olanzapine / Generic mfg. |
| Not yet recruiting | 4 | 20 | | | University of Auckland, Health Research Council | Schizophrenia, Glucose intolerance | | | | |
| Recruiting | 4 | 40 | | | Bristol Meyers Squibb Pharmaceuticals, Bristol Meyers Squibb Pharmaceuticals | Schizophrenic and schizoaffective disorder | | | | |
| Completed | 4 | 150 | | | Federal University of Tocantins, Irmandade da Santa Casa de Misericordia de Sao Paulo | Agitation in psychiatric emergencies, Agressiviness in psychiatric emergencies | | | | |
ACTRN12610000954022: An open randomised clinical trial involving Haloperidol, Olanzapine, Quetiapine, Risperidone, and Ziprasidone in first episode never-treated psychosis |
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| Completed | 4 | 150 | | | Lilly, Fundacio La Marato TV3 | Antipsychotic discontinuation in first episode psychosis | | | | |
ACTRN12614000551695: Efficacy and tolerability of asenapine compared with olanzapine in borderline personality disorder: a randomized controlled trial |
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| Recruiting | 4 | 80 | | | Centre for Personality Disorders, Psychiatric Clinic, Department of Neuroscience, University of Turin, Italy, Centre for Personality Disorders, Psychiatric Clinic 1, Department of Neuroscience, University of Turin, Italy | Borderline personality disorder | | | | |
ChiCTR2000029615: Olanzapin Versus Dexmethasone, With 5-HT3 RA and Aprepitant, to Prevent Nausea and Vomiting Induced by Full Dose Single-Day Cisplatin-Based Chemotherapy: a Non-Inferiority, Randomized, Controlled, Phase III, Multi-Center Clinical Trial |
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| Not yet recruiting | 4 | 520 | | Olanzapine ;Dexmethasone | The Fifth Affiliated Hospital of Sun Yat-Sen University; The Fifth Affiliated Hospital of Sun Yat-Sen University, The Fifth Affiliated Hospital of Sun Yat-Sen University | Chemotherapy-induced Nausea and Vomitting | | | | |
NCT00007774: To Determine if Olanzapine is More Cost Effective Than Haloperidol for the Treatment of Schizophrenia |
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| Completed | 4 | 600 | US | Haloperidol, Olanzapine | US Department of Veterans Affairs, Eli Lilly and Company | Schizoaffective Disorder, Schizophrenia | 06/01 | | | |
NCT00378183: A Study Comparing Three Strategies to Switch Patients With Schizophrenia or Schizoaffective Disorder to Risperidone After Unsuccessful Treatment With Olanzapine. |
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| Completed | 4 | 120 | US | risperidone | Janssen, LP | Schizoaffective Disorder, Schizophrenia | | 05/02 | | |
NCT00169065: Effectiveness of Clozapine Versus Olanzapine for Treatment-resistant Schizophrenia |
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| Completed | 4 | 38 | US | Clozapine, Olanzapine | Harvard Medical School (HMS and HSDM), National Institute of Mental Health (NIMH), Dartmouth-Hitchcock Medical Center, Commonwealth Research Center, Massachusetts, Eli Lilly and Company | Schizophrenia | 06/02 | 06/02 | | |
NCT00036088: Olanzapine Versus An Active Comparator in the Treatment of Schizophrenia |
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| Completed | 4 | 530 | US, Europe, RoW | Olanzapine | Eli Lilly and Company | Schizophrenia | | 07/02 | | |
NCT00034580: Olanzapine Versus Active Comparator in the Treatment of Bipolar I Disorder |
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| Completed | 4 | 326 | US | olanzapine, risperidone | Eli Lilly and Company | Bipolar Disorder | | 08/02 | | |
NCT00237861: Effectiveness of Atypical Versus Conventional Antipsychotics in Treating Schizophrenia |
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| Completed | 4 | | US | risperidone, olanzapine, quetiapine | Yale University, National Institute of Mental Health (NIMH) | Schizophrenia | 12/02 | | | |
