olanzapine / Generic mfg. |
ChiCTR-TRC-12002273: Effects of paliperidone extended-release tablets (paliperidone ER) and olanzapine on metabolic profile, insulin resistance and beta-cell function in schizophrenic patients: a randomized 12-week study |
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| Completed | N/A | 80 | | paliperidone extended-release ;olanzapine | First Affiliated Hospital, College of Medicine, Zhejiang University; Level of the institution:, Key Medical Disciplines Funds in Zhejiang Province | Schizophrenia | | | | |
ChiCTR-TRC-14004854: A randomized, controlled, multi-center clinical trial to study the treatment resistant schizophrenia (TRS) in Zhejiang province |
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| Completed | N/A | 200 | | Paliperidone Extended-Release Tablets ;Olanzapine | First Affiliated Hospital, Zhejiang University School of Medicine; None, self-financing | Schizophrenia | | | | |
ChiCTR-OPC-16009742: A 12-week prospective pilot study to compare metabolic effects of aripiprazole VS olanzapine in drug-naive patients with first-onset schizophrenia |
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| Completed | N/A | 40 | | aripiprazole ;aripiprazole ;olanzapine ;olanzapine | Jiangxi Mental Health Centre; Jiangxi Mental Health Centre, The Science and Technology Projects of the Health and Family Planning Commission of Jiangxi Province (20157041) | Schizophrenia | | | | |
ChiCTR-ORC-16008061: Herbal medicine for metabolic syndrome due to olanzapine in hospitalized patients with schizophrenia:a retrospective controlled study |
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| Completed | N/A | 523 | | TCM combinate with olanzapine ;olanzapine | Tongde Hospital of Zhejiang Province; Tongde Hospital of Zhejiang Province, First-phase Research Fund for Young Medical Investigators of Zhejiang Province | Schizophrenia | | | | |
ChiCTR-IOR-14005304: A randomized, 13-week study assessing the efficacy and safety of paliperidone palmitate and olanzapine in first-episode schizophrenic patients |
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| Recruiting | N/A | 100 | | Palm trees risperidone long-acting injection Paley ;Control | First Affiliated Hospital, College of Medicine, Zhejiang University; First Affiliated Hospital, College of Medicine, Zh, National Natural Science Foundation (81301158) | Schizophrenic | | | | |
ChiCTR-OOC-15006331: Effcets of 5-HTR2A, DRD2,and COMT genes polymorphisms and drug plasma concentration on antipsychotic response to olanzapine in treatment of early-onset schizophrenia |
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| Not yet recruiting | N/A | 100 | | Nil | First Affiliated Hospital Kunming Medical University; None, The National Natural Science Foundation of China | early-onset schizophrenia | | | | |
ChiCTR2000032477: Clinical study for olanzapine treating critically ill patients with delirium |
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| Completed | N/A | 80 | | olanzapine ;dexmedetomidine | Tongde Hopsital of Zhejiang Province; Tongde Hopsital of Zhejiang Province, Department sources | critically ill patients with delirium | | | | |
ChiCTR-IOR-16009579: The multi-dimensional evaluation of the individualized treatment of atypical antipsychotics |
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| Not yet recruiting | N/A | 800 | | Olanzapine ;Risperidone ;Aripiprazole ;Amisulpride | Shanghai Mental Health Center; Shanghai Mental Health Center, The project to promote the municipal hospital clinical skills and innovation action for three year | schizophrenia | | | | |
ChiCTR1800016687: Research on the therapeutic effect and safety of electropuncture on metabolic syndrome due to olanzapine and risperidone |
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| Recruiting | N/A | 30 | | electropuncture ;shame electropuncture | Beijing Anding Hospital affiliated to Capital Medical University; Beijing Anding Hospital affiliated to Capital Medical University, Capital Medical University | Capital Medical University | | | | |
