| topiramate / Generic mfg. |
ChiCTR-TRC-10001131: The efficacy and safety of topiramate and valproate in treatment of Chinese patients with partial and generalised epilepsy: a multi-center, long-term follow up randomised controlled trial |
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| Completed | 4 | 1000 | | The initial dosage for adolescents and adults was 25 milligram twice per day, with a weekly escalation of 25 milligram per day. ;The starting dosage of VPA for adolescents and adults was 400 mg/d, with a weekly escalation of 100mg/d until the target dosage (800-1800 mg/d) was reached. The maximum dosage was 2000 mg/d for adolescents and adults. | Chongqing Medical University; Xian-Janssen Pharmaceutical LTD., Xian-Janssen Pharmaceutical LTD. | Epilepsy | | | | |
| Completed | 4 | 1008 | | SRVPA ;TPM | The first affiliated hospital of Chongqing Medical University; Level of the institution：, This study was funded by National Natural Science of China No. 81071039, the Preeminent Medical Doctors' Foundation in Chongqing Medical University | Epilepsy | | | | |
| Completed | 4 | 220 | | Topiramate ;Ginkgo Biloba Extrai | Children's Hospital Affiliated to Chongqing Medical University; Children's Hospital Affiliated to Chongqing Medical University, Graduate student' funds | Pediatric Migraine | | | | |
ChiCTR-TRC-13005005: A Clinical Study of Topiramate's Efficacy and Safety to Treat Post-Thoracotomy Pain |
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| Recruiting | 4 | 240 | | Topiramate (25mg/piece) ;Topiramate (25mg/piece) | the Fourth Military Medical University; the Fourth Military Medical University, selffinancing | Post-Thoracotomy Pain | | | | |
2006-004373-10: The effect of short term Topiramate treatment on insulin secretion, glucose- and lipid metabolism in obese women |
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| Ongoing | 4 | 13 | Europe | Topiramate, | Top institute of Pharmaceutical Research | ObesityDiabetes MellitusMetabolic syndrome | | | | |
ChiCTR-IPR-17013122: The effects and safety of topiramate or metformin on obesity induced by antipsychotics in patients with mental disorders: a randomized clinical trial |
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| Completed | 4 | 62 | | Topiramate ;Metformin | Huaian 3rd People's Hospital, Jiangsu Province; Huaian 3rd People's Hospital, The sources of funding were mainly from huaian city science and technology bureau and huaian 3rd people's hospital, Jiangsu Province | Obesity caused by antipsychotics | | | | |
ChiCTR1800019629: A clinical trial for the research of Tianshu capsule to prevent migraine attack by modulating gut microbiota |
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| Recruiting | 4 | 450 | | oral administration of Tianshu Capsule ;oral administration of topiramate ;oral administration of placebo | Neurology Department of Chinese PLA General Hospital; Chinese PLA General Hospital, Beijing Municipal Science Foundation | migraine | | | | |
STANDLOW, NCT03689114: Low vs. Standard Daily Doses of Antiepileptic Drugs in Newly Diagnosed, Previously Untreated Epilepsy |
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| Active, not recruiting | 4 | 374 | Europe | Low dose carbamazepine, low carbamazepine, Standard dose carbamazepine, Standard carbamazepine, Low dose levetiracetam, Low levetiracetam, Standard dose levetiracetam, Standard levetiracetam, Low dose valproate, Low valproate, Standard dose valproate, Standard valproate, Low dose zonisamide, Low zonisamide, Standard dose zonisamide, Standard zonisamide, Low dose oxcarbazepine, Low oxcarbazepine, Standard dose oxcarbazepine, Standard oxcarbazepine, Low dose topiramate, Low topiramate, Standard dose topiramate, Standard topiramate, Low dose lamotrigine, Low lamotrigine, Standard dose lamotrigine, Standard lamotrigine, Low dose gabapentin, Low gabapentin, Standard dose gabapentin, Standard gabapentin | Mario Negri Institute for Pharmacological Research, Azienda Ospedaliera San Gerardo di Monza, Ministry of Health, Italy | Epilepsies, Partial | 06/24 | 08/24 | | |
