Not yet recruiting

4

150

 

Melbourne Health, Baxter Healthcare Corporation

Acute Kidney Injury; Sepsis; Septic Shock

 

 

Not yet recruiting

4

1500

 

The George Institute, NHMRC

Acute Renal Failure

 

 

Ongoing

4

100

Europe

COSMOFER, VENOFER, MONOFER, B03AB04, , Solution for infusion in administration system, COSMOFER, VENOFER, MOnofer

Hull and East Yorkshire Hospitals NHS Trust

patients with known chonic kidney disease with functional or absolute Iron deficiency Anaemia, and are greater than 18 years will be given repleacement iron therapy accoring to current local protocols and NICE guidelines

 

 

Ongoing

4

30

Europe

Simdax, Concentrate and solvent for solution for infusion, Simdax

Sahlgrenska Universitetssjukhuset/Sahlgrenska, Sahlgrenska Academy

Acute kidney injury postoperatively in connection with heart surgery Akut njursvikt i samband med hjärtkirurgi, Acute renal failure Akut njursvikt, Diseases [C] - Cardiovascular Diseases [C14]

 

 

Ongoing

4

220

Europe

Visipaque, Niopam, Visipaque, Niopam

NHS Tayside

Peripheral vascular or renovascular disease being investigated by angiography

 

 

Ongoing

4

40

Europe

OMNIPAQUE, OMNIPAQUE, OMNIPAQUE

CHU Saint-Etienne

critically ill patients hospitalised in inetnsive care unit

 

 

Ongoing

4

40

Europe

Zyvoxid 600 mg, Meropenem Eberth 1g, Zyvoxid 600 mg (Pfizer), Meropenem Eberth 1g, Zyvoxid 600 mg (Pfizer), Meropenem Eberth 1g

Department of Pharmacy Unversitätsmedizin Mainz, Department of Pharmacy Universitätsmedizin Mainz

Sepsis and acute renal failure (ARF) are pathological entities that commonly co-exist in patients admitted to intensive care. Antibiotic dosing in septic patients with ARF can be complicated and may result in either underdosing, causing treatment failure and antibiotic resistance, or overdosing resulting in drug toxicity. The aim of this study is to collect pharmacokinetic data for evaluating underdosing or overdosing of linezolid and meropenem in patients receiving renal replacement therapy.

 

 

Ongoing

4

44

Europe

Anticoagulant and preservative solution for blood, Heparin sodium

Fernando Sánchez, Fernando Sánchez, Hospital Universitario de La Plana

Acute renal failure (ARF). Insuficiencia renal aguda., Acute renal failure is the inability of the kidneys to perform their functions to purify and clean the blood, and in this setting we use machines to temporarily replace renal function. La insuficiencia renal es la incapacidad de los riñones para realizar sus funciones de purificar y limpiar la sangre, por lo que se recurre a máquinas para sustituir temporalmente la función renal., Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Therapeutic techniques [E02]

 

 

Terminated

4

20

Europe

Central venous access, Pump-assisted circuit, Continuous renal replacement therapy, CRRT, Heparin sodium, Non-fractional heparin, Heparin, Regional citrate anticoagulation, Blood and ultrafiltrate samples

Fernando Sanchez, Hospital Universitario de la Plana, Hospital General Universitario de Castellón

Acute Kidney Injury

04/21

04/21

Not yet recruiting

4

200

 

Intravenous infusion of 0.9% sodium chloride injection at a rate of 1.0 ml/(kg·h) 6 h before and 12 h after contrast injection+ Lithium carbonate sustained release tablets 300mg/600mg qd oral for 3 days ;Intravenous infusion of 0.9% sodium chloride injection at a rate of 1.0 ml/(kg·h) 6 h before and 12 h after contrast injection+ placebo qd oral for 3 days

The First Affiliated Hospital of Zhengzhou University; The First Affiliated Hospital of Zhengzhou University, Self-supporting

Contrast induced acute kidney injury

 

 

Recruiting

4

90

 

