, Diffuse Intrinsic Pontine Glioma
08/24
02/25
NCT04095221: A Study of the Drugs Prexasertib, Irinotecan, and Temozolomide in People With Desmoplastic Small Round Cell Tumor and Rhabdomyosarcoma

Active, not recruiting
1/2
21
US
Prexasertib, Irinotecan
Memorial Sloan Kettering Cancer Center
Desmoplastic Small Round Cell Tumor, Rhabdomyosarcoma
09/24
09/24
NCT04796012: VITAS: Atezolizumab in Combination With Chemotherapy for Pediatric Relapsed/Refractory Solid Tumors

Recruiting
1/2
23
US
Atezolizumab, Tecentriq, Vincristine, Vincristine Sulfate Injection, Oncovin, Vincasar PES, Vincrex, Irinotecan, Irinotecan Hydrochloride Injection, Campto, Temozolomide, Temozolomide Capsules, Temodar
University of Texas Southwestern Medical Center
Solid Tumor, Rhabdomyosarcoma
01/25
01/25
NCT06006273: A Phase Ib Trial of Eribulin in Combination With Irinotecan and Temozolamide in Children With Relapsed or Refractory Solid Tumors

Recruiting
1/2
48
US
Eribulin, Irinotecan, Temozolomide
M.D. Anderson Cancer Center
Refractory Solid Tumors
12/26
12/28
FaR-RMS, NCT04625907 / 2018-000515-24: An Overarching Study for Children and Adults With Frontline and Relapsed RhabdoMyoSarcoma

Recruiting
1/2
1672
Europe, RoW
Irinotecan, Actinomycin D, Dactinomycin, Doxorubicin, Ifosfamide, Vincristine, Vinorelbine, Cyclophosphamide, Temozolomide, radiotherapy, Regorafenib
University of Birmingham
Rhabdomyosarcoma
06/30
06/30

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