| venlafaxine extended release / Generic mfg. |
| Recruiting | 4 | 2688 | | | Brain Resource, Brain Resource | Major Depressive Disorder (MDD) | | | | |
NCT00644982: A Comparison of Sertraline Versus Venlafaxine XR in the Treatment of Major Depression |
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| Completed | 4 | 163 | RoW | sertraline, Zoloft, venlafaxine XR | Pfizer's Upjohn has merged with Mylan to form Viatris Inc. | Depressive Disorder, Major | | 09/03 | | |
NCT00067912: Duloxetine vs. Active Comparator for the Treatment of Depression |
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| Completed | 4 | 480 | Canada | Duloxetine Hydrochloride, Venlafaxine Extended Release | Eli Lilly and Company | Depression | | 03/04 | | |
NCT00071695: Duloxetine vs. Active Comparator in the Treatment of Patients With Depression |
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| Completed | 4 | 320 | Europe | Duloxetine Hydrochloride, Venlafaxine Extended Release | Eli Lilly and Company | Depression | | 05/04 | | |
NCT00177528: Safety and Efficacy of Venlafaxine XR in Elderly Patients With Major Depression |
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| Completed | 4 | 70 | US | venlafaxine-XR | University of Pittsburgh | Depression | 11/04 | | | |
| Completed | 4 | 347 | US | Bupropion Hydrochloride Extended-release, Extended-release Venlafaxine | GlaxoSmithKline | Depressive Disorder, Major, Major Depressive Disorder (MDD) | 05/05 | 05/05 | | |
NCT00046020: Study Evaluating Venlafaxine ER in Recurrent Depression |
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| Completed | 4 | 1096 | US | Venlafaxine ER | Wyeth is now a wholly owned subsidiary of Pfizer | Depressive Disorder, Major, Recurrence | 10/05 | 10/05 | | |
NCT00546923: Study Evaluating Venlafaxine Extended-Release in Depressed and Anxious Patients |
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| Completed | 4 | 210 | RoW | Venlafaxine XR | Wyeth is now a wholly owned subsidiary of Pfizer | Anxiety Disorders, Depression | | 06/06 | | |
NCT00021528: Sequenced Treatment Alternatives to Relieve Depression (STAR*D) |
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| Completed | 4 | 4000 | US | citalopram, BuproprionSR, buspirone, Lithium, mirtazapine, nortriptyline, sertraline, tranylcypromine, VenlafaxineXR, Cognitive Therapy, T3 (Triiodothyronine) | National Institute of Mental Health (NIMH) | Depression | | 09/06 | | |
NCT00641927: Antidepressant Therapy for Bipolar II Major Depression |
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| Completed | 4 | 90 | US | Venlafaxine, Effexor-XR, Lithium Carbonate, Lithium | Stanley Medical Research Institute | Bipolar Type II Disorder | 10/06 | 10/06 | | |
NCT00188643: Venlafaxine Versus Lamotrigine in the Treatment of Bipolar I/II Depression |
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| Completed | 4 | 40 | Canada | Venlafaxine and Lamotrigine | University Health Network, Toronto | Bipolar Disorder | | 01/07 | | |
NCT00401726: Open-Label, Randomized Study Evaluating Treatment With Venlafaxine Extended-Release Plus Dialogues Time to Talk Program |
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| Completed | 4 | 537 | US | Venlafaxine ER, Dialogues Time to Talk Program | Wyeth is now a wholly owned subsidiary of Pfizer | Depressive Disorder, Major | | 10/07 | | |
NCT00474708: Study Comparing the Efficacy of Venlafaxine XR Vs. SSRIs and Conventional Antidepressants in Depressed Patients |
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| Completed | 4 | 1151 | RoW | Effexor, SSRI | Wyeth is now a wholly owned subsidiary of Pfizer | Major Depressive Disorder | 03/08 | 03/08 | | |
NCT00200902: Evaluation of Depression Symptoms and Brain Activity Associated With Response to Treatment of Depression |
