| topiramate / Generic mfg. |
NCT00902473: Bioequivalence Study of Topiramate Tablets 25mg Under Fed Conditions |
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| Completed | N/A | 18 | Canada | Topiramate | Ranbaxy Laboratories Limited | Healthy | 09/01 | 10/01 | | |
NCT00901784: Bioequivalence Study of Topiramate Tablets 25mg Under Fasting Conditions |
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| Completed | N/A | 28 | Canada | Topiramate | Ranbaxy Laboratories Limited | Healthy | 09/01 | 10/01 | | |
NCT00304603: Mode of Action of Topiramate in the Treatment of Obese Patients With and Without Type 2 Diabetes Mellitus |
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| Completed | N/A | 1145 | US | No intervention | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Obesity, Diabetes Mellitus Type 2 | 04/05 | 04/05 | | |
NCT00297349: A Study of the Safety of Topiramate Given in Combination With Other Medications in Adults and Children With Seizures |
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| Completed | N/A | 153 | Europe | Topiramate | Janssen Cilag Pharmaceutica S.A.C.I., Greece | Seizures, Epilepsy | | 06/05 | | |
| Completed | N/A | 120 | US | dextromethorphan, topiramate, Donepezil | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Johns Hopkins University | Rett Syndrome | | | | |
NCT00065923: Treatment of Self-Injurious Behavior in Individuals With Prader-Willi Syndrome |
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| Completed | N/A | 10 | US | Topiramate | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Prader-Willi Syndrome, Self-Injurious Behavior | 12/05 | | | |
NCT00286923: Does Topiramate Adjust the Excitability of the Brain in Migraine Sufferers? |
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| Unknown status | N/A | 10 | US | Topiramate | Emerald City Headache Organization, Ortho-McNeil Neurologics, Inc. | Migraine, Chronic Headache | | 08/06 | | |
NCT00297336: An Observational Study Evaluating the Safety of Topiramate for the Prevention of Migraine |
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| Completed | N/A | 80 | Europe | Topiramate | Janssen Cilag Pharmaceutica S.A.C.I., Greece | Migraine Disorders | | 02/07 | | |
NCT00297323: An Observational Study of the Safety of Topiramate in Adults and Children With Epilepsy |
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| Completed | N/A | 80 | Europe | Topiramate | Janssen Cilag Pharmaceutica S.A.C.I., Greece | Seizures, Epileptic | | 02/07 | | |
| Completed | N/A | 209 | RoW | No intervention | Janssen-Cilag Ltd. | Migraine | 07/08 | 07/08 | | |
NCT00768677: Topiramate for Binge Eating Disorder Among Adolescents |
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| Completed | N/A | | US | topiramate | The Zucker Hillside Hospital | Eating Disorders, Bulimia Nervosa | | | | |
NCT01030094: A Cross-sectional Study to Investigate the Effect of Topiramate on Bone and Mineral Metabolism in Female Participants With Epilepsy |
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| Completed | N/A | 140 | RoW | Topiramate, Carbamazepine, Valproic acid, Normal control | Janssen Korea, Ltd., Korea | Seizures, Convulsions, Epilepsy, Osteopenia, Osteoporosis | 04/09 | 04/09 | | |
NCT01682681: An Observational Study to Evaluate Long-term Retention Rate of Topiramate in Participants With Epilepsy |
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| Completed | N/A | 1234 | RoW | Topiramate | Janssen Korea, Ltd., Korea | Epilepsy | 05/09 | 05/09 | | |
NCT00731900: Pharmacogenetic Study for Topiramate-Induced Cognitive Dysfunction |
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| Unknown status | N/A | 100 | RoW | | National Taiwan University Hospital | Cognitive Dysfunction | 12/09 | 12/09 | | |
NCT00794313: Quantification of the Antidyskinetic Effect of Amantadine and Topiramate in Parkinson's Disease |
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| Terminated | N/A | 3 | US | Amantadine 300 mg, Topiramate, Topamax, Sugar Pill | Oregon Health and Science University | Parkinson's Disease | 06/10 | 06/10 | | |
NCT01096420: Acupuncture in Chronic Migraine: A Randomized Controlled Trial |
