| Trintellix (vortioxetine) / Lundbeck, Takeda |
NCT02559947: The Relationship Among Changes in Brain Network Activation in Adult Outpatients With Major Depressive Disorder |
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| Not yet recruiting | 4 | 50 | US | Vortioxetine, Brintellix | Psychiatric Medicine Associates, L.L.C., Takeda Pharmaceuticals North America, Inc., ElMindA Ltd | Major Depressive Disorder | 10/17 | 10/18 | | |
2017-004030-28: Changes in mental capacity and weight gain during antidepressant treatment. |
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| Ongoing | 4 | 320 | Europe | Tablet, Brintellix | Psychiatric Research Unit, Psychiatric Research Unit | Major Depressive Disorder., Major Depression, Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
ChiCTR1900024858: Comparison of the efficacy and safety of vortioxetine and escitalopram in depression and the corresponding changes in Brain-Gut axis |
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| Recruiting | 4 | 130 | | vortioxetine ;escitalopram | The First Affiliated Hospital, College of Medicine, Zhejiang University; The First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang key research and development project funding: 1 million yuan (2015C03040) | Major Depressive Disorder | | | | |
ChiCTR1900026697: Efficacy and safety of Vortioxetine Hydrobromide Tablets (Xin Da Yue) and Venlafaxine Hcl Sustained-Release Capsules (Yi Nuo Si) in the treatment of patients with physical symptoms of depression: a randomized controlled trial |
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| Not yet recruiting | 4 | 60 | | Vortioxetine Hydrobromide Tablets (Xin Da Yue) ;Venlafaxine Hcl Sustained-Release Capsules (Yi Nuo Si) | Peking University Sixth Hospital, Peking University Institute of Mental Health; Peking University Sixth Hospital, Lundbeck | Depression | | | | |
| Completed | 4 | 362 | Europe | Vortioxetine, Brintellix, Trintellix, Sertraline, Zoloft, citalopram, Elopram, Escitalopram, Entact, Paroxetine, Daparox, Fluoxetine, Prozac, Fluvoxamine | Azienda Ospedaliera Universitaria Integrata Verona, University of Catania | Major Depressive Disorder | 02/23 | 02/23 | | |
| Completed | 4 | 131 | RoW | Vortioxetine, Brintellix®, valprote, Depakine | First Affiliated Hospital of Zhejiang University, Zhejiang University | Bipolar Depression | 06/23 | 08/23 | | |
| Active, not recruiting | 4 | 88 | US | Vortioxetine, Brintellix, Placebo | Northwell Health, Takeda | Schizophrenia, Negative Symptoms | 10/23 | 06/24 | | |
| Recruiting | 4 | 20 | Europe | Vortioxetine | IRCCS San Raffaele Roma | Depression | 07/23 | 07/23 | | |
VENUS, NCT05104918: Vortioxetine as a Novel Anti-depressant With Improvement in Cognitive Abilities |
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| Not yet recruiting | 3 | 500 | NA | Vortioxetine, VORSCOT tablets, Venlafaxine, Venlafexine | Scotmann Pharmaceuticals, Rawalpindi Medical College | Major Depressive Disorder | 04/22 | 06/22 | | |
NCT04818099: Vortioxetine in the Treatment of Depression Associated With Head and Neck Cancers Undergoing Radiotherapy |
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| Recruiting | 3 | 208 | RoW | Vortioxetine 10 mg, Placebo | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Sun Yat-sen University, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Brain Hospital Affiliated to Guangzhou Medical University | Radiation Injuries | 10/23 | 04/24 | | |
NCT06025474: Comparison of Vortioxetine Versus Other Antidepressants With Pregabalin Augmentation in Burning Mouth Syndrome |
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| Recruiting | 3 | 203 | Europe | Vortioxetine 20Mg Tab, Brintellix, Paroxetine 20 Mg Oral Tablet, Sertraline 50 MG, Citalopram 20mg, Escitalopram 10mg, Duloxetine 60 MG, Pregabalin 75mg | Federico II University | Burning Mouth Syndrome | 10/23 | 07/24 | | |