Betamethasone 8mg intravenous drip ;Betamethasone 16mg intravenous drip ;Intravenous drip of equal amount of normal saline

The Second Xiangya Hospital of Central South University; The Second Xiangya Hospital of Central South University, Project funding

Acute Kidney injury

 

 

Terminated

4

3

US

Sodium bicarbonate, Standard of Care

West Virginia University

COVID, Coronavirus, Coronavirus Infection, AKI, Acute Kidney Injury

07/21

07/21

Ongoing

4

80

Europe

Film-coated tablet, Jardiance

Amsterdam UMC, The European Research Executive Agency (REA)

Cardiac surgery-associated acute kidney injury cardio-chirurgie geassocieerde nierinsufficiëntie, Kidney injury occurring after cardiac surgery Nier schade die optreed na een hart operatie, Diseases [C] - Symptoms and general pathology [C23]

 

 

Not yet recruiting

4

360

 

Intravenous injection of ulinastatin ;Placebo (0.9% normal saline)

Renji Hospital, Shanghai Jiaotong University School of Medicine; Renji Hospital, Shanghai Jiaotong University School of Medicine, self-financing

acute kidney injury

 

 

Recruiting

4

114

 

balance solution ;human albumin solution

Beijing You'an Hospital Affiliated to Capital Medical University; Beijing You'an Hospital Affiliated to Capital Medical University, China Primary Heaith Care Foundation -Youan Foundation of Liver Disease and AIDS

acute kidney injury

 

 

Recruiting

4

120

 

Intravenous infusion of dexmedetomidine 0.4 ug/kg/h during surgery ;Intravenous infusion of normal saline 0.4 ug/kg/h during surgery

The Third Medical Center of PLA General Hospital; The Third Medical Center of PLA General Hospital, 2020 Capital Health Development Research Project

Acute kidney injury

 

 

Recruiting

4

264

RoW

Vitamin C, Control (Normal saline)

Yonsei University

Acute Kidney Injury

12/22

12/22

Recruiting

4

286

 

Supplement sodium glycerophosphate on the basis of conventional replacement fluid ;Conventional replacement fluid

Xinqiao Hospital of Army Medical University; Xinqiao Hospital of Army Medical University, The training program for clinical medical research of the army military medical university

acute kidney injury

 

 

Ongoing

4

784

Europe

Film-coated tablet, Forxiga

Amsterdam UMC, Netherlands Organisation for Health Research and Development

Cardiac Surgery-Associated Acute Kidney Injury cardiochirurgie geassocieerde nierinsufficiëntie, Kidney failure following cardiac surgery Nierschade optredend na hartoperaties, Diseases [C] - Symptoms and general pathology [C23]

 

 

Not yet recruiting

4

590

Europe

Concentrate and solvent for concentrate for solution for infusion

Monash University

Acute kidney injury (AKI) is a common complication of cardiac surgery. AKI is defined according to KDIGO criteria in 3 severity stages.KDIGO creatinine-based criteria for diagnosis and staging of AKIStage Serum creatinineI 1.5–1.9 times baseline within 7 days; or = 26.5 µmol/l (= 0.3 mg/dl) increase within 48 hII 2.0–2.9 times baseline within 7 daysIII = 3.0 times baseline within 7 days; or Increase to = 353.6 µmol/l (= 40 mg/dl); or Initiation of renal replacement therapy Danno renale acuto associato alla cardiochirurgia. Il danno renale acuto (AKI) è una complicanza comune della cardiochirurgia. L'AKI è definito in tre stadi di gravità in accordo alle linee guida KDIGO.Creatinina sierica I 1,5-1,9 volte il basale entro 7 giorni; o = aumento di 26,5 µmol/l (= 0,3 mg/dl) entro 48 oreII 2,0–2,9 volte il basale entro 7 giorniIII = 3,0 volte il basale entro 7 giorni; o Aumento a = 353,6 µmol/l (= 40 mg/dl); o Inizio della terapia sostitutiva renale, Acute kidney injury associated with cardiac surgery causes a loss of kidney function and urine production as well as a retention of substances normally eliminated through the urine. Il danno renale acuto associato alla cardiochirurgia causa una perdita della funzionalità renale e della produzione di urine e una ritenzione delle sostanze normalmente eliminiate attraverso le urine., Diseases [C] - Symptoms and general pathology [C23]