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| Completed | N/A | 68 | RoW | acupuncture, topiramate | Kuang Tien General Hospital | Patients With Chronic Migraine | 08/10 | 08/10 | | |
NCT00777218: Cognitive Side Effects of Commonly Prescribed Medications in Pediatric Migraine |
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| Withdrawn | N/A | 0 | US | propranolol, Inderal, zonisamide, Zonegran, topiramate, Topamax | University of South Alabama | Migraine | 12/10 | 07/11 | | |
NCT01390909: Clinical and Economic Burden of Uncontrolled Epilepsy: Analyses From a Medicaid Database and a Private Health Plan Database |
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| Completed | N/A | 12386 | US | Anti-epileptic drug (AED), Mysoline® is a registered trademark of Valeant Pharmaceuticals, Neurotin® is registered trademark of Pfizer, Inc, Vimpat® is a registered trademark of UCB Pharma, Tegretol® is a registered trademark of Novartis Pharmaceuticals, Trileptal® is a registered trademark of Novartis Pharmaceuticals, Sabril® is a registered trademark of Lundbeck Inc, Felbatol® is a registered trademark of MedPointe, Topamax® is a registered trademark of Ortho-McNeill-Janssen Pharmaceuticals, Depakote® is a registered trademark of Abbott Laboratories, Zonegran® is a registered trademark of Dainippon Pharmaceutical C. Ltd., Gabatril® is a registered trademark of Cephalon, Keppra® is registered trademark of UCB Pharma, Zarontin® is a registered trademark of Pfizer, Lamictal® is a registered trademark of GlaxoSmithKline, Luminal® is a registered trademark of Abbott Laboratories, Dilantin® is a registered trademark of Pfizer, Lyrica is registered trademark of Pfizer | GlaxoSmithKline | Epilepsy | 01/11 | 01/11 | | |
NCT00396734: The Effects of Pharmacotherapy on Brain Mechanisms Underlying Cocaine Dependence. |
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| Suspended | N/A | 40 | RoW | Provigil (Modafinil), Topamax (Topiramate) | Hadassah Medical Organization | Opioid-Related Disorders, Cocaine-Related Disorders | 04/11 | 04/11 | | |
NCT00732108: Is Topiramate Effective in Treating Dizziness in Patient's With Migraine-Associated Dizziness |
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| Withdrawn | N/A | 0 | US | topiramate, Topamax, lactulose placebo pill, placebo pill | University of California, San Francisco, American Academy of Otolaryngology-Head and Neck Surgery Foundation | Migraine, Headache, Dizziness | 08/11 | | | |
NCT01384279: The Therapeutic Effects of Topiramate and Metformin on Second Generation Antipsychotics-induced Obesity |
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| Completed | N/A | 25 | RoW | metformin, topiramate | Beitou Armed Forces Hospital, Taipei, Taiwan | Obesity | 12/11 | 01/12 | | |
NCT00956696: Topiramate Treatment for Patients With Epilepsy and Learning Disability : A Prospective Observational Study |
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| Unknown status | N/A | 50 | RoW | topiramate, Topamax | Chinese University of Hong Kong | Epilepsy | 06/12 | 06/13 | | |
NCT01408641: Topiramate for Alcohol Use in Posttraumatic Stress Disorder |
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| Terminated | N/A | 4 | US | Topiramate, Topamax, Placebo | University of Maryland, Baltimore, US Department of Veterans Affairs | Alcohol Dependence, Alcoholism, Alcohol Abuse, Alcohol Use Disorder, PTSD, Posttraumatic Stress Disorder | 07/13 | 08/13 | | |
NCT01868204: Pharmacogenetic and Neurofunctional Brain Areas Study in Obese Patients With Binge Eating Disorder |
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| Unknown status | N/A | 60 | RoW | | Instituto Nacional de PsiquiatrÃa Dr. Ramón de la Fuente | Obesity, Binge Eating Disorder | 12/13 | 03/14 | | |
NCT01161017: Mechanism-based Choice of Therapy for Pain: Can Successful Prevention of Migraine be Coupled to a Psychophysical Pain Modulation Profile? |
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| Completed | N/A | 67 | RoW | Amitriptyline, Topiramate | Rambam Health Care Campus | Migraine | 05/14 | 05/14 | | |
