olanzapine / Generic mfg.  >>  Phase N/A
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43 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
olanzapine / Generic mfg.
ChiCTR-TRC-12002273: Effects of paliperidone extended-release tablets (paliperidone ER) and olanzapine on metabolic profile, insulin resistance and beta-cell function in schizophrenic patients: a randomized 12-week study

Completed
N/A
80
 
paliperidone extended-release ;olanzapine
First Affiliated Hospital, College of Medicine, Zhejiang University; Level of the institution:, Key Medical Disciplines Funds in Zhejiang Province
Schizophrenia
 
 
ChiCTR-TRC-14004854: A randomized, controlled, multi-center clinical trial to study the treatment resistant schizophrenia (TRS) in Zhejiang province

Completed
N/A
200
 
Paliperidone Extended-Release Tablets ;Olanzapine
First Affiliated Hospital, Zhejiang University School of Medicine; None, self-financing
Schizophrenia
 
 
ChiCTR-OPC-16009742: A 12-week prospective pilot study to compare metabolic effects of aripiprazole VS olanzapine in drug-naive patients with first-onset schizophrenia

Completed
N/A
40
 
aripiprazole ;aripiprazole ;olanzapine ;olanzapine
Jiangxi Mental Health Centre; Jiangxi Mental Health Centre, The Science and Technology Projects of the Health and Family Planning Commission of Jiangxi Province (20157041)
Schizophrenia
 
 
ChiCTR-ORC-16008061: Herbal medicine for metabolic syndrome due to olanzapine in hospitalized patients with schizophrenia:a retrospective controlled study

Completed
N/A
523
 
TCM combinate with olanzapine ;olanzapine
Tongde Hospital of Zhejiang Province; Tongde Hospital of Zhejiang Province, First-phase Research Fund for Young Medical Investigators of Zhejiang Province
Schizophrenia
 
 
ChiCTR-IOR-14005304: A randomized, 13-week study assessing the efficacy and safety of paliperidone palmitate and olanzapine in first-episode schizophrenic patients

Recruiting
N/A
100
 
Palm trees risperidone long-acting injection Paley ;Control
First Affiliated Hospital, College of Medicine, Zhejiang University; First Affiliated Hospital, College of Medicine, Zh, National Natural Science Foundation (81301158)
Schizophrenic
 
 
ChiCTR-OOC-15006331: Effcets of 5-HTR2A, DRD2,and COMT genes polymorphisms and drug plasma concentration on antipsychotic response to olanzapine in treatment of early-onset schizophrenia

Not yet recruiting
N/A
100
 
Nil
First Affiliated Hospital Kunming Medical University; None, The National Natural Science Foundation of China
early-onset schizophrenia
 
 
ChiCTR2000032477: Clinical study for olanzapine treating critically ill patients with delirium

Completed
N/A
80
 
olanzapine ;dexmedetomidine
Tongde Hopsital of Zhejiang Province; Tongde Hopsital of Zhejiang Province, Department sources
critically ill patients with delirium
 
 
ChiCTR-IOR-16009579: The multi-dimensional evaluation of the individualized treatment of atypical antipsychotics

Not yet recruiting
N/A
800
 
Olanzapine ;Risperidone ;Aripiprazole ;Amisulpride
Shanghai Mental Health Center; Shanghai Mental Health Center, The project to promote the municipal hospital clinical skills and innovation action for three year
schizophrenia
 
 
ChiCTR1800016687: Research on the therapeutic effect and safety of electropuncture on metabolic syndrome due to olanzapine and risperidone

Recruiting
N/A
30
 
electropuncture ;shame electropuncture
Beijing Anding Hospital affiliated to Capital Medical University; Beijing Anding Hospital affiliated to Capital Medical University, Capital Medical University
Capital Medical University
 
 
ChiCTR1800019255: A Clinical Study for the Tiaoweichengqi Decoction on Treating the Metabolic Syndrom Induced by Olanzapine

Not yet recruiting
N/A
120
 
Tiaoweichengqi Decoction and placebo tablet ;Metformin and palcebo decoction
Shanghai Jiao Tong University School of Medicine, Shanghai Mental Health Center; Shanghai Jiao Tong University School of Medicine, Shanghai Mental Health Center, The Bootstrap Class Project of Traditional Chinese Medicine of Science and Technology Commission of Shanghai Municipality
schizophrenia
 
 
ChiCTR1900027767: Efficacy and safety of adjunctive low-concentration sevoflurane for the treatment of hospitalized acute schizophrenia: a multicenter, randomized, active-controlled clinical trial.