NCT00034801: Olanzapine Versus Active Comparator in the Treatment of Depression in Patients With Schizophrenia |
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| Completed | 4 | 378 | US | olanzapine, ziprasidone | Eli Lilly and Company | Depression, Schizophrenia, Schizoaffective Disorder | | 03/03 | | |
NCT00331825: Risperidone and Olanzapine for the Schizophrenic Patients With Neuroleptic-Induced Acute Dystonia or Parkinsonism |
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| Completed | 4 | 70 | RoW | Risperidone and Olanzapine | Taoyuan Psychiatric Center, Ministry of Health and Welfare, Executive Yuan, R.O.C. Taiwan, Department of Health | Schizophrenia, Extrapyramidal Syndrome | | 07/03 | | |
NCT00044187: The Assessment of a Weight-Gain Agent for the Treatment of Olanzapine-Associated Anti-Obesity Agent in Patients With Schizophrenia, Schizophreniform Disorder, Schizoaffective Disorder, and Bipolar I Disorder |
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| Completed | 4 | 130 | US | Sibutramine | Eli Lilly and Company | Schizophrenia, Psychotic Disorders, Bipolar Disorder | | 09/03 | | |
NCT00485823: Assessment of a Weight Management Program for Weight Gain in Patients With Schizophrenia |
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| Completed | 4 | 48 | RoW | Olanzapine Hydrochloride, Weight Management Program | Eli Lilly and Company | Schizophrenic Disorders | | 09/03 | | |
NCT00486005: Weight Gain Management in Patients With Schizophrenia |
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| Completed | 4 | 74 | RoW | Olanzapine Hydrochloride, Nizatidine, Placebo | Eli Lilly and Company | Schizophrenia | | 10/03 | | |
NCT00621998: Risperidone and Olanzapine for the Schizophrenic Patients With Neuroleptic-Induced Tardive Dyskinesia |
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| Completed | 4 | 60 | RoW | risperidone, olanzapine | Taoyuan Psychiatric Center, Ministry of Health and Welfare, Executive Yuan, R.O.C. Taiwan, Department of Health | Neuroleptic-Induced Tardive Dyskinesia | 12/03 | 06/04 | | |
NCT00485498: Managing Acute Schizophrenia, a Comparison Between Two Atypical Antipsychotics |
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| Completed | 4 | 122 | RoW | Olanzapine Hydrochloride, Risperidone | Eli Lilly and Company | Schizophrenia | | 12/03 | | |
NCT00177567: Treatment of Geriatric Bipolar Mood Disorders: A Pilot Study |
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| Completed | 4 | 60 | US | lithium carbonate, Depakote-ER, risperidone, olanzapine, paroxetine, bupropion, lamotrigine, venlafaxine, tranylcypromine, mirtazapine | University of Pittsburgh | Bipolar Disorder | | 01/04 | | |
NCT00182013: Open-Label Comparative Study of Risperidone Versus Olanzapine Versus Quetiapine for Mania in Children and Adolescents With Bipolar I and Bipolar II Disorder |
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| Completed | 4 | 106 | US | Risperidone, Olanzapine, Quetiapine | Massachusetts General Hospital | Bipolar Spectrum Disorder | 02/04 | | | |
NCT00181935: Risperidone Versus Olanzapine for Mania in Preschool Children 4 to 6 Years of Age With Bipolar Disorder |
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| Completed | 4 | 40 | US | risperidone (Risperdal), olanzapine (Zyprexa) | Massachusetts General Hospital | Bipolar Disorder, Mania | | 07/04 | | |
| Completed | 4 | | US | Risperidone, Olanzapine, Quetiapine | US Department of Veterans Affairs | Schizophrenia | | 09/04 | | |
NCT00592930: Olanzapine in the Treatment of Anorexia Nervosa |
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| Completed | 4 | 20 | US | olanzapine, placebo | Northwell Health, Eli Lilly and Company | Anorexia Nervosa | 12/04 | 12/04 | | |
| Completed | 4 | 1600 | US | perphenazine, olanzapine, quetiapine, risperidone, ziprasidone, clozapine, fluphenazine decanoate | National Institute of Mental Health (NIMH) | Schizophrenia | | 12/04 | | |