ChiCTR1800019255: A Clinical Study for the Tiaoweichengqi Decoction on Treating the Metabolic Syndrom Induced by Olanzapine |
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| Not yet recruiting | N/A | 120 | | Tiaoweichengqi Decoction and placebo tablet ;Metformin and palcebo decoction | Shanghai Jiao Tong University School of Medicine, Shanghai Mental Health Center; Shanghai Jiao Tong University School of Medicine, Shanghai Mental Health Center, The Bootstrap Class Project of Traditional Chinese Medicine of Science and Technology Commission of Shanghai Municipality | schizophrenia | | | | |
ChiCTR1900027767: Efficacy and safety of adjunctive low-concentration sevoflurane for the treatment of hospitalized acute schizophrenia: a multicenter, randomized, active-controlled clinical trial. |
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| Recruiting | N/A | 50 | | antipsychotics (Risperidone/Paliperidone/Olanzapine) and Sevoflurane ;antipsychotics (Risperidone/Paliperidone/Olanzapine) | Guangzhou Women and Children's Medical Center; Guangzhou Women and Children's Medical Center, National Natural Science Foundation of China (81671116 and 81870823) | schizophrenia | | | | |
NCT06200584: Synergistic Effect of Vitamin E & D in Reducing Risk of Effects Associated With Atypical Anti-psychotics |
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| Completed | N/A | 140 | RoW | Risperidone, neuroleptics, Olanzapine, Quetiapine, Risperidone and Vitamin D and Vitamin E, vitamin, Olanzapine and Vitamin D and Vitamin E, Quetiapine and Vitamin D and Vitamin E | Dr Rabia Arshad | Antipsychotics and Neuroleptics Toxicity | 06/21 | 06/21 | | |
ChiCTR2000031071: Clinical Study of Olanzapine combined with Danggui Chengqi mixture in the treatment of schizophrenia |
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| Not yet recruiting | N/A | 160 | | Taking Danggui Chengqi mixture and Olanzapine ;Taking a placebo of Danggui Chengqi mixture and Olanzapine | Mental health center affiliated to Medical College of Shanghai Jiaotong University; Shanghai Jiao Tong University School of Medicine, Shanghai Mental Health Center, Shanghai Health Commission Key Specialty Training Program of Traditional Chinese medicine | Schizophrenia | | | | |
ChiCTR1900027708: Clinical study on evidence-based optimization scheme of ICU delirium treatment with traditional Chinese medicine |
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| Recruiting | N/A | 210 | | Western medicine basic standard treatment + traditional Chinese medicine mixture 30g po Q6h × 7 days ;Basic standard treatment of western medicine + olanzapine tablets 5~20mg po qd × 7 days; ;Western medicine basic standard treatment + placebo 30g po Q6h × 7 days | Affiliated Hospital of Chengdu University of traditional Chinese Medicine; Affiliated Hospital of Chengdu University of traditional Chinese Medicine, Science and Technology Project of Sichuan Province | Intensive Care Delirium | | | | |
ChiCTR2000036717: Clinical study based on intestinal flora on the treatment of Xiexin Decoction on Metabolic syndrome caused by Olanzapine |
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| Not yet recruiting | N/A | 120 | | Xiexin Decoction ;metformin | Shanghai Mental Health Center; Shanghai Mental Health Center, Shanghai Shenkang Hospital Development Center | Metabolic syndrome of Schizophrenia patients | | | | |
ChiCTR2000037076: Effect of ketogenic diet combined with olanzapine on metabolic disorder and cognitive symptoms in schizophrenia |
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| Recruiting | N/A | 200 | | base diet with olanzapine ;ketogenic diet with olanzapine | Shanghai Mental Health Center; Shanghai Mental Health Center, Shanghai Shenkang Hospital Development Center | Schizophrenia | | | | |
NCT06040944: Antipsychotic Induced Hyperprolactinemaia as Risk Factor for Periodontitis in Schizophrenic Patients |
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| Completed | N/A | 64 | RoW | antipsychotic drugs inducing hyperprolactinemia, antipsychotic drugs not inducing hyperprolactinemia | Fayoum University | Schizophrenia Spectrum and Other Psychotic Disorders, Periodontal Diseases | 10/22 | 11/22 | | |