 

 

Completed

4

30

US

Standard of Care, Angiotensin II

Alexander Flannery

Septic Shock, Acute Kidney Injury

07/23

07/23

Enrolling by invitation

4

30

US

Angiotensin II, Norepinephrine, Vasopressin, Epinephrine

University of California, Los Angeles

Cirrhosis, Liver, End Stage Liver DIsease, Acute Kidney Injury, Liver Transplant; Complications

09/24

12/24

Completed

4

155

RoW

Empagliflozin 25 MG, Jardiance 25 mg

University of Sao Paulo General Hospital

Diabetes Mellitus, Type 2, Coronary Artery Disease, Coronary Artery Bypass Surgery, Acute Kidney Injury

01/24

01/24

Recruiting

4

200

US

Ketamine, Propofol

Mayo Clinic

Cardiac Surgery

12/24

12/24

Terminated

4

105

US

AlloSure, PAXGene

George Washington University, CareDx, VirginiaBio Analytics, LLC

Kidney Injury, Kidney Failure, Kidney Failure, Chronic, Kidney Failure, Acute, Kidney Diseases, Kidney Transplant Rejection, Kidney Transplant Infection, Kidney Transplant; Complications, Kidney Disease, Chronic, Kidney Ischemia

12/22

12/22

Recruiting

4

40

RoW

Furosemide Injection, Furosemide stress test

Chiang Mai University

Acute Kidney Injury

06/24

06/24

Active, not recruiting

4

140

RoW

use of florescein

Saglik Bilimleri Universitesi

Contrast-induced Nephropathy, Acute Kidney Injury

08/24

12/24

Recruiting

4

104

RoW

Terlipressin, Glypressin, normal saline, normal sodium

Beijing Tsinghua Chang Gung Hospital

Acute Kidney Injury, Liver Transplant; Complications

06/24

06/24

Completed

4

620

 

acute kidney injury, cardiac surgery

 

 

4

216

RoW

Nitric Oxide, Placebo

Beijing Anzhen Hospital

Acute Kidney Injury, Nitrous Oxide, Acute Type a Aortic Dissection

10/25

06/26

Not yet recruiting

4

400

 

STS 80 mg,was diluted in 250 mL of 0.9% saline and administered intravenously over 2 hours period before and 3 days after the operation ;only received hydration

The First Affiliated Hospital of He'nan University; The First Affiliated Hospital of He'nan University, None

contrast-induced acute kidney injury

 

 

Not yet recruiting

4

160

 

hydrated by Sodium bicarbonate Ringer injection; hydrated by saline (medicine)

Department of Emergency, Shandong Provincial Hospital; Shandong Provincial Hospital, Horizontal research

acute kidney injury after contrast media

 

 

Recruiting

4

124

RoW

Trimetazidine 35 mg, Vastarel MR, Allopurinol 300 MG, Zyloric 300mg, Normal saline, 0.9 NS

Beni-Suef University, Cairo University

AKI - Acute Kidney Injury

09/25

09/25

Recruiting

4

60

Europe

Tinzaparin continuous infusion, Tinzaparin bolus

Tampere University Hospital

Acute Kidney Injury, Renal Replacement Therapy, Anticoagulants

12/25

12/25

Recruiting

4

300

 

Standard hydration regimen was given before and after angiography according to the guidelines. At the same time, ulinastatin 20wu was given intravenously 1 day before angiography, and ulinastatin 20wu was continued to be given twice a day after angiography for 2 days.; Before angiography, 1000ml of 0.9% sodium chloride injection was administered intravenously (completed within 12 hours); After contrast examination, 1000ml of 0.9% sodium chloride injection was administered (completed within 12 hours)

Chinese PLA General Hospital; Chinese PLA General Hospital, Self-funding

coronary heart disease, contrast-associated acute kidney injury

 