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| Completed | 4 | 88 | US | Venlafaxine (Effexor), Duloxetine (Cymbalta), Escitalopram (Lexapro), Placebo, Interpersonal Clinical Interaction (ICI) | University of California, Los Angeles, National Center for Complementary and Integrative Health (NCCIH), Eli Lilly and Company, Wyeth is now a wholly owned subsidiary of Pfizer | Depression | 06/09 | 06/09 | | |
NCT00788944: Determine The Percentage Of Depressed Outpatients Who Do Not Effectively Metabolize Extended-release Venlafaxine HCl |
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| Completed | 4 | 971 | US | blood draw | Wyeth is now a wholly owned subsidiary of Pfizer | Depression | 07/09 | 07/09 | | |
NCT00177671: Antidepressant Medication Plus Donepezil for Treating Late-life Depression |
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| Completed | 4 | 220 | US | Escitalopram, Lexapro, Donepezil, aricept, Venlafaxine, effexor XR, Placebo, Duloxetine, cymbalta | University of Pittsburgh, National Institute of Mental Health (NIMH) | Depression, Dementia | 09/09 | 09/09 | | |
NCT00183274: Effectiveness of Long-Term Versus Short-Term Treatment of Generalized Anxiety Disorder With Venlafaxine XR |
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| Completed | 4 | 268 | US | Venlafaxine XR, selective serotonin and norepinephrine reuptake inhibitors, Effexor, Effexor XR, Venlafaxine hydrochloride extended release, Trevilor, Lanvexin, Placebo | University of Pennsylvania, National Institute of Mental Health (NIMH) | Anxiety Disorders | 09/09 | 09/09 | | |
| Completed | 4 | 665 | US | SSRI + placebo, escitalopram, placebo, Escitalopram + Bupropion SR, bupropion-SR, Venlafaxine XR + Mirtazapine, venlafaxine-XR, mirtazapine | National Institute of Mental Health (NIMH) | Major Depressive Disorder | 09/09 | 09/09 | | |
COATS, NCT00150839: Hippocampal Volume in Young Patients With Major Depression Before and After Combined Antidepressive Therapy |
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| Completed | 4 | 80 | Europe | Mirtazapine, Remergil SolTab (R), Venlafaxine, Trevilor retard (R) | University of Erlangen-Nürnberg Medical School | Depressive Disorder, Major | 12/09 | 12/09 | | |
NCT00878748: Study Evaluating Effexor XR in Chinese Subjects With Major Depressive Disorder |
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| Withdrawn | 4 | 0 | NA | Effexor XR, Effexor XR discontinue | Wyeth is now a wholly owned subsidiary of Pfizer | Major Depressive Disorder | 10/11 | 10/11 | | |
NCT00282828: Improving Treatment Outcomes in Pharmacotherapy of Generalized Social Anxiety Disorder |
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| Completed | 4 | 397 | US, Canada | Sertraline, Venlafaxine, Placebo, Clonazepam | Massachusetts General Hospital, National Institute of Mental Health (NIMH) | Social Phobia | 12/11 | 12/11 | | |
| Completed | 4 | 133 | US | venlafaxine XR, Effexor XR, placebo, identically encapsulated inactive substance | University of Washington, University of Michigan, Shirley Ryan AbilityLab, University of Alabama at Birmingham, Baylor Health Care System, University of Miami, New York University | Major Depressive Disorder, Dysthymia, Spinal Cord Injuries | 09/12 | 09/12 | | |
2013-000170-30: Effects of oxycodon and venlafaxine on human pain processing Oxycodon og venlafaxins effekter på det humane smertenetværk |
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| Completed | 4 | 20 | Europe | oxycodon, venlafaxine, Modified-release capsule, hard, Oxycontin, Efexor Depot | Mech-Sense, Aalborg University Hospital, Aalborg University Hospital, The Danish Council for Strategic Research, Grünenthal GmbH | Healthy volunteers - pain, Pain, Diseases [C] - Nervous System Diseases [C10] | | | | |
| Completed | 4 | 126 | Europe | Venlafaxine, Trevilor retard, Quetiapine, Seroquel | Max-Planck-Institute of Psychiatry | Depression | 04/14 | 08/14 | | |
