Online Trial Tracker - Larvol Sigma

Trial + Data / Events

Status

Region

Interventions

Sponsor

Conditions

Primary compl

Study compl

irinotecan / Generic mfg.

NCT00954876: Study of Capecitabine and Cetuximab as First-Line Therapy in Patients With Metastatic Wild Type Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Colorectal Cancer

Withdrawn

capecitabine and cetuximab

Translational Genomics Research Institute, Eli Lilly and Company

Metastatic Colorectal Cancer

01/10

NCT00735436: A Study of Gliadel Followed by Avastin + Irinotecan for Glioblastoma Multiforme (GBM)

Terminated

Gliadel/Avastin/CPT-11, bevacizumab, irinotecan

Duke University, Eisai Inc., Genentech, Inc.

Malignant Glioma, Glioblastoma Multiforme, Gliosarcoma

07/11

10/12

NCT00597402: Avastin in Combination With Radiation (XRT) & Temozolomide, Followed by Avastin, Temozolomide and Irinotecan for Glioblastoma (GBM) and Gliosarcomas

Completed

125

Avastin, Bevacizumab, Temozolomide, Temodar, Radiation Therapy (XRT), Irinotecan, CPT-11, Camptosar

Duke University, Genentech, Inc., Schering-Plough

Glioblastoma, Gliosarcoma, Brain Tumor

08/11

05/13

NCT01313884: Cyclophosphamide, Doxorubicin, Vincristine w/ Irinotecan and Temozolomide in Ewings Sarcoma

Terminated

Irinotecan, Camptosar, Campto, Vincristine, Oncovin, leurocristine, Temozolomide, Temodar, Temodal, Doxorubicin, Adriamycin, hydroxydaunorubicin, Cytoxan, Cyclophosphamide, Endoxan, Neosar, Procytox, Revimmune, cytophosphane, Pegfilgrastim, Neulasta

Stanford University, Amgen

Bone Cancer, Ewing's Sarcoma

07/14

NCT01814501: Panitumumab and Chemotherapy in Patients With Advanced Colorectal Cancer After Prior Therapy With Bevacizumab

Unknown status

panitumumab, ABX-EGF, MOAB ABX-EGF, monoclonal antibody ABX-EGF, Vectibix, irinotecan hydrochloride, Campto, Camptosar, CPT-11, irinotecan, U-101440E, fluorouracil, 5-fluorouracil, 5-Fluracil, 5-FU, leucovorin calcium, CF, CFR, LV

John Hays, Amgen

Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum, Recurrent Colon Cancer, Recurrent Rectal Cancer, Signet Ring Adenocarcinoma of the Colon, Signet Ring Adenocarcinoma of the Rectum, Stage IV Colon Cancer, Stage IV Rectal Cancer

12/19

Pan-MSI-ACSE, NCT06333314: Dostarlimab for Locally Advanced or Metastatic Cancer (Non-colorectal/Non-endometrial) With Tumor dMMR/MSI

Not yet recruiting

120

Europe

Dostarlimab, Chemotherapy

UNICANCER, National Cancer Institute, France, GlaxoSmithKline

Pancreatic Adenocarcinoma, Ampulla of Vater Carcinoma, Adrenocortical Carcinoma, Neuroendocrine Carcinoma, Soft Tissue Sarcoma, Small Bowel Adenocarcinoma, Duodenum Adenocarcinoma, Gastric Adenocarcinoma

10/28

09/30

Actuate 1801, NCT03678883: 9-ING-41 in Patients With Advanced Cancers

Active, not recruiting

350

Europe, Canada, US

9-ING-41, Gemcitabine - 21 day cycle, Gemzar, Doxorubicin., Doxil, Adriamycin, Lomustine, CCNU, Gleostine, Carboplatin., Paraplatin, Nab paclitaxel., Abraxane, Protein-bound paclitaxel, Nanoparticle albumin-bound paclitaxel, Paclitaxel., Taxol, Gemcitabine - 28 day cycle, Irinotecan, Camptosar

Actuate Therapeutics Inc.

Cancer, Pancreatic Cancer, Sarcoma, Renal Cancer, Refractory Cancer, Refractory Neoplasm, Refractory Non-Hodgkin Lymphoma, Pancreatic Adenocarcinoma, Resistant Cancer, Neoplasm Metastasis, Neoplasm of Bone, Neoplasm, Breast, Neoplasm of Lung, Neoplasms,Colorectal, Neoplasms Pancreatic, Malignant Glioma, Malignancies, Malignancies Multiple, Bone Metastases, Bone Neoplasm, Bone Cancer, Pancreas Cancer, Pancreatic Neoplasms, Breast Neoplasms, Acute T Cell Leukemia Lymphoma

11/24

11/25

ONSEMBLE, NCT05593328: Study of Onvansertib in Combination With FOLFIRI and Bevacizumab Versus FOLFIRI and Bevacizumab for Second Line Treatment of Metastatic Colorectal Cancer in Participants With a Kirsten Rat Sarcoma Virus Gene (KRAS) or Neuroblastoma-RAS (NRAS) Mutation

Active, not recruiting

Onvansertib, FOLFIRI, Bevacizumab

Cardiff Oncology

Colorectal Cancer, Metastatic Colorectal Cancer

11/25

04/26

NCT05457829: Doxorubicin Hydrochloride Liposome Combined With Irinotecan Versus VIT Regimen in the Treatment of Pediatric Rhabdomyosarcoma

Not yet recruiting

Doxorubicin Hydrochloride Liposome+Irinotecan, Temozolomide+Irinotecan+Vincristine

Sun Yat-sen University, CSPC Ouyi Pharmaceutical Co., Ltd.

