molibresib (GSK525762) / GSK  >>  Phase 1
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3 Trials

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Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
molibresib (GSK525762) / GSK
NCT02706535: A Cross-over Study to Evaluate the Effect of Itraconazole and Rifampicin on the Pharmacokinetics (PK) of GSK525762 in Healthy Female Subjects of Non Child Bearing Potential

Completed
1
29
US
GSK525762 Besylate Tablets, Itraconazole 200 mg, Rifampicin 300 mg
GlaxoSmithKline
Drug Interactions, Neoplasms
01/17
01/17
NCT03150056: Dose Escalation and Dose Expansion Study of GSK525762 in Combination With Androgen Deprivation Therapy in Participants With Castrate-resistant Prostate Cancer

Hourglass Jul 2020 - Dec 2020 : Proof-of-concept data from trial in mCRPC
Terminated
1
73
Europe, US, RoW
GSK525762, Abiraterone, Enzalutamide, Prednisone
GlaxoSmithKline
Solid Tumours
07/20
06/21
NCT03925428: Testing a New Anti-cancer Drug Combination, Entinostat and GSK525762C, for Advanced and Refractory Solid Tumors and Lymphomas

Withdrawn
1
0
NA
Entinostat, HDAC inhibitor SNDX-275, MS 27-275, MS-275, SNDX-275, Molibresib, GSK-525762A, GSK525762, I-BET 762
National Cancer Institute (NCI)
Advanced Lymphoma, Advanced Malignant Solid Neoplasm, Ann Arbor Stage III B-Cell Non-Hodgkin Lymphoma, Ann Arbor Stage III T-Cell Non-Hodgkin Lymphoma, Ann Arbor Stage IV B-Cell Non-Hodgkin Lymphoma, Ann Arbor Stage IV T-Cell Non-Hodgkin Lymphoma, Refractory B-Cell Non-Hodgkin Lymphoma, Refractory Lymphoma, Refractory Malignant Solid Neoplasm, Refractory Pancreatic Carcinoma, Refractory T-Cell Non-Hodgkin Lymphoma, Stage II Pancreatic Cancer AJCC v8, Stage IIA Pancreatic Cancer AJCC v8, Stage IIB Pancreatic Cancer AJCC v8, Stage III Pancreatic Cancer AJCC v8, Stage IV Pancreatic Cancer AJCC v8, Unresectable Pancreatic Carcinoma
09/20
09/20

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