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| Not yet recruiting | 4 | 20 | | | University of Auckland, Health Research Council | Schizophrenia, Glucose intolerance | | | | |
| Recruiting | 4 | 40 | | | Bristol Meyers Squibb Pharmaceuticals, Bristol Meyers Squibb Pharmaceuticals | Schizophrenic and schizoaffective disorder | | | | |
ACTRN12614000551695: Efficacy and tolerability of asenapine compared with olanzapine in borderline personality disorder: a randomized controlled trial |
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| Recruiting | 4 | 80 | | | Centre for Personality Disorders, Psychiatric Clinic, Department of Neuroscience, University of Turin, Italy, Centre for Personality Disorders, Psychiatric Clinic 1, Department of Neuroscience, University of Turin, Italy | Borderline personality disorder | | | | |
ChiCTR2000029615: Olanzapin Versus Dexmethasone, With 5-HT3 RA and Aprepitant, to Prevent Nausea and Vomiting Induced by Full Dose Single-Day Cisplatin-Based Chemotherapy: a Non-Inferiority, Randomized, Controlled, Phase III, Multi-Center Clinical Trial |
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| Not yet recruiting | 4 | 520 | | Olanzapine ;Dexmethasone | The Fifth Affiliated Hospital of Sun Yat-Sen University; The Fifth Affiliated Hospital of Sun Yat-Sen University, The Fifth Affiliated Hospital of Sun Yat-Sen University | Chemotherapy-induced Nausea and Vomitting | | | | |
ChiCTR-TNRC-10001112: The study on clinical and biological characters of bipolar depression and the treatment scheme optimizing |
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| Completed | 4 | 640 | | Lithium, Sodium valproate, Lamotrigine, MECT, Sertraline, Citalopram, Escitalopram, venlafaxine, Quetiapine, Olanzapine, Risperidone, sulpiride | Guangzhou Scientific and Technological Bureau, Guangzhou Board of Health; Guangzhou first people's hospital, The Tackling Key Problems of Guangzhou Scientific and Technological Project | bipolar depressive disorder | | | | |
ChiCTR-RNC-09000522: The genetic association study on individual difference of therapeutic effects of antipsychotic medication |
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| Completed | 4 | 900 | | Risperidone 2-6mg/d; Olanzapine 5-20mg/d; Aripiprazole 10-30mg/d | the Sixth Hospital, Peking University; Ministry of Science and Technology of the People′s Republic of China, Ministry of Science and Technology of the People′s Republic of China | schizophrenia | | | | |
ChiCTR-TRC-13003554: Olanzapine-valproate combination versus olanzapine or valproate monotherapy in the treatment of bipolar manic episodes: a randomized, controlled trial |
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| Completed | 4 | 120 | | Taking valproate ;Taking olanzapine ;Taking olanzapine and valproate | Department of Psychiatric, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Second Affiliated Hospital of Zhejiang University School of Medicine, Technology Foundation of Zhejiang Province (2010C33038); Health Foundation of Zhejiang Province (2011KYA073); Medical Technology Program Foundation of Zhejiang Province (2012KYA101) | bipolar I disorder mania-episode | | | | |
| Completed | 4 | 3000 | | Perphenazine 16-64 mg/d (N=250) or Haloperidol 6-20 mg/d (N=250) ;Risperidone 2-6mg/d ;Olanzapine 5-20 mg/d ;Quetiapine 400-750mg/d ;Aripiperazole 10~30 mg/d ;Ziprasidone 80-160 mg/d | The Sixth Hospital / Institute of Mental Health, Peking University; The Ministry of Science and Technology, The National High Technology Research and Development Program of China (863 program) | Schizophrenia | | | | |
ChiCTR-RNC-09000521: The genetic association study on individual difference of therapeutic effects of antipsychotic medication |