Rhabdomyosarcoma, Child

06/26

07/26

NCT00996346: Phase I/II Study of Irinotecan and Temsirolimus in Patients With Refractory Sarcomas

	In combination with irinotecan for metastatic sarcoma
	Nov 2013 - Nov 2013: In combination with irinotecan for metastatic sarcoma

Terminated

1/2

Irinotecan&Temsirolimus:Arm1, Level 1, Irinotecan = Camptosar, Campto, or CPT-11, Temsirolimus = Toricel or CCI-779, Irinotecan&Temsirolimus:Arm 1, Level 2, Irinotecan&Temsirolimus:Arm 2, Level 1

New Mexico Cancer Care Alliance, Wyeth is now a wholly owned subsidiary of Pfizer

Sarcoma

11/11

11/13

NCT03009058 / 2016-001459-28: Study of IMM 101 in Combination With Standard of Care in Patients With Metastatic or Unresectable Cancer

Terminated

1/2

Europe

IMM-101, Heat killed M. obuense (NCTC) 13365), Gemcitabine, GEMZAR, Nabpaclitaxel, Abraxane, Capecitabine, Folinic Acid, Leucovorin, Fluorouracil, 5FU, Irinotecan, Campto, Camptosar, Oxaliplatin, Eloxatin, cetuximab, Erbitux, Anti-PD1, pembrolizumab (KEYTRUDA),, nivolumab (OPDIVO), Ipilimumab, YERVOY, Cyclophosphamide, cytophosphane

Immodulon Therapeutics Ltd

Metastatic Cancer

08/17

NCT03245450 / 2016-003352-67: Study Evaluating the Safety and Efficacy of Eribulin Mesilate in Combination With Irinotecan Hydrochloride in Children With Refractory or Recurrent Solid Tumors

Completed

1/2

Europe

Eribulin mesilate, E7389, Irinotecan hydrochloride, (S)-4,11-diethyl-39 3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]-indolizino[1,2-b]quinolin-9-4-yl-[1,4'-bipiperidine]-1'-carboxylate, monohydrochloride, trihydrate

Eisai Inc.

Refractory or Recurrent Solid Tumors, Rhabdomyosarcoma, Non-Rhabdomyosarcoma Soft Tissue Sarcoma, Ewing Sarcoma

05/21

PM1183-A-014-15, NCT02611024: Pharmacokinetic Study of Lurbinectedin in Combination With Irinotecan in Patients With Selected Solid Tumors

Recruiting

1/2

320

Europe, US

Lurbinectedin, PM01183, Irinotecan

PharmaMar

Advanced Solid Tumors, Glioblastoma, Soft Tissue Sarcoma (Excluding GIST), Endometrial Carcinoma, Epithelial Ovarian Carcinoma, Mesothelioma, Gastroenteropancreatic Neuroendocrine Tumor, SCLC, Gastric Carcinoma, Pancreatic Adenocarcinoma, Colorectal Carcinoma, Neuroendocrine Tumors

03/26

NCT01837862: A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas

Recruiting

1/2

Mebendazole, Vermox, Vincristine, Oncovin, Carboplatin, Paraplatin, Temozolomide, Temodar, Bevacizumab, Avastin, Irinotecan, CPT-11, Camptosar

Julie Krystal, Janssen Pharmaceuticals

Pilomyxoid Astrocytoma, Pilocytic Astrocytoma, Glioma, Astrocytic, Optic Nerve Glioma, Pleomorphic Xanthoastrocytoma, Glioblastoma Multiforme, Anaplastic Astrocytoma, Gliosarcoma, Diffuse Intrinsic Pontine Glioma, DIPG, Low-grade Glioma, Brainstem Glioma

04/24

04/25

SARC037, NCT04067115: A Phase I/II Study to Evaluate the Safety of Trabectedin in Combination With Irinotecan in Ewing Sarcoma Patients

Active, not recruiting

1/2

Trabectedin 1 MG [Yondelis], Irinotecan, tumor biopsy, 3'-Deoxy-3'-18F Fluorothymidine (18F-FLT) Imaging, 18F-FLT Imaging

Sarcoma Alliance for Research through Collaboration, Janssen Scientific Affairs, LLC, National Institutes of Health (NIH), National Cancer Institute (NCI)

Ewing Sarcoma

06/24

NCT03709680 / 2021-003444-25: Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors

Active, not recruiting

1/2

128

Europe, Canada, US, RoW

Palbociclib, Ibrance, Temozolomide, Temodar, Irinotecan, Campto, Topotecan, Hycamtin, Cyclophosphamide, Cytoxan

Pfizer, Children's Oncology Group (COG)

Ewing Sarcoma, Solid Tumors, Rhabdoid Tumor, Rhabdomyosarcoma, Neuroblastoma, Medulloblastoma, Diffuse Intrinsic Pontine Glioma

08/24

02/25



	Diseases Companies Products Productz Mechanisms of Action Sites