Neoplasms, Glandular and Epithelial  >>  sorafenib  >>  Phase 1
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15 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
sorafenib / Generic mfg.
NCT00956436: Sorafenib With BIIB022 in Hepatocellular Carcinoma (HCC)

Completed
1b
40
US, Europe, RoW
BIIB022, IGF-1R, Liver Cancer, Hepatocellular Carcinoma, Monoclonal Antibody, Sorafenib, HCC, Nexavar
Biogen
Hepatocellular Carcinoma
04/11
04/11
S-TACE, NCT00478374: Sorafenib With TACE to Treat Hepatocellular Carcinoma

Completed
1
21
Europe
Sorafenib, Transarterial chemoembolisation with doxorubicin
University of Bern
Hepatocellular Carcinoma
01/09
01/09
NCT00466232: Phase I Study of Weekly Topotecan in Combination With Sorafenib in Treatment of Relapsed Small Cell Lung Cancer

Completed
1
16
US
Topotecan, Hycamtin, Sorafenib, Nexavar
HealthPartners Institute
Small Cell Carcinoma, Lung Cancer
12/09
03/10
NCT00873002: Panobinostat and Sorafenib in Treating Patients With Liver Cancer That is Metastatic and/or Cannot Be Removed by Surgery

Terminated
1
3
US
panobinostat, sorafenib tosylate
Case Comprehensive Cancer Center, National Cancer Institute (NCI)
Liver Cancer
05/10
06/10
NCT01131689: Trial of S-1 in Combination With Sorafenib for Patients With Advanced Hepatocellular Carcinoma

Checkmark P1 data
Jun 2011 - Jun 2011: P1 data
Completed
1
20
RoW
sorafenib, TS-1
Samsung Medical Center
Hepatocellular Carcinoma
09/10
09/11
NCT00093613: Sorafenib in Treating Patients With Recurrent or Progressive Malignant Glioma

Completed
1
47
US
sorafenib tosylate, BAY 43-9006, BAY 43-9006 Tosylate Salt, BAY 54-9085, Nexavar, SFN, pharmacological study, pharmacological studies
National Cancer Institute (NCI)
Adult Anaplastic Astrocytoma, Adult Anaplastic Oligodendroglioma, Adult Giant Cell Glioblastoma, Adult Gliosarcoma, Recurrent Adult Brain Tumor
10/10
12/11
NCT00375310: Phase I Study of Gemcitabine, Sorafenib and Radiotherapy in Patients With Unresectable Pancreatic Cancer

Completed
1
27
US
Gemcitabine, Sorafenib, Gemzar ( gemcitabine), Sorafenib (BAY 43-9006), Radiotherapy
Indiana University School of Medicine, Amgen
Pancreatic Cancer, Adenocarcinoma of the Pancreas
11/10
11/14
NCT00635791: Phase I Study of Vorinostat and Sorafenib in Advanced Cancer

Checkmark P1 data
Mar 2012 - Mar 2012: P1 data
Completed
1
36
US
Sorafenib, NexAVAR, Vorinostat, Zolinza
University of Colorado, Denver, Merck Sharp & Dohme LLC, Bayer
Malignant Solid Tumour, Renal Cell Carcinoma, Non Small Cell Lung Carcinoma
10/11
03/12
NCT01011010: Sorafenib Tosylate and Chemoembolization With Doxorubicin Hydrochloride and Mitomycin in Treating Patients With Liver Cancer That Cannot Be Removed By Surgery

Completed
1
11
US
doxorubicin hydrochloride, mitomycin C, sorafenib tosylate, laboratory biomarker analysis, pharmacological study
UNC Lineberger Comprehensive Cancer Center, National Cancer Institute (NCI)
Liver Cancer
12/12
09/17
NCT00418496: Interleukin-2 With Sorafenib (BAY 43-9006) for Unresectable or Metastatic Clear Cell Renal Carcinoma (RCC) and Metastatic Melanoma

Completed
1
17
US
Aldesleukin, Proleukin, Sorafenib, Nexavar
Ohio State University Comprehensive Cancer Center, Bayer, Novartis
Renal Cancer, Melanoma
02/13
10/13
NCT00976170: Study of GC33 and Sorafenib in Combination in Advanced or Metastatic Liver Cancer (Hepatocellular Carcinoma)

