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| Ongoing | 3 | 80 | Europe | Retisert, Retisert, Retisert | National Institutes of Health, National Eye Institute | Non-infectious uveitis (inflammatory eye disease) | | | | |
2011-001078-25: Long term follow-up clinical trial to the MUST trial which investigates which treatment of systemic steroid treatment and a steroid implant which is inserted into the eye gives the best visual outcome for patients with chronic eye inflammation. |
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| Ongoing | 3 | 31 | Europe | Retisert, C05AA10, Retisert, Retisert | National Institute of Health, National Eye Institute, National Institute of Health, National Eye Institute | Non-infectious pan, intermediate and posterior uveitis (inflammatory eye disease) | | | | |
2017-003243-37: Macular Edema Ranibizumab v. Intravitreal anti-inflammatory Therapy (MERIT) Trial |
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| Not yet recruiting | 3 | 240 | Europe | Lucentis, Ozurdex, Methotrexate, EU/1/06/374/001, Injection, Intravitreal implant in applicator, Lucentis, Ozurdex, Methotrexate | MUST Coordinating Centre, John Hopkins Bloomberg School of Public Health | Uveitic macular oedema, Swelling of part of the retina called the macula, which is responsible for fine vision, occuring due to inflammation in the eye (uveitis), Diseases [C] - Eye Diseases [C11] | | | | |
2018-001931-27: Comparison of therapeutic strategies in childhood ARthritiS Confronto di strategie terapeutiche nell'artrite idiopatica giovanile |
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| Not yet recruiting | 3 | 260 | Europe | Solution for infusion in pre-filled syringe, Powder and solution for solution for injection, Reumaflex, Enbrel | IRCCS Istituto Giannina Gaslini, AIFA, Compagnia di San Paolo, Pfizer | Juvenile idiopathic arthritis (JIA) is an umbrella term that encompasses a heterogeneous group of disorders characterised by prolonged synovial inflammation that may cause destructive damage to joint structures. Permanent changes may also develop in extraarticular organs, particularly the eye (as a complication of chronic anterior uveitis), or may result from side effects of medications. L’artrite idiopatica giovanile (AIG) è una malattia cronica caratterizzata da infiammazione persistente alle articolazioni; i segni tipici di infiammazione alle articolazioni sono dolore, gonfiore e limitazione dei movimenti. "Idiopatica" significa che non conosciamo la causa della malattia e "giovanile", in questo caso, significa che l’inizio dei sintomi di solito avviene prima dei 16 anni d’età., Juvenile idiopathic arthritis (JIA) is a chronic disease characterized by persistent inflammation of the joints, pain, swelling and limitation of motion. L’artrite idiopatica giovanile (AIG) è una malattia cronica caratterizzata da infiammazione persistente alle articolazioni, dolore, gonfiore e limitazione dei movimenti., Diseases [C] - Immune System Diseases [C20] | | | | |
2019-003638-18: A study to see how safe and how well an investigational medicinal product will work to treat active non-infectious uveitis of the posterior segment of the eye. Uno studio per vedere quanto è sicuro e quanto funziona un medicinale sperimentale per trattare l'uveite non infettiva attiva del segmento posteriore dell'occhio. |
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| Not yet recruiting | 3 | 200 | Europe | Opsiria, Predni-POS 1% sospensione oftalmica, Pred Forte 1% collirio sospensione, Prednisolone acetato sospensione ad uso oftalmico USP, 1%, [DE-109], [NA], Solution for injection, Eye drops, suspension, Predni-POS 1% sospensione oftalmica, Pred Forte 1% collirio sospensione, Prednisolone acetato sospensione ad uso oftalmico USP, 1% | SANTEN INCORPORATED, Santen Incorporated | Active, Non-Infectious Uveitis of the Posterior Segment of the Eye. uveite non infettiva attiva del segmento posteriore dell'occhio, Non-Infectious posterior Uveitis. uveite non infettiva posteriore, Body processes [G] - Ocular Physiological Phenomena [G14] | | | | |
2019-002366-12: Adalimumab vs Conventional ImmunoSuppression for Corticosteroid-sparing for Uveitis (ADVISE) Trial |