 

Recruiting

4

1300

Europe

Biomarker (ER/PR) guided lymphadenectomy, Biomarker guided weekly taxane treatment in endometrial/ ovarian cancer

Haukeland University Hospital

Endometrial Cancer

12/20

12/33

Completed

4

70

 

Shockwave therapy for 9 weeks (12 sessions) vs Sham therapy(no enegry delivered) 9 weeks (12 sessions)

The Chinese University of Hong Kong; Level of the institution：, Departmental research funding, Division of Urology, Department of Surgery, CUHK

Erectile dysfunction

 

 

Completed

4

20

 

tadalafil 5mg vs 10 mg ;single dose of tadalafil 20mg

Jinling Hospital; None, Lilly del Caribe Inc

erectile dysfunction

 

 

Ongoing

4

28

Europe

Vardenafil (hidrocloride), Levitra, Levitra

Unidad de Neuroinmunología

Erectile Dysfunction

 

 

Ongoing

4

40

Europe

Vardenafil (hidrocloride), Levitra 5 MG, Levitra 10 MG, Levitra 20 MG, Levitra 5 MG, Levitra 10 MG, Levitra 20 MG

Dr Antoni Gual, Hospital Clínic de Barcelona, Unitat d\'Alcohologia de la Generalitat de Catalunya

Disfunción Eréctil / Erectile Dysfunction

 

 

Ongoing

4

170

Europe

Simvastatin, Zocor, Zocor

University of Hertfordshire

Erectile dysfunction

 

 

Recruiting

4

53

 

patients treated with low intensity shock waves ;The procedure used in the control group was the same as that of the treatment group. But the equipment probe did not emit a shock wave during treatment, only the sound was the same as the treatment group, and the visual, auditory and operative were the same as real treatment.

The first affiliated Hospital of Guangzhou medical University; The first affiliated Hospital of Guangzhou medical University, High level university clinical research promotion project of Guangzhou medical university

erectile dysfunction

 

 

Not yet recruiting

4

400

Europe

Film-coated tablet, Tadalafil Polpharma 10 mg, film-coated tablets

Zakłady Farmaceutyczne Polpharma S.A., Zakłady Farmaceutyczne Polpharma S.A.

Erectile Dysfunction Zaburzenia Erekcji, Dysfunction, known as impotence; inability to get and keep a peniserection sufficient for sexual activity. Problemy ze wzwodem, zwane impotencją; niezdolność uzyskania iutrzymania wzwodu członka wystarczającego do satysfakcjonującegoodbycia stosunku seksualnego., Diseases [C] - Male diseases of the urinary and reproductive systems [C12]

 

 

Recruiting

4

70

 

pancreatic kininogenase 240u / TID, tadalafil tablets 5mg / QD ;tadalafil tablets 5mg / QD

Department of Urology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences; Changzhou Qianhong Bio-pharma Co., Ltd, self-funded

diabetes mellitus-associated erectile dysfunction

 

 

Not yet recruiting

4

40

RoW

Dapoxetine/Tadalafil 30/20 mg film coated tablet, Tada Plus

Neutec Ar-Ge San ve Tic A.Åž

Premature Ejaculation, Erectile Dysfunction, Safety Issues

01/23

10/23

Recruiting

4

118

 