2021-001333-38: Clinical trial to study the effect of an already authorized drug on other pathologies by administering it to people with a recent diagnosis of schizophrenia. Ensayo clínico para estudiar el efecto que tiene un fármaco ya autorizado en otras patologías administrándolo en personas con reciente diagnóstico de esquizofrenia. |
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| Not yet recruiting | 2/3 | 50 | Europe | VORTIOXETINA, HALOPERIDOL, Pimozida, Olanzapina, Risperidona, Chlorpromazine, Thioridazine, Quetiapine, Ziprasidone, aripiprazole, N06AX26, N05AD01, NO5AG02, NO5A H03, NO5AX08, N05AA01, N05AC02, N05AH04, N05AE04, N05AX12, Tablet, Capsule, hard, BRINTELLIX | Fundación Pública Andaluza para la Gestión de la Investigación en Salud de Sevilla (FISEVI), Consejería de salud | Early schizophrenia Esquizofrenia temprana, Newly evolving schizophrenia Esquizofrenia de reciente evolución, Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
NCT03485274: Substance Misuse To Psychiatric Disorders for Cannabis |
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| Completed | 2/3 | 37 | RoW | Vortioxetine, Treatment as Usual | The University of Hong Kong, Queen Mary Hospital, Hong Kong | Cannabis Use Disorder, Depressive State, Anxiety State, Depression, Anxiety Disorders, Pharmacotherapy | 02/23 | 04/23 | | |
| Recruiting | 2/3 | 37 | Europe | Vortioxetine, Usual Antipsychotic Treatment, TAU | Fundación Pública Andaluza para la gestión de la Investigación en Sevilla | Cognitive Impairment With Primary Psychotic Disorder, Negative Symptoms With Primary Psychotic Disorder | 12/24 | 12/25 | | |
NCT04498897: Vortioxetine for Treatment of Depressive Mood and Alcohol Use |
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| Recruiting | 2 | 128 | RoW | Vortioxetine, Acamprosate | Hanyang University Seoul Hospital | Depressive Disorder, Major, Alcoholism | 04/21 | 04/21 | | |
2019-001836-69: Treatment of Patients with Mild Cognitive Impairment measuring Brain Function with Functional Magnetic Resonance Imaging |
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| Not yet recruiting | 2 | 45 | Europe | Vortioxetine, Capsule, hard, Brintellix 10mg, Brintellix 20mg | Medical University of Vienna, Medical University of Vienna | Mild cognitive impairment, Mild cognitive impairment, Diseases [C] - Nervous System Diseases [C10] | | | | |
| Completed | 2 | 200 | Canada | Vortioxetine, Placebo | Brain and Cognition Discovery Foundation | Post-COVID-19 Condition, Post-COVID-19 Syndrome, Cognitive Impairment | 02/23 | 02/23 | | |
STAMD, NCT05814640: Sequenced Treatment Alternatives to Relieve Adolescent Depression (STAR-AD) |
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| Recruiting | 1/2 | 520 | RoW | Fluoxetine, Sertraline, Vortioxetine, Duloxetine, Aripiprazole, Lithium Carbonate, Olanzapine, GCBT | First Affiliated Hospital of Chongqing Medical University, The Second Affiliated Hospital of Chongqing Medical University, Children's Hospital of Chongqing Medical University, Southwest Hospital, China, Central South University | Depression, Sequestra | 12/25 | 07/27 | | |
ChiCTR2300073164: Bioequivalence Study of Vortioxetine Hydrobromide Tablets in Healthy Chinese Subjects Under Fasting and Fed Conditions |
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| Completed | 1 | 64 | | In fasting condition, subjects took the test preparation in the first cycle, and took the reference preparation in the second cycle ;In fasting condition, subjects took the reference preparation in the first cycle, and took the test preparation in the second cycle ;In fed study, subjects took the test preparation in the first cycle, and took the reference preparation in the second cycle ;In fed study, subjects took the reference preparation in the first cycle, and took the test preparation in the second cycle | Hebei General Hospital; CSPC Ouyi Pharmaceutical Co., Ltd, CSPC Ouyi Pharmaceutical Co., Ltd. | N/A | | | | |