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| Completed | 4 | 2100 | | Risperidone 2-6mg/d; Olanzapine 5-20mg/d; Qutiapine 400-750mg/d; Ziprasidone 80-160 mg/d; Aripiprazole 10-30mg/d; Clozapine 200-600 mg/d; Perphenazine 20-60 mg/d | Sixth Hospital, Peking University; Ministry of Health, China, Ministry of Health, China. | schizophrenia | | | | |
2005-001606-66: OLANZAPINE VS LAMOTRIGINE ADD-ON TO LITHIUM:EFFICACY ON ANXIETY SYMPTOMS IN REMITTING BIPOLAR PATIENTS |
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| Ongoing | 4 | | Europe | ZYPREXA VELOTAB*28 CPR 5 MG, LAMICTAL*25MG 28 CPR DISP., ZYPREXA VELOTAB*28 CPR 5 MG, LAMICTAL*25MG 28 CPR DISP. | AZIENDA SANITARIA OSPEDALIERA \"S. GIOVANNI BATTISTA DI TORINO\" | EFFICACY ON ANXIETY SYMPTOMS IN REMITTING BIPOLAR PATIENTS | | | | |
2007-004897-26: Memantine for the Long Term Management of Neuropsychiatric Symptoms in Alzheimer\'s disease - MAIN-AD |
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| Ongoing | 4 | 300 | Europe | Memantine, Risperidone, Ebixa, Risperdal, Zyprexa, Seroquel, Haloperidol (proprietary), Ebixa, Risperdal, Zyprexa, Seroquel, Haloperidol (proprietary) | King\'s College London, North Essex Partnership NHS Foundation Trust | Alzheimer\'s disease | | | | |
ChiCTR-OPC-15007529: Comparasion of metabolic side-effect of olanzapine or ziprasidone monotherapy, ziprasidone replacement andziprasidone joint olanzapine treatment on schizophrenia or schizophrennia like patients— an opne, controlled study |
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| Not yet recruiting | 4 | 120 | | Treat with Ziprazidone ;Treat with Olanzapine ;Treat with olanzapine at the first week and then replaced by ziprazidone ;Treat with ziprazidone and olanzapine combindly | The department of psychiatry, Xijing Hospital; Xijing Hospital, From the department of psychiatry. | schizophrenia | | | | |
2018-000178-31: Metabolic Dysfunctions Associated with Pharmacological Treatment of Schizophrenia Alteraciones metabólicas asociadas al tratamiento farmacológico de la esquizofrenia |
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| Ongoing | 4 | 48 | Europe | Olanzapine, Aripiprazole, Tablet, Olanzapine, Aripiprazole | Fundación para la Investigación e Innovación Biosanitaria de Asturias (FINBA), Fundación para la Investigación e Innovación Biosanitaria de Asturias (FINBA) | Schizophrenia Esquizofrenia, Schizophrenia Esquizofrenia, Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
ChiCTR-IPR-16009208: The safety of Paliperidone Extended-Release Tablets and Olanzapine in treating patients with schizophrenia |
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| Recruiting | 4 | 120 | | Paliperidone Extended-Release Tablets ;Olanzapine | The Seventh People's Hospital of Shaoxing City; the seventh people’s hospital of Shaoxing City, the seventh people’s hospital of Shaoxing City | schizophrenia | | | | |
2018-002267-25: THE EFFECT OF GENETIC AND EPIGENETIC DISPOZITIONS ON THE EFFICIENCY AND SAFETY OF OLANZAPINE PSYCHOSIS THERAPY VLIV GENETICKÝCH A EPIGENETICKÝCH DISPOZIC NA ÚČINNOST A BEZPEČNOST LÉČBY PSYCHÓZ OLANZAPINEM |
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| Not yet recruiting | 4 | 200 | RoW | Tablet | Fakultní nemocnice Brno, Fakultní nemocnice Brno/Masarykova univerzita | Psychoses, Psychoses, Psychiatry and Psychology [F] - Behavioral Disciplines and Activities [F04] | | | | |
2017-002406-12: HAMLETT. Handling Antipsychotic Medication: Long-term Evaluation of Targeted Treatment. A study comparing continuation versus discontinuation/dose reduction of antipsychotic medication in patients remitted after a first episode of psychosis HAMLETT. Handling Antipsychotic Medication: Lange termijn evaluatie van specifiek toegepaste medicatie. Vergelijking tussen het doorgaan met antipsychotische medicatie bij patiënten die hersteld zijn van eerste psychotische episode en vroegtijdig afbouwen/stoppen. |