SWITCH, NCT04312503: Observational Study on the Effect of Switch to Lurasidone in Subjects With Schizophrenia" |
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| Completed | N/A | 95 | Europe | Lurasidone, Latuda, aripiprazole, olanzapine, quetiapine or risperidone | Aziende Chimiche Riunite Angelini Francesco S.p.A | Schizophrenia | 10/22 | 10/22 | | |
ChiCTR2100049259: Clinical study of Yueju pill combined with olanzapine in the treatment of negative symptoms of schizophrenia |
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| Not yet recruiting | N/A | 110 | | Take Yueju pill formula granules ;Take Yueju pill placebo formula granules | Mental Health Center, Shanghai Jiao Tong University School of Medicine; Mental Health Center, Shanghai Jiao Tong University School of Medicine, Special Project on Integrating Chinese and Western Medicine in General Hospitals in 2020 (ZHYY-ZXYJHZX-202004) | Schizophrenia | | | | |
| Recruiting | N/A | 200 | Europe | | Charite University, Berlin, Germany | Major Depression, Alzheimer's Disease, Alcoholism, Schizophrenia | 12/22 | 12/22 | | |
ChiCTR2100042829: A randomized controlled study comparing the effectiveness of the triple olanzapine / dexamethasone regimen in the prevention of nausea and vomiting (CINV) caused by hyperemetic chemotherapy |
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| Recruiting | N/A | 578 | | Fosapistan + Olanzapine + Palonosetron ;Fosapitan + Dexamethasone + Palonosetron | The First Affiliated Hospital of Xinxiang Medical College; The First Affiliated Hospital of Xinxiang Medical College, CSCO-Hausson Cancer Research Fund | Malignant tumor | | | | |
NCT06159322: Characterizing Response to Antipsychotics in Schizophrenia |
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| Recruiting | N/A | 40 | Canada | Olanzapine, Zyprexa, Clozapine, Clozaril | The Royal Ottawa Mental Health Centre, The Royal's Institute of Mental Health Research | Schizophrenia, Schizoaffective Disorder | 01/24 | 01/24 | | |
NCT05600790: Mechanism of Mindfulness Based Online Intervention in Reducing Emotional Distress |
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| Active, not recruiting | N/A | 300 | RoW | Mindfulness Intervention for Emotional Distress | Peking University | Emotional Distress | 02/23 | 02/23 | | |
NCT04218981: Definitive Selection of Neuroimaging Biomarkers for the Diagnosis and Treatment to Common Mental Disorders |
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| Recruiting | N/A | 200 | RoW | Antipsychotic drugs, MRI scan, Mood stabilizer, Paroxetine | Central South University | Common Mental Disorder | 06/23 | 12/23 | | |
ChiCTR2300073922: Application of Olanzapine population pharmacokinetic model in acute agitation |
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| Recruiting | N/A | 100 | | Model group was given 5mg of olanzapine orally on the first day, and fasting blood sampling was performed on the second morning to check blood drug concentration. According to the patient's blood drug concentration, the recommended dose was predicted by the Olanzapine PPK model (the optimal drug concentration was set at 60ng/ml).Add directly to the recommended dose on the evening of the second day ;In the control group, 5mg olanzapine was taken on the first day, 5mg was added daily, and the dosage was gradually increased to 20mg olanzapine daily. | Beijing Anding Hospital affiliated to Capital Medical University; Beijing Anding Hospital affiliated to Capital Medical University, Beijing Anding Hospital affiliated to Capital Medical University | acute agitation | | | | |
ChiCTR2200064709: Study on the Mechanism of Chaihu Prescription in Intervention of Schizophrenia |
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| Not yet recruiting | N/A | 120 | | Take olanzapine ;take Olanzapine+CLMD ;no ;take Chaihu | Hunan Brain Hospital; Hunan Brain Hospital, Hunan Brain Hospital | schizophrenia | | | | |
NCT05606224: The Effects and Mechanisms of Mindfulness Intervention for Emotional Distress |