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| Not yet recruiting | 3 | 222 | Europe | Adalimumab, Azathioprine/Imuran, Methotrexate/Rheumatrex, Mycophenolate/mofetil 500mg tablets, Cyclosporine Neoral, Prograf 0.5 mg hard capsules, Mycophenolate mofetil 250mg Capsules, Mycophenolate mofetil 500 mg powder for concentrate for solution for infusion., SANDIMMUN® Concentrate for Solution for Infusion 50mg/ml., EU/1/96/005/002 CellCept, PL 00101/0483 PL 00101/0387-0389, PL 30306/0154, PL 20075/0395, Injection, , Tablet, Capsule, Capsule, hard, Infusion, Adalimumab, Azathioprine/Imuran, Methotrexate/Rheumatrex, Mycophenolate/mofetil 500mg tablets, Cyclosporine Neoral, Prograf 0.5 mg hard capsules, Mycophenolate mofetil 250mg Capsules, Mycophenolate mofetil 500 mg powder for concentrate for solution for infusion., SANDIMMUN® Concentrate for Solution for Infusion 50mg/ml. | Johns Hopkins University | Uveitic macular oedema, Swelling of part of the retina called the macula, which is responsible for fine vision, occuring due to inflammation in the eye (uveitis), Diseases [C] - Eye Diseases [C11] | | | | |
ChiCTR2100049467: A Pragmatic, Randomized Clinical Trial of Coronavirus (COVID-19) Vaccinations in Uveitis |
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| Not yet recruiting | 3 | 1314 | | prompt vaccination strategies ;deferred vaccination strategies | The First Affiliated Hospital of Chongqing Medical University; The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology (CSTC, 2008CA5003) | uveitis | | | | |
NCT05070728: Safety and Efficacy of an Injectable Fluocinolone Acetonide Intravitreal Insert (FAI) |
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| Terminated | 3 | 12 | US | Sham Injector, Sham Comparator, FAI Insert, Active Drug | EyePoint Pharmaceuticals, Inc. | Uveitis, Uveitis, Posterior, Uveitis, Intermediate | 10/22 | 04/23 | | |
2022-001622-29: A Multicentre Study to Evaluate the Safety and Efficacy of the Eye Implant ILUVIEN® in Children with non-infectious uveitis affecting the posterior segment of the eye Estudio multicéntrico para evaluar la seguridad y la eficacia del implante ocular ILUVIEN® en niños con uveítis no infecciosa que afecta el segmento posterior del ojo |
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| Not yet recruiting | 3 | 25 | Europe | ILUVIEN 190 micrograms intravitreal implant in applicator, Intravitreal implant in applicator, ILUVIEN 190 micrograms intravitreal implant in applicator | Alimera Sciences Europe Limited, Alimera Sciences Europe Limited | Non-Infectious Uveitis affecting the posterior segment Uveítis no infecciosa que afecta el segmento posterior del ojo, Non-Infectious Uveitis affecting the posterior segment Uveítis no infecciosa que afecta el segmento posterior del ojo, Diseases [C] - Eye Diseases [C11] | | | | |
URBA, NCT04117698: Multicenter, Randomized Study Evaluating the Value of Antitubercular Treatment During Recurent Anterior Uveitis |
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| Not yet recruiting | 3 | 116 | NA | Antitubercular treatment (RIFATER ©), Ethambutol, RIFINAH © | Assistance Publique - Hôpitaux de Paris | Uveitis, Anterior | 05/23 | 05/23 | | |
NCT05042609: A Study of TRS01 in Subjects With Active Non-infectious Anterior Uveitis Including Subjects With Uveitic Glaucoma |
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| Completed | 3 | 142 | Europe, US | TRS01, FDA approved steroid eye drop (masked) | Tarsier Pharma | Non-infectious Anterior Uveitis, Uveitic Glaucoma | 06/23 | 06/23 | | |
ChiCTR1900026160: A Phase III, Multi-Center, Randomized, Double-Blind, Controlled, Safety and Efficacy Study for a Fluocinolone Acetonide Intravitreal (FAI) Insert in Subjects With Chronic Non-Infectious Uveitis Affecting the Posterior Segment of the Eye |
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| Recruiting | 3 | 150 | | Intravitreal FAI insert ;Sham Injection | The First Affiliated Hospital of Chongqing Medical University; The First Affiliated Hospital of Chongqing Medical University, Fully self-raised | uveitis | | | | |
NCT04088409 / 2019-000119-10: A Study of Baricitinib (LY3009104) in Participants From 2 Years to Less Than 18 Years Old With Active JIA-Associated Uveitis or Chronic Anterior Antinuclear Antibody-Positive Uveitis |
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| Active, not recruiting | 3 | 40 | Europe | Baricitinib, LY3009104, Adalimumab | Eli Lilly and Company | Uveitis | 07/23 | 07/28 | | |
JAKUVEITE, NCT05651880: Efficacy and Tolerance of Baricitinib, a JAK Inhibitor, in the Treatment of Refractory Non-infectious Non-anterior Uveitis |
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| Not yet recruiting | 3 | 33 | NA | Baricitinib 4 MG | University Hospital, Rouen | Active Non-anterior Non-infectious Uveitis | 08/23 | 08/26 | | |