NCT02098941: Evaluate Retention Rate of Topiramate, Levetiracetam and Oxcarbazepine in a Long-term Epilepsy Treatment |
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| Unknown status | N/A | 2500 | RoW | | Seoul National University Hospital, Janssen Korea, Ltd., Korea | Epilepsy | 09/14 | 12/14 | | |
NCT03125525: Clinical Experience With Transcutaneous Supraorbital Nerve Stimulation in Refractory Migraine |
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| Completed | N/A | 37 | NA | Cefaly device, transcutaneous supraorbital nerve stimulation with Cefaly | Corfu Headache Clinic | Migraine | 06/16 | 06/16 | | |
| Completed | N/A | 300 | NA | baclofen 2%, baclofen, Bupivacaine hydrochloride 1%, Bupivacaine hydrochloride, Cyclobenzaprine hydrochloride 2%, Cyclobenzaprine hydrochloride, Diclofenac Sodium 3%, Diclofenac Sodium, Flurbiprofen 10%, Flurbiprofen, Gabapentin 6%, Gabapentin, Ketamine 10%, Ketamine, Lidocaine 2%, Lidocaine, Prilocaine 2.5%, Prilocaine, Meloxicam 0.09%, Meloxicam, Sumatriptan 5%, Sumatriptan, Tizanidine 0.1%, Tizanidine, Topiramate 2.5%, Topiramate, Capsaicin, USP 0.0375%, Capsaicin, Menthol, NF 5.00 %, Menthol | Express Specialty Pharmacy | Arthritis, Tendonitis, Gout, Radiculopathy, Muscle Spasms, Synovitis, Migraine, Headache | 12/16 | 02/17 | | |
NCT02113787: Switchability Study Between Brand and Generic Topiramate |
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| Completed | N/A | 24 | RoW | Pharmacokinetic study | Seoul National University Hospital | Epilepsy | 03/17 | 05/17 | | |
ChiCTR-ONC-16008130: Different frequency of transcutaneous electrical nerve stimulation in migraine prophylactic treatment |
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| Not yet recruiting | N/A | 80 | | TENS 2Hz ;TENS100Hz ;TENS 2Hz/100Hz ;topiramate | Department of Neurology, Chinese PLA General Hospital; Chinese PLA General Hospital, self-financing | migraine | | | | |
| Withdrawn | N/A | 0 | NA | Relaxation Therapy, Topiramate, Standard of Care, Abortive Medication (Naproxen and Sumatriptan) | NYU Langone Health | Migraine | 10/17 | 10/17 | | |
NCT03354507: Use of Sodium Bicarbonate in Patients Treated With Topiramate |
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| Unknown status | N/A | 40 | Canada | Sodium bicarbonate | McMaster Children's Hospital | Epilepsy, Metabolic Acidosis, Tubular Acidosis; Renal | 12/18 | 12/18 | | |
NCT03767062: Peripheral Nerve Block and Topiramate in the Treatment of Medication Overuse Headaches |
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| Completed | N/A | 90 | RoW | Topamax, Greater Occipital Nerve Block + Supratrochlear Nerve Block | Ataturk University | Medication Overuse Headache, Chronic Migraine, Headache | 03/19 | 03/19 | | |
NCT03712917: Comparison of Therapeutic Effects of Greater Occipital Nerve Block, Topiramate, and Flunarizine on Episodic Migraine |
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| Completed | N/A | 120 | RoW | Greater Occipital Nerve Block, Topiramate, Flunarizine | Ataturk University | Migraine | 03/19 | 03/19 | | |
NCT04043702: Combination of Topiramate and Empagliflozin is Considered a Good Option for the Treatment of Obesity |
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| Completed | N/A | 200 | RoW | The intervention being studied, "empagliflozine", "jardiance®"), "topiramate", "conviban®" | Ministry of Health and Population, Egypt | Obesity | 07/19 | 07/19 | | |
NCT02169830: Trial of Nortriptyline and Topiramate in the Initial Treatment of Vestibular Migraine |
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| Terminated | N/A | 35 | US | nortriptyline, Nortriptyline HCI, Topiramate, Topamax, Diet Modification | St. Louis University | Migraine Disorders | 10/19 | 10/19 | | |
NCT04154813: Study on the Optimal Strategy of Chinese Patients With Bulimia Nervosa After Fluoxetine Treatment |
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| Recruiting | N/A | 550 | RoW | Topiramate, Fluoxetine, cognitive behavioral therapy (CBT), dialectical behavior therapy (DBT) | Shanghai Mental Health Center, Huadong Hospital, Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine | Fluoxetine | 11/21 | 11/22 | | |