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| Not yet recruiting | 4 | 512 | Europe | RISPERIDONE, OLANZAPINE, QUETIAPINE, ARIPIPRAZOLE, HALOPERIDOL, SULPIRIDE, PALIPERIDONE, PIMOZIDE, LURASIDONE, CLOZAPINE, AMISULPRIDE, TIAPRIDE, SERTINDOLE, CHLORPROTHIXENE, CID5073, CID135398745, CID5002, CID60795, CID3559, CID5355, CID115237, CID16362, CID213046, CID135398737, CID2159, CID5467, CID60149, CID667467, CIS5311507, Tablet, RISPERIDONE, OLANZAPINE, QUETIAPINE, ARIPIPRAZOLE, HALOPERIDOL, SULPIRIDE, PALIPERIDONE, PIMOZIDE, LURASIDONE, CLOZAPINE, AMISULPRIDE, TIAPRIDE, SERTINDOLE, CHLORPROTHIXENE | University Medical Center Groningen, ZonMw | HAMLETT compares regular treatment guidelines for patients in remission after a first episode of psychosis, namely continuation with antipsychotic medication for at least one year, with early dose reduction/discontinuation. HAMLETT vergelijkt de reguliere behandeling van patiënten in remissie na een eerste psychotische episode zoals beschreven in de richtlijnen, namelijk het continueren van antipsychotica voor minstens 1 jaar, met het vroegtijdig afbouwen/stoppen met medicatie., HAMLETT compares continuation versus early discontinuation of antipsychotic medication in patients who have recovered from their first episode of psychosis. HAMLETT vergelijkt de reguliere behandeling van patiënten die hersteld zijn van een eerste psychose, namelijk minimaal 1 jaar antipsychotica gebruiken, met vroegtijdig afbouwen/stoppn met medicatie, Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
| Not yet recruiting | 4 | 60 | Europe | DM-Aripiprazole, DM-Olanzapine, DM- Quetiapine, DM-Risperidone, Tablet, Aripiprazole, Olanzapine, Quetiapine, Risperidone | Otsuka Pharmaceutical, Otsuka Pharmaceutical | Schizophrenia, Schizoaffective Disorder, or First Episode Psychosis, Schizophrenia, Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
ChiCTR1900023483: Clinical Observation of the Efficacy and Safety of Ziprasidone Mesylate for Injection Combined with Oral Antipsychotics in the Treatment of Agitation Symptoms of Schizophrenia: A Multicenter Study in Shaanxi Area |
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| Recruiting | 4 | 140 | | Ziprasidone Mesylate for Injection Combined With Olanzapine, Aripiprazole ;Ziprasidone Mesylate for Injection Sequential Olanzapine, Aripiprazole, Ziprasidone | Xi'an Mental Health Center; Xi'an Mental Health Center, Self-financing | Schizophrenia | | | | |
ChiCTR1800016707: Effects of Four Antipsychotics on Social Cognitive Function and Metabolism in Patients with Stable Schizophrenia |
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| Recruiting | 4 | 275 | | clozapine ;chlorpromazine ;risperidone ;olanzapine ;no | Mental Health Center of Xuhui District Shanghai; Mental Health Center of Xuhui District Shanghai, Shanghai Municipal Commission of Health and Family Planning | schizophrenia | | | | |
ChiCTR1800018424: Olanzapine-based Quadruple or Triple Antiemetic Regimens For Prevention Multi-day Cisplatin Chemotherapy Induced-nausea and Vomiting: A Prospective Randomized Controlled Clinical Trial |
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| Recruiting | 4 | 50 | | Quadruple antiemetic regimen ;Triple antiemetic regimen | Ordos Central Hospital, Inner Mongolia; Ordos Central Hospital, Inner Mongolia, Ordos Central Hospital Project | Malignant tumor | | | | |