Recruiting
N/A
50
 
antipsychotics (Risperidone/Paliperidone/Olanzapine) and Sevoflurane ;antipsychotics (Risperidone/Paliperidone/Olanzapine)
Guangzhou Women and Children's Medical Center; Guangzhou Women and Children's Medical Center, National Natural Science Foundation of China (81671116 and 81870823)
schizophrenia
 
 
NCT06200584: Synergistic Effect of Vitamin E & D in Reducing Risk of Effects Associated With Atypical Anti-psychotics

Completed
N/A
140
RoW
Risperidone, neuroleptics, Olanzapine, Quetiapine, Risperidone and Vitamin D and Vitamin E, vitamin, Olanzapine and Vitamin D and Vitamin E, Quetiapine and Vitamin D and Vitamin E
Dr Rabia Arshad
Antipsychotics and Neuroleptics Toxicity
06/21
06/21
ChiCTR2000031071: Clinical Study of Olanzapine combined with Danggui Chengqi mixture in the treatment of schizophrenia

Not yet recruiting
N/A
160
 
Taking Danggui Chengqi mixture and Olanzapine ;Taking a placebo of Danggui Chengqi mixture and Olanzapine
Mental health center affiliated to Medical College of Shanghai Jiaotong University; Shanghai Jiao Tong University School of Medicine, Shanghai Mental Health Center, Shanghai Health Commission Key Specialty Training Program of Traditional Chinese medicine
Schizophrenia
 
 
ChiCTR1900027708: Clinical study on evidence-based optimization scheme of ICU delirium treatment with traditional Chinese medicine

Recruiting
N/A
210
 
Western medicine basic standard treatment + traditional Chinese medicine mixture 30g po Q6h × 7 days ;Basic standard treatment of western medicine + olanzapine tablets 5~20mg po qd × 7 days; ;Western medicine basic standard treatment + placebo 30g po Q6h × 7 days
Affiliated Hospital of Chengdu University of traditional Chinese Medicine; Affiliated Hospital of Chengdu University of traditional Chinese Medicine, Science and Technology Project of Sichuan Province
Intensive Care Delirium
 
 
ChiCTR2000036717: Clinical study based on intestinal flora on the treatment of Xiexin Decoction on Metabolic syndrome caused by Olanzapine

Not yet recruiting
N/A
120
 
Xiexin Decoction ;metformin
Shanghai Mental Health Center; Shanghai Mental Health Center, Shanghai Shenkang Hospital Development Center
Metabolic syndrome of Schizophrenia patients
 
 
ChiCTR2000037076: Effect of ketogenic diet combined with olanzapine on metabolic disorder and cognitive symptoms in schizophrenia

Recruiting
N/A
200
 
base diet with olanzapine ;ketogenic diet with olanzapine
Shanghai Mental Health Center; Shanghai Mental Health Center, Shanghai Shenkang Hospital Development Center
Schizophrenia
 
 
NCT06040944: Antipsychotic Induced Hyperprolactinemaia as Risk Factor for Periodontitis in Schizophrenic Patients

Completed
N/A
64
RoW
antipsychotic drugs inducing hyperprolactinemia, antipsychotic drugs not inducing hyperprolactinemia
Fayoum University
Schizophrenia Spectrum and Other Psychotic Disorders, Periodontal Diseases
10/22
11/22
SWITCH, NCT04312503: Observational Study on the Effect of Switch to Lurasidone in Subjects With Schizophrenia"