NCT05516251: Transcutaneous Supraorbital Nerve Stimulator Versus Topiramate in Prevention of Recurrent Migraine |
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| Recruiting | N/A | 200 | RoW | Transcutaneous Supraorbital Nerve Stimulator, Topiramate 25Mg Tab | Tongji Hospital | Migraine, Classic | 04/23 | 09/23 | | |
| Recruiting | N/A | 80 | Europe | Ketamine, Perampanel, Any anti-epileptic and anesthetic therapy, excluding Ketamine and Perampanel, Levetiracetam, Valproate, Phenytoin, Lacosamide, Topiramate, Propofol, Midazolam, Thiopental | University of Milano Bicocca, Azienda Ospedaliera San Gerardo di Monza, Azienda Ospedaliero-Universitaria di Modena, Azienda Ospedaliera Universitaria Integrata Verona, Ospedale Centrale Bolzano, Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia, Azienda Ospedaliero-Universitaria Careggi, Azienda Ospedaliero-Universitaria di Parma, Santa Chiara Hospital, Ospedale M. Bufalini Cesena, Azienda Ospedaliera Brotzu, Istituto Di Ricerche Farmacologiche Mario Negri | Status Epilepticus, Cardiac Arrest | 06/24 | 09/24 | | |
NCT06322407: Ultrasound-guided Stellate Ganglion Block for Treatment of Chronic Migraine in Adult |
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| Not yet recruiting | N/A | 206 | RoW | Stellate Ganglion Block (SGB), Ultrasound-guided Stellate Ganglion Block (SGB), standardized drug treatment, topiramate plus ibuprofen | Beijing Tiantan Hospital | Chronic Migraine | 12/25 | 12/25 | | |
NCT02808533: Topiramate and Schizophrenia: Effects on Weight and Psychopathology |
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| Recruiting | N/A | 50 | Canada | Topiramate, Topamax, Placebo | Centre for Addiction and Mental Health, Ontario Ministry of Health and Long Term Care | Schizophrenia, Schizoaffective Disorder | 07/24 | 07/24 | | |
NCT03511118: Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants |
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| Recruiting | N/A | 1600 | Canada, US | Tranexamic acid (TXA), labetalol, metformin, nifedipine, clindamycin, oxycodone, azithromycin, escitalopram, sertraline, ondansetron, Ciprofloxacin, Doxycycline, Levofloxacin, Methylphenidate, Sumatriptan, Citalopram, Cyclobenzaprine, Furosemide, Gabapentin, Hydrochlorothiazide, Hydroxyurea, Rosuvastatin, Topiramate, Trazodone, Valganciclovir, Venlafaxine, Verapamil, Remdesivir, Anakinra, Tocilizumab, Fluvoxamine, Amoxicillin, Bupropion, Duloxetine, Hydrocodone, Levetiracetam, Paroxetine, Buprenorphine | Duke University, The Emmes Company, LLC, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Lactating Women on Select DOI, Breastfed Infants of Mothers on Select DOI | 09/24 | 09/24 | | |
TOLERASIT, NCT05209997: Observational, Real-life, Retrospective, Data Collection, Use Sibutramine/Topiramate in Overweight Comorbidities/Obesity |
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| Not yet recruiting | N/A | 1500 | RoW | Source document data collection | Eurofarma Laboratorios S.A. | Overweight, Obesity | 04/25 | 12/25 | | |
| Recruiting | N/A | 1000 | Europe | Valproic acid, carbamazepine, phenobarbital, phenytoin, levetiracetam, lamotrigine, topiramate, oxcarbazepine, stiripentol, clobazam, brivaracétam, felbamate, lacosamide, rufinamide, gabapentine, pregabaline, sultiame, tiagabine, vigabatrine, mesuximide, primidone, perampanel, ethosuximide, zonisamide, cannabidiol, genetic polymorphisms | Assistance Publique - Hôpitaux de Paris | Epilepsy | 06/26 | 06/26 | | |
| Recruiting | N/A | 10400 | | carbamazepine ;sodium valproate ;lamotrigine ;topiramate ;oxcarbazepine ;levetiracetam ;gabapentin ;phenytoin ;phenobarbital ;clonazepam ;The antiepileptic drug 1 which will obtain marketing authorization in China in the future ;The antiepileptic drug 2 which will obtain marketing authorization in China in the future ;The antiepileptic drug 3 which will obtain marketing authorization in China in the future | The Department of Neurology, the First Affiliated Hospital of Wenzhou Medical University; The First Affiliated Hospital of Wenzhou Medical University, Wenzhou Medical Association | epilepsy | | | | |