| Terminated | 4 | 11 | Europe | olanzapine, LY170053, Zyprexa, haloperidol, zuclopentixol | Eli Lilly and Company | Bipolar Disorder | 04/05 | 04/05 | | |
NCT00050206: Olanzapine Versus Placebo in the Treatment of Mania in Adolescents With Bipolar I Disorder |
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| Completed | 4 | 130 | US | Olanzapine, Placebo | Eli Lilly and Company | Bipolar Disorder | | 05/05 | | |
NCT00183625: Supported Employment and Skills Training in Conjunction With Pharmacotherapy in Schizophrenia Patients |
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| Completed | 4 | 107 | US | Individual Placement and Support (Supported Employment), Social Skills Training, Olanzapine, Risperidone | University of California, Los Angeles, National Institute of Mental Health (NIMH), US Department of Veterans Affairs | Schizophrenia | 06/05 | 09/06 | | |
NCT00191828: A Study on Induced Weight Gain During Atypical Antipsychotic Treatment and Its Management With Psychoeducational Programme |
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| Completed | 4 | 60 | Europe | olanzapine | Eli Lilly and Company | Weight Gain | | 08/05 | | |
NCT00100776: Efficacy of High Dose Olanzapine for the Treatment of Schizophrenia and Schizoaffective Disorder |
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| Completed | 4 | 600 | US | Olanzapine | Eli Lilly and Company | Schizophrenia, Schizoaffective Disorder | | 11/05 | | |
NCT00221481: An Evaluation of Divalproex vs. Olanzapine for Alcohol Abuse Relapse Prevention in Patients With Bipolar Disorder |
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| Withdrawn | 4 | 0 | US | divalproex or olanzapine | Mayo Clinic, University of California, Los Angeles | Bipolar Disorder | | 03/06 | | |
NCT00182507: Olanzapine in the Treatment of Hair Pulling (Trichotillomania) |
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| Completed | 4 | 34 | Canada | Olanzapine | Hamilton Health Sciences Corporation, Eli Lilly and Company | Trichotillomania | | 03/06 | | |
NCT00108368: The Effects of Risperidone and Olanzapine on Thinking |
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| Completed | 4 | | US | Risperidone, Olanzapine | US Department of Veterans Affairs, Janssen, LP | Schizophrenia, Psychotic Disorders | | 03/06 | | |
| Completed | 4 | 80 | Canada | Olanzapine & Quetiapine | Hamilton Health Sciences Corporation, AstraZeneca | Schizophrenia | | 03/06 | | |
NCT00090012: Comparison of Continuing Olanzapine to Switching to Quetiapine in Overweight or Obese Patients With Schizophrenia and Schizoaffective Disorder |
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| Completed | 4 | 340 | US | Olanzapine, Quetiapine | Eli Lilly and Company | Schizophrenia, Schizoaffective Disorder | | 03/06 | | |
| Completed | 4 | 180 | Europe | Olanzapine | Eli Lilly and Company | Bipolar Disorder | | 03/06 | | |
NCT00191555: Efficacy Study of Switching Stabilized Schizophrenic Patients From Conventional to Atypical Antipsychotic Treatment |
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| Completed | 4 | 360 | Europe | olanzapine, haloperidol | Eli Lilly and Company | Schizophrenia | | 05/06 | | |
NCT00048828: Treating Drug-Resistant Childhood Schizophrenia |
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| Completed | 4 | 41 | US | Olanzapine, Clozapine | Northwell Health, National Institute of Mental Health (NIMH) | Schizophrenia | 06/06 | 06/06 | | |
| Completed | 4 | 120 | Europe, RoW | olanzapine, carbamazepine | Eli Lilly and Company | Bipolar Disorder | | 06/06 | | |
| Completed | 4 | 500 | RoW | Aripiprazole, Solian, Olanzapine, Seroquel, Risperidone | Korea Otsuka Pharmaceutical Co., Ltd. | Schizophrenia | 06/06 | 10/07 | | |
NCT00048802: Treatment and Outcome of Early Onset Bipolar Disorder |