| Active, not recruiting | 3 | 222 | Europe, Canada, US, RoW | Adalimumab (ADA), Adalimumab, Humira, Conventional immunosuppression (CON), Azathioprine, Imuran , Cyclosporine, Methotrexate, Rheumatrex, Mycophenolate, CellCept, Cyclosporine, Sandimmune, Neoral, Tacrolimus, Prograf | JHSPH Center for Clinical Trials | Uveitis | 04/24 | 09/24 | | |
TYNI, NCT05486468: The Use of Two YUTIQ Versus Sham for Treatment of Chronic Non Infectious Intraocular Inflammation Affecting the Posterior Segment |
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| Recruiting | 3 | 30 | US | Yutiq 0.18 MG Drug Implant, Sham Injection | Texas Retina Associates, Eye Point Pharmaceuticals | Uveitis, Uveitis, Posterior, Uveitis, Anterior, Uveitis, Intermediate | 12/23 | 12/24 | | |
| Not yet recruiting | 3 | 120 | NA | Adalimumab, Mycophenolate Mofetil | Assistance Publique - Hôpitaux de Paris | Non Infectious Uveitis | 06/27 | 11/27 | | |
CLARITY, NCT06431373: A Study of Brepocitinib in Adults With Active, Non-Infectious, Non-Anterior Uveitis |
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| Not yet recruiting | 3 | 220 | NA | Brepocitinib PO QD, Placebo PO QD | Priovant Therapeutics, Inc. | Uveitis, Posterior, Uveitis, Intermediate, Uveitis | 08/26 | 08/27 | | |
| Not yet recruiting | 3 | 212 | | Usual immunosuppressive therapy plus Adalimumab ;Usual immunosuppressive therapy plus low-dose IL-2 ;Usual immunosuppressive therapy plus Adalimumab plus low-dose IL-2 ;Usual immunosuppressive therapy | The First Affiliated Hospital of Chongqing Medical University; The First Affiliated Hospital of Chongqing Medical University, National Natural Science Foundation of China; Chongqing Key Laboratory of Ophthalmology | Behçet’s uveitis | | | | |
Co-THEIA, NCT04798755: Efficacy, Safety and Costs of Methotrexate, Adalimumab, or Their Combination in Non-infectious Non-anterior Uveitis |
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| Recruiting | 3 | 192 | Europe | Methotrexate, Adalimumab, Adalimumab+Methotrexate | Hospital San Carlos, Madrid | Uveitis | 10/24 | 10/25 | | |
NCT05642312: A Study to Investigate Vamikibart in Participants With Uveitic Macular Edema |
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| Recruiting | 3 | 225 | Europe, Canada, US, RoW | Vamikibart, RO7200220, Sham | Hoffmann-La Roche | Uveitic Macular Edema | 06/25 | 06/25 | | |
NCT05642325: Vamikibart in Participants With Uveitic Macular Edema |
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| Recruiting | 3 | 225 | Europe, Japan, US, RoW | Vamikibart, RO7200220, Sham | Hoffmann-La Roche | Uveitic Macular Edema | 06/25 | 06/25 | | |
ACTRN12605000485639: A Multicenter, Randomized, Double-Masked Controlled Study to Evaluate the Safety and Efficacy of an Intravitreal Fluocinolone Acetonide (0.59 and 2.1 mg) Implant in Patients with Non-Infectious Uveitis Affecting the Posterior Segment of the Eye |
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| Active, not recruiting | 2/3 | 40 | | | Bausch & Lomb (Rochester), Bausch & Lomb (Rochester) | Non-infectious Posterior Uveitis | | | | |
NCT04162314: Beta-1,3/1,6-D-Glucan Ganoderma Lucidum on Non-infectious and Idiopathic Uveitis |
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| Recruiting | 2/3 | 20 | RoW | Beta-1,3/1,6-D-Glucan Ganoderma lucidum, PsP, Placebos | Fakultas Kedokteran Universitas Indonesia | Uveitis | 09/21 | 12/21 | | |
| Not yet recruiting | 2/3 | 99 | NA | Topical ganciclovir versus oral valganciclovir versus placebo | Francis I. Proctor Foundation, National Taiwan University, Chulalongkorn University, Khon Kaen University | Uveitis, Anterior, Cytomegalovirus Infections | 12/21 | 04/22 | | |
NCT05337332: Results of Suprachoroidal Steroids Injections in Two Chorioretinal Diseases |
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| Recruiting | 2/3 | 50 | RoW | Triamcinolone Acetonide, Suprachoroidal triamcinolone acetonide injection (SCTA) | Benha University | Central Serous Chorioretinopathy, Irvine-Gass Syndrome, Pars Planitis, Cystoid Macular Edema | 05/23 | 06/23 | | |
STACCATO, NCT03586284: Systemic and Topical Antivirals for Control of Cytomegalovirus Anterior Uveitis: Treatment Outcomes |
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| Recruiting | 2/3 | 99 | US, RoW | Valganciclovir Hydrochloride, Ganciclovir Sodium, Placebo Oral Tablet, Topical placebo | University of California, San Francisco, Huang Pacific Foundation, Khon Kaen University, King Chulalongkorn Memorial Hospital | Cytomegalovirus Anterior Uveitis | 03/25 | 03/25 | | |