Completed
N/A
95
Europe
Lurasidone, Latuda, aripiprazole, olanzapine, quetiapine or risperidone
Aziende Chimiche Riunite Angelini Francesco S.p.A
Schizophrenia
10/22
10/22
ChiCTR2100049259: Clinical study of Yueju pill combined with olanzapine in the treatment of negative symptoms of schizophrenia

Not yet recruiting
N/A
110
 
Take Yueju pill formula granules ;Take Yueju pill placebo formula granules
Mental Health Center, Shanghai Jiao Tong University School of Medicine; Mental Health Center, Shanghai Jiao Tong University School of Medicine, Special Project on Integrating Chinese and Western Medicine in General Hospitals in 2020 (ZHYY-ZXYJHZX-202004)
Schizophrenia
 
 
RAHND, NCT02439099: Retinoic Acid Homeostasis in Neuropsychiatric Diseases

Recruiting
N/A
200
Europe
Charite University, Berlin, Germany
Major Depression, Alzheimer's Disease, Alcoholism, Schizophrenia
12/22
12/22
ChiCTR2100042829: A randomized controlled study comparing the effectiveness of the triple olanzapine / dexamethasone regimen in the prevention of nausea and vomiting (CINV) caused by hyperemetic chemotherapy

Recruiting
N/A
578
 
Fosapistan + Olanzapine + Palonosetron ;Fosapitan + Dexamethasone + Palonosetron
The First Affiliated Hospital of Xinxiang Medical College; The First Affiliated Hospital of Xinxiang Medical College, CSCO-Hausson Cancer Research Fund
Malignant tumor
 
 
NCT06159322: Characterizing Response to Antipsychotics in Schizophrenia

Recruiting
N/A
40
Canada
Olanzapine, Zyprexa, Clozapine, Clozaril
The Royal Ottawa Mental Health Centre, The Royal's Institute of Mental Health Research
Schizophrenia, Schizoaffective Disorder
01/24
01/24
NCT05600790: Mechanism of Mindfulness Based Online Intervention in Reducing Emotional Distress

Active, not recruiting
N/A
300
RoW
Mindfulness Intervention for Emotional Distress
Peking University
Emotional Distress
02/23
02/23
NCT04218981: Definitive Selection of Neuroimaging Biomarkers for the Diagnosis and Treatment to Common Mental Disorders

Recruiting
N/A
200
RoW
Antipsychotic drugs, MRI scan, Mood stabilizer, Paroxetine
Central South University
Common Mental Disorder
06/23
12/23
ChiCTR2300073922: Application of Olanzapine population pharmacokinetic model in acute agitation

Recruiting
N/A
100
 
Model group was given 5mg of olanzapine orally on the first day, and fasting blood sampling was performed on the second morning to check blood drug concentration. According to the patient's blood drug concentration, the recommended dose was predicted by the Olanzapine PPK model (the optimal drug concentration was set at 60ng/ml).Add directly to the recommended dose on the evening of the second day ;In the control group, 5mg olanzapine was taken on the first day, 5mg was added daily, and the dosage was gradually increased to 20mg olanzapine daily.
Beijing Anding Hospital affiliated to Capital Medical University; Beijing Anding Hospital affiliated to Capital Medical University, Beijing Anding Hospital affiliated to Capital Medical University
acute agitation
 
 
ChiCTR2200064709: Study on the Mechanism of Chaihu Prescription in Intervention of Schizophrenia

Not yet recruiting
N/A
120
 
Take olanzapine ;take Olanzapine+CLMD ;no ;take Chaihu
Hunan Brain Hospital; Hunan Brain Hospital, Hunan Brain Hospital
schizophrenia
 
 
NCT05606224: The Effects and Mechanisms of Mindfulness Intervention for Emotional Distress

Recruiting
N/A
200
RoW
internet-based mindfulness intervention for emotional distress
Peking University, Nanjing Brian Hospital, Capital Medical University, Beijing Tiantan Hospital, Foshan Mental Health Center
Emotional Disorder
08/23
08/23
NCT05891015: The Mechanism of Mindfulness Intervention to Alleviate Emotional Distress in Patients With Emotional Disorders