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| Completed | 4 | 40 | US | Lithium, Olanzapine, Divalproex, Risperidone, Quetiapine, Ziprasidone, Aripriprazole | Northwell Health, National Institute of Mental Health (NIMH) | Bipolar Disorder | 08/06 | 08/06 | | |
NCT00103571: Olanzapine Versus Aripiprazole in the Treatment of Acutely Ill Patients With Schizophrenia |
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| Completed | 4 | 600 | US | Olanzapine, Aripiprazole | Eli Lilly and Company | Schizophrenia | | 08/06 | | |
NCT00071253: Depakote Monotherapy, Olanzapine Monotherapy, and Combination Therapy of Depakote Plus Olanzapine in Stable Subjects During the Maintenance Phase of Bipolar Illness |
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| Terminated | 4 | 180 | US | Divalproex Sodium (Delayed-Release Tablets), Divalproex Sodium (Extended-Release Tablets), Olanzapine | Abbott | Bipolar Disorder | | | | |
NCT00685334: Effectiveness of Atypical Antipsychotic Medication for Outpatients With Anorexia Nervosa |
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| Completed | 4 | 22 | US, Canada | Olanzapine, zyprexa, Aripiprazole, Abilify | New York State Psychiatric Institute, National Institute of Mental Health (NIMH) | Eating Disorders | 09/06 | 09/06 | | |
| Completed | 4 | | Europe | ziprasidone or olanzapine, hyperinsulinaemic euglycaemic clamp, microdialysis (skeletal muscle) | Medical University of Vienna | Healthy Male Volunteers | | | | |
NCT00094549: Olanzapine vs. Comparator and Placebo in the Treatment of Patients With Bipolar I Disorder |
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| Completed | 4 | 500 | US, Europe, RoW | olanzapine, divalproex sodium, placebo | Eli Lilly and Company | Bipolar Disorder | | 12/06 | | |
NCT00239109: Ziprasidone Versus Olanzapine In The Treatment Of Schizophrenia. |
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| Completed | 4 | 112 | Europe | Ziprasidone, Olanzapine, Scales, measures of the body (Weight...), Serum analysis | Pfizer's Upjohn has merged with Mylan to form Viatris Inc. | Schizophrenia | | 02/07 | | |
NCT00148564: Energy Homeostasis Under Treatment With Atypical Antipsychotics |
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| Completed | 4 | 40 | Europe | olanzapine, Zyprexa, Ziprasidone, Zeldox | Charite University, Berlin, Germany | Schizophrenia | 03/07 | 06/07 | | |
| Completed | 4 | 24 | US | Ziprasidone | North Suffolk Mental Health Association, Pfizer | Schizophrenia | | 03/07 | | |
NCT00418171: Large Simple Trial (LST) Of Cardiovascular Safety Of Ziprasidone And Olanzapine- (Zodiac) |
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| Completed | 4 | 18239 | US | Ziprasidone, Olanzapine | Pfizer | Schizophrenia | | 04/07 | | |
| Completed | 4 | 125 | US | Olanzapine, Risperidone | Northwell Health, National Institute of Mental Health (NIMH), The Zucker Hillside Hospital | Schizophrenia | 05/07 | 05/07 | | |
| Completed | 4 | 116 | US | Risperidone, Risperdal, Olanzapine (enrollment closed in this treatment), Zyprexa, Molindone, Moban | University of North Carolina, Chapel Hill, National Institute of Mental Health (NIMH) | Schizophrenia | 05/07 | 05/07 | | |
NCT00208819: A Comparison of Two Standard Therapies in the Management of Dementia With Agitation |
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| Completed | 4 | 50 | US | risperidone, quetiapine, olanzapine, divalproex | Emory University, Abbott | Senile Dementia, Alzheimer Type, Dementia, Alzheimer Type, Alzheimer Disease, Dementia | | 07/07 | | |
NCT00088049: Study of Olanzapine vs. Aripiprazole in the Treatment of Schizophrenia |
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| Completed | 4 | 560 | US | Olanzapine, Aripiprazole | Eli Lilly and Company | Schizophrenia | | 07/07 | | |
NCT00351936: A Placebo-Controlled, Cross-Over Trial of Aripiprazole |
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| Completed | 4 | 16 | US | Aripiprazole, placebo | North Suffolk Mental Health Association, Eli Lilly and Company | Schizophrenia | 07/07 | 07/07 | | |