2020-000102-28: Does the glucagon-like peptide-1 receptor agonist semaglutide prevent deterioration of metabolic state in prediabetic or diabetic patients with schizophrenia treated with the antipsychotic compounds clozapine or olanzapine? Kan tillægsbehandling med glukagonlignende peptid-1 receptoragonisten semaglutid forebygge forværring af metaboliske forstyrrelser hos prediabetiske og diabtetiske skizofrene patienter, der er i behandling med olanzapin eller clozapin? |
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| Not yet recruiting | 4 | 104 | Europe | Suspension for injection in pre-filled pen, Ozempic | Mental Healt Center Copenhagen, Novo Nordisk, Region Hovedstaden Psykiatri | Schizophrenia spectrum disorder F20-F29, Mental Health Psykisk sygdom, Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
ChiCTR2100048848: Effect of histamine receptor system on cognitive function and olanzapine induced weight change in schizophrenia |
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| Completed | 4 | 31 | | betahistine | Beijing Huilongguan Hospital ; Beijing Huilongguan Hospital, Self-funded project | schizophrenia | | | | |
| Recruiting | 4 | 2000 | | Risperidone ;Olanzapine ;Aripiperazole ;Quetiapine | 国家科技部; Peking University Sixth Hospital, The Ministry of Science and Technology | Schizophrenia | | | | |
2021-003588-85: Individualized care with antipsychotics in patients suffering from schizophrenia spectrum disorders |
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| Not yet recruiting | 4 | 100 | Europe | Olanzapine, Risperidone, Tablet, , Aripiprazole, Olanzapine, Risperidone | UCLouvain, FNRS | Schizophrenia, schizoaffective disorders,psychosis not otherwise specified, and dellusional disorders, psychosis, Psychiatry and Psychology [F] - Mental Disorders [F03] | | | | |
ChiCTR2100045323: Randomized controlled study of the combination regimen of Thalidomide and olanzapine + 5-HT receptor antogonist + hormonotherapy for the prevention of delayed nausea and vomiting induced by highly emetogenic chemotherapy |
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| Recruiting | 4 | 140 | | Thalidomide 100mg qd1-5 ;Olanzapine 10mg d1-4 | Hainan General Hospital; Hainan general hospital, None | Nausea and Vomiting Induced by Highly Emetogenic Chemotherapy | | | | |
ChiCTR2000036826: Association of Related Gene Polymorphisms With Cisplatin Multiday Chemotherapy-Induced Nausea and Vomiting |
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| Recruiting | 4 | 198 | | Olanzapine based triple antiemetic regimen ;Aripitan based triple antiemetic regimen | Ordos Central Hospital, Inner Mongolia; Ordos Central Hospital, Inner Mongolia, Inner Mongolia Medical University projects、Innovation and Entrepreneurship Project of Ordos Health Commission、Independent scientific research project of Ordos Central Hospital | Malignant tumor | | | | |
ChiCTR2000040566: Low dose olanzapine in the prevention and treatment of carboplatin induced nausea and vomiting: a prospective randomized controlled trial |
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| Recruiting | 4 | 100 | | Olanzapine based triple antiemetic regimen ;Standard two combination antiemetic regimen | Ordos Central Hospital, Inner Mongolia; Ordos Central Hospital, Inner Mongolia, Innovation and Entrepreneurship Project of Ordos Health Commission, Independent scientific research project of Ordos Central Hospital | Malignant tumor | | | | |
NCT03571126: Olanzapine for the Prevention and Treatment of Nausea and Vomiting Induced by Chemotherapy of Lung Cancer |
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| Recruiting | 4 | 156 | RoW | Olanzapine, Placebos | Zunyi Medical College, Zunyi First People's Hospital, Affiliated Hospital of North Sichuan Medical College, Sichuan Cancer Hospital and Research Institute, Guizhou Provincial People's Hospital, Affiliated Hospital of Southwest Medical University | Chemotherapy-induced Nausea and Vomiting, Lung Cancer | 10/22 | 08/23 | | |