Not yet recruiting
N/A
200
RoW
Mindfulness Intervention for Emotional Distress(MIED)
Peking University
Emotional Distress, Emotional Disorder
11/23
12/25
NCT04341467: Amisulpride Treatment for BPSD in AD Patients

Recruiting
N/A
76
RoW
Amisulpride, Solian, Olanzapine, Oulanning
Tianjin Anding Hospital
BPSD, Amisulpride, Olanzapine, Dementia of the Alzheimer Type
12/23
05/24
NCT06128408: The Characteristics of Treatment Resistant Schizophrenia From the Illness Onset

Not yet recruiting
N/A
300
NA
risperidone, olanzapine, aripiprazole
Peking University
Treatment-resistant Schizophrenia
10/24
10/24
ChiCTR2200057743: Clinical evaluation and network pharmacological study on the mechanism of Xiaochengqi Decoction in the treatment of Yangming Fu heat type of schizophrenia

Not yet recruiting
N/A
60
 
On the basis of olanzapine treatment with Xiaochengqi decoction ;Olanzapine treatment
The Second Affiliated Hospital of Xinxiang Medical College; The Second Affiliated Hospital of Xinxiang Medical College, He'nan psychiatric research center
Yangming Fu heat type of schizophrenia
 
 
ChiCTR2300072552: Clinical study of Jiangtang decoction on improving Olanzapine induced weight gain based on regulating gut microbiota

Not yet recruiting
N/A
72
 
Antipsychotic drugs and life guidance: (1) Single antipsychotic treatment of Olanzapine: Zaipule Tablets (marketed drug), 5 mg/tablet, 28 tablets/box, produced by Lilly (China) Suzhou Pharmaceutical Co., Ltd. Specialized doctors from the Third Hospital of Chaoyang District will prescribe according to the approved product information instructions in China and adjust the dosage based on the individual reactions of patients. In principle, the study drug dose should be adjusted to the treatment dose within one week of enrollment. (2) Guidelines for exercise, daily life, and daily life: Moderate exertion, avoiding heavy physical activity, and vigorous exercise. (3) Take Jiangtang decoction granules, 1 bag each time, bid. Jiangtang decoction granules: processed and provided by Beijing Kangrentang Pharmaceutical Co., LTD. ;Antipsychotic drugs and life guidance: (1) Single antipsychotic treatment of Olanzapine: Zaipule Tablets (marketed drug), 5 mg/tablet, 28 tablets/box, produced by Lilly (China) Suzhou Pharmaceutical Co., Ltd. Specialized doctors from the Third Hospital of Chaoyang District will prescribe according to the approved product information instructions in China and adjust the dosage based on the individual reactions of patients. In principle, the study drug dose should be adjusted to the treatment dose within one week of enrollment. (2) Guidelines for exercise, daily life, and daily life: Moderate exertion, avoiding heavy physical activity, and vigorous exercise.
Peking University First Hospital; Peking University First Hospital, Beijing Traditional Chinese Medicine Technology Development Fund Project
Olanzapine induced weight gain
 
 
NCT06035003: Mechanism of Mindfulness-Based Online Intervention in Enhancing Cognitive Flexibility

Active, not recruiting
N/A
595
RoW
Internet-based Mindfulness Intervention for Emotional Distress (iMIED)
Peking University
Emotional Distress
02/24
02/24
NCT05833399: Correlation of Genetic Variations With Clinical Response in Substance Use Disorder

Recruiting
N/A
200
RoW
Quetiapine, olanzapine, mirtazapine, carbamazepine, sertraline, amitriptyline, chlorpromazine and risperidone, Seroquel, Olapex, Remeron, Tegretol, Moodapex, Tryptizol, Neurazine and Apexidone.
Alexandria University
Substance Use Disorders, Substance Dependence
03/24
12/24
NCT06288854: Efficacy of Olanzapine on Weight Gain in Advanced Gynecologic Cancer With Paclitaxel and Carboplatin: a Double Blind, Placebo-controlled Randomized Trial