NCT00231335: Efficacy and Safety Study of Escitalopram Augmentation in Treatment Resistant Schizophrenia |
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| Completed | 4 | 30 | US | escitalopram | Emory University, Forest Laboratories | Schizophrenia, Schizoaffective Disorder | | 07/07 | | |
| Terminated | 4 | 29 | Europe, RoW | ziprasidone hydrochloride, Geodon, Zeldox, olanzapine | Pfizer's Upjohn has merged with Mylan to form Viatris Inc. | Acute Mania, Bipolar Disorder, Manic | 07/07 | 01/08 | | |
NCT00419653: Modulation of Regional Brain Activation in Schizophrenic Patients by Pharmacological Therapy |
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| Terminated | 4 | 19 | Europe | Amisulpride, Olanzapine, Haloperidol | University of Jena, Sanofi | Schizophrenia | 09/07 | 09/07 | | |
NCT00287820: Comparative Effects of Chronic Treatment With Olanzapine and Risperidone on Glucose and Lipid Metabolism |
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| Completed | 4 | 46 | US | Olanzapine, ayprexa, olanzapine, zyprexa, risperidone, riperidal | Nathan Kline Institute for Psychiatric Research, Eli Lilly and Company | Schizophrenia, Diabetes, Metabolic Syndrome, Hyperglycemia | | 09/07 | | |
PREFERENCE, NCT00324051: Patient's Preference Between Conventional Oral Olanzapine Tablet vs Olanzapine Orodispersible Tablet |
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| Completed | 4 | 284 | Europe, RoW | olanzapine therapy | Eli Lilly and Company | Schizophrenia | 09/07 | 09/07 | | |
| Completed | 4 | 80 | RoW | amisulpride, solian, Olanzapine, zyprexa, Conventional antipsychotics, conventional antipsychotic | Taipei Veterans General Hospital, Taiwan, National Science Council, Taiwan | Tardive Dyskinesia, Neurocognitive Function | 12/07 | 12/07 | | |
ACPIOS, NCT00654576: Effectiveness of Antipsychotic Combination With Psychosocial Intervention on Outcome of Patients With Schizophrenia |
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| Completed | 4 | 1400 | RoW | Chlorpromazine, Sulpiride, Clozapine, Olanzapine, Risperidone, Quetiapine, Aripitrazole, psychosocial intervention | Central South University, Shanghai Mental Health Center, Sichuan University, Capital Medical University, Nanjing Medical University, Jiangxi Mental Hospital, Hunan Mental Hospital, Guangzhou Mental Hospital, Chongqing Metal Institute, Henan Mental Hospital | Schizophrenia | 12/07 | 12/07 | | |
NCT00854919: Effectiveness and Safety of Atypical Antipsychotic Agents in Augmenting SSRI-Refractory Obsessive-Compulsive Disorder |
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| Completed | 4 | | Japan | atypical antipsychotic drug, exposure response prevention | Osaka City University | SSRI-Refractory Obsessive-Compulsive Disorder | 12/07 | 12/07 | | |
PLATYPUS, NCT00303602: Comparing the Effect of Under the Tongue Olanzapine Versus Swallowed Olanzapine on Body Mass Index (A Ratio of Weight to Height) |
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| Completed | 4 | 149 | US, Canada, Europe, RoW | Sublingual orally disintegrating olanzapine (SODO), LY170053, Zydis, Oral olanzapine, Zyprexa | Eli Lilly and Company | Schizophrenia, Schizoaffective Disorder, Bipolar Disorder | 12/07 | 12/07 | | |
NCT00337662: Efficacy Study of Early Onset of Antipsychotic Drug Action in Schizophrenia |
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| Completed | 4 | 628 | US, RoW | olanzapine, LY170053, Zyprexa, risperidone | Eli Lilly and Company | Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorder | 12/07 | 12/07 | | |
NCT01149577: Effect of Olanzapine on Sleep Electroencephalogram (EEG) in Schizophrenia Patients |
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| Completed | 4 | 25 | RoW | Olanzapine | Central Institute of Psychiatry, Ranchi, India | Schizophrenia, Sleep | 12/07 | 04/09 | | |