ChiCTR2200063095: Efficacy and safety of topiramate and flunarizine in the prevention of migraine |
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| Not yet recruiting | 4 | 128 | | Topiramate ;Flunarizine | Sichuan Panzhihua Central Hospital; Sichuan Panzhihua Central Hospital, No | migraine | | | | |
NCT05759845: Topiramate, Amitriptyline Monotherapy and Combination Therapy in Migraine Prophylaxis |
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| Enrolling by invitation | 4 | 150 | RoW | Topiramate 25Mg Tab, Amitriptyline 25 Mg Oral Tablet, topiramate 25mg plus amitriptyline 25mg | Dr. Reaz Mahmud | Migraine | 02/23 | 05/23 | | |
NCT05663749: Topiramate vs Metformin on Cardio-Metabolic Profile in Schizophrenia on Atypical Antipsychotics |
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| Completed | 4 | 60 | RoW | Metformin, Dibeta SR, Metgen, Glycomet, Topiramate, Topamax, Topirol, Topaz | All India Institute of Medical Sciences, Bhubaneswar | Metabolic Syndrome, Schizophrenia | 07/23 | 08/23 | | |
NCT04404439: Treatment of Tinnitus With Migraine Medications |
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| Recruiting | 4 | 150 | US | Nortriptyline + topiramate, Verapamil + paroxetine, Placebo | University of California, Irvine | Tinnitus, Subjective, Tinnitus | 12/23 | 12/23 | | |
NCT06089356: Zolmitriptane as Prophylaxis for Chilhood Migraine |
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| Recruiting | 4 | 90 | RoW | zolmitriptanee, zolmitriptane tablet, topiramate, topiramate tablet, Valproate, Valproate tablet | Tanta University | Migraine | 01/24 | 01/24 | | |
NCT05582837: Treatment of Meniere's Disease With Migraine Medications |
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| Recruiting | 4 | 100 | US | nortriptyline + topiramate, Pamelor, Topamax | University of California, Irvine | Ménière | 12/26 | 12/26 | | |
GENESIS, NCT04759196: Generating Evidence on NonEpileptic, Stereotypical and Intermittent Symptoms (NESIS) in Chronic Subdural Hematomas |
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| Recruiting | 4 | 56 | Canada | Topamax, Topiramate, TPM, Levetiracetam, LEV, Keppra | Université de Sherbrooke | Chronic Subdural Hematoma, Epilepsy; Seizure, Cortical Depression; Cortical Depolarization, Nonepileptic, Stereotypical and Intermittent Symptoms, NESIS | 09/24 | 12/24 | | |
PREMI, NCT06499116: Comparison of the Effectiveness of First-line Preventive Treatment of Migraine in Primary Care |
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| Not yet recruiting | 4 | 460 | NA | Topiramate, Acomicil, Flunarizine, Sibelium, Amitriptyline, Tryptizol, Propranolol, Sumial | Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina, Institut Català de la Salut, Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | Migraine | 12/26 | 12/26 | | |
ChiCTR2200061160: Study of topiramate on changes of body composition in migraine patients and rats |
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| Not yet recruiting | 4 | 120 | | topiramate ;Flunarizine hydrochloride | The Second Attached Hospital Of Fujian Medical University; The Second Attached Hospital Of Fujian Medical University, The Second Attached Hospital Of Fujian Medical University | migraine | | | | |
| Active, not recruiting | 4 | 82 | US | Cognitive Behavioral Therapy for Insomnia, CBT-I, Sleep Hygiene Education, SHE | VA Office of Research and Development, Coatesville Veterans Affairs Medical Center | Alcohol Use Disorder With Insomnia | 07/24 | 12/24 | | |