Completed
1
42
US, RoW
GC33(RO5137382), Sorafenib
Chugai Pharmaceutical, Hoffmann-La Roche
Hepatocellular Carcinoma
07/13
09/14
NCT00384969: Sorafenib and RAD001 Renal Cell Carcinoma

Completed
1
21
US
RAD001 and Sorafenib
University of California, San Francisco, Novartis
Renal Cell Carcinoma
12/13
03/14
NCT01518413: Dose Escalation Study of Sorafenib and Irinotecan Combination Therapy in Pediatric Patients With Solid Tumors

Checkmark ASCO 2014
May 2014 - May 2014: ASCO 2014
Completed
1
17
US
sorafenib, irinotecan
HMeany
Rhabdomyosarcoma and Other Soft Tissue Sarcomas, Ewing's Sarcoma Family of Tumors, Osteosarcoma, Neuroblastoma, Brain Tumors
01/15
01/15
NCT02101593: Ph 1 Trial of ADI PEG 20 Plus Sorafenib to Treat Patients With Liver Cancer

Completed
1
8
US
ADI-PEG 20, arginine deiminase formulated with polyethylene glycol
Polaris Group
Hepatocellular Carcinoma
02/16
03/16
NCT01383343: Sorafenib Tosylate, Bevacizumab, Irinotecan Hydrochloride, Leucovorin Calcium, and Fluorouracil in Treating Patients With Metastatic Colorectal Cancer

Checkmark ASCO-GI 2014
Jan 2014 - Jan 2014: ASCO-GI 2014
Completed
1
17
US
Bevacizumab, Anti-VEGF, Anti-VEGF Humanized Monoclonal Antibody, Anti-VEGF rhuMAb, Avastin, Bevacizumab Biosimilar BEVZ92, Bevacizumab Biosimilar BI 695502, Bevacizumab Biosimilar FKB238, Immunoglobulin G1 (Human-Mouse Monoclonal rhuMab-VEGF Gamma-Chain Anti-Human Vascular Endothelial Growth Factor), Disulfide With Human-Mouse Monoclonal rhuMab-VEGF Light Chain, Dimer, Recombinant Humanized Anti-VEGF Monoclonal Antibody, rhuMab-VEGF, Fluorouracil, 5-Fluoro-2,4(1H, 3H)-pyrimidinedione, 5-Fluorouracil, 5-Fluracil, 5-FU, AccuSite, Carac, Fluoro Uracil, Fluouracil, Flurablastin, Fluracedyl, Fluracil, Fluril, Fluroblastin, Ribofluor, Ro 2-9757, Ro-2-9757, Irinotecan Hydrochloride, Campto, Camptosar, Camptothecin 11, Camptothecin-11, CPT 11, CPT-11, Irinomedac, U-101440E, Leucovorin Calcium, Adinepar, Calcifolin, Calcium (6S)-Folinate, Calcium Folinate, Calcium Leucovorin, Calfolex, Calinat, Cehafolin, Citofolin, Citrec, Citrovorum Factor, Cromatonbic Folinico, Dalisol, Disintox, Divical, Ecofol, Emovis, Factor, Citrovorum, Flynoken A, Folaren, Folaxin, FOLI-cell, Foliben, Folidan, Folidar, Folinac, Folinate Calcium, folinic acid, Folinic Acid Calcium Salt Pentahydrate, Folinoral, Folinvit, Foliplus, Folix, Imo, Lederfolat, Lederfolin, Leucosar, leucovorin, Rescufolin, Rescuvolin, Tonofolin, Wellcovorin, Sorafenib Tosylate, BAY 43-9006 Tosylate, BAY 54-9085, Nexavar, sorafenib
National Cancer Institute (NCI)
Recurrent Colon Carcinoma, Recurrent Rectal Carcinoma, Stage IVA Colon Cancer, Stage IVA Rectal Cancer, Stage IVB Colon Cancer, Stage IVB Rectal Cancer
02/17
02/17

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