NCT00402324: A Comparison of Olanzapine in Combination With a Mood Stabilizer vs Mood Stabilizer Alone, in Mixed Bipolar Patients |
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| Completed | 4 | 202 | US | olanzapine, LY170053, Zyprexa, placebo, divalproex | Eli Lilly and Company | Bipolar I Disorder | 02/08 | 02/08 | | |
NCT00176436: Atomoxetine for Treatment of Weight Gain in Olanzapine or Clozapine Patients |
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| Completed | 4 | 40 | US | Diet support group, Group counseling and exercise | University of Maryland, Baltimore, Eli Lilly and Company | Schizophrenia | 03/08 | 03/08 | | |
NCT00001656: Comparison of Clozapine vs Olanzapine in Childhood-Onset Psychotic Disorders |
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| Completed | 4 | 25 | US | Olanzapine, "Zyprexa", Clozapine, "Clozaril" | National Institute of Mental Health (NIMH) | Childhood Schizophrenia, Psychotic Disorder, Schizophrenia | 06/08 | 06/08 | | |
NCT00190749: Safety Study of Olanzapine and a Comparator in Patients With Schizophrenia and Schizoaffective Disorder |
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| Completed | 4 | 130 | US | olanzapine, LY170053, Zyprexa, risperidone | Eli Lilly and Company | Schizophrenia, Schizoaffective Disorder | 06/08 | 06/08 | | |
NCT00290121: Appetite Increase in Schizophrenia Patients Treated With Atypical Antipsychotics |
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| Completed | 4 | 25 | Canada | Olanzapine | Université de Montréal, Centre de Recherche de l'Institut Universitaire en santé Mentale de Montréal, Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal, Hopital du Sacre-Coeur de Montreal, Eli Lilly and Company | Schizophrenia | 06/08 | 06/08 | | |
NCT00246259: A Trial Comparing Risperidone Long-Acting Injection With Oral Antipsychotic in the Treatment of Early Psychosis |
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| Completed | 4 | 77 | Canada | Risperidone long-acting injection (LAI), Oral Antipsychotic | Janssen-Ortho Inc., Canada | Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorder, Psychotic Disorders | 12/08 | 12/08 | | |
| Completed | 4 | 219 | US | Risperidone, Risperdal, Risperdal Consta, Olanzapine, Zyprexa, Ziprasidone, Geodon, Quetiapine, Seroquel, Aripiprazole, Abilify | Icahn School of Medicine at Mount Sinai, National Institute of Mental Health (NIMH) | Schizophrenia | 03/09 | 03/09 | | |
NCT00508157 / 2007-001217-42: A Phase 4 Study to Assess the Effects of Aripiprazole Versus Other Atypical Antipsychotics in the Treatment of Schizophrenic Patients With Metabolic Syndrome |
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| Terminated | 4 | 125 | Europe, RoW | Aripiprazole, Abilify, BMS-337039, Continued Antipsychotic (Risperidone or Quetiapine or Olanzapine) | Bristol-Myers Squibb, Otsuka America Pharmaceutical | Metabolic Syndrome, Schizophrenia | 03/09 | 03/09 | | |
NCT00520507: An Investigation of the Sleep Architecture and Consequent Cognitive Changes in Olanzapine-Treated Depressed Patients |
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| Completed | 4 | 27 | Canada | Olanzapine, Placebo | Queen's University, Eli Lilly and Company | Bipolar Disorder, Depression, Depressive Disorder | 05/09 | 05/09 | | |
OCTLPODEPWBD, NCT01864551: Olanzapine Compared to Lamotrigine in the Prevention of Depressive Episode in the Patients With Bipolar Disorder |
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| Completed | 4 | 60 | RoW | Lamotrigine, lamictal, Olanzapine | Tri-Service General Hospital | Bipolar Disorder | 07/09 | 09/12 | | |
NCT00394095: Topiramate vs. Placebo in Preventing Weight Gain in Bipolar Disorder Treated With Olanzapine |
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| Completed | 4 | 31 | US | Topiramate, Topamax, Placebo, Sugar pill | University of Cincinnati, Eli Lilly and Company | Bipolar Disorder, Weight Gain | 08/09 | 09/09 | | |
