| bupropion ER / Generic mfg. |
| Completed | 3 | 300 | US, Canada | Extended-release bupropion hydrochloride | GlaxoSmithKline | Seasonal Affective Disorder | 06/03 | 06/03 | | |
NCT00048360: Attention-Deficit Hyperactivity Disorder (ADHD) Study With Adults |
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| Completed | 3 | 162 | US | Extended-release bupropion hydrochloride | GlaxoSmithKline | Attention Deficit Disorder | 06/03 | 06/03 | | |
NCT00051259: Effects of Antidepressants on Sexual Functioning |
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| Completed | 3 | 420 | US | Extended-Release Bupropion Hydrochloride | GlaxoSmithKline | Major Depressive Disorder (MDD) | 06/04 | 06/04 | | |
NCT00051272: Effects Of Antidepressants On Sexual Functioning In Adults |
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| Completed | 3 | 425 | US | Extended-release Bupropion Hydrochloride | GlaxoSmithKline | Major Depressive Disorder (MDD) | 06/04 | 06/04 | | |
NCT00179244: Risperidone vs. Bupropion ER Augmentation of SSRIs in Treatment-Resistant Depression |
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| Completed | 3 | 30 | US | Rispridone (drug) and Bupropion ER (drug) | Vanderbilt University, Janssen Pharmaceutica | Unipolar Depression | | 04/05 | | |
| Completed | 3 | 268 | US | Extended-release bupropion (HCl) | GlaxoSmithKline | Epilepsy, Major Depressive Disorder (MDD) | 05/05 | 05/05 | | |
| Completed | 3 | 364 | Europe, RoW | bupropion XL | GlaxoSmithKline | Depressive Disorder, Major | 10/05 | 10/05 | | |
NCT00296933: Memory Functioning and Antidepressant Treatment |
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| Completed | 3 | 60 | Canada | Escitalopram, Bupropion XL | University Health Network, Toronto, GlaxoSmithKline, H. Lundbeck A/S | Depression, Major Depressive Disorder | | | | |
ZESCA, NCT00689611: Zyban as an Effective Smoking Cessation Aid for Patients Following an Acute Coronary Syndrome: The Trial |
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| Completed | 3 | 392 | US, Canada, RoW | Bupropion HCl ER, Zyban, Placebo | Mark Eisenberg, Canadian Institutes of Health Research (CIHR), Heart and Stroke Foundation of Canada | Acute Coronary Syndrome, Myocardial Infarction, Smoking | 06/10 | 06/10 | | |
| Completed | 3 | 110 | Europe | Elontril, placebo | University Hospital, Bonn, University of Cologne, Physician of neurology, psychiatry and psychotherapy Horn, MD; Bad Honnef, Charite University, Berlin, Germany, Universität Duisburg-Essen, University of Erlangen-Nürnberg, University of Freiburg, University Medical Center Goettingen, Universität des Saarlandes, Johannes Gutenberg University Mainz, Heidelberg University, Philipps University Marburg Medical Center, Ludwig-Maximilians - University of Munich, University of Rostock, University Hospital Tuebingen, University of Ulm | Apathy in Dementia | 07/14 | 07/14 | | |
2004-003803-19: A Multi-Centre, Randomised, Double-Blind, Parallel-Group, Placebo- and Active-Controlled, Flexible Dose Study Evaluating the Efficacy, Safety and Tolerability ofExtended-Release Bupropion Hydrochloride (150mg - 300mg once daily), Extended-Release Venlafaxine Hydrochloride (75mg - 150mg once daily) and Placebo in Subjects with Major Depressive Disorder. |
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| Completed | 3 | 32 | Europe | Bupropion Hydrochloride Extended Release Tablets, Venlafaxine hydrochloride extended-release capsules, GR67205, Efexor Depot, Efexor Depot | GlaxoSmithKline Research & Development | Major Depressive Disorder (MDD) | | | | |
NCT02191397: Study to Evaluate the Efficacy, Safety and Tolerability of Bupropion Hydrochloride Extended-release Tablet, and Escitalopram Oxalate Capsule in Subjects With Major Depressive Disorder |
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| Completed | 3 | 534 | RoW | Bupropion, Bupropion Matching Placebo, Escitalopram, Escitalopram Matching Placebo | GlaxoSmithKline | Depressive Disorder, Major | 10/16 | 10/16 | | |
ADAPT-2, NCT03078075: Accelerated Development of Additive Pharmacotherapy Treatment () for Methamphetamine Use Disorder |
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| Completed | 3 | 403 | US | Naltrexone: Vivitrol®, Arm: Experimental - Active Medication Combination (AMC), Placebo (PLB) Injectable, Injectable matching (to Naltrexone) placebo, Arm: Placebo Comparator - matched Placebo (PLB), Bupropion: Wellbutrin XL®, Placebo (PLB) Oral, Oral matching (to Bupropion) placebo tablets | University of Texas Southwestern Medical Center, National Institute on Drug Abuse (NIDA), The Emmes Company, LLC | Methamphetamine Use Disorder | 07/19 | 07/19 | | |
NCT00958633: Mood Stabilizer (MS)+ Antidepressant vs MS + Placebo in Maintenance of Bipolar Disorder. |
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| Completed | 3 | 178 | Canada | Escitalopram, Lexapro/Cipralex, Wellbutrin XL, Wellbutrin | University of British Columbia, Canadian Institutes of Health Research (CIHR), GlaxoSmithKline, Lundbeck Canada Inc., Lupin Limited | Bipolar I Disorder | 03/20 | 05/20 | | |
NCT06233799: Trial of Naltrexone/Bupropion for the Treatment of Methamphetamine Use Disorder |
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| Not yet recruiting | 3 | 360 | NA | extended-release naltrexone (XR-NTX), Vivitrol, extended release bupropion (BUP-XL) tablets (BUP-XL), Wellbutrin, iPLB, Placebo injections, oPLB, Placebo tablets | National Institute on Drug Abuse (NIDA) | Methamphetamine-dependence, Methamphetamine Abuse | 10/26 | 04/27 | | |
NCT03996265: Bupropion to Reduce Cancer Related Fatigue in Cancer Survivors |
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| Recruiting | 3 | 422 | US | Bupropion Hydrochloride Controlled-release, Bupropion HCl Controlled-release, Bupropion HCl Extended Release, Bupropion Hydrochloride Extended-Release, Forfivo XL, Wellbutrin SR, Wellbutrin XL, Zyban, Placebo Administration, Quality-of-Life Assessment, Quality of Life Assessment, Questionnaire Administration | University of Rochester NCORP Research Base, National Cancer Institute (NCI) | Be Diagnosed With Cancer and Have Completed Systemic Therapy | 09/25 | 09/25 | | |
NCT00248209: Female Orgasmic Disorder (FOD) and Wellbutrin XL |
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| Completed | 2/3 | 48 | US | Wellbutrin XL, bupropion XL, Wellbutrin XL | Segraves, R., T., M.D., Ph.D., GlaxoSmithKline | Orgasmic Disorder | 04/07 | 04/07 | | |
NCT02111798: Bupropion-Enhanced Contingency Management (CM) for Cocaine Dependence |
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| Completed | 2/3 | 83 | US | Placebo, Bupropion XL, Abstinence Initiation, Relapse Prevention | Johns Hopkins University, National Institute on Drug Abuse (NIDA) | Substance Abuse, Cocaine Dependence | 05/20 | 01/21 | | |