ChiCTR2200064256: Observation of olanzapine on prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy |
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| Not yet recruiting | 4 | 124 | | Oral olanzapine prevents nausea and vomiting after general anesthesia | Taizhou Hospital of Zhejiang Province; Taizhou Hospital of Zhejiang Province, Self-financing | After laparoscopic cholecystectomy under general anesthesia | | | | |
ChiCTR2200059115: Observation of olanzapine on prevention of nausea and vomiting after general anesthesia in gynecological laparoscopic surgery |
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| Not yet recruiting | 4 | 248 | | Oral olanzapine ;Placebo | Taizhou Hospital of Zhejiang Province; Taizhou Hospital of Zhejiang Province, self-funded | N/A | | | | |
ChiCTR2100046303: Fosapitan study on prevention of multiple-day chemotherapy with cisplatin-induced nausea and vomiting by a prospective randomized controlled trial |
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| Recruiting | 4 | 192 | | Four antiemetic program(Day 1: Fosappitan 125mg orally once daily; Palonosetron 0.25mg once daily static push; Olanzapine 5mg orally once a day; Dexamethasone needle 5mg once a day static push; Day 2 and Day 3: Olanzapine 5mg orally once a day; Dexamethasone needle 5mg once daily static push) ;Three antiemetic program(Day 1: palonosetron 0.25mg once daily, dexamethasone 10mg once daily, olanzapine 5mg once daily; Day 2 and Day 3: Olanzapine 5mg orally once a day; Dexamethasone needle 5mg once daily static push) | Oncology Department, Ordos Central Hospital; Ordos Central Hospital, Ordos Central Hospital, Inner Mongolia | Malignant tumor | | | | |
NCT05646264: A Study on the Efficacy of Agomelatine Combined With Antipsychotics to Treat Negative Symptoms in Schizophrenia |
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| Recruiting | 4 | 220 | RoW | Agomelatine | Shanghai Mental Health Center, Tianjin Anding Hospital | Schizophrenia, Negative Symptoms in Schizophrenia | 08/23 | 08/23 | | |
NCT05213143: The Safety and Efficacy of Lurasidone In Subjects With Schizophrenia Switched From Olanzapine |
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| Terminated | 4 | 13 | RoW | Lurasidone | Sumitomo Pharma (Suzhou) Co., Ltd. | Schizophrenia | 11/22 | 11/22 | | |
ChiCTR2000040675: A prospective randomized controlled trial on the pervention of multiple-day chemotherapy-induced nausea and vomiting with delayed administration and standard administration |
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| Not yet recruiting | 4 | 100 | | standard administration of fosapitam and/or olanzapine ;Delaied administration of fosapitam and/or olanzapine | Ordos Central Hospital, Inner Mongolia; Ordos Central Hospital, Inner Mongolia, Innovation and Entrepreneurship Project of Ordos Health Commission, Independent scientific research project of Ordos Central Hospital | Malignant tumor | | | | |
ChiCTR2200061017: Efficacy and safety of olanzapine combined with palonosetron in patients with chemotherapy-related nausea and vomiting of gastrointestinal tumors |
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| Not yet recruiting | 4 | 272 | | Palonosetron 0.25 mg iv d1+Olanzapine 5mg po d1-3 ;Palonosetron 0.25 mg iv d1+Dexamethasone 5mg iv d1 | West China Hospital, Sichuan University; West China Hospital of Sichuan University, QILU PHARMACEUTICAL CO.,LTD | gastrointestinal cancer | | | | |