COATS, NCT00802100: Comparison of Optimal Antipsychotic Treatments for Adults With Schizophrenia |
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| Completed | 4 | 21 | US | Olanzapine, Zyprexa, Perphenazine, Trilafon, Aripiprazole, Abilify, Metformin, Glucophage, Simvastatin, Zocor, Benztropine, Cogentin | National Institute of Mental Health (NIMH) | Schizophrenia | 09/09 | 10/09 | | |
CAMP, NCT00423878: Comparison of Antipsychotics for Metabolic Problems in Schizophrenia or Schizoaffective Disorder |
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| Completed | 4 | 215 | US | Risperidone, Risperdal, Olanzapine, Zyprexa, Quetiapine, Seroquel, Aripiprazole, Abilify | National Institute of Mental Health (NIMH) | Schizophrenia, Schizoaffective Disorder | 10/09 | 03/10 | | |
NCT00704860: Treatment-Resistant Depression, Hippocampus Atrophy and Serotonin Genetic Polymorphism |
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| Completed | 4 | 27 | Canada | Open label pharmacotherapy, All classes of antidepressants, based on patient need | University of Ottawa | Major Depression | 11/09 | 12/10 | | |
NCT00338949: Ziprasidone for Improving Insulin Sensitivity in People With Schizophrenia Who Are at Risk for Diabetes |
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| Completed | 4 | 77 | US | Switch, ziprasidone, Control, risperidone, olanzapine | Veterans Medical Research Foundation, National Institute of Mental Health (NIMH), Pfizer | Schizophrenia, Metabolic Syndrome X, Insulin Resistance | 12/09 | 12/09 | | |
| Withdrawn | 4 | 0 | US | Olanzapine, Metformin, Simvastatin | Duke University | Schizophrenia, Schizoaffective Disorder | 12/09 | 02/10 | | |
| Completed | 4 | 30 | US | Olanzapine, Zyprexa, Aripiprazole, Abilify | Veterans Medical Research Foundation, National Institute of Mental Health (NIMH) | Diabetes | 12/09 | 06/10 | | |
NCT00932529: Use, Effects and Side-effects of Second-generation Antipsychotics in a Naturalistic Setting |
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| Completed | 4 | 226 | Europe | Olanzapine, Zyprexa, Quetiapine, Seroquel, Risperidone, Risperdal, Ziprasidone, Zeldox, Geodon | University of Bergen | Psychotic Disorders | 01/10 | 01/10 | | |
| Completed | 4 | 20 | US | orally-disintegrating olanzapine, Zydis, regular olanzapine, Zyprexa | Vanderbilt University, Eli Lilly and Company | Bipolar Depression | 03/10 | 03/10 | | |
LiTMUS, NCT00667745: Effectiveness of Lithium Plus Optimized Medication in Treating People With Bipolar Disorder |
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| Completed | 4 | 283 | US | Lithium Carbonate, Lithium, Optimized Treatment (OPT) | National Institute of Mental Health (NIMH) | Bipolar Disorder | 03/10 | 03/10 | | |
| Completed | 4 | 50 | US | Olanzapine/Zyprexa, Zyprexa | Stanford University, Eli Lilly and Company | Bipolar Disorder | 06/10 | 06/10 | | |
NCT01016145: Identifying Predictors of Response to Antipsychotics Using a Treatment Algorithm |
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| Unknown status | 4 | 126 | RoW | Antipsychotics, Seroquel, Geodon, Zyprexa, Abilify | University of Sao Paulo | Schizophrenia or Schizoaffective Disorder | 06/10 | 07/10 | | |
| Completed | 4 | 30 | Europe | olanzapine, Solazin, placebo | Niuvanniemi Hospital | Schizophrenia, Schizoaffective Disorder | 07/10 | 07/10 | | |
NCT00245206: Side Effects of Newer Antipsychotics in Older Adults |
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| Completed | 4 | 406 | US | Aripiprazole, Olanzapine, Risperidone, Risperidal | Veterans Medical Research Foundation, National Institute of Mental Health (NIMH) | Schizophrenia, Alzheimer's Disease, Dementia | 10/10 | 10/10 | | |
NCT01303601: Efficacy of Olanzapine Monotherapy for Treatment Bipolar Ⅰ Depression |
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| Completed | 4 | 68 | RoW | olanzapine, Starch | China Medical University, China | Bipolar Disorder, Depression, Bipolar | | 10/10 | | |