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| Recruiting | N/A | 200 | RoW | internet-based mindfulness intervention for emotional distress | Peking University, Nanjing Brian Hospital, Capital Medical University, Beijing Tiantan Hospital, Foshan Mental Health Center | Emotional Disorder | 08/23 | 08/23 | | |
NCT05891015: The Mechanism of Mindfulness Intervention to Alleviate Emotional Distress in Patients With Emotional Disorders |
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| Not yet recruiting | N/A | 200 | RoW | Mindfulness Intervention for Emotional Distress(MIED) | Peking University | Emotional Distress, Emotional Disorder | 11/23 | 12/25 | | |
| Recruiting | N/A | 76 | RoW | Amisulpride, Solian, Olanzapine, Oulanning | Tianjin Anding Hospital | BPSD, Amisulpride, Olanzapine, Dementia of the Alzheimer Type | 12/23 | 05/24 | | |
NCT06128408: The Characteristics of Treatment Resistant Schizophrenia From the Illness Onset |
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| Not yet recruiting | N/A | 300 | NA | risperidone, olanzapine, aripiprazole | Peking University | Treatment-resistant Schizophrenia | 10/24 | 10/24 | | |
ChiCTR2200057743: Clinical evaluation and network pharmacological study on the mechanism of Xiaochengqi Decoction in the treatment of Yangming Fu heat type of schizophrenia |
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| Not yet recruiting | N/A | 60 | | On the basis of olanzapine treatment with Xiaochengqi decoction ;Olanzapine treatment | The Second Affiliated Hospital of Xinxiang Medical College; The Second Affiliated Hospital of Xinxiang Medical College, He'nan psychiatric research center | Yangming Fu heat type of schizophrenia | | | | |
ChiCTR2300072552: Clinical study of Jiangtang decoction on improving Olanzapine induced weight gain based on regulating gut microbiota |
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| Not yet recruiting | N/A | 72 | | Antipsychotic drugs and life guidance: (1) Single antipsychotic treatment of Olanzapine: Zaipule Tablets (marketed drug), 5 mg/tablet, 28 tablets/box, produced by Lilly (China) Suzhou Pharmaceutical Co., Ltd. Specialized doctors from the Third Hospital of Chaoyang District will prescribe according to the approved product information instructions in China and adjust the dosage based on the individual reactions of patients. In principle, the study drug dose should be adjusted to the treatment dose within one week of enrollment. (2) Guidelines for exercise, daily life, and daily life: Moderate exertion, avoiding heavy physical activity, and vigorous exercise. (3) Take Jiangtang decoction granules, 1 bag each time, bid. Jiangtang decoction granules: processed and provided by Beijing Kangrentang Pharmaceutical Co., LTD. ;Antipsychotic drugs and life guidance: (1) Single antipsychotic treatment of Olanzapine: Zaipule Tablets (marketed drug), 5 mg/tablet, 28 tablets/box, produced by Lilly (China) Suzhou Pharmaceutical Co., Ltd. Specialized doctors from the Third Hospital of Chaoyang District will prescribe according to the approved product information instructions in China and adjust the dosage based on the individual reactions of patients. In principle, the study drug dose should be adjusted to the treatment dose within one week of enrollment. (2) Guidelines for exercise, daily life, and daily life: Moderate exertion, avoiding heavy physical activity, and vigorous exercise. | Peking University First Hospital; Peking University First Hospital, Beijing Traditional Chinese Medicine Technology Development Fund Project | Olanzapine induced weight gain | | | | |
NCT06035003: Mechanism of Mindfulness-Based Online Intervention in Enhancing Cognitive Flexibility |
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| Active, not recruiting | N/A | 595 | RoW | Internet-based Mindfulness Intervention for Emotional Distress (iMIED) | Peking University | Emotional Distress | 02/24 | 02/24 | | |
NCT05833399: Correlation of Genetic Variations With Clinical Response in Substance Use Disorder |