| Completed | 4 | 1 | RoW | electroencephalogram biofeedback, EB, electrical brain stimulation, EBS, ultra-low frequency transcranial magnetic stimulation, ULF-TMS, Sertraline Hydrochloride, SSRI, Clonazepam, Alprazolam, Metoprolol, beta blocker, Olanzapine, Pravastatin Sodium 20 MG, Sacubitril Valsartan Sodium Hydrate, ARNI | Pachankis, Yang I., M.D., First Affiliated Hospital of Chongqing Medical University | COVID-19 Vaccine Adverse Reaction | 03/24 | 03/24 | | |
NCT06133114: Psychopharmacological Treatment of Emotional Distress |
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| Recruiting | 4 | 80 | US | Clonazepam, TAU, Olanzapine, Buprenorphine | Icahn School of Medicine at Mount Sinai | Suicide Crisis Syndrome, Psychological Distress | 10/26 | 10/26 | | |
NCT04892199: Does GLP-1RA Prevent Deterioration of Metabolic State in Prediabetic and Diabetic Patients Treated With Antipsychotic Medication? |
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| Recruiting | 4 | 104 | Europe | Semaglutide, 1.34 mg/mL, Semaglutide-placebo | Anders Fink-Jensen, MD, DMSci | Metabolic Disturbance, Schizophrenia, Type 2 Diabetes, Clozapine, GLP-1, Olanzapine | 07/24 | 12/24 | | |
ChiCTR2200063052: A comparative study of olanzapine oral solution film, ziprasidone mesylate for injection and haloperidol injection in the treatment of acute agitation symptoms of schizophrenia |
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| Not yet recruiting | 4 | 60 | | Olanzapine oral dissolution film ;ziprasidone injection ;haloperidol injection | The Third Hospital of Fuyang; The Third Hospital of Fuyang, In-Hospital Funding | Schizophrenia | | | | |
NCT05590923: Steroid-sparing Therapy (Olanzapine) Versus Dexamethasone-based Therapy for Chemotherapy-induced Nausea and Vomiting |
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| Recruiting | 4 | 104 | US | OLA group: Olanzapine, Steroid-sparing therapy, DEX group: Dexamethasone, Steroid therapy | The Guthrie Clinic | Chemotherapy-induced Nausea and Vomiting | 11/24 | 11/24 | | |
NCT05741502: An Exploratory Analysis of Immune and Inflammatory Response Associated With Clozapine |
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| Recruiting | 4 | 60 | US | Clozapine, Antipsychotics,Other (non-Clozapine), Including Olanzapine, Risperidone, Paliperidone, Quetiapine, Aripiprazole, Ziprasidone, Lurasidone, Cariprazine, and all Typical antipsychotics | Ohio State University | Treatment-resistant Schizophrenia | 03/26 | 06/26 | | |
NCT05737511: Efficacy of Hydroxyzine for Patients With Panic Disorder |
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| Not yet recruiting | 4 | 80 | NA | Hydroxyzine, Atarax, Vistaril, Escitalopram Oxalate, citalopram, fluoxetine, fluvoxamine, paroxetine, paroxetine CR, sertraline, venlafaxine XR,, Alprazolam, clomipramine, clonazepam, diazepam, imipramine, lorazepam, mirtazapine, reboxetine, Bupropion SR, divalproex, duloxetine, gabapentin, levetiracetam, milnacipran, moclobemide, olanzapine, phenelzine, quetiapine, risperidone, tranylcypromine | Sultan Qaboos University | Panic Disorder | 12/26 | 12/26 | | |
NCT04478838: "Extended" (Alternate Day) Antipsychotic Dosing |
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| Recruiting | 4 | 120 | Canada | Risperidone, Risperdal, Olanzapine, Zyprexa, Apo-Olanzapine, Sandoz-Olanzapine | Centre for Addiction and Mental Health | Schizophrenia and Related Disorders, Drug Administration Schedule, Drug Therapy, Antipsychotic Agents | 09/27 | 09/28 | | |
ChiCTR2300069325: The mechanism of olanzapine-induced lipid metabolism disorders by activating ER stress PERK-CHOP signaling axis (a prospective cohort study) |
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| Not yet recruiting | 4 | 600 | | N/A ;N/A | Nanchong Central Hospital; Nanchong Central Hospital, self-funded | Schizophrenia spectrum disorder | | | | |
