| Hepacid (pegargiminase) / Polaris Pharma |
| Withdrawn | 2 | 10 | US | Nivolumab, BMS-936558, CMAB819, MDX-1106, NIVO, Nivolumab Biosimilar CMAB819, ONO-4538, Opdivo, Pegargiminase, ADI-PEG 20, pegylated arginine deiminase, Resection, Surgical Resection | M.D. Anderson Cancer Center | Resectable Hepatocellular Carcinoma | 02/23 | 02/23 | | |
NCT06034977: Phase 2 Study of ADI-PEG 20 Plus Lenvatinib Treatment in Subjects With Unresectable Hepatocellular Carcinoma |
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| Recruiting | 2 | 120 | RoW | ADI-PEG20, pegylated arginine deiminase | Chang Gung Memorial Hospital | Hepatocellular Carcinoma | 07/26 | 07/26 | | |
NCT05842512: Study of ADI-PEG 20 Versus Placebo in Subjects With NASH |
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| Recruiting | 2 | 40 | RoW | ADI-PEG20, Pegargiminase, Placebo | Polaris Group | Nonalcoholic Steatohepatitis (NASH) | 12/27 | 01/28 | | |
NCT06006286: A Study Evaluating Atezolizumab and Bevacizumab Plus ADI-PEG 20 in Patients With Locally Advanced / Metastatic Hepatocellular Carcinoma |
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| Withdrawn | 1/2 | 10 | US | Atezolizumab, Bevacizumab, ADI-PEG 20 | M.D. Anderson Cancer Center | Metastatic Hepatocellular Carcinoma | 11/23 | 11/23 | | |
NCT05813327: Neoadjuvant ADI-PEG 20 + Ifosfamide + Radiotherapy in Soft Tissue Sarcoma |
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| Recruiting | 1/2 | 35 | US | ADI PEG20, PEGylated arginine deiminase, Ifosfamide, ifex, Radiotherapy, Mesna, sodium 2-mercaptoethane sulfonate | Washington University School of Medicine, Polaris Group | Soft Tissue Sarcoma, Sts, Sarcoma,Soft Tissue | 01/26 | 01/28 | | |
NCT06085729: Phase I/II Study of PEGylated Arginine Deiminase (ADI-PEG20) With Carboplatin and Cabazitaxel in Men With Aggressive Variant Prostate Cancers (AVPC) |
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| Recruiting | 1/2 | 30 | US | ADI-PEG 20, Cabazitaxel, Jevtana®, Carboplatin, Paraplatin® | M.D. Anderson Cancer Center | Prostate Cancer | 12/25 | 12/27 | | |
NCT05616624: ADI-PEG 20 in Combination With Gemcitabine and Docetaxel After Progression on Frontline Therapy in Non-small Cell and Small Cell Lung Cancers |
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| Recruiting | 1/2 | 114 | US | ADI-PEG 20, PEGylated arginine deiminase, Gemcitabine, Gemzar, Docetaxel, Taxotere | Washington University School of Medicine, Polaris Group | Non Small Cell Lung Cancer, Non-small Cell Lung Cancer, Small-cell Lung Cancer, Small Cell Lung Carcinoma | 12/27 | 12/32 | | |