| Completed | 4 | 468 | US, Canada | venlafaxine XR plus aripiprazole, effexor XR, abilify, venlafaxine plus placebo | University of Pittsburgh | Depression | 09/14 | 09/14 | | |
NCT02058693: Adjunctive Mixed Salts Amphetamine for Depressed Adults With Incomplete Response to Current Antidepressant Therapy |
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| Completed | 4 | 41 | US | mixed salts amphetamine, Adderall | Rush University Medical Center | Major Depressive Disorder | 12/14 | 12/14 | | |
| Completed | 4 | 12 | US | Venlafaxine IR and Venlafaxine XR, Effexor and Effexor XR | North Dakota State University, Neuropsychiatric Research Institute, Fargo, North Dakota | Roux en Y Gastric Bypass, Sleeve Gastrectomy | 03/15 | 03/15 | | |
NCT00926835: Effect of Antidepressants on the Treatment for Korean Major Depressive Disorder Patients |
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| Terminated | 4 | 692 | RoW | paroxetine, Seroxat, Escitalopram, lexapro, Venlafaxine XR, Efexor XR, Paroxetine+Bupropion, Seroxat, wellbutrin, Paroxetine+Lamotrigine, seroxat, lamictal, Paroxetine+Lithium, seroxat, lithan, Escitalopram+Mirtazapine, lexapro, remeron, Escitalopram+Aripiprazole, lexapro, abilify, Paroxetine + Venlafaxine XR, seroxat, efexor XR | Ministry of Health & Welfare, Korea | Major Depressive Disorder | 05/15 | 07/15 | | |
NCT01916824: Effects of Treatment on Decision-making in Major Depression |
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| Completed | 4 | 53 | US | Any FDA Approved Antidepressant, Sertraline, Zoloft, Citalopram, Celexa, Escitalopram, Lexapro, Paroxetine, Paxil, Fluoxetine, Prozac, Vilazodone, Viibryd, Venlafaxine XR, Effexor XR, Desvenlafaxine, Pristiq, Duloxetine, Cymbalta, Bupropion, Wellbutrin, Mirtazapine, Remeron | Emory University | Major Depressive Disorder, Healthy Controls | 12/15 | 12/15 | | |
2005-000826-22`ACTRN12616001342404: 4 - weeks, double blind, parallel, randomized study: Comparison of repetitive transcranial magnetic stimulation (rTMS) and venlafaxine (Effectin ER) in the treatment of resistant depressive disorder |
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| Ongoing | 4 | 60 | Europe | Efectin ER, Efectin ER, Efectin ER | Psychiatric Centre Prague, Kowloon Central Cluster Grant | Macular hole retinal detachment in high myopes | | | | |
2004-002788-25: Hippocampal volume in young adults with moderate to severe depression before and after combined antidepressant therapy |
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| Ongoing | 4 | 160 | Europe | Trevilor retard, Remergil Soltab, VENLA, | Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg | moderate to severe depression (episodes and recurrent diseases) | | | | |
2004-002482-20: A Pilot Study to Test the Effect of Treating Depression Associated with Rueumatoid Arthritis (RA) using Venlaflaxine |
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| | 4 | 20 | Europe | Efexor XL 75 mg (venlafaxine), NA, Efexor XL 75 mg, Efexor XL 75 mg | Newcastle upon Tyne Hospitals NHS Trust | Symptoms of Depression as defined by the Hospital Anxiety and Depression Questionnaire associated with Rheumatoid Arthritis | | 10/07 | | |
| Ongoing | 4 | 40 | Europe | Valdoxan, Trevilor retard, Valdoxan, Trevilor retard, Valdoxan, Trevilor retard | Inn-Salzach-Klinikum gGmbH | Diagnosis of depression; ICD-10: F32.x, F33.x | | | | |
| Withdrawn | 4 | 0 | US | Venlafaxine XR, Effexor, EMDR, Eye Movement Desensitization Reprocessing, Placebo, Sugar pill | Bayne-Jones Army Community Hospital | Posttraumatic Stress Disorder | 01/16 | 01/16 | | |
MEDEX, NCT02407704: A Multi-level Life-span Characterization of Adult-depression and Effects of Medication and Exercise |