ChiCTR-TNRC-10001112: The study on clinical and biological characters of bipolar depression and the treatment scheme optimizing |
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| Completed | 4 | 640 | | Lithium, Sodium valproate, Lamotrigine, MECT, Sertraline, Citalopram, Escitalopram, venlafaxine, Quetiapine, Olanzapine, Risperidone, sulpiride | Guangzhou Scientific and Technological Bureau, Guangzhou Board of Health; Guangzhou first people's hospital, The Tackling Key Problems of Guangzhou Scientific and Technological Project | bipolar depressive disorder | | | | |
ChiCTR-RNC-09000522: The genetic association study on individual difference of therapeutic effects of antipsychotic medication |
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| Completed | 4 | 900 | | Risperidone 2-6mg/d; Olanzapine 5-20mg/d; Aripiprazole 10-30mg/d | the Sixth Hospital, Peking University; Ministry of Science and Technology of the People′s Republic of China, Ministry of Science and Technology of the People′s Republic of China | schizophrenia | | | | |
PROACTIVE, NCT00330863: Preventing Relapse in Schizophrenia: Oral Antipsychotics Compared To Injectables: Evaluating Efficacy |
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| Completed | 4 | 357 | US | Risperidone microspheres, Risperdal Consta, Risperidone, Risperdal, Olanzapine, Zyprexa, Quetiapine, Seroquel, Ziprasidone, Geodon, Aripiprazole, Abilify, Paliperidone, Invega | Northwell Health, National Institute of Mental Health (NIMH) | Schizophrenia, Schizoaffective Disorder | 01/11 | 01/11 | | |
| Completed | 4 | 144 | US | risperidone, Risperdal, olanzapine, Zyprexa, aripiprazole, Abilify | Washington University School of Medicine, National Institute of Mental Health (NIMH) | Aggression, Attention Deficit-Hyperactivity, Oppositional Defiant Disorder, Pervasive Development Disorders, Bipolar Disorder | 03/11 | 07/11 | | |
ACTRN12607000591459: The effects of droperidol and olanzepine in addition to midazolam for sedating very agitated patients: a multi-centre, randomised, controlled clinical trial |
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| Completed | 4 | 320 | | | Austin Hospital, Australasian College for Emergency Medicine Research Foundation | severe agitation | | | | |
ChiCTR-TRC-13003554: Olanzapine-valproate combination versus olanzapine or valproate monotherapy in the treatment of bipolar manic episodes: a randomized, controlled trial |
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| Completed | 4 | 120 | | Taking valproate ;Taking olanzapine ;Taking olanzapine and valproate | Department of Psychiatric, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Second Affiliated Hospital of Zhejiang University School of Medicine, Technology Foundation of Zhejiang Province (2010C33038); Health Foundation of Zhejiang Province (2011KYA073); Medical Technology Program Foundation of Zhejiang Province (2012KYA101) | bipolar I disorder mania-episode | | | | |
NCT00690235: Demonstrate the Effects of Pramlintide on Weight Reduction in Schizophrenia |
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| Completed | 4 | 33 | US | Pramlintide, Amylin, Placebo, sterile saline | University of Texas Southwestern Medical Center, Amylin Pharmaceuticals, LLC. | Schizophrenia, Schizoaffective Disorder, Diabetes, Weight Gain | 08/11 | 08/11 | | |
| Completed | 4 | 3000 | | Perphenazine 16-64 mg/d (N=250) or Haloperidol 6-20 mg/d (N=250) ;Risperidone 2-6mg/d ;Olanzapine 5-20 mg/d ;Quetiapine 400-750mg/d ;Aripiperazole 10~30 mg/d ;Ziprasidone 80-160 mg/d | The Sixth Hospital / Institute of Mental Health, Peking University; The Ministry of Science and Technology, The National High Technology Research and Development Program of China (863 program) | Schizophrenia | | | | |
| Completed | 4 | 501 | US | iloperidone, Fanapt™ | Novartis | Schizophrenia | 01/12 | 01/12 | | |