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| Recruiting | N/A | 200 | RoW | Quetiapine, olanzapine, mirtazapine, carbamazepine, sertraline, amitriptyline, chlorpromazine and risperidone, Seroquel, Olapex, Remeron, Tegretol, Moodapex, Tryptizol, Neurazine and Apexidone. | Alexandria University | Substance Use Disorders, Substance Dependence | 03/24 | 12/24 | | |
NCT06288854: Efficacy of Olanzapine on Weight Gain in Advanced Gynecologic Cancer With Paclitaxel and Carboplatin: a Double Blind, Placebo-controlled Randomized Trial |
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| Not yet recruiting | N/A | 48 | NA | weight gain each group, body weight | Rajavithi Hospital | Weight Gain | 03/25 | 06/25 | | |
ChiCTR2200065886: Effects of transcranial magnetic stimulation (TMS) on olanzapine-induced weight gain for patients with schizophrenia spectrum disorders |
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| Not yet recruiting | N/A | 156 | | A total of 12 sessions of sham rTMS were provided for twice per week for 6 weeks ;A total of 12 sessions of high frequency rTMS were provided for twice per week for 6 weeks ;A total of 30 sessions of high frequency rTMS were provided for 5 times per week for 6 weeks | Xiamen Xianyue Hospital; Xiamen Xianyue Hospital, Science and Technology Planning Project of Xiamen City (No. 3502Z20214ZD1276); National Key Research and Development Program (No. 2019YFA0706204) | Schizophrenia spectrum disorders | | | | |
ChiCTR2300071979: The study on mechanism of olanzapine-induced appetite increase in patients |
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| Not yet recruiting | N/A | 174 | | None | Shanghai Mental Health Center; Shanghai Mental Health Center, Self-raised funds | Schizophrenia | | | | |
ChiCTR2100054528: Mechanism of mTORC1/SREBP pathway in olanzapine-induced lipid metabolism abnormalities and metformin treatment in schizophrenia |
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| Recruiting | N/A | 100 | | OlanzapineOlanzapine + metformin ;Olanzapine | Shandong Mental Health Center; Shandong Mental Health Center, Shandong Mental Health Center | schizophrenia | | | | |
NCT05889234: Multimodal Magnetic Resonance Imaging-based Study of Electroconvulsive Efficacy Prediction in Adolescents With Depression: a Multicenter Prospective Cohort Study |
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| Recruiting | N/A | 180 | RoW | Modified Electroconvulsive Therapy, Conventional pharmacotherapy | First Affiliated Hospital of Chongqing Medical University, The Second Affiliated Hospital of Chongqing Medical University, Second Xiangya Hospital of Central South University | Major Depressive Disorder, Magnetic Resonance Imaging, Electroconvulsive Therapy | 12/24 | 01/26 | | |
ChiCTR2200063225: Clinical study on the effect of electroacupuncture on scalp points on cognitive function in schizophrenia |
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| Not yet recruiting | N/A | 60 | | Olanzapine and sham electroacupuncture ;Olanzapine and electroacupuncture | Xiamen Xianyue Hospital ; Xiamen Xianyue Hospital, Project Funds of Xiamen Xianyue Hospital | schizophrenia | | | | |
NCT00512070: Melatonin Metabolism Abnormality in Patients With Schizophrenia or Schizoaffective Disorder Treated With Olanzapine |
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| Active, not recruiting | N/A | 20 | US | olanzapine and melatonin, Olanzapine (Zyprexa) | Seattle Institute for Biomedical and Clinical Research, Eli Lilly and Company | Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Obesity, Metabolic Syndrome | 12/25 | 12/25 | | |
| Recruiting | N/A | 200 | US | Antipsychotics, Non-antipsychotic medication, Antidepressants, Benzodiazepines, No Medication | Icahn School of Medicine at Mount Sinai, Erasmus Medical Center, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Antipsychotics, Pregnancy | 08/27 | 08/27 | | |
| Recruiting | N/A | 1200 | Europe | Dexamethasone phosphate, Isotonic sodium chloride (0.9%), Olanzapine 10 MG, Placebo capsule, Flow-targeted hemodynamic management, Pressure-targeted hemodynamic management, Low tidal-volume ventilation, No ventilation | Rigshospitalet, Denmark | Coronary Artery Disease, Aortic Valve Disease | 12/27 | 12/27 | | |