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| Completed | 4 | 31 | US | Venlafaxine XR, Effexor XR, Aerobic Exercise, Physical Activity, Cardiovascular Exercise, Lorazepam, Ativan | Kirk Erickson, PhD | Depression, Depressive Disorder, Major, Depressive Disorder, Unipolar Depression, Major Depressive Disorder | 11/16 | 12/16 | | |
| Completed | 4 | 67 | Europe | Venlafaxine extended release, EFFEXOR | Institut National de la Santé Et de la Recherche Médicale, France | Major Depressive Disorder, Major Depressive Episode | 05/18 | 05/18 | | |
NCT03522987: Anxiety and Depression in Epilepsy: A Pilot Treatment Study |
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| Withdrawn | 4 | 0 | US | Escitalopram 10mg, Lexapro | Wake Forest University Health Sciences | Anxiety, Depression, Epilepsy | 05/18 | 05/18 | | |
NCT03464383: Anxiety and Depression in Epilepsy: A Treatment Study |
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| Completed | 4 | 69 | US | Escitalopram 10mg, Lexapro, Referral to Psychiatry, Survey only | Wake Forest University Health Sciences | Anxiety, Depression, Epilepsy | 09/19 | 09/19 | | |
| Unknown status | 4 | 2688 | Europe, US, RoW | Escitalopram, Lexapro, Sertraline, Zoloft, Venlafaxine-XR, Effexor | BRC Operations Pty. Ltd. | Major Depressive Disorder | 12/19 | 12/19 | | |
ChiCTR1900026697: Efficacy and safety of Vortioxetine Hydrobromide Tablets (Xin Da Yue) and Venlafaxine Hcl Sustained-Release Capsules (Yi Nuo Si) in the treatment of patients with physical symptoms of depression: a randomized controlled trial |
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| Not yet recruiting | 4 | 60 | | Vortioxetine Hydrobromide Tablets (Xin Da Yue) ;Venlafaxine Hcl Sustained-Release Capsules (Yi Nuo Si) | Peking University Sixth Hospital, Peking University Institute of Mental Health; Peking University Sixth Hospital, Lundbeck | Depression | | | | |
| Completed | 4 | 278 | Canada, US | Aripiprazole, Abilify, Repetitive transcranial magnetic stimulation (rTMS), Venlafaxine XR, Effexor XR | Massachusetts General Hospital, Patient-Centered Outcomes Research Institute | Treatment Resistant Major Depressive Disorder | 04/22 | 04/22 | | |
2021-006108-34: Trial Examining Methods for Antidepressant Discontinuation Methoden om antidepressiva te stoppen vergeleken. De TEMPO-studie |
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| Ongoing | 4 | 200 | Europe | Paroxetine, Venlafaxine ER, Tablet | AmsterdamUMC (location VUmc), ZonMW | Major Depressive Disorder Depressie, Depression Depressie, Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
NCT04961190: A Comparison of Prolonged Exposure Therapy, Pharmacotherapy, and Their Combination for PTSD |
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| Recruiting | 4 | 300 | US | Prolonged Exposure Therapy, Pharmacotherapy with paroxetine or venlafaxine XR, Pharmacotherapy with Paxil or Effexor XR | University of Pennsylvania, Patient-Centered Outcomes Research Institute, Corporal Michael J. Crescenz VA Medical Center, Coatesville VA Medical Center, Milwaukee VA Medical Center, North Texas Veterans Healthcare System, San Diego Veterans Healthcare System, VA Palo Alto Health Care System | Posttraumatic Stress Disorder | 02/26 | 02/26 | | |
NCT05737511: Efficacy of Hydroxyzine for Patients With Panic Disorder |
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| Not yet recruiting | 4 | 80 | NA | Hydroxyzine, Atarax, Vistaril, Escitalopram Oxalate, citalopram, fluoxetine, fluvoxamine, paroxetine, paroxetine CR, sertraline, venlafaxine XR,, Alprazolam, clomipramine, clonazepam, diazepam, imipramine, lorazepam, mirtazapine, reboxetine, Bupropion SR, divalproex, duloxetine, gabapentin, levetiracetam, milnacipran, moclobemide, olanzapine, phenelzine, quetiapine, risperidone, tranylcypromine | Sultan Qaboos University | Panic Disorder | 12/26 | 12/26 | | |