On the first day, take 60 mg of Eddenafil Citrate tablets. Take clarithromycin tablets 500mg twice a day from the third to the fifth day. On the sixth day, take 500 mg of clarithromycin tablets and 60 mg of aldenafil citrate tablets simultaneously in the morning, and 500 mg of clarithromycin tablets in the afternoon. ;On the first day, take 60 mg of Eddenafil Citrate tablets. Take rifampicin capsules 600 mg once a day from the third to the ninth day. On the tenth day, take both 600 mg of rifampicin capsules and 60 mg of aldinafil citrate tablets. ;On the first day, take 60 mg of Eddenafil Citrate tablets. Take cimetidine tablets 400mg twice a day from the third to the fifth day. On the sixth day, take 400 mg of cimetidine tablets and 60 mg of aldenafil citrate tablets in the morning, and 400 mg of cimetidine tablets in the afternoon. ;On the first day, take 30mg once a day, once a day, and from the second to sixth days, take 30mg three times a day. On the seventh day, take 30mg once a day, once a day. ;60 mg nifedipine controlled-release tablet was taken on the first day, 60 mg nifedipine controlled-release tablet was taken on the morning of the second day, 60 mg aidenafil citrate tablet was taken on the afternoon, 60 mg nifedipine controlled-release tablet was taken on the third to the fourth day, 60 mg nifedipine controlled-release tablet was taken on the morning of the fifth day, 60 mg aidenafil citrate tablet simulant was taken on the afternoon, and 60 mg nifedipine controlled-release tablet was taken on the sixth day. ;60 mg nifedipine controlled-release tablet was taken on the first day, 60 mg nifedipine controlled-release tablet was taken on the morning of the second day, 60 mg aldenafil citrate tablet simulant was taken on the afternoon, 60 mg nifedipine controlled-release tablet was taken on the third to the fourth day, 60 mg nifedipine controlled-release tablet was taken on the morning of the fifth day, 60 mg aldenafil citrate tablet was taken on the afternoon, and 60 mg nifedipine controlled-release tablet was taken on the sixth day. ;On the first day, 60 mg of aldenafil citrate tablets and 200 mL of warm water were taken at the same time. After the washing period (seven days), 60 mg of aldenafil citrate tablets and 200 mL of Baijiu aqueous solution were taken on the ninth day. ;On the first day, 60 mg of adenafel citrate tablets and 200 mL of Baijiu aqueous solution were taken at the same time. After the washing out period (seven days), 60 mg of adenafel citrate tablets and 200 mL of warm water were taken on the ninth day. ;On the first day, take 60 mg of aldenafil citrate tablets. After a 7-day washout period, take 60 mg of dapoxetine hydrochloride tablets on the ninth day. After a 7-day washout period, take 60 mg of aldenafil citrate tablets and 60 mg of dapoxetine hydrochloride tablets on the seventeenth day. ;On the first day, take 60 mg of dapoxetine hydrochloride tablets. After a 7-day washout period, on the ninth day, take both 60 mg of aldenafil citrate tablets and 60 mg of dapoxetine hydrochloride tablets. After a 7-day washout period, take 60 mg of aldenafil citrate tablets at approximately 8:00 on the seventeenth day. ;On the first day, take both 60 mg of aldenafil citrate tablets and 60 mg of dapoxetine hydrochloride tablets. After a 7-day washout period, take 60 mg of aldenafil citrate tablets on the ninth day. After a 7-day washout period, take 60 mg of dapoxetine hydrochloride tablets on the seventeenth day.

Peking University First Hospital; Youcare Pharmaceutical Group Co, Ltd., Provided by Youcare Pharmaceutical Group Co, Ltd.

Erectile dysfunction

 

 

Not yet recruiting

4

20

US

XYOSTED 75 milligram (mg) in 0.5 ML Auto-Injector

Tulane University, Louisiana State University Health Sciences Center in New Orleans, Antares Pharma Inc.

Multiple Sclerosis, Erectile Dysfunction, Testosterone Deficiency

12/25

12/25

Not yet recruiting

4

200

NA

using Indocyanine Green, IV Indocyanine Green injection, Nerve-sparing robot-assisted laparoscopic radical prostatectomy

Ankara University

Prostate Cancer Adenocarcinoma, Erectile Dysfunction Following Radical Prostatectomy

12/25

03/26

Completed

4

8

US

CellCept, Mycophenolate Mofetil, ACTHar gel, ACTHar, H.P. ACTHar Gel, Repository corticotropin

Columbia University

Lupus Nephritis

01/24

01/24

Not yet recruiting

4

400

 

IVFAustralia Pty L.t.d., IVFAustralia Pty L.t.d., Melbourne IVF, Virtus Health Limited

Subfertility