Not yet recruiting
N/A
48
NA
weight gain each group, body weight
Rajavithi Hospital
Weight Gain
03/25
06/25
ChiCTR2200065886: Effects of transcranial magnetic stimulation (TMS) on olanzapine-induced weight gain for patients with schizophrenia spectrum disorders

Not yet recruiting
N/A
156
 
A total of 12 sessions of sham rTMS were provided for twice per week for 6 weeks ;A total of 12 sessions of high frequency rTMS were provided for twice per week for 6 weeks ;A total of 30 sessions of high frequency rTMS were provided for 5 times per week for 6 weeks
Xiamen Xianyue Hospital; Xiamen Xianyue Hospital, Science and Technology Planning Project of Xiamen City (No. 3502Z20214ZD1276); National Key Research and Development Program (No. 2019YFA0706204)
Schizophrenia spectrum disorders
 
 
ChiCTR2300071979: The study on mechanism of olanzapine-induced appetite increase in patients

Not yet recruiting
N/A
174
 
None
Shanghai Mental Health Center; Shanghai Mental Health Center, Self-raised funds
Schizophrenia
 
 
ChiCTR2100054528: Mechanism of mTORC1/SREBP pathway in olanzapine-induced lipid metabolism abnormalities and metformin treatment in schizophrenia

Recruiting
N/A
100
 
OlanzapineOlanzapine + metformin ;Olanzapine
Shandong Mental Health Center; Shandong Mental Health Center, Shandong Mental Health Center
schizophrenia
 
 
NCT05889234: Multimodal Magnetic Resonance Imaging-based Study of Electroconvulsive Efficacy Prediction in Adolescents With Depression: a Multicenter Prospective Cohort Study

Recruiting
N/A
180
RoW
Modified Electroconvulsive Therapy, Conventional pharmacotherapy
First Affiliated Hospital of Chongqing Medical University, The Second Affiliated Hospital of Chongqing Medical University, Second Xiangya Hospital of Central South University
Major Depressive Disorder, Magnetic Resonance Imaging, Electroconvulsive Therapy
12/24
01/26
ChiCTR2200063225: Clinical study on the effect of electroacupuncture on scalp points on cognitive function in schizophrenia

Not yet recruiting
N/A
60
 
Olanzapine and sham electroacupuncture ;Olanzapine and electroacupuncture
Xiamen Xianyue Hospital ; Xiamen Xianyue Hospital, Project Funds of Xiamen Xianyue Hospital
schizophrenia
 
 
NCT00512070: Melatonin Metabolism Abnormality in Patients With Schizophrenia or Schizoaffective Disorder Treated With Olanzapine

Active, not recruiting
N/A
20
US
olanzapine and melatonin, Olanzapine (Zyprexa)
Seattle Institute for Biomedical and Clinical Research, Eli Lilly and Company
Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Obesity, Metabolic Syndrome
12/25
12/25
MAIA, NCT06049953: Maternal And Infant Antipsychotic Study

Recruiting
N/A
200
US
Antipsychotics, Non-antipsychotic medication, Antidepressants, Benzodiazepines, No Medication
Icahn School of Medicine at Mount Sinai, Erasmus Medical Center, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Antipsychotics, Pregnancy
08/27
08/27
GLORIOUS-II, NCT05635227: Dexamethasone, Olanzapine, Hemodynamics, and Ventilation in Cardiac Surgery

Recruiting
N/A
1200
Europe
Dexamethasone phosphate, Isotonic sodium chloride (0.9%), Olanzapine 10 MG, Placebo capsule, Flow-targeted hemodynamic management, Pressure-targeted hemodynamic management, Low tidal-volume ventilation, No ventilation
Rigshospitalet, Denmark
Coronary Artery Disease, Aortic Valve Disease
12/27
12/27

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