NCT04456777: Effect of Vortioxetine on Cognitive Symptoms in Patients With Schizophrenia |
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| Recruiting | 1 | 120 | RoW | Vortioxetine | Alen Greš | Cognitive Deficit | 07/22 | 07/22 | | |
NCT05417087: Single Dose Oral Bioequivalence Study of Vortioxetine Hemihydrobromide Orally Disintegrating Tablets |
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| Completed | 1 | 48 | RoW | Vortioxetine Hemihydrobromide Orally Disintegrating Tablets, SF001 ODT, Vortioxetine Hydrobromide Tablets, Trintellix | Seasons Biotechnology (Taizhou) Co., Ltd. | Major Depressive Disorder (MDD) | 09/22 | 09/22 | | |
NCT05416957: Food Effect Bioavailability Study of Vortioxetine Hemihydrobromide Orally Disintegrating Tablets |
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| Completed | 1 | 24 | RoW | Vortioxetine Hemihydrobromide Orally Disintegrating Tablets, SF001 ODT | Seasons Biotechnology (Taizhou) Co., Ltd. | Major Depressive Disorder (MDD) | 10/22 | 10/22 | | |
NCT05416762: Single Dose Study to Evaluate Dose-proportionality of Vortioxetine Hemihydrobromide Orally Disintegrating Tablets |
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| Completed | 1 | 30 | RoW | Vortioxetine Hemihydrobromide Orally Disintegrating Tablets 5mg, SF001 ODT 5mg, Vortioxetine Hemihydrobromide Orally Disintegrating Tablets 10mg, SF001 ODT 10mg, Vortioxetine Hemihydrobromide Orally Disintegrating Tablets 20mg, SF001 ODT 20mg | Seasons Biotechnology (Taizhou) Co., Ltd. | Major Depressive Disorder (MDD | 11/22 | 11/22 | | |
ACTRN12622000610730: Recovery Training of Emotion and Cognition with Vortioxetine for Depression (RECOVER-D) Study |
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| Recruiting | N/A | 40 | | | Royal Melbourne Hospital, The Royal Melbourne Hospital Foundation , The University of Melbourne | Depression | | | | |
NCT05267873: Combining Data Sources to Identify Effect Moderation for Personalized Mental Health |
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| Active, not recruiting | N/A | 14146 | US | Duloxetine, Vortioxetine | Johns Hopkins Bloomberg School of Public Health, Duke University, Patient-Centered Outcomes Research Institute, National Institute of Mental Health (NIMH) | Depressive Disorder, Major | 12/21 | 12/24 | | |
NCT05952713: Comparative Responses to 15 Different Antidepressants in Major Depressive Disorder |
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| Completed | N/A | 73336 | Europe | Antidepressant, sertraline, citalopram, fluoxetine, paroxetine, escitalopram, reboxetine, venlafaxine, duloxetine, mirtazapine, vortioxetine, agomelatine, amitriptyline, imipramine | Mental Health Services in the Capital Region, Denmark, University of Copenhagen | Major Depressive Disorder | 07/23 | 07/23 | | |
NCT05840861: Using 18F-FPEB PET to Identify mGLUR5 Availability in Affective Disorders |
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| Recruiting | N/A | 59 | RoW | Vortioxetine, Quetiapine | Central South University | Major Depressive Disorder, Bipolar Disorder | 08/23 | 09/23 | | |
NCT05932407: A Database Survey of Comparison The Risk of Haemorrhage Between Vortioxetine Tablet Treatment and Selective Serotonin Reuptake Inhibitor (SSRI) Treatment in Participants With Depression |
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| Not yet recruiting | N/A | 115000 | NA | Vortioxetine Tablet, TRINTELLIX Tablets, SSRI | Takeda | Major Depressive Disorder | 07/24 | 07/24 | | |
STRATIDEP, NCT05866575: Prediction of the Therapeutic Response in Depression Based on Neuro-computational Modeling Assessment of Motivation |
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| Not yet recruiting | N/A | 136 | Europe | escitalopram, vortioxetine | Centre Hospitalier St Anne | Major Depressive Disorder | 11/25 | 12/26 | | |